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Hello and welcome back to season three of What Do Scientists Do?
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This is the show where we talk to expert guests and learn about what science they do, how
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they do it, and why they do it.
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My name is Mab and today I got to talk to Colin Vibert.
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Colin teaches us all about a field called biostatistics and how we can use math to make health care
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better.
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But what are statistics and how does Chat GPT help our computer programs?
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And what does all of this have to do with why writing skills matter?
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We're doing math after all.
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Well, we answer these questions and more.
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So let's jump in and find out.
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Hello and welcome back to What Do Scientists Do?
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This is a show where we talk to wickedly smart guests and learn all about what they do and
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what science has got to do with it.
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Today we're going to talk about a field called biostatistics.
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So biostatistics as a word might seem complicated, but we can actually break it down into smaller
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parts and we get to recognizable bits.
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So you probably recognize the word bio or the study of living things.
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And then we also have statistics.
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So statistics goes hand in hand with probability usually.
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And this is something you might have learned about in school.
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So statistics is all about collecting and looking at data about certain things.
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So if we put this whole word pizza together into a whole pizza again, we actually have
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the study of data and using data to figure out how living things work.
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So that's just kind of the Mab analysis, Mab synthesis of what this all means.
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So luckily we actually have an expert here to talk to us about what that actually means.
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So here's Colin.
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So hi Colin, thank you so much for joining us today.
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Do you want to introduce yourself with your name and pronouns?
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Yeah.
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My name is Colin Vibert and my pronouns are he, him and his.
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And what kind of scientist are you?
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I am a biostatistician.
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So I think your description was very accurate.
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And I work with in the life sciences, pharmaceutical industry, and also have done some work in other
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areas in healthcare.
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Yeah, so something that I kept kind of running into when I was looking at biostatistics
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was how much it has to do with healthcare.
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So what do you do in healthcare?
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What does a biostatistician do in healthcare?
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A biostatistician in healthcare will often be working either at a hospital or a pharmaceutical
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company or an agency and they will be helping for a disease area or for a medical product
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will be looking to understand the product better or understand the disease better.
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And we do that with numbers, essentially.
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Yeah, so numbers, we get all of this data, maybe hospitals are constantly collecting
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data about how many patients there are or maybe what kind of diseases or illnesses are
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bringing them into the hospital.
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And then you take all that data and you work it into knowledge or understanding?
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Yeah, exactly.
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So in Canada and in most countries, but in Canada, we have a lot of science that gets
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published and we also have agencies that require for pharmaceutical products output to be recommended
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and recorded.
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So when a product is being developed, we need to be very open and transparent about how
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well it works and what are the possible safety risks.
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And we use data for understanding that better.
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This all kind of feeds into the scientific method as well.
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So you maybe have a hypothesis, so you have a question and then you maybe have an experiment.
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And then after your experiment is done, you have all of this data or the results.
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And then from there, you just have raw numbers.
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So you need to know what to do with the actual numbers, right?
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Absolutely.
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Yeah, with statistics, having a plan and following through with the plan is very important.
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Yeah, exactly.
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You want to be able to have numbers that you can kind of work with.
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So do you specifically work with like collecting data about pharmaceuticals or do you work
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in a hospital?
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Yeah, so I work right now for a company that is doing work with pharmaceutical companies.
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And so we're focused on the performance of different pharmaceutical products and medical
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devices on how they perform for a specific disease.
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Okay, that's really cool.
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So if you're comparing treatments, for example, maybe if you're comparing different cancer
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treatments, if one treatment is more efficient than the other.
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Exactly.
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Awesome.
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So this might be kind of a tricky question here.
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But if you had to summarize what you do to like, if Colin had a billboard across Canada,
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what would you put on your billboard to summarize what you do?
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Well, that's a good question.
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I would put I would say planning.
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I plan a lot and I do computer coding a lot.
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And I am thinking and reading and doing research for understanding data methods and data analysis
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better.
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So when you talk about planning, what kind of things do you have to plan for?
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Yeah, so whenever you want to do just like you said with the scientific method, whenever
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you want to do a study before you do the study, you have to have a good understanding of what
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you want to do and what data you want to collect.
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That means you need to have a plan written out of what you're going to actually end up
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doing before you do it.
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And so what that means is, let's say you want to study how well a medical device is performing
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for a disease, you need to first specify, well, what are we going to measure when we
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say that we want to see if the device is performing well?
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What score do we use to measure that?
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So we would plan by thinking about what score is important, what scores are important, additional
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data, demographic data, so data about like the age of the patients, the race of the patients,
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the location, all of that is also important to figure out how we're going to characterize
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our population.
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Because with health studies, it's very important that you are collecting accurate populations
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that represent the patients and the disease correctly.
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If you don't, then the conclusions you arrive at will be biased.
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So you want to make sure that you're collecting enough data that represent what's actually
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going on.
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So one of the things about statistics, Colin, you could correct me if I'm wrong, but I'm,
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I don't do this for a living and it's been a while since I took a stats course.
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But one thing about stats is that stats aims to collect small representations, comparatively
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small representations about a wider population because it's just not possible to ask every
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single person every single question.
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So what statistics tries to do is ask a couple people, a diverse and representative group
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of people, a couple things to then get an idea or try to predict a larger population.
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So it sounds like in health sciences as well, you want to make sure that you're predicting
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accurately because these are people's health and wellness on the line.
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You want to make sure that you're doing a good job to represent everybody, which I think
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is really cool and something that I never really thought about, I guess.
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Yeah, that's, that's exactly right on.
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You want, you know, if you have, let's say, let's say the medical device could be given
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to 10,000 people in North America.
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You would, you would not really be able to go out and collect from all 10,000 people.
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So you use statistics to try to understand how this device performs with a much smaller
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sample, say 100.
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And I guess another thing that's kind of sticking out to me is that you work in health care.
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And at least when I was younger, I thought working in health care meant being a doctor
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or being a nurse.
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And it's cool to see, I mean, that your job is just one example of working in health care
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and the health care industry that has an impact on people's health and wellness without being,
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you know, a doctor or a nurse, but still being kind of health oriented.
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There's a lot of people working behind the scenes on health, which is something I think
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I always forget about and maybe other people do.
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Absolutely.
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I would say from my experience so far, I don't have experience working as a health care worker,
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as say a frontline health care worker, like a nurse, a doctor, a physician's assistant,
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but it is very important.
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I found and I believe this, that monitoring disease and monitoring the performance of
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the products that are used to treat disease are very, very frequently and continuously done
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so that you have a good understanding of how well the treatments are and how well and how
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much better you can be.
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I think that's really an important part of health care is that we're always thinking
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of developing better treatments to help patients more.
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And so that's what the research avenue brings.
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Whereas if you're a frontline worker, you're doing your very best to treat with the means
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you have available.
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So your job is kind of looking in the future and trying to come up with ways to make health
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care in the future better as well.
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Exactly.
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Yeah.
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Cool.
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So another question is you mentioned computer programming and I was just curious about how
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much your job is sitting in front of a database and doing the nitty gritty computer programming
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and like what computer programming and coding has to do with your job?
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Yeah, I would say so I as a biostatistician, I do a lot of work in the R programming language.
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There are also other languages like SAS and SPSS that can do computer programming to some
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extent, but R is a very popular one right now.
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And I would say probably 50 to 60 percent of my day is spent on a given day doing some
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coding in some form.
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But I am someone who is because I have a math and statistics background from university,
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I'm kind of known within my company as being someone who is a math and stats and coding
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person.
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So they go to me.
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Other biostatisticians are a little bit less number less coding focused and they can still
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do really, really great work and bring a lot to the table and contribute more on the planning
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and methods phase.
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But in terms of in terms of a division of what I do, I do probably 50 ish percent coding
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and then the other the other amount of what I do is done in terms of planning or writing.
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Report writing is also important.
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And I think this is something that sometimes people will think students will think.
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And I remember I thought this when I was in high school that, you know, there's there's
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an art stream and then there's a science stream.
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And you don't if you're you know, if you're artsy, you you you can write.
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And if you if you do science, you can't write.
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And that changes.
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You have to develop your writing skill.
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The further along in science you go, there's a lot of writing in science and it's it's
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a different kind of writing than creative writing.
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But but yeah, I'd say that's the other the other part of what I do for for work.
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But not to derail the coding part.
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A lot of a lot of what I do is is looking at our double checking in either books or
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online to make my code better.
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Or recently, I don't know if I should say this, Chat GPT is helpful to we're very at
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my company.
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We're very open with it.
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And in school, it's it's a little bit more of a controversial topic, but it's it's been
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it's been helpful there.
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But yeah, yeah, that's a good amount of coding, I'd say it's important.
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I love that you brought up writing and report writing because so often I know I didn't think
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I was like, OK, science will have like a science report here and there.
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But a lot of science is a lot of writing.
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And in the last couple episodes of this podcast, actually, we've talked a lot about how creative
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creativity and science kind of go hand in hand.
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So I think it's I don't know.
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Did you want to touch on that a little bit more about if creativity has anything to do
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with your day to day?
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Yeah, I'd say creativity is very important.
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Usually it's it's easy to just kind of think that with statistics that you just understand
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everything at some point and that there's nothing more to do and that and there's definitely
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a bit of a temptation to think that, oh, the computer once I have once I have enough computer
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code written, it'll just be automatic and I won't have to do anything.
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And there's conveniences that come with having good coding skills and things set up that
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you can repeat.
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But I think that part is what takes away from some of the creativity.
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And what's important in this field is always thinking of ways to solve problems.
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And you need creativity for that.
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So you need to be thinking of what what are some other ways that I could approach this
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problem and what are some other ways that I could analyze this data that would be valid
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and that would help to reduce the bias in the data and in the analysis?
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Because bias is always an issue in health research and it's always a very big concern
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because we need to be as unbiased as possible and as focused on getting the most representative
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sample that we can of our population.
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So I think for those for those major things, creativity is very important because it keeps
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you it keeps you active, it keeps you engaged, it keeps you reading and thinking about how
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you can solve problems.
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And I guess this might also come back to planning where you want to have a strong plan so that
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you can kind of problem solve before the problems turn into unsolvable problems or before your
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entire database is skewed or biased or anything like that.
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Exactly and I think I think it's planning and creativity can go hand in hand.
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You can plan for creative time.
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So you can you can set part of your day to be a time to do research and a time to think
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and a time to think about how to how to tackle the problem more.
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So it can really yeah it can go it doesn't it doesn't have to be one or the other.
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So it's kind of switch gears a little bit here.
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Do you have a favorite science or industry kind of thing that you've done before?
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I would say I really like the work that we do at my company right now is really interesting
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because we do we do something called indirect comparisons.
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And indirect comparisons are basically trying to compare two different studies that didn't
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didn't compare something within the studies.
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So it's taking data from one study taking data from another study and putting them together
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and doing it in the right way.
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And I find there's a lot there's a lot of nuance and there's a lot of interesting pitfalls
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that you can fall into if you are not careful.
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So it's it's it's it's something that you need to really be thinking about and be working
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as a team on.
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So I find I find that is is very rewarding when we get when we complete a project in
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in that area and are able to deliver something really helpful to our clients because they
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gain valuable information from from seeing the comparisons that we have to make that
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they wouldn't otherwise be able to see if they just read what's published.
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I think one of my favorite things coming from a research background was when I could actually
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connect the dots as well and have something here and have something here and finally make
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a connection and have it not confirmed because science is always like evolving.
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And that's a whole other discussion for a podcast that's much longer than 30 minutes
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about whether or not things can be confirmed for real.
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But having things like OK, because we did this, this happened.
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That was one of the coolest and most rewarding things.
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And it sounds like to be able to do that on such a large scale with different like health
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studies, I can see how that would be really rewarding and just really wicked and cool.
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Yeah, making making connections is really that's the best part.
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I really I enjoy it.
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It makes you feel like you have have some expertise in an area.
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And that's that's something that is very rewarding and it's very it's very helpful and clients
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appreciate it too when they when they know that you're a reliable expert.
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So kind of the last question here, this is kind of similar to the billboard question.
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What is one thing you think everyone should know about your topic?
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You will probably need to do statistics at some point, but you don't need to do too much.
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And and it's something that you can approach it, take some time, think about it and come
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back to it.
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You don't have to force it.
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And I think that's really something that that dissuades people from doing going down math
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and statistics in general, is they will run into a wall and get frustrated.
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And you will get frustrated, probably, and you will make mistakes, but just just give
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it some time.
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Take some time and and and see see what turns out and and and how important it is to talk
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to people and be social about the problems you're you're having and and how what they
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think would be a good solution.
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So yeah, I think patience and being being kind of talkative at a good team player.
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So important, and I think being a good team player is important for every job, but maybe
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sometimes not something you'd think about when you're thinking about really hard math.
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But I mean, it's important everywhere just to kind of wrap up.
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Is there any kind of question you'd like to go back to or anything else you'd kind of
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like to say or expand on?
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I guess if if statistics, if biostatistics doesn't sound too appealing to you, there's
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also just statistics in general, which is something that would be used across the board
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for any for any science.
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And there's a lot of overlap there.
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There's different levels of precision needed in different different areas of interest,
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but you can really add statistics and pair it to any other science industry and you'll
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be able to work with researchers and work with labs easier.
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100% if you're going into science or thinking about going into science, statistics are going
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to be there.
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So you might as well try to have a good relationship with statistics and try to make them your
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friend.
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Exactly.
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Well, thank you so much, Colin.
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I learned so much today.
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It was so to talk to you.
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Yeah, thanks.
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Thanks a lot for having me, Mab.
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It was it was great to be a part of this.
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A humongous thank you to Colin for joining us today on What Do Scientists Do?.
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I had a great time learning about biostatistics and as always a ginormous thank you to everybody
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listening out there.
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If you're commuting, if you're in the back of your parent and guardian's car, if you're
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biking home safely with a helmet on and obeying all traffic signals, I hope you're having
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a great time listening as well.
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For more science fun, you can find us on Twitter or Instagram at SuperNOVAatDal.
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Do you have a question that you'd like answered by one of our experts?
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Send us an email or a voice recording at whatdoscientistsdo@superstaff.ca and we might
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just answer your question on the phone.
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Show no phone.
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Thank you so much for listening and we will see you but not hear you next episode.
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Bye bye for now.
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This show was made by SuperNOVA at Dalhousie University, a network member of Actua.
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For more information on our workshops, summer camps, and more, visit supernova.dal.ca.