GLP-1 Split Dosing: This Is NOT Microdosing

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Is taking smaller GLP-1 doses multiple times per week actually "microdosing"? Not necessarily.

This episode separates split dosing from true dose reduction and explains the pharmacokinetic logic using semaglutide, tirzepatide, and retatrutide. John breaks down half-life, peaks, troughs, total exposure, and why changing the schedule does not automatically mean using less drug.

We also examine the major evidence gap: once-weekly dosing has a strong clinical foundation for semaglutide and tirzepatide, while retatrutide remains investigational — and direct randomized evidence showing routine split dosing is superior is not established.

Educational only. No individualized dosing protocols are provided.