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In this episode of The Feldman Protocol, how much does mitochondrial energy metabolism shape long-term health outcomes — and what does that mean for how we interpret cardiovascular, immune, and metabolic research? Dave sits down with Chris Masterjohn (PhD) to explore his mitochondrial testing company and what enzyme-complex patterns may reveal about individual nutritional needs, his longstanding model of LDL oxidation and plaque formation, the emerging pressure-based hypothesis in Crohn's disease research, concerns he raises about polyunsaturated fatty acids and long-term trial design, and the state of peer review and research transparency.
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⏱ Chapters
0:00 – Cold open & intro
1:13 – Chris introduces his mitochondrial testing work
3:36 – ATP, LDL receptors & cellular energy
8:32 – Idiosyncratic nutritional needs & CoQ10 case
14:06 – Exercise, longevity & gymnast data
22:18 – Biomechanics, T cell activation & cancer hypothesis
28:43 – Crohn's disease, pressure hypothesis & diet
38:29 – Paleo, Weston Price & dietary history
47:25 – Causal inference, language in research & peer review
58:28 – Dave's early lipid energy model presentation
1:01:33 – Chris's longstanding LDL oxidation model
1:09:04 – Transcytosis, innate immunity & plaque dynamics
1:30:07 – Monogenic FH, Bradford Hill & LDL debate
1:49:14 – The KETO-CTA study & plaque progression data
1:58:15 – Seed oils: history, trial design & oxidative liability
2:24:01 – Short vs. long-term trial evidence on seed oils
2:46:02 – Research incentives, NIH funding & open data
2:54:35 – Audience questions, diet & supplements
3:00:01 – Where to find Chris Masterjohn
#FeldmanProtocol #DaveFeldman #ChrisMasterjohn #Mitochondria #LDL #Cholesterol #SeedOils #Atherosclerosis #LipidHypothesis #CrohnsDisease #NutritionScience #PeerReview #MetabolicHealth #CardiovascularResearch #LipidEnergyModel #PUFA #VitaminE #ResearchTransparency #Longevity
