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If you've been following a low-histamine diet for months and still reacting, this episode is going to reframe everything.
Most histamine protocols treat this as a food supply problem. Avoid the aged cheese, take the DAO enzyme, cut the fermented foods. But for women whose symptoms track with their cycle, flare before their period, or seem to be getting worse despite all the right interventions, the food list is never going to be enough.
We go deep into the work of Dr. Ray Peat, biologist and physiologist, to make the case that histamine excess in women is fundamentally a hormonal and metabolic problem. Estrogen directly multiplies mast cells and activates them to release histamine. Progesterone stabilizes them. Thyroid function governs the entire hormonal environment. And a gut producing endotoxin feeds back into estrogen production in ways that keep the whole cycle running.
We cover:
- Why estrogen is the primary upstream driver of histamine excess in women
- The estrogen-histamine feedback loop and why it intensifies around your period
- What thyroid function has to do with histamine and why it's almost never addressed
- Why seed oils and low-carb approaches may be worsening the problem
- The gut-endotoxin-estrogen connection
- The heavy metal and liver piece that changed everything for me personally
- What Peat actually recommended, and what to bring to your provider
Resources
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Follow the host, Claudia, on Instagram, check out Elham's Castor Oil for the best organic castor oil in luxurious amber glass, and enjoy her deep-dives on Substack
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