# Stratum Corneum
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The stratum corneum (Latin for 'horned/horny layer') is the outermost layer of the epidermis of the tetrapod skin. In human skin, it consists of a stratified squamous epithelium made of 15 to 20 layers of corneocytes, flattened, terminally differentiated keratinocytes that have lost their nuclei or organelles. The filamentous keratin within the cytoplasm of these cells forms a semi-impermeable cuticle that protects underlying tissues from external insults such as dehydration, infection, direct chemical exposure and mechanical abrasion.
Do retinoids thin your skin? Mastering Retinoids: Dermal Remodelling vs. Stratum Corneum Thinning
I break down the histological reality of how retinoids affect the cellular matrix.While social media often warns that these ingredients "thin" the skin, the peer-reviewed evidence tells a different story of epidermal compaction and dermal thickening. In this episode, I specifically explore:
The Sc…
Addressing the Skin Microbiome with Topical Engineered Microbes with Francisco Salva Azitra TRANSCRIPT
Francisco Salva, President and CEO of Azitra, Inc., is leveraging the microbial bacteria that comprise the skin microbiome and exploring novel methods to deliver precision medicines to the skin. Azitra has genetically engineered specific strains of these microbes to produce proteins that are missi…
Addressing the Skin Microbiome with Topical Engineered Microbes with Francisco Salva Azitra
Francisco Salva, President and CEO of Azitra, Inc., is leveraging the microbial bacteria that comprise the skin microbiome and exploring novel methods to deliver precision medicines to the skin. Azitra has genetically engineered specific strains of these microbes to produce proteins that are missi…
794: Needle-Free Regenerative Medicine: Exosomes, Hair Growth, & The Science of Juvasonic with Dr. Sanjay Batra
In this episode of Beauty Bytes, I am exploring the frontier of needle-free regenerative medicine with Dr. Sanjay Batra, a globally recognized scientist and the creator of Juvasonic. We discuss how his device uses a unique combination of sonic vibration and dermabrasion to open the stratum corneu…
Dermatologist Guide: Retinoids, Skin Barrier Health, and Lessons from Asian Skin
Do retinoids thin the skin? No. In fact, they induce dermal remodeling that strengthens your skin’s foundation. But if you’re Asian, the answer to the retinoid burn is more nuanced than the standard pea-sized amount instruction.
📌 Why do retinoids irritate Asian skin more?
The Asian skin phenotype…
A Breakthrough in Exosome Skincare ft. Madhavi Gavini of Droplette
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In this special episode of Skin Anarchy, Dr. Ekta Yadav welcomes back Madhavi Gavini, founder of Droplette—one of the earliest science-forward brands featured on the show. What once felt like a radically different approach to skincare technology now feels increasingly relevant as t…
Episode 981: Electrical Burns
Contributor: Travis Barlock, MD
Educational Pearls:
Quick Statistics on Electrical Burns: Electrical burns compose roughly 2 to 9% of all burns that come into emergency departments.
The majority of patients who receive electrical burns are male, typically aged 20's to 30's, accounting for 80 t…
Ep. 32: The ‘Health’ Lies We’ve Been Sold with Paul Saladino, MD
This conversation with Dr. Paul Saladino is a call to investigate the why behind our habits, our headlines, and our health beliefs. In a world full of fear-based marketing—from sunscreens to snack bars—his perspective invites a more grounded perspective rooted in science.
Paul doesn’t just challen…
199. The Skin Barrier, Skin Health, and Skin Longevity with Olga Goldberger from IOKA Skin+Science
In this episode, we are joined by Olga Goldberger, founder of IOKA Skin + Science. Olga holds a Master’s degree in Molecular Biology, and she strived to create a skincare system that applied science to active botanical ingredients that would penetrate the skin and support skin health on the cellula…
Skin Anatomy & Absorption Explained: How Peptides Work in Skincare + Top Tips for Beginners (2026 Guide)
Don't Get Played By Marketing...
In this 20-minute masterclass, we break down skin anatomy (epidermis, dermis, hypodermis), how ingredients actually penetrate the barrier (intercellular, transcellular, transfollicular routes + 500 Dalton rule), and why peptides like Palmitoyl Tripeptide-1, Palmi…
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