LRRK2 Kinase Activity Regulates Parkinson's Disease-Relevant Lipids at the Lysosome
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.19.521070v1?rss=1
Authors: Maloney, M. T., Wang, X., Ghosh, R., Andrews, S. V., Maciuca, R., Masoud, S. T., Caprioli, R. M., Chen, J., Chiu, C.-L., Davis, S. S., Ho, A. C.-N., Nguyen, H. N., Propson, N. E., Reyzer, M. L., Davi ...
Paternal Presence: Alvaro de Vicente on "Being There"
In G. K. Chesterton's Orthodoxy, he tells a sort of parable in which children are given space to play on a mountain top surrounded by steep precipices on all sides. At first the children are left to play on the mountain top without any walls. Fearful of falling off one of the edges, they all hud ...
Teaching: A Professional Vocation
"The mind," Plutarch wrote, "is not a vessel that needs filling, but wood that needs igniting." The teacher's job, then, is not so much transferring data about the world from his mind to the students, but leading them to fall in love with the world that they see as good. The same is true for pre ...
On Grades: The Parents' Perspective
Be careful that in encouraging a grade, you don't shortchange growth; for a grade ought to be a means to growth, helping students—and their parents—see where they are so they can know where to go. Ideally, grades are the beginning of a conversation about what lies underneath the surface: the "wh ...
Dangerously Good: Forming Great Souls
Where to begin with the lofty, almost nebulous virtue of magnanimity—what St. Thomas Aquinas called "stretching forth of the soul to great things"? Of course we want to raise great-souled children, who even outstrip us in their vision of the good and their commitment to serving it. But words alo ...
Advice for the College Launch
"Picture yourself here."
"Become all you can be."
"This will be the best four years of your life."
The college pitch to high school seniors is alluring—though it doesn't sketch a very clear life plan for a young person entering higher education. As Heights Headmaster Alvaro de Vicente points ...
Alvaro de Vicente on Choosing a College—Or Not
As more families scrutinize their post-high school options for virtue and value, the field has perhaps never been wider. Choosing a path carefully, with the right balance of priorities, should be the goal for every high school graduate.
Before serving as our headmaster, Mr. Alvaro de Vicente wa ...
Alvaro de Vicente on Crafting and Sharing a School Vision
This year's Heights Forum Art of Teaching Boys Conference brought together motivated educators from across the country (and beyond) to discuss a new vision for boys' education. The overwhelming follow-up questions: How can I craft and communicate a new vision back at my school? How does a school ...
Alvaro de Vicente on Men for the World: On Every Man's Vocation
Admittedly, today's world is far from the Garden where the world began.
If we think of our vocations as "recovering the Garden," we may wonder whether it is best to go out into the world with a missionary spirit or retreat to morally safer spaces and protect the flame. Which has the better impa ...
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