Trascrizione completa di 129: Coffee, Caffeine & Your Body

about 400 milligrams per day as an amount that's not generally associated with negative side effects. 00:05:18.720 --> 00:05:28.160 And this is a population level benchmark, so this is not like a personal goal or guarantee for anyone. 00:05:28.560 --> 00:05:33.439 Yeah, like it you're not gonna like run out there and be like, oh, the FDA said that it's okay, so you should. 00:05:33.759 --> 00:05:34.000 Right. 00:05:34.160 --> 00:05:43.360 And so, like, if you're someone who may maybe feel jittery after they've had like 150 milligrams of caffeine, you don't need to work your way up to 400. 00:05:43.519 --> 00:05:43.839 Yeah. 00:05:44.160 --> 00:05:45.360 It's not gonna be good. 00:05:45.600 --> 00:05:51.199 Yeah, that's like that's what we mean by like population level and not not specific at all. 00:05:52.959 --> 00:06:03.199 And like we also might say that like 400 milligrams across the whole day isn't the same experience as a single large dose all at once. 00:06:03.439 --> 00:06:12.720 And I guess speaking of like the day, this kind of segues into our next part about like caffeine and the clock is our second arm that we're trying to go through. 00:06:12.959 --> 00:06:20.879 So, how like some people drink coffee earlier in the day, some people, like your dad, are able to like consider drinking it late at night and like technically be fine. 00:06:21.120 --> 00:06:23.279 What do we understand about that so far? 00:06:23.680 --> 00:06:29.600 So we do understand that caffeine can still be in your system after the obvious buzz has faded away. 00:06:29.839 --> 00:06:45.839 In a randomized crossover trial, a 100 milligram dose did not significantly disrupt sleep in that study when it was taken up to four hours before bed, while a 400 milligram dose affected sleep when it was taken within 12 hours. 00:06:46.240 --> 00:06:49.519 So much larger effect that crosses into bedtime. 00:06:49.759 --> 00:06:51.920 12 hours is kind of a long day. 00:06:52.000 --> 00:06:52.720 It's a whole day. 00:06:52.959 --> 00:06:57.040 And so this did not create a universal four-hour rule or 12-hour rule. 00:06:57.120 --> 00:07:02.800 It just shows that dose and timing do interact and a larger later dose. 00:07:03.199 --> 00:07:03.439 Yeah. 00:07:03.600 --> 00:07:09.600 So then when people like look at sleep, I think a lot of people tend to think about like sleep onset. 00:07:10.160 --> 00:07:14.959 But is that that it doesn't seem like that's all anyone should be considering. 00:07:15.360 --> 00:07:18.319 So in considering sleep, you should look at the full night. 00:07:18.399 --> 00:07:20.399 So how long did you sleep? 00:07:20.560 --> 00:07:23.199 How settled did you feel in your sleep? 00:07:23.360 --> 00:07:27.199 Did you wake at all or more often than usual? 00:07:27.439 --> 00:07:30.240 Because some of us do wake up in the middle of the night regularly. 00:07:30.639 --> 00:07:31.839 What were you doing at 3 a.m. 00:07:32.000 --> 00:07:32.800 the other night? 00:07:33.279 --> 00:07:34.560 Last night I wasn't doing anything. 00:07:34.720 --> 00:07:35.600 Oh, great. 00:07:35.839 --> 00:07:36.720 Well, we'll talk about it. 00:07:36.959 --> 00:07:37.279 Fell asleep. 00:07:37.439 --> 00:07:38.800 We'll talk about our morning later, guys. 00:07:40.879 --> 00:07:44.000 Um, and how you function the next day. 00:07:44.480 --> 00:07:46.319 And that's not the same for everyone, right? 00:07:46.480 --> 00:07:48.399 Like sleep like at night. 00:07:48.560 --> 00:07:50.319 Like some people do sleep during the day. 00:07:50.480 --> 00:07:58.480 It's like for a shift worker, that like a coffee after lunch really doesn't mean a whole lot because it's like not the same time at all. 00:07:58.720 --> 00:08:02.720 Um, the the relevant clock is time before a planned sleep. 00:08:02.959 --> 00:08:12.480 So if you want to test the timing, you keep the drink about the same, and you could move it earlier for several days and just change one variable so the result is you can interpret the result. 00:08:12.560 --> 00:08:14.319 That's like a little soft science that we're doing here. 00:08:14.399 --> 00:08:15.279 That's all we're really doing. 00:08:15.360 --> 00:08:18.639 We're doing little experiments all the time when we make these changes. 00:08:19.279 --> 00:08:26.079 The the 400 milligram study in that sleep study was a single large dose, and it was wasn't an instruction. 00:08:26.319 --> 00:08:33.120 Some results describe averages, and a small trial really can't give every listener a personal cutoff by any means. 00:08:33.279 --> 00:08:36.399 So essentially the practical conclusion is much narrower. 00:08:36.720 --> 00:08:46.000 Note the approximate dose, place it on your own sleep clock, and use your own response to refine your plan if you're using caffeine in a specific way. 00:08:46.879 --> 00:08:49.039 So now we're gonna talk a little bit more about the person. 00:08:49.120 --> 00:08:55.279 We're gonna explore some metabolism, sensitivity to caffeine, and tolerance buildup that people have. 00:08:55.679 --> 00:09:01.519 So caffeine is cleared mainly through liver enzymes, and the pace varies person to person. 00:09:01.759 --> 00:09:07.279 Genetics can play a role, but so can pregnancy, smoking status, liver health, and certain medicines. 00:09:07.840 --> 00:09:11.600 You literally don't need a genetic test to make a practical decision on this. 00:09:11.759 --> 00:09:18.720 You need to notice that another person's coffee schedule is reliably not necessarily a prescription for yours. 00:09:19.039 --> 00:09:21.919 If you've got a friend who's like, I mean, we even do this too. 00:09:22.000 --> 00:09:32.159 Like, I'm routinely having like two cups of coffee and bringing some to work and buying some from Acme and like drinking it all day. 00:09:32.799 --> 00:09:34.159 You drink coffee all day? 00:09:34.480 --> 00:09:41.360 Yeah, probably for different reasons that of course if anyone who listens to this podcast could

diagnose themselves, your stimulant. 00:09:41.600 --> 00:09:42.080 Yeah. 00:09:42.720 --> 00:09:45.519 You have like a cup of coffee in the morning. 00:09:46.559 --> 00:09:47.200 Hi, Papa. 00:09:49.200 --> 00:09:49.840 My little buddy. 00:09:50.159 --> 00:09:57.759 And that's like kind of what you do, but I think you're also very intentional because like your you tend to be very sensitive during the day to coffee and your sleep at night. 00:09:58.080 --> 00:10:00.320 I can be drinking it at 3 p.m. 00:10:00.559 --> 00:10:01.840 and it doesn't matter. 00:10:02.159 --> 00:10:04.639 So that's because you have ADHD. 00:10:05.360 --> 00:10:06.000 Maybe. 00:10:06.240 --> 00:10:11.279 Um so but never can't can't have what you haven't diagnosed. 00:10:11.440 --> 00:10:14.480 So um it's also hard to get a stimulant around here. 00:10:16.639 --> 00:10:20.399 So, you know, what we're saying here is that well, we can get back to it. 00:10:20.480 --> 00:10:23.440 So let me talk about clearance and sensitivity. 00:10:23.600 --> 00:10:25.519 They tend to be related but not identical. 00:10:25.679 --> 00:10:33.519 I'm talking about like how fast someone gets rid of caffeine from their body and when someone then when someone takes a dose, how much does that affect them? 00:10:33.759 --> 00:10:40.399 So, for example, like we did here, two people can have a similar amount of coffee in the body and experience it differently. 00:10:40.639 --> 00:10:46.799 And the fact that the buzz disappeared does not necessarily mean that the caffeine has disappeared either. 00:10:47.120 --> 00:10:55.360 So that's one reason that someone can say, coffee never keeps me awake, while still learning something when they move the last dose earlier in the day. 00:10:55.440 --> 00:11:02.080 Like they may feel a little bit something different if they moved it earlier in the day, even if they feel like they didn't, if they weren't kept awake. 00:11:02.240 --> 00:11:08.639 So then with repeated use, people can develop tolerance to some of caffeine's more noticeable effects. 00:11:08.879 --> 00:11:16.559 Regular users can develop withdrawal symptoms, and these commonly look like a headache, fatigue, sleepiness, or trouble concentrating. 00:11:16.720 --> 00:11:19.200 Oops, and when they suddenly stop. 00:11:19.840 --> 00:11:25.600 So part of the lift from the first coffee of the day may be relief of an overnight withdrawal. 00:11:25.919 --> 00:11:30.639 It would be too strong, though, to say that caffeine only reverses withdrawal. 00:11:30.879 --> 00:11:39.840 Studies don't necessarily re report that or support that as a universal explanation for why someone feels better in the morning after drinking coffee. 00:11:40.320 --> 00:11:48.720 But it is one reason to separate that, like I feel better after coffee from coffee is correcting an underlying deficiency that I have. 00:11:49.919 --> 00:11:56.480 And all of this to say, none of this makes regular coffee use a character flaw or necessarily a problem. 00:11:56.720 --> 00:12:02.080 It simply changes how you might cut back if you're looking to lessen your coffee use. 00:12:02.320 --> 00:12:06.480 A gradual reduction is usually more comfortable than stopping abruptly. 00:12:06.720 --> 00:12:12.480 A smaller serving, maybe, half calf, or moving one drink to decaf. 00:12:13.039 --> 00:12:16.559 The general benchmark also does not overrule symptoms. 00:12:16.799 --> 00:12:30.639 People who have jitters, anxiety, or disrupted sleep, palpitations, or stomach symptoms are all reasons to consider or reconsider the amount or timing of when drinking coffee works well for you. 00:12:30.960 --> 00:12:42.080 Nikki, what do um the pregnancy overlords ACOG say about the American College of Obstetrics and Gynecology say about caffeine in pregnancy? 00:12:42.639 --> 00:12:46.000 The pregnancy overlords are telling us to stay. 00:12:46.720 --> 00:12:58.799 I don't mean us as in like me included because she's not pregnant, um, are telling the royal us that staying below 200 milligrams per day during pregnancy is probably the advised number. 00:12:59.120 --> 00:13:00.480 That was awesome. 00:13:00.720 --> 00:13:04.799 There and there are other medical conditions and medicines that can also change that plan. 00:13:04.960 --> 00:13:12.639 So any any clinician or pharmacist can specifically help, but I do tend to notice that like sometimes people are just like drinking too much caffeine. 00:13:12.799 --> 00:13:21.360 Like there is one guy who he was just like he was young, he was like, Yeah, I'm doing zins and three energy drinks and coffee in the morning. 00:13:21.440 --> 00:13:23.919 And he's like, I feel like I'm like floating outside of my body. 00:13:24.000 --> 00:13:26.000 And I was like, Yeah, no kidding, brother. 00:13:26.320 --> 00:13:29.200 That's absolutely I think I know why. 00:13:30.639 --> 00:13:33.600 So, Nikki, can you help us understand? 00:13:33.679 --> 00:13:35.679 Like, there is some science. 00:13:35.840 --> 00:13:39.519 People have done some research on coffee, actually, lots. 00:13:39.759 --> 00:13:41.200 It goes back and forth. 00:13:41.440 --> 00:13:47.279 Um, can you tell us what coffee research can and cannot tell us? 00:13:48.399 --> 00:13:50.320 What was that coffee we had in Bali? 00:13:52.559 --> 00:13:53.600 Cat Poo Gino? 00:13:53.919 --> 00:13:54.720 Oh, what was there? 00:13:54.799 --> 00:13:56.720 Is it it was a specific cat. 00:13:57.679 --> 00:14:02.159 Oh, the um do you think they researched that? 00:14:02.960 --> 00:14:03.759 The luwak. 00:14:04.000 --> 00:14:05.039 Oh yeah, the luok. 00:14:07.360 --> 00:14:20.159 There have been long-term studies linked to moderate coffee consumption with a lower risk of several health outcomes, including some liver disease, type 2 diabetes, and all-cause mortality. 00:14:20.559 --> 00:14:27.200 This can be reassuring to people who enjoy coffee, but most of these findings are observational. 00:14:27.600 --> 00:14:35.360 Um, researchers

compare people with different habits, so they are not assigning people to either drink coffee or avoid it for decades. 00:14:35.840 --> 00:14:42.240 And coffee drinkers and non-drinkers can differ in can differ in many other ways. 00:14:43.440 --> 00:14:43.679 Yeah. 00:14:43.840 --> 00:14:47.759 So like an association isn't necessarily a prescription. 00:14:47.919 --> 00:14:53.840 Um we're not going around here saying like tell a non-coffee drinker to start for disease prevention by any means. 00:14:54.080 --> 00:15:00.000 And nor are we saying that we tell a coffee drinker that, well, if you drink more, it must be better. 00:15:00.240 --> 00:15:03.360 Some studies also find associations with decaf too. 00:15:03.440 --> 00:15:08.720 So it's another reason not to reduce every long-term finding to like it's the caffeine itself. 00:15:09.279 --> 00:15:13.919 It still does not prove the responsible compound or prove cause and effect. 00:15:14.080 --> 00:15:23.039 We've talked about research and we've talked about if you have followed along with the show, you know, that observational research is a nice thing, but it can only tell us so much. 00:15:25.360 --> 00:15:27.919 So, what can we really take away from this, Nikki? 00:15:28.480 --> 00:15:33.200 So the most useful takeaway is personal and practical. 00:15:33.360 --> 00:15:35.279 You have to ask yourself a couple questions. 00:15:35.519 --> 00:15:39.919 So, asking, what am I actually drinking and how much caffeine is in it? 00:15:40.240 --> 00:15:44.080 When am I drinking it relative to my planned sleep? 00:15:44.320 --> 00:15:46.480 Um, what job is it serving? 00:15:46.639 --> 00:15:50.480 So, is it just something you like to do in the morning? 00:15:50.879 --> 00:15:55.440 Um, because it's like a cozy warm drink in the morning. 00:15:55.679 --> 00:15:59.279 Is it for alertness by habit or a relief of withdrawal? 00:15:59.360 --> 00:16:01.039 And then what's happening after you drink it? 00:16:01.200 --> 00:16:02.559 So are you focusing better? 00:16:03.759 --> 00:16:14.080 Like someone here, um, or are you jittery, having palpitations, reflux, um, having like a shorter night's sleep? 00:16:14.720 --> 00:16:20.799 And then, of course, if there's like pregnancy medication, any other health things in there. 00:16:22.159 --> 00:16:31.120 And so at the end of the day, that kind of brings us back to the three questions or the three items we're trying to cover here: dose, clock, and person. 00:16:31.919 --> 00:16:37.919 If you enjoy coffee and you tolerate it and it works for you in your life, you don't need to feel guilty about it. 00:16:38.080 --> 00:16:43.759 And if you don't drink it, the research that we shared here isn't necessarily a reason to start. 00:16:44.000 --> 00:16:53.039 And if caffeine is costing you sleep or causing you symptoms, that might be some useful information, but it's not a failure of willpower by any means. 00:16:53.440 --> 00:17:01.200 So this week maybe you can take a look

at a coffee that you drink often, um, find the approximate caffeine amount. 00:17:01.360 --> 00:17:02.720 Ollie agrees. 00:17:03.919 --> 00:17:08.079 Um, place it on your sleep clock and see what you notice. 00:17:08.319 --> 00:17:15.039 And you may learn that nothing needs to change, or maybe your whole entire routine needs to change. 00:17:15.680 --> 00:17:16.319 Yeah. 00:17:16.880 --> 00:17:17.279 All right. 00:17:17.359 --> 00:17:22.000 So we can um thank you for hopefully you learned something about coffee here. 00:17:22.160 --> 00:17:23.519 We're gonna banterize here. 00:17:23.599 --> 00:17:29.519 I feel like you brought up a bali and the luwak coffee quite a bit that um we still haven't used that. 00:17:29.599 --> 00:17:32.720 I we have oodles now, and I think we're just gonna keep it at this point. 00:17:33.039 --> 00:17:35.279 Um, my hope is that it's good for a year. 00:17:35.680 --> 00:17:38.079 Because we're zooming up on that soon. 00:17:39.039 --> 00:17:43.279 Um that oh buddy. 00:17:43.519 --> 00:17:46.400 So that coffee was so interesting. 00:17:46.559 --> 00:17:56.559 Um, for those who don't know, do you would you like to think there's a dog outside who's communicating with him? 00:17:59.279 --> 00:18:01.039 It's another piranha. 00:18:01.359 --> 00:18:02.720 So they took this coffee. 00:18:02.799 --> 00:18:06.160 They um there were farmers, there were coffee bean farmers in Bali. 00:18:06.400 --> 00:18:07.519 I think we talked about this before. 00:18:07.680 --> 00:18:08.559 Oh, did we already? 00:18:08.720 --> 00:18:10.079 Yeah, like after we got back from Bali. 00:18:10.240 --> 00:18:11.680 Oh my gosh, we probably did. 00:18:12.480 --> 00:18:15.039 The loyal listeners will know we don't need to talk about it again. 00:18:15.279 --> 00:18:15.680 That's fair. 00:18:15.759 --> 00:18:17.119 All right, so there's cat poop coffee. 00:18:17.200 --> 00:18:18.319 They basically digest the beans. 00:18:18.559 --> 00:18:19.039 Go Google it. 00:18:19.200 --> 00:18:21.279 You can go Google, it's called luac coffee. 00:18:21.519 --> 00:18:23.279 Um, what's new and different? 00:18:23.519 --> 00:18:25.680 So we went to a new restaurant. 00:18:25.920 --> 00:18:27.359 Oh my gosh, we did. 00:18:27.519 --> 00:18:28.799 We need to talk about the waitress. 00:18:31.519 --> 00:18:32.000 Go ahead. 00:18:32.079 --> 00:18:33.279 What's your perspective? 00:18:33.359 --> 00:18:35.039 Uh share your perspective about the waitress. 00:18:35.359 --> 00:18:38.319 Well, we went to Dear Daphne and Britain House. 00:18:38.400 --> 00:18:45.920 It was like a Mediterranean slash like Middle Eastern-ish flair. 00:18:46.799 --> 00:18:50.079 Yeah, because I don't think that Afghanistan is in the Mediterranean. 00:18:50.240 --> 00:18:50.480 Yeah. 00:18:50.640 --> 00:18:54.880 I might feel I might seem unlearned at this point, but it was really good. 00:18:55.599 --> 00:18:56.240 It was good. 00:18:56.559 --> 00:18:58.319 Nothing beats like Soraya. 00:18:58.880 --> 00:19:00.079 But yeah, it's a tough one. 00:19:00.160 --> 00:19:03.039 I'm not, I wouldn't be like dying to go back there, but it was good. 00:19:03.359 --> 00:19:04.160 I'm glad we tried it. 00:19:04.319 --> 00:19:04.480 Yeah. 00:19:04.559 --> 00:19:05.359 I'm glad we went. 00:19:05.519 --> 00:19:06.480 It was really cute in there too. 00:19:06.720 --> 00:19:08.079 My little mocktail was cute. 00:19:08.319 --> 00:19:08.799 Yeah. 00:19:09.039 --> 00:19:13.680 Um, so then the waitress who was like, fine. 00:19:17.839 --> 00:19:22.720 She's like talking up Eddie, and then she's like, Oh, can I get you another drink love? 00:19:23.440 --> 00:19:23.839 Yeah. 00:19:24.079 --> 00:19:25.200 And then Eddie looks at me. 00:19:25.359 --> 00:19:26.000 I was like, oh. 00:19:26.240 --> 00:19:27.599 And I'm like, well, I gotta go. 00:19:27.839 --> 00:19:31.519 The rest of my night is booked and busy because I have to plan a murder now. 00:19:33.519 --> 00:19:37.680 But then she like called me love, and I was like, oh, this is just like who she is. 00:19:37.920 --> 00:19:39.680 This is the gender-neutral trope. 00:19:40.160 --> 00:19:40.799 Yeah. 00:19:41.440 --> 00:19:42.480 I was scared. 00:19:43.200 --> 00:19:43.920 It was so funny. 00:19:44.000 --> 00:19:57.039 Like, there's like women or like, I guess men too, who are like, oh, if my like husband or wife or like if I die, I would want my husband or wife to, you know, find someone in love again, not me. 00:19:58.000 --> 00:20:00.319 I'll rise from the dead and come haunt you. 00:20:00.559 --> 00:20:02.000 That was the real use in me. 00:20:03.200 --> 00:20:04.400 That was so funny. 00:20:04.640 --> 00:20:14.000 There was one that like I saw that I was like watching it and I was like, and I don't I don't watch reels that often, people, but when I was watching, I was like, that's so funny. 00:20:14.160 --> 00:20:16.000 That's definitely something Nikki would do. 00:20:16.160 --> 00:20:17.759 And you had reposted it. 00:20:18.000 --> 00:20:18.240 Yeah. 00:20:18.480 --> 00:20:28.079 If my like ghost is watching some girl touch your arm at my funeral, I'm I'm getting standing straight up out of that casket. 00:20:28.319 --> 00:20:32.240 It's like I'm here if you ever need me. 00:20:32.480 --> 00:20:32.799 Yeah. 00:20:33.039 --> 00:20:33.839 That was the thing. 00:20:34.160 --> 00:20:34.960 So funny. 00:20:35.279 --> 00:20:37.759 But she ain't going anywhere anytime soon, folks. 00:20:38.000 --> 00:20:38.720 Nope. 00:20:39.039 --> 00:20:40.240 The um I liked it. 00:20:40.319 --> 00:20:40.960 It was good. 00:20:41.119 --> 00:20:45.599 Uh we were big Himachi people, seemingly, because we enjoyed it in San Diego. 00:20:46.079 --> 00:20:46.960 Hamachi crudo. 00:20:47.680 --> 00:20:48.799 We enjoyed it here. 00:20:49.039 --> 00:20:49.759 It was so good. 00:20:49.839 --> 00:20:51.519 Well, is the crudo the sauce? 00:20:51.599 --> 00:20:58.640 The is that was like a now that I've tried it, because we got to do a fun

thing today that we'll talk about, but we tried chimchuri again. 00:20:59.039 --> 00:21:01.519 And I think now I have a or chutney. 00:21:02.000 --> 00:21:02.400 Wait. 00:21:02.559 --> 00:21:02.880 Uh-oh. 00:21:03.119 --> 00:21:04.480 Today at Dan and Mo's? 00:21:04.640 --> 00:21:05.279 Yeah. 00:21:07.359 --> 00:21:07.920 Uh-oh. 00:21:08.799 --> 00:21:10.079 I know it wasn't chutney. 00:21:10.400 --> 00:21:11.039 Chimchuri. 00:21:11.279 --> 00:21:11.839 Yeah. 00:21:12.400 --> 00:21:14.240 I'm like 85% sure. 00:21:14.720 --> 00:21:15.440 I don't know, but it was good. 00:21:15.920 --> 00:21:16.559 I'll take 85. 00:21:16.640 --> 00:21:17.599 It was delicious green. 00:21:17.839 --> 00:21:18.160 Yeah. 00:21:18.400 --> 00:21:19.440 So we did that. 00:21:19.599 --> 00:21:22.480 And I think that's what the the himachi was in. 00:21:22.960 --> 00:21:24.240 That some chives. 00:21:24.480 --> 00:21:24.640 Yeah. 00:21:24.799 --> 00:21:27.839 So I'm like, oh my, like that flavor profile was similar. 00:21:28.160 --> 00:21:29.119 Delicious. 00:21:29.359 --> 00:21:32.799 And then of course the like pita breads with all the dips. 00:21:32.960 --> 00:21:34.559 There were like I I thought there were nine. 00:21:34.640 --> 00:21:36.000 I think there were actually like 12. 00:21:36.160 --> 00:21:36.559 Yeah. 00:21:36.799 --> 00:21:37.519 A lot of dip. 00:21:37.680 --> 00:21:38.720 That hummus was really good. 00:21:38.880 --> 00:21:39.759 It's great hummus. 00:21:40.079 --> 00:21:45.440 And whatever that like Afghan one was, I have no idea what it was, but it was good. 00:21:45.680 --> 00:21:46.880 Yeah, that was delicious. 00:21:46.960 --> 00:21:48.160 I liked the beet one. 00:21:48.319 --> 00:21:53.279 And then there was one, it's a flavor, because we had it in Bali and it it tasted like it. 00:21:53.440 --> 00:21:56.000 And like I dipped in there and I was like, oh my god, I'm back there. 00:21:56.160 --> 00:21:56.480 Yeah. 00:21:56.880 --> 00:21:58.079 Which was so fun. 00:21:59.039 --> 00:21:59.759 Go if you can. 00:22:00.160 --> 00:22:01.200 Can guys, it was great. 00:22:01.519 --> 00:22:02.480 Yeah, it was good. 00:22:06.880 --> 00:22:09.119 Um, and then you enjoyed your mocktail. 00:22:09.200 --> 00:22:10.160 I should have gone with that one. 00:22:10.319 --> 00:22:12.559 I should have gone with the gin one. 00:22:12.720 --> 00:22:13.839 Yeah, that would have been good. 00:22:14.079 --> 00:22:19.519 I I don't know what I was thinking getting uh an espresso martini but at the beginning of a meal. 00:22:20.480 --> 00:22:22.160 That was yeah, it's like an after dinner drink. 00:22:22.400 --> 00:22:23.119 It's an after dinner drink. 00:22:23.200 --> 00:22:24.000 She sold me on it though. 00:22:24.079 --> 00:22:28.160 She was like, it's one of the best in the city, and like I don't know. 00:22:29.279 --> 00:22:30.319 Did you like her? 00:22:31.119 --> 00:22:32.480 Is that why you listened to her? 00:22:33.200 --> 00:22:34.079 No, no. 00:22:34.559 --> 00:22:36.880 I not that no shit. 00:22:37.119 --> 00:22:38.640 Actually, I I abstained. 00:22:38.799 --> 00:22:43.359 I played the fifth uh on this this this medium here. 00:22:43.599 --> 00:22:50.160 Um so that was great, and we kind of like oh gosh, we were supposed to go for ice cream last night. 00:22:51.039 --> 00:22:52.000 Oh my god. 00:22:52.319 --> 00:22:56.079 Oh yeah, because we were like in a walk back and we were getting ice cream, we were kind of full. 00:22:56.319 --> 00:22:56.640 Yeah. 00:22:56.799 --> 00:23:06.799 Oh, but the um merguez, the lamb merguez, it came in a skewer, which didn't not need to come in a skewer, but it was just like maybe like inch thick tube of lamb meat. 00:23:06.960 --> 00:23:11.599 Yeah, it was a kebab that would resemble a sausage, but it was a kebab. 00:23:12.079 --> 00:23:22.880 And you just kind of like we cut it because that's how we went about it, and I I couldn't see me like managing a kebab that like weighed a pound, basically. 00:23:23.119 --> 00:23:23.680 Yeah, it was big. 00:23:23.920 --> 00:23:24.799 That was really tasty. 00:23:25.119 --> 00:23:26.079 And then we got this other thing. 00:23:26.160 --> 00:23:29.759 It reminded it was like a fried cheese square. 00:23:30.400 --> 00:23:32.799 Yeah, and it had like honey and pistachios on it. 00:23:33.200 --> 00:23:35.119 It resembled baked brie, but it was more savory. 00:23:37.039 --> 00:23:41.359 Oh, it was Halloumi or whatever No, it wasn't that one. 00:23:41.920 --> 00:23:42.319 I don't know. 00:23:42.559 --> 00:23:43.119 But it was good. 00:23:43.359 --> 00:23:44.160 Yeah, it was tasty. 00:23:45.119 --> 00:23:45.839 That was good. 00:23:46.000 --> 00:23:51.839 And then should we um you have any other thoughts about the new restaurant that we tried? 00:23:52.559 --> 00:23:53.200 Restaurant. 00:23:53.599 --> 00:23:56.480 What about the uh gosh, the scary? 00:23:56.960 --> 00:24:00.720 Are you up to explaining what happened this morning or are you gonna save that? 00:24:02.079 --> 00:24:03.119 Oh yeah. 00:24:03.519 --> 00:24:08.160 Because I feel like it's a it's like ripe with imagery for you to describe. 00:24:08.559 --> 00:24:10.079 It was quite the morning. 00:24:12.079 --> 00:24:16.720 Basically, I was getting a bone out of Ollie's mouth on our walk this morning. 00:24:17.039 --> 00:24:17.839 You set the scene. 00:24:17.920 --> 00:24:18.319 It's dark. 00:24:18.720 --> 00:24:19.680 It's dark, it's raining. 00:24:20.640 --> 00:24:22.400 This is like 6 45 this morning. 00:24:22.640 --> 00:24:23.920 So the sun's not up yet, really. 00:24:24.079 --> 00:24:26.559 Yeah, it's dark and darker because it's raining. 00:24:26.640 --> 00:24:30.240 I'm like, all right, Ollie, let's just like go out and pay because I don't know when it's gonna stop raining. 00:24:30.319 --> 00:24:30.799 Like, whatever. 00:24:30.880 --> 00:24:33.680 We'll do a quick little like half-block loop. 00:24:34.160 --> 00:24:40.480 So he finds a bone, he I like hear it crunch,

and I'm like, oh God, it's like in pieces in his mouth. 00:24:40.559 --> 00:24:43.279 So I get the one piece out, he bites my finger. 00:24:43.440 --> 00:24:47.599 Okay, and then I go back in and he bites and like punctures my nail. 00:24:48.079 --> 00:24:48.880 And it hurt. 00:24:49.039 --> 00:24:51.920 Like, I like the base where it's like your nail meets like your cuticle. 00:24:52.160 --> 00:24:52.880 Uh huh. 00:24:53.279 --> 00:24:54.400 It hurts so bad. 00:24:54.480 --> 00:24:57.680 And I'm like, oh my god, my hand is just like pouring blood. 00:24:57.759 --> 00:24:58.319 It's raining. 00:24:58.400 --> 00:24:59.119 I'm like, oh my God. 00:24:59.200 --> 00:25:00.799 All right, like let's go back inside. 00:25:00.960 --> 00:25:01.920 So we come back in. 00:25:02.079 --> 00:25:05.200 I don't know how you made it down the street in this condition, how I found you. 00:25:05.359 --> 00:25:10.079 And I basically like vasovagled because the pain was so bad. 00:25:10.319 --> 00:25:14.079 Do you want to give a brief what vasovagal is for dummies? 00:25:14.400 --> 00:25:39.359 Yeah, so like if you when you experience such a stimulus that your rest and digest nervous system goes in overload and overshoots everything, so all your blood vessels dilate, everything becomes leakier, so you sweat, your blood pressure drops, and like all of a sudden you're feeling like you're gonna faint. 00:25:39.599 --> 00:25:44.960 Also, your like nausea system gets way thrown off whack. 00:25:45.039 --> 00:25:47.519 So if you've never thrown up in your life, you might. 00:25:47.839 --> 00:25:49.119 So then that's that's that. 00:25:49.359 --> 00:25:55.119 So, like, and I started like feeling it outside because I was like getting really hot, but it was humid. 00:25:55.279 --> 00:25:57.680 I had a raincoat on, so I was like, all right, whatever. 00:25:57.759 --> 00:26:06.160 It's just like humid and I have long sleeves, and then I came inside and I'm like holding like a wrapping like a paper towel over my finger. 00:26:06.240 --> 00:26:09.200 I'm like, oh my God, I'm like nauseous because this hurts so bad. 00:26:09.279 --> 00:26:10.240 Like, what the heck? 00:26:10.400 --> 00:26:17.119 And then, like, all within like seven seconds, I put two and two together and realized like what was probably happening. 00:26:17.599 --> 00:26:20.720 And then like my like head felt weird. 00:26:20.799 --> 00:26:21.839 I was getting sweatier. 00:26:22.160 --> 00:26:26.079 I had to run to the bathroom because I was gonna throw up, and I'm just like sitting there in front of the toilet. 00:26:26.160 --> 00:26:33.119 Like, one, I should have like grabbed something cold out of the freezer before I came in here, but then I call Eddie because he's still asleep. 00:26:33.359 --> 00:26:44.160 I get up early on the weekends and he's still asleep, so I call him because I'm like, well, if this is good, if what's happening or if what I think is happening is happening, I might pass out. 00:26:44.240 -->

00:26:53.119 So, like, I should probably tell my husband if like I'm gonna be passed out on the bathroom, let him know that he might find me passed out on the bathroom floor. 00:26:54.000 --> 00:26:57.200 So then I puke, he gets me something cold for my neck. 00:26:57.279 --> 00:27:04.160 I didn't pass out, so like maybe the cold thing worked, or it was I was or I wasn't going to, but never seen you puke before. 00:27:04.319 --> 00:27:04.799 Yeah. 00:27:05.119 --> 00:27:14.000 So my perspective is I'm like dead asleep in the world, and then I hear the I'm like, who's calling me? 00:27:14.160 --> 00:27:14.880 Oh my god. 00:27:15.039 --> 00:27:21.039 I did hear the door like close pretty quick, and I was like, oh, here comes the perpetrator. 00:27:21.119 --> 00:27:25.839 Um piranha, a little piranha, and I was like, Oh, all right, that's what's going on here. 00:27:26.000 --> 00:27:28.880 And oh, the poor girl is like distraught. 00:27:29.119 --> 00:27:32.720 And I was like, oh my God, but at this moment, I don't know what's happening. 00:27:32.880 --> 00:27:34.960 It's like, what am I walking into down here? 00:27:35.200 --> 00:27:38.240 Like there's a million awful thoughts are running through my head. 00:27:38.400 --> 00:27:41.440 And I get there and then I come to this site, her doubled over the toilet. 00:27:41.519 --> 00:27:43.440 I've never seen this woman puke. 00:27:43.519 --> 00:27:54.319 Her like body and like I hate not that people like throwing up, but like if I feel sick or like a little twinge of nausea, like I'm taking zoofrade, I am not throwing up. 00:27:54.400 --> 00:27:55.599 I hate throwing up. 00:27:55.759 --> 00:27:57.920 I do everything I can to avoid it. 00:27:58.240 --> 00:28:01.519 But that's just like it's just and I'm a pukey boy. 00:28:01.599 --> 00:28:02.720 Yeah, it's just like the opposite. 00:28:02.960 --> 00:28:05.200 You puke every other week, it seems. 00:28:05.519 --> 00:28:13.039 But you're you're like moniker, your gold star is like or tombstone, like Nicole Rufo, never puke. 00:28:13.359 --> 00:28:15.279 Yeah, rest in peace. 00:28:15.680 --> 00:28:17.519 There's a lot of your mother's not gonna like this. 00:28:17.599 --> 00:28:21.519 There's too much like end-of-life talk there. 00:28:21.680 --> 00:28:26.240 But um, yeah, no, you and you turned around real quick. 00:28:26.480 --> 00:28:27.519 Yeah, real quick. 00:28:27.759 --> 00:28:30.240 Once I had a blood pressure again, it felt great. 00:28:30.559 --> 00:28:31.440 Yeah, that was crazy. 00:28:31.599 --> 00:28:38.000 So then I kind of figured I was like, what if this scenario played out and like you didn't call me and let me know, or I like missed the phone call. 00:28:38.160 --> 00:28:41.119 And Nikki's been known to like go through a whole lot. 00:28:41.200 --> 00:28:42.240 I I live seven lives. 00:28:42.319 --> 00:28:44.960 I have a full day before Eddie wakes up. 00:28:45.119 --> 00:28:46.160 Yeah, it's true. 00:28:46.400 --> 00:28:48.559 And then like she'll be like, Oh, I did this. 00:28:48.720 --> 00:28:51.920 I I like I also like downplay things regularly. 00:28:52.000 --> 00:28:56.240 So I would have been like, oh, we went for a walk, I got the grocery order, I cleaned the entire house. 00:28:56.319 --> 00:28:59.039 I like passed out two hours ago, but it's fine now. 00:28:59.680 --> 00:29:07.680 She does, she just downplayed a lot, and I was I would not have put it past her um to do that at all. 00:29:08.079 --> 00:29:09.680 That was a spooky one. 00:29:09.759 --> 00:29:13.440 So then the tricky thing is that, and and this might help someone someday. 00:29:13.519 --> 00:29:32.559 This is not a nail traffic episode, but if you have a lot of blood under your fingernail, you can with a medical professional, of course, wink wink, um, you can actually like take a sharp sterilized object and like drill a nail, like a hole in your nail to relieve the pressure. 00:29:32.799 --> 00:29:35.839 This happened to me because a couple years ago, oh yeah. 00:29:36.319 --> 00:29:38.799 After Matt's bachelor party, this happened to me. 00:29:38.960 --> 00:29:40.079 And I was like, oh my god. 00:29:40.160 --> 00:29:49.839 And the very next day, I was heading to the procedure clinic in residency, and we had these things, and it's like a hot pen knife, and like they did it to my nail, and I was like, Oh, I feel so much better. 00:29:50.079 --> 00:29:52.720 So now I'm trying to convince Nikki to let me do this. 00:29:53.200 --> 00:29:54.559 It doesn't even look that bad. 00:29:54.880 --> 00:29:56.480 It's not like built up under my nail. 00:29:56.640 --> 00:29:58.000 Yeah, but you gotta do it promptly. 00:29:58.160 --> 00:29:58.799 Oh, okay. 00:29:59.119 --> 00:30:07.200 So I order stuff from Amazon to try to make it happen, but um, and some deodorant because we needed some, but and some augmentin. 00:30:07.359 --> 00:30:09.279 I got full service PCP. 00:30:09.440 --> 00:30:12.720 Yes, he orders the med, he goes to CVS to pick it up. 00:30:13.039 --> 00:30:15.920 I do pay for it as well. 00:30:16.480 --> 00:30:17.119 Lucky duck. 00:30:17.279 --> 00:30:18.319 Okay, it was like two dollars. 00:30:18.640 --> 00:30:19.200 That's fair. 00:30:19.359 --> 00:30:29.279 Um yeah, so sometimes if this a little educational here, a little splash, you can consider getting antibiotics to prevent infection ahead of time during a dog bite. 00:30:29.680 --> 00:30:36.079 Yeah, especially if your dog like occasionally eats poop sometimes on the streets of Philadelphia. 00:30:36.319 --> 00:30:39.440 And you don't know like who this came from. 00:30:39.599 --> 00:30:44.880 Was it a person, an animal, both? 00:30:46.799 --> 00:30:48.720 Who could it be? 00:30:51.200 --> 00:31:05.359 I always gotta like hunt for the little things that you say that I need to edit out that like if there was an unedited version that our show I'm sure our audience would love, but I have to play it straight for whoever Overlord is listening to me right

now and listening to us. 00:31:07.200 --> 00:31:08.319 Well that was fun. 00:31:08.559 --> 00:31:09.519 And now here we are. 00:31:10.640 --> 00:31:11.440 Now here we are. 00:31:15.039 --> 00:31:17.279 Wait, did we have something else funny to talk about? 00:31:17.599 --> 00:31:18.640 I can't remember. 00:31:20.079 --> 00:31:27.599 Oh well now I don't maybe this was more funny in the moment if you were there. 00:31:29.759 --> 00:31:31.440 The wartime lifeguard. 00:31:33.119 --> 00:31:38.240 Oh she's gonna she's gonna feel so bad about this. 00:31:38.400 --> 00:31:39.680 She was already sensitive. 00:31:40.000 --> 00:31:40.799 No, it was fun. 00:31:41.039 --> 00:31:48.480 It was funny because of our like and the her grandm her grandmother being a lifeguard was not funny. 00:31:48.799 --> 00:31:50.000 Not funny, very serious. 00:31:50.240 --> 00:31:58.720 So our loyal listener and close personal brother, Vanessa, we were talking about how like she and I were swimmers when we were younger, and then how I lifeguarded. 00:31:59.119 --> 00:32:00.799 We were all swimmers when we were younger. 00:32:01.039 --> 00:32:02.319 You're disgusting. 00:32:03.119 --> 00:32:15.839 And then she brings up how her grandmother used to lifeguard during the time where most grandparents are around and you know, young and sprightly during the time of World War II. 00:32:16.079 --> 00:32:23.039 And she said she was a lifeguard because all the men got drafted to war. 00:32:23.200 --> 00:32:29.359 So then she was a lifeguard at like this pool, like that, like we had been to that had like swimming there, whatever. 00:32:29.599 --> 00:32:35.039 But she specifically used the term my grandmother was a wartime lifeguard. 00:32:36.160 --> 00:32:45.119 So Ebbie and I are sitting here like rapping trying to rack our brains, how her grandmother was like lifeguarding like soldiers. 00:32:46.319 --> 00:32:50.240 I'm like, would she like watching like the navy and the ocean? 00:32:50.400 --> 00:32:51.920 Like, what do you mean? 00:32:52.960 --> 00:32:56.880 And we kept cracking up about it, and she seemed so confused why we thought it was funny. 00:32:57.039 --> 00:33:05.759 And then at some point I was like, I don't want to be, I'm not trying to be disrespectful, I just don't understand the like and she's like, no, you idiot. 00:33:05.920 --> 00:33:09.359 She was just a lifeguard when World War II was going on. 00:33:10.720 --> 00:33:12.559 Which is a really cool thing. 00:33:15.119 --> 00:33:21.680 Also, isn't it funny that like all like the men were lifeguards? 00:33:22.079 --> 00:33:26.240 I know like it was the dream back then, and like women didn't have to work. 00:33:27.279 --> 00:33:35.440 But now, like, at least when I was a lifeguard, it was like mostly girls, like there were guys, and now it's just like, well, why are the boys here? 00:33:35.759 --> 00:33:48.799 Perhaps there's been a big gender switch in the employment of I have a habit of female-dominated jobs, babysitting,

lifeguarding, nursing. 00:33:49.200 --> 00:33:50.000 Bing bang boom. 00:33:50.400 --> 00:33:51.680 We can't deal with the men. 00:33:53.119 --> 00:33:54.880 Unless you're at home, you got two. 00:33:56.720 --> 00:33:57.759 Two boys at home. 00:33:58.000 --> 00:33:58.400 Oh yeah. 00:33:58.480 --> 00:33:59.599 I thought that was funny. 00:33:59.839 --> 00:34:02.799 That because we're dumb, not because correct. 00:34:02.960 --> 00:34:03.200 Yeah. 00:34:03.920 --> 00:34:05.519 Sweet Virginia was a lifeguard. 00:34:06.079 --> 00:34:07.839 Sweet, sweet Virginia. 00:34:08.639 --> 00:34:10.880 I think that was her grandmother. 00:34:11.119 --> 00:34:12.480 Or her great grandmother. 00:34:12.960 --> 00:34:14.000 We're gonna get a correction. 00:34:14.239 --> 00:34:15.599 We are sorry, brother. 00:34:15.840 --> 00:34:17.519 Hopefully we'll get some fan mail. 00:34:17.840 --> 00:34:19.119 Because her sister's name is Virginia. 00:34:19.519 --> 00:34:23.519 Hopefully we can get some fan mail to then include a voice message. 00:34:23.679 --> 00:34:27.679 I really wish we could play our voice messages. 00:34:27.920 --> 00:34:28.000 Yeah. 00:34:28.400 --> 00:34:28.800 Fan mail. 00:34:29.199 --> 00:34:30.159 No, we can't. 00:34:31.760 --> 00:34:33.119 Unless people paid us. 00:34:34.800 --> 00:34:39.599 Then we could put some like guys, we're way funnier than we're allowed to be. 00:34:39.840 --> 00:34:40.960 Um yeah, we really are. 00:34:41.119 --> 00:34:59.280 It's a shame for anyone who doesn't know us personally on this PG family-friendly podcast that like if one were to suggest that they would give us three to five dollars a month to listen to premium unedited full bore content. 00:34:59.599 --> 00:35:01.199 I would I would set that up. 00:35:01.440 --> 00:35:01.840 I would. 00:35:01.920 --> 00:35:04.320 I would set that up in a separate place. 00:35:04.880 --> 00:35:06.000 We could do that. 00:35:06.159 --> 00:35:07.760 That is something that could happen. 00:35:08.000 --> 00:35:13.519 If anyone was interested, I know there are a certain number of you who are out there every single week tuning in. 00:35:13.760 --> 00:35:14.159 We see you. 00:35:14.320 --> 00:35:14.800 We see you. 00:35:14.960 --> 00:35:15.599 Well, I don't. 00:35:15.679 --> 00:35:16.079 He does. 00:35:16.239 --> 00:35:17.519 I see you every week. 00:35:17.760 --> 00:35:24.960 About the same number of people, and then people from our other audiences around the world who are interested in the medical stuff come in. 00:35:25.280 --> 00:35:31.039 But I see you people, and if you're interested, let me know. 00:35:31.280 --> 00:35:32.800 Give us your money. 00:35:33.679 --> 00:35:35.280 That's not what this is about, though. 00:35:35.440 --> 00:35:36.320 Um, how do you feel? 00:35:36.480 --> 00:35:38.320 You feel I feel energized after this. 00:35:38.400 --> 00:35:41.920 And you were kind of like in the beginning, you were like, but now I feel it. 00:35:42.639 --> 00:35:43.039 Feel good? 00:35:43.280 --> 00:35:43.840 I feel it, yeah. 00:35:44.000 --> 00:35:45.440 All right, let's end on the high. 00:35:45.679 --> 00:35:48.239 Thank you for coming back to another episode of Your Checkup. 00:35:48.320 --> 00:35:52.800 Hopefully, you were able to learn something for yourself, a loved one, or a neighbor. 00:35:53.119 --> 00:35:54.800 You could find us on Instagram. 00:35:54.960 --> 00:36:03.519 You can find us on Threads, you can also send us an email, yourcheckuppod at gmail.com, but most importantly, stay healthy, my friends. 00:36:03.679 --> 00:36:05.519 Until next time, I'm Ed Deleski. 00:36:05.679 --> 00:36:06.800 I'm Nicola Ruffo. 00:36:06.960 --> 00:36:07.920 Thank you and goodbye. 00:36:08.239 --> 00:36:08.800 Bye. 00:36:14.400 --> 00:36:18.639 This information may provide a brief overview of diagnosis, treatment, and medications. 00:36:18.800 --> 00:36:22.719 It's not exhaustive and is a tool to help you understand potential options about your health. 00:36:22.880 --> 00:36:27.440 It doesn't cover all details about conditions, treatments, or medications for a specific person. 00:36:27.599 --> 00:36:30.960 This is not medical advice or an attempt to substitute medical advice. 00:36:31.119 --> 00:36:36.239 You should contact a healthcare provider for personalized guidance based on your unique circumstances. 00:36:36.400 --> 00:36:40.960 We explicitly disclaim any liability relating to the information given or its use. 00:36:41.119 --> 00:36:45.039 This content doesn't endorse any treatments or medications for a specific patient. 00:36:45.280 --> 00:36:49.199 Always talk to your healthcare provider for a complete information tailored to you. 00:36:49.360 --> 00:36:51.119 In short, I'm not your doctor. 00:36:51.360 --> 00:36:52.159 I am not your nurse. 00:36:52.320 --> 00:36:56.000 And make sure you go get your own checkup with your own personal doctor.