Trascrizione completa di Report from Longevity Summit Dublin 2024

of the talks I've seen 28 00:02:46.439 --> 00:02:50.479 earlier versions of them in previous years, but in all cases there was more 29 00:02:50.719 --> 00:02:59.039 news closer to clinical trials with various compounds, companies evolving pivoting from something that 30 00:02:59.120 --> 00:03:02.719 initially had seem to work and then had given some problems, and they were 31 00:03:02.719 --> 00:03:08.479 pivoting to something which had more recent to be successful. The session started before 32 00:03:08.599 --> 00:03:12.919 nine o'clock in the morning, half past eight, I think was the target, 33 00:03:13.319 --> 00:03:16.120 and continued till after six. So there was lots and lots to choose 34 00:03:16.159 --> 00:03:20.759 from, and if I pick out a few, I'm inevitably going to miss 35 00:03:20.759 --> 00:03:25.120 at a great deal that was also meritorious. But let me pick maybe three 36 00:03:25.199 --> 00:03:34.319 themes which I think some particularly striking. The first was animal super ages. 37 00:03:34.680 --> 00:03:38.960 And the reason I like this theme is I think it's a narrative that members 38 00:03:38.960 --> 00:03:44.360 of the general public can relatively easily get behind before they get lost and discussions 39 00:03:44.360 --> 00:03:49.599 about well, if there was aging, there might be overpopulation or something like 40 00:03:49.639 --> 00:03:54.599 that. They can easily engage instead in the details of the fashionating lives of 41 00:03:54.680 --> 00:04:00.240 some very long lived animals. So we had, for example, but the 42 00:04:00.319 --> 00:04:03.120 species of fish which I'd only heard a little bit about before, called the 43 00:04:03.319 --> 00:04:08.439 buffalo fish, which is a little bit like a carp but something separate. 44 00:04:08.840 --> 00:04:13.639 And what's remarkable but these fish, which can be found in various inland fresh 45 00:04:13.719 --> 00:04:18.279 waters in North America, is that we're fairly sure by a number of reasons 46 00:04:18.319 --> 00:04:24.519 that many of them are over one hundred years old. And sometimes people shrug 47 00:04:24.600 --> 00:04:29.519 and say, well, it's true some water creatures do live long lives, 48 00:04:29.600 --> 00:04:34.680 but that's only because they're living in very cold and deep surroundings. And if 49 00:04:34.720 --> 00:04:39.160 it's very cold and very deep, then life slows down. But that's not 50 00:04:39.199 --> 00:04:43.000 at all the case with these buffalo fish. They live in shallow water, 51 00:04:43.199 --> 00:04:46.240 they live in warm water, and it's quite remarkable what they were doing. 52 00:04:46.360 --> 00:04:53.240 So that was a fascinating discussion. Another creature we heard about was bats. 53 00:04:54.120 --> 00:05:00.199 Lots and lots of bats, different species. And sometimes people say all creatures 54 00:05:00.240 --> 00:05:03.079 have the same sort of number of beats of the heart, and so some 55 00:05:03.279 --> 00:05:09.519 creatures

have slow beating hearts and that's why they live longer, and other creatures 56 00:05:09.519 --> 00:05:13.759 have fast beating hearts and they live shorter. But that's completely invalidated, first 57 00:05:13.759 --> 00:05:17.319 of all by birds, many of whom have fast beating hearts and live six 58 00:05:17.439 --> 00:05:24.160 decades or more. It is certainly invalidated by bats, and we had from 59 00:05:24.519 --> 00:05:29.600 emmateealing such in Dublin, who has spent she said, probably thirty years of 60 00:05:29.600 --> 00:05:33.680 her life investigating the long lived species of bats and how they managed to do 61 00:05:33.720 --> 00:05:41.639 it. So that was fascinating as well. And bats are remarkable not just 62 00:05:41.720 --> 00:05:46.959 because they have mechanisms to help them live long, even at a high temperature, 63 00:05:46.279 --> 00:05:50.560 but they have mechanisms to fight off viral infections. Now, bats are 64 00:05:50.600 --> 00:05:58.279 sometimes notorious as the origins of many viruses that cross species and infect humans. 65 00:05:58.839 --> 00:06:03.639 Well, the other things say about bats is they often coexist with viruses and 66 00:06:03.680 --> 00:06:10.879 if you try to inflict new viruses onto bats, they get the viruses, 67 00:06:10.879 --> 00:06:14.839 they have a high viral load, but they don't get ill. As a 68 00:06:14.839 --> 00:06:18.360 result, they don't get inflamed. So people are studying like crazy, and 69 00:06:18.439 --> 00:06:24.560 the reason to study these super long lived animals is that we can find out 70 00:06:24.800 --> 00:06:30.480 how nature has achieved this long lived animals in various ways, and we can 71 00:06:30.519 --> 00:06:33.959 copy some of the mechanisms. Perhaps the most famous long lived animal is the 72 00:06:34.120 --> 00:06:39.839 naked mole rat, which is a youth social animal lives in burrows under the 73 00:06:39.879 --> 00:06:44.759 ground, and there is typically one queen and all the other creature. All 74 00:06:44.800 --> 00:06:49.920 the other females are infertile. But what we learned in that particular talk was 75 00:06:50.800 --> 00:06:57.399 that the naked mole rat probably has at least seven different mechanisms compared to humans 76 00:06:57.839 --> 00:07:02.000 that allows it to fight off the normal hallmarks of aging. So people have 77 00:07:02.079 --> 00:07:10.000 often pointed out things about its hyloloronic acid in the extracellular matrix of its skin. 78 00:07:10.560 --> 00:07:14.680 That's one people have pointed out its mechanisms to fight off cancer. Well, 79 00:07:14.720 --> 00:07:17.120 it seems that these creatures have at least seven different mechanisms, which is 80 00:07:17.160 --> 00:07:21.439 remarkable. And again we can learn. And the last animal I'll mention isn't 81 00:07:21.560 --> 00:07:27.879 yet a long lived animal. It's the domestic cat. And the reason I 82 00:07:27.920 --> 00:07:31.519 mention this is there's a startup created by two people each called Alex, each 83 00:07:31.680 --> 00:07:38.199 aged about thirty, each with already a good track record. They both admit 84 00:07:38.360 --> 00:07:43.360 to loving their cats very much. They say there's been a number of startups 85 00:07:43.439 --> 00:07:48.120 targeting dog long lived long lived dogs, and they have ideas for how to 86 00:07:48.279 --> 00:07:54.560 allow middle aged cats to be given a new lease of life, and they've 87 00:07:54.600 --> 00:08:00.839 studied this quite carefully. To bring a treatment to cats require some veterans approvals. 88 00:08:01.000 --> 00:08:05.120 There are regulations but they are nothing like so audius as bringing our treatment 89 00:08:05.240 --> 00:08:09.199 to humans. So they think that with a favorable wind, and they already 90 00:08:09.199 --> 00:08:13.240 have some significant funding behind them the favorable wind, they could be in what's 91 00:08:13.319 --> 00:08:18.240 known as conditional approval with their therapies within eighteen months, and then they will 92 00:08:18.240 --> 00:08:24.319 have another five years to demonstrate that there are no significant adverse problems. So 93 00:08:24.360 --> 00:08:28.639 it could be that within a couple of years or thirty months, there will 94 00:08:28.680 --> 00:08:33.240 already be cat owners who are delighted that their cats have a new lease of 95 00:08:33.279 --> 00:08:37.519 life. So that's theme number one I might pick out, super aging animals. 96 00:08:37.360 --> 00:08:41.799 Briefly, theme number two I might pick out is we can call it 97 00:08:41.039 --> 00:08:46.679 nanoparticles. Many of us in the transhumanist world have long looked forward to what 98 00:08:46.720 --> 00:08:52.919 we imagine would be nanotechnology. There would be drexelarian after named after Eric Drexler 99 00:08:54.120 --> 00:08:58.120 Drexelularian factories and nanosurgery and such like, and much of that hasn't happened. 100 00:08:58.480 --> 00:09:05.840 But so two fascinating talks each different kinds of nanoparticles particles that had been assembled 101 00:09:05.879 --> 00:09:11.360 by what's known as click chemistry, which is a way of assembling something remarkably 102 00:09:11.480 --> 00:09:16.399 different. So one was a talk by a company called Nanautics, and they 103 00:09:16.440 --> 00:09:24.480 have a four layer nanoparticle that can be programmed to take out of the blood 104 00:09:24.480 --> 00:09:30.759 stream something called signaling molecules. So they have a whole theory that many diseases 105 00:09:30.879 --> 00:09:35.200 are caused not by what goes wrong inside individual cells, but what goes wrong 106 00:09:35.320 --> 00:09:39.840 inside the signaling between cells, and this is sometimes called the signal home and 107 00:09:41.559 --> 00:09:46.919 Nanoutics have been working for quite a number of years and their progress is coming 108 00:09:46.919 --> 00:09:54.159 along very impressively on mechanisms to remove some of the mistakes

in the immune system 109 00:09:54.480 --> 00:09:56.559 which leads to a whole number of diseases. So that was impressive, but 110 00:09:56.639 --> 00:10:01.440 it wasn't the only nanoparticle that cut my tension. There's a company called Ocean 111 00:10:01.600 --> 00:10:05.480 Technologies, which actually was a spin out from Sense quite a while ago, 112 00:10:05.960 --> 00:10:11.960 and initially they targeted snolytics and they've had some promising results from their analytics. 113 00:10:11.960 --> 00:10:16.200 But what they have also done is they have realized that some of their methods 114 00:10:16.240 --> 00:10:22.720 which they were developing can be much more widely applicable. And the speaker Matthew 115 00:10:22.720 --> 00:10:26.120 Schultz, the CEO of Ocean Technologies. He talked about the possibility to have 116 00:10:26.200 --> 00:10:33.600 a different delivery mechanism for changing some of our genetic makeup. So we currently 117 00:10:33.799 --> 00:10:41.200 often have a choice between some viral vectors and the liquid nanoparticles, but there 118 00:10:41.240 --> 00:10:45.960 are drawbacks of both, Matthew explained, And they have a different kind of 119 00:10:46.039 --> 00:10:52.639 nanoparticle which is called a fusogenic lipid nanoparticle which allows more precise targeting. So 120 00:10:52.720 --> 00:10:56.399 again it's using the latest ideas of chemistry, and they had a whole number 121 00:10:56.480 --> 00:11:01.200 of ideas of how this could work out. Finally, before I hand back 122 00:11:01.240 --> 00:11:05.799 the microphone, otherwise I will speak all day about their fascinating talks over four 123 00:11:05.840 --> 00:11:11.720 days. The third them I'll pick out is artificial intelligence for longevity treatments. 124 00:11:13.080 --> 00:11:16.759 We had a great talk first thing in the morning by Ben Gutzel about some 125 00:11:16.799 --> 00:11:22.799 of the things Singularity Nets spinouts are doing. That is different companies there, 126 00:11:24.039 --> 00:11:30.039 but the one that really caught my attention was a progress support by Alex Zavaronkov 127 00:11:30.120 --> 00:11:35.240 in Silico medicine, and they have made very significant progress with now two drugs 128 00:11:35.279 --> 00:11:41.399 discovered by their AI mechanisms. Two drugs are now in phase true trials with 129 00:11:41.519 --> 00:11:46.320 humans, and the whole number of others. What they are doing is they 130 00:11:46.440 --> 00:11:50.399 are short cutting process of drug discovery which has got far too long, far 131 00:11:50.440 --> 00:11:56.559 too complicated. Too many drugs get bogged down earlier in that mechanism and that 132 00:11:56.639 --> 00:12:03.960 long series of bile and tests, and with a whole variety of different kinds 133 00:12:03.000 --> 00:12:09.200 of AIS. Alex sometimes describes it as a zoo of AI generative AIS and 134 00:12:09.840 --> 00:12:16.720 so on. They're able to come up with hypotheses for what targets in the 135 00:12:16.960 --> 00:12:22.440 molecular machinery biomolecular machinery should be addressed by interventions in order to deal with various 136 00:12:22.440 --> 00:12:28.720 diseases, and then what molecules can be created. So it's not like imagining 137 00:12:28.720 --> 00:12:33.039 a picture in response to a prompt, it's imagining a molecule in response to 138 00:12:33.080 --> 00:12:37.320 a prompt. And they can come up with things which then can more reliably 139 00:12:37.440 --> 00:12:41.960 go through their trials more quickly. So Alex has gone on from leaps and 140 00:12:43.039 --> 00:12:46.720 bounds from when I first met him nearly fifteen years ago. So these are 141 00:12:46.759 --> 00:12:50.320 three themes which caught my attention, but there's at least ten other themes. 142 00:12:50.720 --> 00:12:54.279 In each case. I was impressed at the progress and the audience I could 143 00:12:54.320 --> 00:13:00.559 tell was impressed to, as often came up during the quite extensive networking. 144 00:13:01.039 --> 00:13:05.000 So these are some opening thoughts from myself trying to convey some of the excitement 145 00:13:05.240 --> 00:13:09.840 and the inspiration which I had picked up at the conference. Excellent. Thank 146 00:13:09.919 --> 00:13:18.120 you very much David for that thorough and succinct overview. I think you definitely 147 00:13:18.600 --> 00:13:24.159 touched on many of the major themes at Longevity sum at Dublin, and there 148 00:13:24.159 --> 00:13:31.240 will be a few others that we will explore throughout this salon. I will 149 00:13:31.279 --> 00:13:37.320 also add that just before he left, Alex Javrankov interviewed me for about five 150 00:13:37.440 --> 00:13:43.080 minutes and this is part of his own podcasts, so hopefully that interview will 151 00:13:43.120 --> 00:13:48.120 be coming out in the not too distant future. And I will also point 152 00:13:48.159 --> 00:13:54.519 out for those who would like to know more about the Cat Health Company and 153 00:13:54.720 --> 00:14:01.440 its efforts, we did interview one of its co founders, Alexandre Voda on 154 00:14:01.679 --> 00:14:07.279 April tenth, twenty twenty two, so please check out our Virtual Enlightenment Salon 155 00:14:07.759 --> 00:14:15.159 with him. And now I would like to go to DDA Kernel of Heals 156 00:14:15.360 --> 00:14:22.000 and AFT Techno Prague. He was one of the speakers at Longevity Summit Dublin 157 00:14:22.200 --> 00:14:28.440 just earlier today and he spoke about challenges with health data and some of the 158 00:14:28.480 --> 00:14:37.559 obstacles that current legislation, especially in the European Union, would pose to the 159 00:14:37.679 --> 00:14:43.240 use of such health data for longevity research and scientific research more generally. So, 160 00:14:43.639 --> 00:14:48.559 DDA, are you able to share some of your remarks and impressions at 161 00:14:48.559 --> 00:14:54.759 this time? Yes, I will try. I don't know how good is 162

00:14:54.840 --> 00:14:58.120 the sound, because I cannot hear you so good, but I suppose you 163 00:14:58.159 --> 00:15:03.000 can hear me. We can hear you, Uh okay, So yeah, 164 00:15:03.399 --> 00:15:13.120 I think David made a great summary. It was far very very interesting days 165 00:15:13.200 --> 00:15:20.600 with a diversity of speakers and with the opportunity to meet many people that I 166 00:15:20.759 --> 00:15:28.200 already met and also many people I never met. Yes, I was speaking, 167 00:15:28.320 --> 00:15:31.240 like you said about shaking of HELL data. For me, that is 168 00:15:31.399 --> 00:15:39.679 one of the let's say, fascinating and sometimes a bit depressing aspect of modern 169 00:15:39.720 --> 00:15:46.720 technologies. It makes makes it possible to it makes it terretically possible and easy 170 00:15:46.759 --> 00:15:52.639 to share data, but it makes it also possible and easy not to share 171 00:15:52.720 --> 00:16:00.279 HELL data and to protect it for IP reasons, for privacy reasons. And 172 00:16:00.399 --> 00:16:06.200 I spoke, among other things about Big Mutter, national American company who is 173 00:16:06.200 --> 00:16:10.679 called i q v I and who has a lot of held that up but 174 00:16:10.799 --> 00:16:19.000 it doesn't shade. So that was my intervention to them. But what can 175 00:16:19.039 --> 00:16:23.480 I say. I'm sorry, I'm in the airport and it I had difficulties 176 00:16:23.519 --> 00:16:30.960 to find to find the place to be more school U. So, like 177 00:16:30.639 --> 00:16:37.200 I think David, for me, the most probably the most impressive discussion was 178 00:16:37.240 --> 00:16:45.720 about this buffalo fishes who really seem not to each and uh who even more 179 00:16:45.759 --> 00:16:57.080 than that, seemed to be yeah, kind of having less uh less virginity 180 00:16:57.159 --> 00:17:04.400 when the age than before. So it's very very interesting and I think that 181 00:17:04.480 --> 00:17:12.160 I will organize and maybe actually we could organize here I don't know, uh 182 00:17:12.640 --> 00:17:19.680 conference, small conference with the guy who was speaking and on an other team, 183 00:17:21.480 --> 00:17:26.599 uh did this for during the four this I had, they were, 184 00:17:26.920 --> 00:17:33.000 like in many other places, quite a few discussions concerning artificial intelligence. And 185 00:17:33.160 --> 00:17:38.759 I hope that we will be able to organize during the next Dubling conference one 186 00:17:38.960 --> 00:17:45.640 workshop only about this and also in the next months. So that's it for 187 00:17:45.759 --> 00:17:52.000 the moment. Yeah, I will let you all all right. Thank you 188 00:17:52.119 --> 00:17:59.119 very much, d DA. We appreciate your remarks as well. And in 189 00:17:59.200 --> 00:18:06.000 terms of buffalo, yes, this was quite new information for the vast majority 190 00:18:06.039 --> 00:18:12.480 of the attendees at the summit. The researcher who presented it

is Professor Alec 191 00:18:12.920 --> 00:18:21.519 Lackman. You can look him up here via his faculty profile at the University 192 00:18:21.680 --> 00:18:26.960 of Minnesota, and I also have various follow up questions that I hope to 193 00:18:27.440 --> 00:18:34.720 ask him in the not too distant future. One other key subject area that 194 00:18:34.839 --> 00:18:41.519 was discussed at the Longevity Summit, and indeed there was a succession of presentations 195 00:18:41.559 --> 00:18:49.240 on it, is the exceptional longevity of super centenarians. So there were presenters 196 00:18:49.279 --> 00:18:59.279 from the Gerontology Research Group, from longevit Quest, and also from Natalie Coles 197 00:18:59.680 --> 00:19:08.640 who who is a long time collector of biomarker data from super centenarians, so 198 00:19:08.720 --> 00:19:15.200 she actually goes to visit them and collect, for instance, blood samples and 199 00:19:15.880 --> 00:19:22.200 other data about their health characteristics to enable us to try to figure out what 200 00:19:22.400 --> 00:19:30.119 is it that could account for their exceptional longevity. And another individual who was 201 00:19:30.200 --> 00:19:37.440 present at the Longevity Summit who is an expert on supercentenarians himself is our friend 202 00:19:37.799 --> 00:19:41.559 Victor Byork, and I was quite pleased to be able to follow up with 203 00:19:42.039 --> 00:19:51.119 Victor regarding everything that has happened for him during the three years since our prior 204 00:19:51.200 --> 00:19:56.559 Virtual Enlightenment salaon, and now I will play the interview that I did with 205 00:19:56.680 --> 00:20:02.640 Victor. Please prepare any questions that you might have for him, because he 206 00:20:02.720 --> 00:20:08.279 will be available after that interview to respond to them. So the Victor, 207 00:20:08.519 --> 00:20:14.160 it is good to speak with you again. Of course, you have been 208 00:20:14.400 --> 00:20:21.079 our guest for a prior Virtual Enlightenment salon back in twenty twenty one, and 209 00:20:21.839 --> 00:20:29.039 we also helped you with the Victor Run Virtual race when you were raising funds 210 00:20:29.119 --> 00:20:37.000 for your stay at I Core Therapeutics in New York. So now you are 211 00:20:37.279 --> 00:20:42.039 a longevity consultant, so tell us about how you made that transition and what 212 00:20:42.079 --> 00:20:47.920 your work involves. Thank you very much, Sinadi. So, as many 213 00:20:47.920 --> 00:20:49.920 of you know, I have been very involved in this feel for a very 214 00:20:49.960 --> 00:20:56.519 long time, and I decided to dedicate my career to understand and create impact 215 00:20:56.640 --> 00:21:02.359 in this field. So a bit the after that I worked at iCore, 216 00:21:02.759 --> 00:21:10.279 I proceeded and moved to Switzerland and I moved and I worked there as a 217 00:21:10.319 --> 00:21:15.839 business developer where I helped find the potentially interesting companies. And after a year 218 00:21:15.880 --> 00:21:19.960 there, I moved on and I set up my own business where I help 219 00:21:21.559 --> 00:21:27.400 funds in space to understand specific challenges like scientific due diligence, landscaping interesting areas, 220 00:21:29.400 --> 00:21:34.839 and also I helped private individuals who are interested in the field to understand 221 00:21:34.880 --> 00:21:41.000 specific challenges and avoid being fooled by all the snake oil that also exists. 222 00:21:41.400 --> 00:21:45.200 So it is a very enjoyable experience. And it was actually a bit of 223 00:21:45.240 --> 00:21:48.400 a coincidence that I managed to get multiple clients at once and I set up 224 00:21:48.440 --> 00:21:55.119 my own company and I moved to the Mediterranean island Malta, which I very 225 00:21:55.160 --> 00:21:59.319 much enjoy. So I'm lucky to be able to work with my interest. 226 00:22:00.519 --> 00:22:06.680 And you are a great example of an individual who has been able to make 227 00:22:06.720 --> 00:22:11.920 a living in the longevity field as a self employed person, and that is 228 00:22:11.960 --> 00:22:19.400 really quite remarkable. What would you say is the skill set and the pathway 229 00:22:19.480 --> 00:22:25.960 that led you there in terms of what needed to happen in order for you 230 00:22:26.079 --> 00:22:30.200 to have a career like this. First of all, the basics is that 231 00:22:30.240 --> 00:22:37.240 you have some kind of degree, but it's not necessarily behind scientific degree. 232 00:22:37.599 --> 00:22:41.039 In my case, I'm like a biologist. Actually stopped out with medical school, 233 00:22:41.079 --> 00:22:44.559 but I didn't want to work as a doctor, so I want to 234 00:22:44.559 --> 00:22:48.240 work as a scientist. But then I talk about how do I position myself 235 00:22:48.279 --> 00:22:52.960 to create the maximum amount of impact in the in the field, So that 236 00:22:53.079 --> 00:22:57.960 is always in the in the back of my mind to think in that's the 237 00:22:59.039 --> 00:23:03.880 target. That way, and if you're very, very passionate about something, 238 00:23:03.039 --> 00:23:08.279 that usually shines through and you will be able to get clients and the people 239 00:23:08.319 --> 00:23:12.680 who will support support you. So they are multiple ways. There's not a 240 00:23:12.880 --> 00:23:19.079 one size fits all, yes, and certainly for people who are interested in 241 00:23:19.160 --> 00:23:22.519 doing something like this, they will need to figure out what their skill set 242 00:23:22.759 --> 00:23:26.559 is and how they can forge their own path. But in the meantime, 243 00:23:26.839 --> 00:23:33.920 the longevity field itself has evolved. How would you characterize the major changes that 244 00:23:34.000 --> 00:23:40.759 have occurred in the past several years, especially since we last spoke in twenty 245 00:23:40.839 --> 00:23:45.319 twenty one. Yeah, for the past several

years we started, including like 246 00:23:45.079 --> 00:23:49.559 a seven to ten year of horizon as well. Then it gets very interesting 247 00:23:49.599 --> 00:23:55.599 because most of the field that's really appeared since then. It has gone from 248 00:23:55.640 --> 00:24:02.640 fringe to almost mainstream in that regard, and there's a lot of capital coming 249 00:24:02.640 --> 00:24:07.480 into it right now. And even the COVID pandemic did not crush the interest. 250 00:24:07.920 --> 00:24:14.759 And I do think many new areas have opened up that we didn't think 251 00:24:14.799 --> 00:24:17.559 of before. It was not on time twenty eleven that we knew that you 252 00:24:17.599 --> 00:24:22.720 could rerunate mice by removing them cells, and now that has really emerged into 253 00:24:22.759 --> 00:24:29.119 a large biotech area with very very serious people involved. So in the salary 254 00:24:29.160 --> 00:24:33.880 programming as they have been speaking about today as well, it's very interesting what 255 00:24:33.880 --> 00:24:36.480 you can actually do. We don't know the path to the clinic, but 256 00:24:36.519 --> 00:24:41.200 we know a lot of fundamental science is known, so we can actually shorter 257 00:24:41.559 --> 00:24:44.960 and understand aiding in a way that was not possible before. Because if you 258 00:24:45.319 --> 00:24:49.119 said curating fifty years ago, that was really a fringesting not only because of 259 00:24:49.160 --> 00:24:52.960 how it was perceived, but because you didn't have the molecular tools to do 260 00:24:53.000 --> 00:25:00.519 anything. But now we have so many techniques crisper all the lab, throw 261 00:25:00.759 --> 00:25:07.039 tissues and cells and re understand what's going on AI. So now it's not 262 00:25:07.079 --> 00:25:08.920 as ridiculous anymore to think that we can do a lot when it comes to 263 00:25:08.960 --> 00:25:15.440 health span and lifespan for yes. Indeed, and hopefully that perception that we 264 00:25:15.519 --> 00:25:21.240 can do a lot will continue to spread because that ultimately is what will continue 265 00:25:21.279 --> 00:25:25.640 to support this industry. And the research. Now, you said one of 266 00:25:25.680 --> 00:25:32.200 your activities as a consultant is to help your clients distinguish between legitimate research and 267 00:25:32.400 --> 00:25:37.640 snake oil. And how do you help them identify the differences. What do 268 00:25:37.640 --> 00:25:41.880 you look for in terms of both promising signs and red flags. You have 269 00:25:41.920 --> 00:25:47.640 to be really good at reading scientific papers carefully, and you have to understand 270 00:25:47.720 --> 00:25:52.880 the common flaws and the distinguished marketing and hype from what is acxually reality. 271 00:25:53.000 --> 00:25:57.000 But you can't be over the cautious either, because then you would end up 272 00:25:57.160 --> 00:26:02.640 doing nothing in that regard. So you have to strike a balance between

everything 273 00:26:02.680 --> 00:26:08.039 from safety to credibility. What works, what doesn't work. What is something 274 00:26:08.039 --> 00:26:11.799 that is plausible enough that you can tell them that this is an actionable thing 275 00:26:11.839 --> 00:26:17.480 to do, whether it's in the investment or implementation of a lifestyle change. 276 00:26:18.119 --> 00:26:22.079 You have to find that balance, and that's a very large area. You 277 00:26:22.119 --> 00:26:27.119 have to consider very new scientific papers and stay on top of things to be 278 00:26:27.160 --> 00:26:30.440 able to do that in a good way. Yes, indeed, Now, 279 00:26:30.680 --> 00:26:37.200 one of the areas of interest that you've cultivated and made part of your extensive 280 00:26:37.240 --> 00:26:41.920 knowledge base is the study of super centenarians. And you've met many of them. 281 00:26:41.960 --> 00:26:47.240 You've met Emma Morano, who used to be the oldest person on Earth 282 00:26:47.359 --> 00:26:52.559 when you met her, and we had an interesting discussion a couple of days 283 00:26:52.599 --> 00:27:00.359 ago about the attributes of these super centenarians and what some of the commonalities are. 284 00:27:00.400 --> 00:27:07.839 One of the comments that you mentioned is essentially most people die because of 285 00:27:07.880 --> 00:27:11.960 something that is their weakest link, and they could be fairly well off in 286 00:27:12.039 --> 00:27:18.599 terms of their other attributes, and somehow these super centenarians have avoided at least 287 00:27:18.640 --> 00:27:22.079 longer than others being killed by their weakest link. So could you talk a 288 00:27:22.119 --> 00:27:27.599 bit more about that. Yes, indeed, so humans age at roughly similar 289 00:27:27.680 --> 00:27:33.000 rates, but their rates are not exactly identical. And we have the hallmarks 290 00:27:33.000 --> 00:27:36.440 of aiding, whether you call say it's nine hallmarks or twelve hallmarks or even 291 00:27:36.440 --> 00:27:40.720 more. They feedback upon each other, so and one thing goes wrong, 292 00:27:41.039 --> 00:27:45.359 other things snap as well. So in order to become a supercentinario, I 293 00:27:45.400 --> 00:27:48.799 mean, you wouldn't need to age slowly in a rather coherent way across multiple 294 00:27:48.839 --> 00:27:53.079 tissues, but also not to have a particular link. So I think, 295 00:27:53.119 --> 00:27:56.440 for example, the slowest aiding person in the world on a molecular level might 296 00:27:56.480 --> 00:28:02.240 have died at eighty because of a weak link rather than move on to So 297 00:28:03.400 --> 00:28:07.759 the question is if you were measure aiding, it's really how long would you 298 00:28:07.799 --> 00:28:12.440 live if you live to the most phrase state possible without hitting a particular endpoint 299 00:28:12.799 --> 00:28:18.319 that causes death. But it's a very interesting area because when it comes to 300 00:28:18.359 --> 00:28:25.759 lifestyle, we know that not being overweight and not smoking gives a much better 301 00:28:25.960 --> 00:28:29.880 chance of leaving to ninety. But when the consultation scenario, and it's less 302 00:28:29.920 --> 00:28:34.200 clear often what actually caused them to live that long, and it can't be 303 00:28:34.799 --> 00:28:40.079 often done to single g in either, so far, so it's interesting. 304 00:28:40.319 --> 00:28:47.759 So it's essentially that they've avoided catastrophic failure in their organism from every single possible 305 00:28:47.799 --> 00:28:51.960 source of their failure. They're still aging and they can still be very frail, 306 00:28:52.160 --> 00:28:56.799 but it's just that no system has critically failed enough to kill them exactly. 307 00:28:56.799 --> 00:29:00.920 So in a sense, rod than I'm thinking of them as like positively 308 00:29:00.240 --> 00:29:04.799 enhanced with a very specific gene or some something, you can think of them 309 00:29:04.799 --> 00:29:11.200 as abnormally normal. Think of if you want somebody who just functions normally and 310 00:29:11.319 --> 00:29:15.559 abnormally well, then you end up living a very long time and that's also 311 00:29:15.599 --> 00:29:18.000 when you look at a phenotype, they don't. There are more females than 312 00:29:18.039 --> 00:29:22.319 men, for example, but there's no like a very distinct I mean it 313 00:29:22.359 --> 00:29:27.839 doesn't. There's no ethnicity that prevents you from reaching one hundred and ten, 314 00:29:29.200 --> 00:29:33.680 and there's no particular phenotype. It's not like in mice where you have the 315 00:29:33.759 --> 00:29:37.200 aims dwarf mouse. There there is a mutant that lives very long, but 316 00:29:37.359 --> 00:29:41.480 the supers scenarios can be of average height and average appearance. There's no just 317 00:29:41.519 --> 00:29:47.200 that correct balance of not having a catastrophic event and not having anything particularly wrong 318 00:29:47.200 --> 00:29:51.680 with them, so abnormally normal rather than enhanced in a particular way. This 319 00:29:51.759 --> 00:29:59.119 is very interesting and actually this discussion has led me to an insight that could 320 00:29:59.400 --> 00:30:03.519 guide a lot of people in their lives. So, of course, in 321 00:30:03.640 --> 00:30:08.759 order to be successful, one has to have a talent or an activity where 322 00:30:10.079 --> 00:30:14.519 one excels to a significant extent more so than the rest. And for instance, 323 00:30:14.519 --> 00:30:18.519 for you, it would be your knowledge of the longevity field, because 324 00:30:18.519 --> 00:30:22.000 you're able to deploy that into your career and you're focusing on that. And 325 00:30:22.559 --> 00:30:27.200 each one of us has a talent like that that we could develop to the 326 00:30:27.240 --> 00:30:33.480 maximum and we also need to avoid these catastrophic sources of failure that could literally 327 00:30:33.960 --> 00:30:37.559 kill

us, and we need to mind each other aspect of our lives to 328 00:30:37.599 --> 00:30:44.680 the extent that it won't kill us. But we don't have to correct every 329 00:30:44.799 --> 00:30:49.759 single minor flaw, and we don't have to strive for perfection or excellence in 330 00:30:49.839 --> 00:30:55.960 everything, Like not everybody needs to be a super athlete, not everybody needs 331 00:30:55.960 --> 00:31:02.160 to excel in every academic discipline or even say every social skill. They just 332 00:31:02.200 --> 00:31:06.960 have to be good enough not to fail catastrophically at it. So what do 333 00:31:07.000 --> 00:31:14.039 you think of that approach as a way of maximizing longevity and also still being 334 00:31:14.799 --> 00:31:21.559 successful in life without stressing about it too much. Yes, I think that 335 00:31:21.680 --> 00:31:26.480 is a very very good point. And something that the distinguishes people who are 336 00:31:26.599 --> 00:31:30.880 centenarians is that they often have a strong purpose in life. It's not very 337 00:31:30.960 --> 00:31:34.920 easy to quantify by probing their blood or something, but they tend to have 338 00:31:36.279 --> 00:31:41.759 low stress levels. They tend to not worry about mine or things. Even 339 00:31:41.799 --> 00:31:45.880 if they had had a life that seemed harder towards an outsider, they have 340 00:31:45.000 --> 00:31:51.559 not internalized it. And yes, indeed, as for longevity, you're only 341 00:31:51.599 --> 00:31:53.720 as strong as Eurekish link. So you can live a really long time even 342 00:31:53.759 --> 00:32:01.559 if you have not optimized every cell of your body in that regard. So 343 00:32:01.599 --> 00:32:06.240 that's a very good point, Yes indeed, and I think for most of 344 00:32:06.279 --> 00:32:10.720 our viewers this will give them hope. Most people are not going to become 345 00:32:10.799 --> 00:32:15.119 super optimized in every respect, but they don't have to be. They just 346 00:32:15.160 --> 00:32:21.599 have to pay attention to their health and make sure that nothing fails critically. 347 00:32:21.759 --> 00:32:25.920 So thank you for that. I also wanted to get your thoughts about longevity, 348 00:32:25.960 --> 00:32:31.400 Summitt Dublin. So far we've had two days of the summit as of 349 00:32:31.599 --> 00:32:36.680 this recording. What are your impressions. I am very pleased to see that 350 00:32:36.720 --> 00:32:40.559 the movement continues to grow, and apart from the people who tend to go 351 00:32:40.640 --> 00:32:45.200 to a lot of conferences, you also see a lot of fresh faces here 352 00:32:45.200 --> 00:32:52.359 from different disciplines and that's when you have this cross pollination of ideas, you 353 00:32:52.519 --> 00:32:57.039 really can grow the community. So it's very interesting. Yes, indeed, 354 00:32:57.400 --> 00:33:01.279 it has certainly been, and we look forward to the remainder of the event. 355 00:33:01.480 --> 00:33:06.519 I think

that you should try to understand how you can make a contribution, 356 00:33:06.720 --> 00:33:10.799 how what can I do to help with my little piece of this global 357 00:33:12.000 --> 00:33:15.640 movement to accelerate important science. You don't have to be a scientist, but 358 00:33:15.680 --> 00:33:20.839 you can be a communicator or there's so many other things that you can do. 359 00:33:21.000 --> 00:33:23.039 So whatever thing that you feel like you can do, reach out and 360 00:33:23.440 --> 00:33:27.519 you can reach out to me, you can reach out to Jenade. But 361 00:33:28.599 --> 00:33:31.599 think about what can I do to help out to speed up progress? Yes, 362 00:33:31.640 --> 00:33:36.200 indeed, what can one do to help out? Very important question. 363 00:33:36.519 --> 00:33:39.480 Thank you very much, Victor for your time, and I hope that you 364 00:33:39.640 --> 00:33:47.559 enjoy the rest of Longevity Summitt Dublin, thank you very much. All right, 365 00:33:47.640 --> 00:33:53.240 excellent. So that was Victor Byork and now he has joined us Live. 366 00:33:53.440 --> 00:33:58.839 Thank you for being with us. Victor. We do have a question 367 00:33:59.240 --> 00:34:05.599 for you from our friend Alan Crowley. So, Victor wonders who are your 368 00:34:06.240 --> 00:34:10.679 main customers, how do you consult upon what topics? And have you considered 369 00:34:10.679 --> 00:34:15.559 working with city or state leadership? So feel free to address these in turn. 370 00:34:16.599 --> 00:34:21.119 Yes, indeed, so I have both the private individuals who are interested 371 00:34:21.159 --> 00:34:27.199 in a longevity who come to me to understand that we are the science is 372 00:34:27.320 --> 00:34:35.719 currently so I function as an independent consultant. If you want to visit clinic 373 00:34:36.239 --> 00:34:42.280 or a particular MD. I can provide the independent evaluation of scientific claims that 374 00:34:42.320 --> 00:34:45.920 they make. Yeah, and also what the what supplements that are evidence based 375 00:34:45.960 --> 00:34:53.000 and not and the cotting edge medicines that are that have solid scientific data in 376 00:34:53.079 --> 00:35:01.199 mice versus not. And I also and I also can provide people with investment 377 00:35:01.239 --> 00:35:08.079 advice look at different companies. So I helped out some funds as well in 378 00:35:08.159 --> 00:35:15.400 the space. So everything from a very personal start approach to an investment approach. 379 00:35:16.039 --> 00:35:21.400 And yeah, I consulted. It depends very much on who I am 380 00:35:22.679 --> 00:35:27.880 doing it. Usually I work on a retainer basis, so fixed amount of 381 00:35:28.119 --> 00:35:31.599 hours. Sometimes I can do some individual hours if somebody just has a very 382 00:35:31.880 --> 00:35:37.280 limited specific thing. If I would consider working with city or stated leadership, 383 00:35:37.360 --> 00:35:40.760 yes, yes, I will definitely be open to

that. I'm very broad 384 00:35:42.079 --> 00:35:46.119 in my knowledge. I'm very broad in who I am willing to work with 385 00:35:46.320 --> 00:35:52.079 in that regard. So yes, thank you very much, Victor, And 386 00:35:52.199 --> 00:36:00.000 for those who are interested in finding out more about Victor's consulting service, check 387 00:36:00.039 --> 00:36:06.679 out his website. Victor byork Giro Consulting. Alan does have a follow up 388 00:36:06.760 --> 00:36:09.920 question. He wonders, do you have a newsletter. Yes, they have 389 00:36:09.960 --> 00:36:15.960 a very popular newsletter on linked In that I publish, So check out my 390 00:36:15.000 --> 00:36:20.599 LinkedIn page. I have many thousands of followers there and I regulate to try 391 00:36:20.639 --> 00:36:25.719 to be ahead with the new updates on everything from conferences to scientific breakthroughs and 392 00:36:25.760 --> 00:36:31.679 so on. So yes, indeed, and I just posted the link to 393 00:36:31.800 --> 00:36:38.440 Victor's LinkedIn profile right here. You could also find it in our YouTube chat. 394 00:36:38.519 --> 00:36:45.000 Please do check it out. I regularly read Victor's posts from his newsletter. 395 00:36:45.079 --> 00:36:50.679 I find them to be insightful and I find them to provide the kind 396 00:36:50.719 --> 00:36:55.440 of perspective into the longevity industry that it's difficult to find elsewhere, just because 397 00:36:55.519 --> 00:37:04.239 Victor has seen so many different organizationations and has followed various recent trends. But 398 00:37:04.280 --> 00:37:09.639 also his knowledge base is extensive since he has worked in this field for several 399 00:37:09.679 --> 00:37:15.519 decades now, and he has worked as a researcher as well, which I 400 00:37:15.519 --> 00:37:22.599 think distinguishes him from a typical management consultant. For instance, he really knows 401 00:37:22.719 --> 00:37:28.239 this subject matter. So thank you very much, Victor. And we have 402 00:37:28.280 --> 00:37:35.400 a comment from London Futurists. There were two octagenarians attending the summit, one 403 00:37:35.480 --> 00:37:38.039 male, one female. The male was eighty one the female was eighty six, 404 00:37:38.079 --> 00:37:44.239 who both gave the impression of being much younger than their chronological ages, 405 00:37:44.360 --> 00:37:51.159 dancing in a sprightly way. And thank you David for sharing that. Rudy 406 00:37:51.239 --> 00:37:57.119 Hoffman does write that what is worrisome and depressing is that none of these centenarians, 407 00:37:57.440 --> 00:37:59.960 and I would say this is true for the super centenarians, the one 408 00:38:00.239 --> 00:38:05.039 past one hundred and ten are running marathons or doing the kind of youthful activities 409 00:38:05.079 --> 00:38:08.840 that most of us would like as health extenders. He wonders, is he 410 00:38:08.920 --> 00:38:15.639 wrong in that there have been some post one hundred year old people who

have 411 00:38:15.719 --> 00:38:19.199 run marathons. I don't think anyone past the age of one hundred and ten 412 00:38:19.280 --> 00:38:29.079 has run an extended distance, But David, please go ahead with your thoughts. 413 00:38:29.880 --> 00:38:32.639 Yes, I just amuted you on this point. There have been some 414 00:38:32.920 --> 00:38:39.159 very interesting studies near Barzelai in New York has studied the community of super ages 415 00:38:39.199 --> 00:38:44.000 based around New York, and what I learned at the conference is that there 416 00:38:44.000 --> 00:38:49.800 have been similar studies in Leyden, in Holland and also in Poland of not 417 00:38:49.880 --> 00:38:54.639 just individual super ages, but a small families of super ages. So there 418 00:38:54.679 --> 00:39:00.000 was one photograph of four sisters in Leyden in Holland, each of whom were 419 00:39:00.079 --> 00:39:04.920 over ninety years old, and all of them were pretty healthy. So it 420 00:39:05.119 --> 00:39:08.679 is the case that some people who are much older than the norm, they 421 00:39:08.679 --> 00:39:14.239 don't just live longer, they are healthy for longer. And given that there 422 00:39:14.280 --> 00:39:19.679 are in these family groups where in some cases the quality of lifestyle isn't so 423 00:39:19.840 --> 00:39:23.000 great, we have to say. Some of these families of superages included people 424 00:39:23.039 --> 00:39:30.039 who smoked a lot or who didn't eat much vegetables famously, so there must 425 00:39:30.039 --> 00:39:34.880 have been a strong genetic component, we would think. And indeed there are 426 00:39:35.679 --> 00:39:39.559 other signs that you can live healthily. And one photograph that was shown by 427 00:39:39.760 --> 00:39:46.239 Natalie Cole had the Britain's second oldest man who is one hundred and ten or 428 00:39:46.280 --> 00:39:50.880 maybe one hundred and eleven. He was actually standing up unaided, so most 429 00:39:50.880 --> 00:39:52.400 of the time he sits down to be clear, but he did have enough 430 00:39:52.519 --> 00:39:59.599 energy to make a few steps completely unaided. So there is some a good 431 00:39:59.639 --> 00:40:01.800 life quality of life for some of these super ages. So we can learn 432 00:40:02.119 --> 00:40:07.719 not just what allowed them to have so many candles only achaic, but what 433 00:40:07.960 --> 00:40:14.639 gave them the health characteristics of maybe a sixty year old when they were in 434 00:40:14.679 --> 00:40:19.360 their nineties, and it seems there's not one gene that has that result. 435 00:40:20.440 --> 00:40:24.920 Just as nature provides many different animals with different ways to live much longer, 436 00:40:25.320 --> 00:40:30.320 and we have to investigate each of them to see how applicable the mechanisms might 437 00:40:30.360 --> 00:40:32.920 be to introduce into humans. In the same way, it looks like different 438 00:40:32.920 --> 00:40:39.159 parts around the world have discovered different mechanisms whereby these super ages in small local 439 00:40:39.199 --> 00:40:45.039 groups can live significantly longer than the norm in this healthy state. At one 440 00:40:45.079 --> 00:40:49.480 stage it was thought, well, we'll study this and we'll find one gene 441 00:40:49.519 --> 00:40:52.880 which makes all the difference. And there are some genes that show up again 442 00:40:52.880 --> 00:40:55.880 and again. There's something called fox O three, which I think is involved 443 00:40:57.079 --> 00:41:01.920 in the insulin growth signalinger in fact the signaling I can't remember the details. 444 00:41:01.920 --> 00:41:06.320 So they're all one or two that come up quite often. But the likelihood 445 00:41:06.440 --> 00:41:09.920 is that there may be dozens or even schools of separate genetic mechanisms to be 446 00:41:10.119 --> 00:41:15.519 discovered by this. Yeah, so we just talked looking and we should look 447 00:41:15.519 --> 00:41:20.880 a lot more. Yes, thank you very much, David, and I 448 00:41:21.000 --> 00:41:30.119 definitely appreciate that perspective. Also Here's an article about the oldest known marathon runner, 449 00:41:30.199 --> 00:41:35.800 Fauja Singh, who ran a full marathon at the age of one hundred. 450 00:41:35.880 --> 00:41:39.639 This is an article from the official Olympics website. He is nicknamed the 451 00:41:39.679 --> 00:41:45.719 Turbined Tornado and if you can see a picture of him on that article, 452 00:41:45.960 --> 00:41:51.079 he definitely looks much younger and healthier than a typical one hundred year old. 453 00:41:51.400 --> 00:41:57.079 I would like Victor to opine on this. So is it the case that 454 00:41:57.199 --> 00:42:02.960 most of these super centenarians were in need able to be physically active and vigorous 455 00:42:04.320 --> 00:42:13.360 far longer than people typically would be, and their decline tended to happen fairly 456 00:42:13.440 --> 00:42:17.639 late in their lives, like in their one hundreds or one hundred tens. 457 00:42:19.840 --> 00:42:22.800 Yeah, yes, that's absolutely correct. On average. Of course, there's 458 00:42:22.800 --> 00:42:27.519 some people who are able to survive a very long in what we call a 459 00:42:27.599 --> 00:42:31.840 frail state. Now, super scenarios have not been a map MOLECULARI is, 460 00:42:31.960 --> 00:42:37.480 we don't know exactly how they are aiding slower than the average human. We 461 00:42:37.559 --> 00:42:43.599 would need really good digital twins to figure that out, but we can at 462 00:42:43.679 --> 00:42:49.639 least get some rough approximation with so called ADM scores, which means activities for 463 00:42:49.719 --> 00:42:54.519 daily living, which is of course what the physiogically separates people from being able 464 00:42:54.519 --> 00:42:59.320 to function independently and being in a nursing home, because that's not really molecurating, 465 00:42:59.400 --> 00:43:06.079 it's how the the molecular

aging impairs physiology. So, but on average, 466 00:43:06.199 --> 00:43:10.079 people who live too hundred and ten and to be independent until the age 467 00:43:10.079 --> 00:43:13.599 of about one hundred to one hundred and five, and then after one hundred 468 00:43:13.599 --> 00:43:19.320 and five they have a severe enough limitations that they need care, either full 469 00:43:19.360 --> 00:43:22.719 care or partial care. On average, there have been a few instances of 470 00:43:22.760 --> 00:43:28.719 people living completely independently to over one hundred and ten and even driving a car, 471 00:43:28.920 --> 00:43:35.159 but these people have not lived that much longer after that despite that health. 472 00:43:35.960 --> 00:43:39.000 But it's very clearly that if you compare the average eight year old who 473 00:43:39.000 --> 00:43:43.440 is going to live to one hundred and fifteen versus average eight year old, 474 00:43:44.079 --> 00:43:47.360 you will definitely be able to easily point that out. A child could point 475 00:43:47.360 --> 00:43:53.000 that out. It's obvious enough for that. Yes. Indeed, so super 476 00:43:53.000 --> 00:43:59.320 centenarians do live longer in good health. However, and I think this is 477 00:43:59.360 --> 00:44:07.679 extremely imp they do still decline eventually, and indeed at a fairly predictable rate 478 00:44:07.039 --> 00:44:14.800 because aging still affects them, and we highly encourage good lifestyle practices here at 479 00:44:14.800 --> 00:44:20.239 the US Transhumanist Party. But it's important to note none of today's good lifestyle 480 00:44:20.320 --> 00:44:24.639 practices or none of the genetic luck that these super centenarians have right now, 481 00:44:24.679 --> 00:44:29.800 will make them live to one fifty or even one thirty. For that, 482 00:44:29.840 --> 00:44:36.400 we need advances in biomedical science in rejuvenation. So thank you very much, 483 00:44:36.760 --> 00:44:42.760 Victor for your insights. Daniel tweet jokes, does longevity consulting typically come with 484 00:44:42.800 --> 00:44:47.239 a lifetime warranty? So I think that's a bit humorous. But do you 485 00:44:47.239 --> 00:44:52.920 want to say anything on that, Victor. It would be good if it 486 00:44:52.960 --> 00:44:59.039 came with that. I guess something in I should market maybe, yes, 487 00:44:59.079 --> 00:45:02.320 indeed, yes, indeed. All right, So I am going to play 488 00:45:04.199 --> 00:45:09.199 our next interview, which is with a good friend of ours and our foreign 489 00:45:09.239 --> 00:45:19.000 ambassador in Spain, doctor Jose Cordero. I met up with him also in 490 00:45:19.079 --> 00:45:23.880 the evening of the second day of Longevity sum at Dublin, and he was 491 00:45:24.000 --> 00:45:31.599 quite enthusiastic about several key developments that he will mention to us just now. 492 00:45:32.320 --> 00:45:37.920 So here is doctor Jose Cordero. Ladies and gentlemen, we are here at 493 00:45:38.119 --> 00:45:45.440 Longevity s at Dublin with our friend and US Transhumanist Party for an ambassador from 494 00:45:45.519 --> 00:45:50.920 Spain, doctor Jose Cordero. Welcome, Jose, Thank you, Ga Maddie. 495 00:45:51.280 --> 00:45:57.519 We are having this fantastic conference here in Eryonan to promote immortality. Yes, 496 00:45:57.599 --> 00:46:02.039 indeed we are both the Mores and there are many who think like us 497 00:46:02.079 --> 00:46:07.400 here. And you have your book The Death of Death in Spanish and in 498 00:46:07.440 --> 00:46:10.880 German and on your tie. Yes, yeah, the time goes with the 499 00:46:10.920 --> 00:46:16.119 book. I also have it in English, in Chinese, in Russian, 500 00:46:16.639 --> 00:46:23.039 in Italian, in Korean, Japanese and here in German, which is they 501 00:46:23.119 --> 00:46:29.280 change the title In German it means the victory over death. Yes, the 502 00:46:29.360 --> 00:46:34.800 victory over death. May it be achieved soon. So Jose, you were 503 00:46:35.159 --> 00:46:39.599 telling me before that you spoke with Ray Kurtzweil recently and his book The Singularity 504 00:46:39.679 --> 00:46:46.800 is Nearer is coming out. But Ray Kurtzweil has remained convinced that longevity escape 505 00:46:46.880 --> 00:46:52.639 velocity will be reached in five to six years, by twenty twenty nine or 506 00:46:52.800 --> 00:46:57.280 twenty thirty. What reasons does he give for this view? Well, I 507 00:46:57.480 --> 00:47:01.360 love Ray and I have known Ray for over thirty years since I went to 508 00:47:01.519 --> 00:47:07.800 MIT, and he gave lectures at MIT. So he's fantastic. He has 509 00:47:07.840 --> 00:47:14.239 been right about eighty plus percent of his projections over half a century. He's 510 00:47:14.280 --> 00:47:20.639 better than Rasputin. Forget about Rasputin or Nostra Damus, totally horrible. Ray 511 00:47:20.679 --> 00:47:23.800 kris Well is incredible for predicting the future. And in his new book, 512 00:47:24.079 --> 00:47:30.719 The Sigreatest Near There he talks about rich and longevity s cave velocity between twenty 513 00:47:30.800 --> 00:47:36.480 twenty and twenty thirty. And he is seventy six years old. I mean 514 00:47:36.559 --> 00:47:40.039 he's not a baby. He's seventy six years old. And he talks about 515 00:47:40.039 --> 00:47:46.360 how artificial intelligence is coming to save us. Artificial intelligence will be able to 516 00:47:46.440 --> 00:47:52.880 sequence and understand the human genome, all diseases and help us to find how 517 00:47:52.920 --> 00:47:58.239 to stop aging, how to reverse aging. So I think it's incredible. 518 00:47:58.440 --> 00:48:01.519 I wrote to him, he said the manuscript of his book before, and 519 00:48:01.559 --> 00:48:07.239 I said, are you sure that we can reach longevity schedulosity between twenty nine 520 00:48:07.320 --> 00:48:13.039 and twenty thirty And he said yes, And I will not move my prediction. 521 00:48:13.480 --> 00:48:17.039

And I am convinced this is going to happen. And him, I 522 00:48:17.079 --> 00:48:22.159 am convinced that I will not die. This is so incredible, incredible. 523 00:48:22.440 --> 00:48:29.480 You know, raycus well advisionally a fantastic guy. M t is university that's 524 00:48:29.519 --> 00:48:36.519 selling books, and he says he does not then to die, and I 525 00:48:36.559 --> 00:48:40.440 certainly hope that he is correct because that will mean we will not have to 526 00:48:40.480 --> 00:48:46.239 die and tottly because we're younger than him. Yes, yes, So it's 527 00:48:46.239 --> 00:48:52.360 interesting because some significant advances and artificial intelligence would need to occur between now and 528 00:48:52.400 --> 00:48:59.159 then for that to happen. We've had some remarkable advances and large language models 529 00:48:59.239 --> 00:49:07.480 and generative but those systems are still not sufficient to really understand biology or mathematics 530 00:49:07.679 --> 00:49:14.000 to the extent that would be needed to identify viable approaches for reversing senescence. 531 00:49:14.239 --> 00:49:19.480 So does Ray think a new paradigm of artificial intelligences just around the corner. 532 00:49:20.079 --> 00:49:25.559 Yes, yes, and yes, even generative AI. It's new. This 533 00:49:25.800 --> 00:49:31.880 is like three years old. It didn't exist before and now it is whow 534 00:49:31.960 --> 00:49:37.840 you know, you can actually predict what might happen because of this generative AI. 535 00:49:38.000 --> 00:49:45.960 But now more will come, actually intelligent artificial intelligence because generative AI, 536 00:49:45.840 --> 00:49:50.480 you know, finds what has happened in the past and makes a prediction. 537 00:49:51.079 --> 00:49:58.079 But we will have really intelligent artificial intelligence and it will be able to understand 538 00:49:58.599 --> 00:50:02.199 what we cannot. You know, like the human genome. The human genome 539 00:50:02.280 --> 00:50:07.599 is big, it's three gigabytes of data. We have twenty three thousand gens. 540 00:50:08.119 --> 00:50:15.079 We humans, we have brain small brain. Artificial intelligence has no limits. 541 00:50:15.480 --> 00:50:20.639 So yes, a I will help us to become in more time, 542 00:50:22.639 --> 00:50:25.320 I certainly hope. So now you have said before that what you are afraid 543 00:50:25.360 --> 00:50:30.800 of is not artificial intelligence but human stupidity. And there are a lot of 544 00:50:30.840 --> 00:50:37.079 people today who are afraid of artificial intelligence, and some of them provide some 545 00:50:37.159 --> 00:50:42.519 reasoning behind it. Others are just fearful and reactionary. But my question to 546 00:50:42.599 --> 00:50:47.320 you is in the race between artificial intelligence and human stupidity, which side is 547 00:50:47.360 --> 00:50:55.199 winning right now? Well, I think artificial intelligence will win, but we 548 00:50:55.400 --> 00:51:01.119 will

be merged, we will be fused with our official intelligence. My professor 549 00:51:01.159 --> 00:51:07.480 at MIT, Marvin Minski, one of the fathers of artificial intelligence. He 550 00:51:07.559 --> 00:51:12.639 said that we will merge with artificial intelligence, we will become more intelligence. 551 00:51:13.039 --> 00:51:20.400 We will use these artificial intelligence to become better human beings and actually technology is 552 00:51:20.440 --> 00:51:24.559 what makes us different from animals. We are animals with technology, and now 553 00:51:24.960 --> 00:51:30.360 we are animals with artificial intelligence. So I am so excited. You know, 554 00:51:30.400 --> 00:51:34.320 we are going to be incredible things. And as Ray Kurzwan says, 555 00:51:34.480 --> 00:51:38.599 but here in my book The Death of Death, we will reach longevity scale 556 00:51:38.639 --> 00:51:45.960 velocity in twenty thirty. So don't die before twenty thirty because we will be 557 00:51:45.000 --> 00:51:50.679 able to rejuvenate you by then in six years six years, So this is 558 00:51:50.719 --> 00:51:55.559 the best time to be alive and to remain alive. We're between the last 559 00:51:55.840 --> 00:52:01.760 mortal generation and the first in mortal generation. So Jannadi, where do you 560 00:52:01.800 --> 00:52:06.639 want to be? Yes, I definitely want to be part of well, 561 00:52:06.840 --> 00:52:12.840 perhaps the second or third immortal generation, because I want people who are fifty 562 00:52:12.920 --> 00:52:15.239 years older than I am, or even older than that to make it to 563 00:52:15.320 --> 00:52:21.199 longevity escape velocity. But yes, I definitely want to be there with them. 564 00:52:21.639 --> 00:52:28.880 But Jose you had a recent parliamentary election where you ran for the European 565 00:52:29.039 --> 00:52:32.679 Union Parliament on behalf of the Future Party in Spain, so could you tell 566 00:52:32.719 --> 00:52:37.800 us more about that? Yes, and thank you for asking that. Indeed, 567 00:52:37.079 --> 00:52:44.199 on June ninth, we had elections in Europe for the European Parliament, 568 00:52:44.480 --> 00:52:49.000 and we had two longevity parties, one in Germany and one in Spain, 569 00:52:49.400 --> 00:52:57.519 and we were campaigning for biological rejuvenation, for creating an agency for rejuvenation in 570 00:52:57.599 --> 00:53:02.079 Europe, because Europe is getting old and older and we are aging funds and 571 00:53:02.119 --> 00:53:07.840 there are no children. It's actually very sad. There is not a new 572 00:53:07.960 --> 00:53:14.039 generation in many European countries anyway. So I'm happy to tell you I had 573 00:53:14.440 --> 00:53:21.559 six thousand votes in Spain, and also tell you I don't have six thousand 574 00:53:21.599 --> 00:53:25.119 friends in Madrid, so I got a lot of votes in Germany also, 575 00:53:25.599 --> 00:53:31.159 they were close to eighteen nineteen thousand votes, which is a lot of votes, 576 00:53:31.639 --> 00:53:36.960 not enough to become members of the European Parliament, but it is a 577 00:53:36.960 --> 00:53:43.079 good beginning, a fantastic beginning, and this movement is growing in Germany, 578 00:53:43.280 --> 00:53:46.679 in Spain and soon in many other countries of the European Union. And so 579 00:53:47.239 --> 00:53:52.599 for the next European election, which is in five years, we hope to 580 00:53:52.719 --> 00:53:59.440 have some members of the Parliament working on projuvenation. Yes, that would be 581 00:53:59.599 --> 00:54:07.320 a tremendous achievement and it would greatly aid the visibility of the longevity cause as 582 00:54:07.320 --> 00:54:12.400 well as the transhumanist movement. Now, I think all of these votes were 583 00:54:12.639 --> 00:54:15.199 hard earned, and many of the people who voted for you or for the 584 00:54:15.239 --> 00:54:22.599 Party for Biomedical Rejuvenation Research are people who were introduced to these ideas by these 585 00:54:22.639 --> 00:54:29.519 campaigns. So we definitely applaud you for that extensive outreach that you performed. 586 00:54:29.719 --> 00:54:36.679 Now, another way of getting people informed about longevity and the possibilities is through 587 00:54:36.719 --> 00:54:39.480 events like this one Longevity Summitt Dublin. So I wanted to ask you, 588 00:54:39.519 --> 00:54:44.239 what are your impressions of the summit thus far at the end of the second 589 00:54:44.320 --> 00:54:50.000 day, Well, fantastic. The Longevity Summit Dublin is the place for you 590 00:54:50.320 --> 00:54:53.039 to come. If you don't want to die, if you want to write, 591 00:54:53.119 --> 00:54:58.840 don't com don't come here. This is a great place with great signs 592 00:54:59.119 --> 00:55:05.360 with the latest achievements in science. What is happening in epigenetic reprogramming, what 593 00:55:05.519 --> 00:55:10.199 is happening in stem cell therapiest, gene therapist chrisper all of this you will 594 00:55:10.239 --> 00:55:16.760 find out here in Dublin. So I'm pretty excited and happy to this movement 595 00:55:17.119 --> 00:55:23.079 that is growing exponentially, and so in five years we do want to change 596 00:55:23.079 --> 00:55:30.199 the world in five years, ray curse might be and we will have reached 597 00:55:30.440 --> 00:55:37.440 longevity escape velocity, which basically means immortality in the sense that we will live 598 00:55:37.639 --> 00:55:45.400 long enough to live forever, but aging still agent until the year twenty forty 599 00:55:45.400 --> 00:55:51.079 five. That is the magic year when according to Ray, we will have 600 00:55:51.159 --> 00:55:58.119 biological rejuvenation. So two important dates twenty thirty and twenty forty five. Twenty 601 00:55:58.239 --> 00:56:04.559 thirty to reach longevity scale velocity, and the Longevity Scalelocity Foundation, which was 602 00:56:04.599 --> 00:56:08.639 funded by Aubrey the Gray, is working towards that now

with mice with the 603 00:56:08.760 --> 00:56:16.440 robust Mouse Rejuvenation Price. This is a fantastic experiment because mice and humans we 604 00:56:16.559 --> 00:56:22.880 share ninety percent of the genome. Yes, you me, we are similar 605 00:56:22.920 --> 00:56:28.719 to mice ninety percent anyway, So if we can make mice live longer and 606 00:56:28.760 --> 00:56:31.800 longer and longer, we will do this with humans. So that's by twenty 607 00:56:31.920 --> 00:56:37.880 thirty, and then rejuvenation, which is the important part. We will become 608 00:56:38.000 --> 00:56:43.119 younger and younger. It's not that we are going to be immortally old, 609 00:56:43.480 --> 00:56:46.920 no, we are going to be immortally young, yes, And that is 610 00:56:46.960 --> 00:56:52.639 such a wonderful future to look forward to. I certainly hope that Ray is 611 00:56:52.719 --> 00:56:57.679 right and that we are on the cusp of these advances. But they won't 612 00:56:57.719 --> 00:57:00.800 happen automatically. They take hard work from all of the scientists, all of 613 00:57:00.840 --> 00:57:06.360 the technologists, all of the advocates like you, Jose, who have been 614 00:57:07.000 --> 00:57:14.039 at work tirelessly for decades supporting the longevity cause, spreading the word about it, 615 00:57:14.320 --> 00:57:16.599 writing books. So I would encourage everyone to get the Death of Death 616 00:57:16.639 --> 00:57:21.840 and the language of your choice. It's available in English now as well. 617 00:57:22.119 --> 00:57:25.119 And I hope that we can all live long and prosper. Absolutely, I 618 00:57:25.199 --> 00:57:30.239 always say that live long and prosper. I am a fan of a Star 619 00:57:30.400 --> 00:57:37.280 Trek, and I think we are going to begin begin colonizing the galaxy. 620 00:57:37.440 --> 00:57:44.119 It's so beautiful. Elern Most says it. We are the last puly planetary 621 00:57:44.239 --> 00:57:50.920 civilization. We are becoming a multiplanetary civilization. And this is incredible because the 622 00:57:51.639 --> 00:57:58.039 first Martians will be humans. We will be the first Martians, So this 623 00:57:58.119 --> 00:58:01.440 is fantastic. I mean, the future is so beautiful, so beautiful, 624 00:58:01.480 --> 00:58:06.760 and I want to be there and you should be there too. Let's build 625 00:58:06.760 --> 00:58:13.679 it together. Thank you very much, Jose. A pleasure. Indeed, 626 00:58:13.679 --> 00:58:19.000 it was a pleasure to hear from doctor Jose Cordero, and he gave quite 627 00:58:19.599 --> 00:58:25.119 a spirited set of remarks earlier today as well. I wanted to follow up 628 00:58:25.199 --> 00:58:34.840 on Jose's mention of the Robust mouse rejuvenation study that is now sixteen months under 629 00:58:34.880 --> 00:58:40.639 way. And of course this is Aubrey De Grey's flagship project at the Longevity 630 00:58:40.719 --> 00:58:49.599 Escape Velocity Foundation, and Caitlin Lewis, who is the scientist overseeing the project, 631 00:58:49.920 --> 00:58:57.599 provided quite a detail and eloquent update about the progress at Longevity Summit, 632 00:58:57.679 --> 00:59:01.760 Dublin. You can also read all update. The latest update that was published 633 00:59:01.920 --> 00:59:07.320 was on May seventh, twenty twenty four. And these are the survival curves 634 00:59:07.440 --> 00:59:12.360 that we have right now from this study. I am going to show them 635 00:59:12.760 --> 00:59:19.119 briefly, so you can see here for the male mice, there are ten 636 00:59:20.079 --> 00:59:28.480 cohorts and you can see here at the bottom the legend that shows what each 637 00:59:28.519 --> 00:59:35.920 of these colored lines represent. And you can see that the red line showing 638 00:59:36.360 --> 00:59:43.119 the group that received all of the treatments is at i would say about sixty 639 00:59:43.159 --> 00:59:51.719 five percent survival as of the last recorded data point, whereas the thick blue 640 00:59:51.760 --> 00:59:57.400 line showing the group that received none of the treatments. The control group is 641 00:59:57.480 --> 01:00:01.840 below thirty percent as of the latest update, and when these mice were as 642 01:00:01.960 --> 01:00:07.599 old as the mice in the red cohort, this group was only at forty 643 01:00:07.639 --> 01:00:15.280 percent survival. And we see a similar set of patterns with the females. 644 01:00:15.360 --> 01:00:21.719 Now there are some differences by gender which are notable, and in this strain 645 01:00:21.760 --> 01:00:24.639 of mice, the males do actually live longer than the females. But you 646 01:00:24.679 --> 01:00:31.599 can see the significant gap between the red cohort and the Blue cohort as well. 647 01:00:31.639 --> 01:00:37.639 And I would encourage you to explore these graphs and read Aubrey's update as 648 01:00:37.800 --> 01:00:45.400 well. And now, David, you would like to discuss the appearance of 649 01:00:45.639 --> 01:00:51.239 Peter Diamandis as well as the health Span X Prize, which is big news 650 01:00:51.320 --> 01:00:57.800 for the longevity community. Thanks well, First, that just make a little 651 01:00:57.800 --> 01:01:00.800 bit more of a comment about the significance of the RMR one project is. 652 01:01:00.840 --> 01:01:05.880 One thing that impressed me was the number of people at the conference who clearly 653 01:01:05.960 --> 01:01:09.960 understood that this was a breakthrough project. In many ways, it was a 654 01:01:10.000 --> 01:01:16.360 sea change since the approach that Aubrey has been advocating for more than twenty years 655 01:01:16.719 --> 01:01:22.960 has up to now been a divide and conquer approach in which different categories of 656 01:01:23.039 --> 01:01:29.079 damage of aging have each been analyzed and individual treatments have been proposed and developed 657 01:01:29.119 --> 01:01:32.920 and researched for different types of damage. But we're now moving inter phase, 658 01:01:34.119 -->

01:01:37.639 which Kitlin described Kitlin Lewis described in her presentation as it is now time to 659 01:01:37.679 --> 01:01:42.199 combine, in other words, to see how the different treatments, which have 660 01:01:42.280 --> 01:01:49.280 each individually been proven when applied to middle aged mice to extend their remaining lifespan 661 01:01:49.480 --> 01:01:54.880 by perhaps ten or twenty percent, how do these different treatments react when applied 662 01:01:54.880 --> 01:01:58.719 together. And there are different kinds of treatments. So one of the ones 663 01:01:59.079 --> 01:02:02.880 of the four is something that is given in the food, wrappamcin. There's 664 01:02:02.920 --> 01:02:08.000 another one involves a different kind of treatmental together a synalytic. There's another one 665 01:02:08.239 --> 01:02:15.400 that is two for some mice to extend their telomeres. And there's a fourth 666 01:02:15.440 --> 01:02:21.679 as well, which involves the transplant of young hemopoetic stem cells. So four 667 01:02:21.719 --> 01:02:24.920 different kinds of treatments, and it's very important to understand what kind of cross 668 01:02:25.039 --> 01:02:30.239 talk or what kind of influence there might be between the different treatments. So 669 01:02:30.599 --> 01:02:37.760 that's what the project is exploring and it is generating much more data than you 670 01:02:37.840 --> 01:02:42.639 can see just on these graphs. There is lots of data about the how 671 01:02:42.639 --> 01:02:45.960 the animals look, because you can tell often by looking at them, how 672 01:02:45.079 --> 01:02:50.840 curb their spine is, how they're how much they can grip as well, 673 01:02:51.320 --> 01:02:54.800 and their internal organs. So did Cornell is on this call is right when 674 01:02:54.840 --> 01:03:00.239 the emphasises we need to collect health data, and this is health data of 675 01:03:00.239 --> 01:03:05.760 an unprecedented kind. And Kitlin, I thought, gave very clear talk about 676 01:03:05.760 --> 01:03:10.440 this, and they afterwards, ever that I spoke to and people often brought 677 01:03:10.480 --> 01:03:15.280 it up without me raising the topic first, that this is a project of 678 01:03:15.280 --> 01:03:21.320 great significance and people are looking forward eagerly to when we can do version two 679 01:03:21.519 --> 01:03:24.320 of the project, which will, as Kitlin explained, probably have up to 680 01:03:24.480 --> 01:03:30.679 six treatments per mice, and all of the mice, including their controls in 681 01:03:30.679 --> 01:03:34.000 this case, will probably be given wrapper mice in because it is the single 682 01:03:34.039 --> 01:03:37.760 treatment that seems to be the most effective in its own right. We will 683 01:03:37.800 --> 01:03:43.280 also put wheels in each cage for the mice, because mice do like to 684 01:03:43.360 --> 01:03:46.199 run, and when they run it seems that extends their lifespans. As well, 685 01:03:46.239 --> 01:03:51.239 and we'll have four other treatments. That does depend on funds being raised, 686 01:03:51.440 --> 01:03:53.440 and that takes me to the remarks I'd like to come into next, 687 01:03:53.480 --> 01:04:01.559 which is sources are funding for significant rejuvenation projects. Peter de Amandes was interviewed 688 01:04:03.239 --> 01:04:08.559 at the event. Most of the speakers were present, just one or two 689 01:04:08.639 --> 01:04:13.159 for various reasons couldn't make it, and Peter Demands was on what he described 690 01:04:13.199 --> 01:04:16.679 as the first family holiday he'd had for many years, so he broke away 691 01:04:16.679 --> 01:04:24.599 from his holiday and was interviewed by Aubrey on as to the X Prize, 692 01:04:24.599 --> 01:04:29.519 amongst other things. And the X Prize is the world's largest ever prize. 693 01:04:30.599 --> 01:04:35.440 One hundred and one million dollars has been set aside from various sources that I'll 694 01:04:35.480 --> 01:04:42.239 described in a minute, in order to attract people to do something which goes 695 01:04:42.280 --> 01:04:47.920 beyond what we are doing in RMR. RMR is intended to obviously rejuvenate several 696 01:04:47.960 --> 01:04:54.960 different aspects of the mice so that the mice will be protected against aging in 697 01:04:55.159 --> 01:04:59.000 various dimensions. At the same time, well, for our company to win 698 01:05:00.239 --> 01:05:06.239 either one hundred million or ninety million, it depends on how well they do. 699 01:05:06.280 --> 01:05:13.920 They have to demonstrate through treatments applied over a one year period that the 700 01:05:13.960 --> 01:05:18.159 functional strength of your muscles, the functional strength of your immune system, and 701 01:05:18.199 --> 01:05:21.880 the functional ability of your brain, your cognitive strength, that all three of 702 01:05:21.920 --> 01:05:29.400 them have been rejuvenated by ten years, if for the smaller amount of the 703 01:05:29.400 --> 01:05:32.559 prize, or by twenty years for the larger amount of the prize. I 704 01:05:32.639 --> 01:05:39.320 think this is truly game changing, and there are large numbers of people who 705 01:05:39.320 --> 01:05:44.320 are interested and talking about ideas by which they may win this prize. Now, 706 01:05:44.639 --> 01:05:48.400 the prize is set to be awarded hopefully in twenty thirty. If it 707 01:05:48.440 --> 01:05:53.159 isn't ail one by twenty thirty, it makes continue a little bit longer. 708 01:05:53.679 --> 01:05:58.639 Jose Codero was listening carefully to this talk, and he asked a question over 709 01:05:58.800 --> 01:06:03.000 the remote system them to Peter Demander's. He said, well, your friend 710 01:06:03.559 --> 01:06:08.920 Ray Kutzwell, who together with Peter Demanders, the two of them have formed 711 01:06:08.920 --> 01:06:13.119 the Singularity University. Ray Kudswell is convinced in his new book that we will 712 01:06:13.159 --> 01:06:16.880 get to longevity

escape velocity by twenty twenty nine, twenty thirty. What do 713 01:06:16.960 --> 01:06:20.880 you think, Peter and Peter, as you might review in due course, 714 01:06:20.920 --> 01:06:26.800 when you watch the recording was quite diplomatic. I think what he has in 715 01:06:26.800 --> 01:06:30.320 mind is that there are two scenarios that it could be indeed a rapid improvement 716 01:06:30.360 --> 01:06:34.880 in AI, which will accelerate everything. But in case there isn't such a 717 01:06:35.159 --> 01:06:40.440 huge improvement in AI in the short term, then we must extrapolate what we 718 01:06:40.480 --> 01:06:45.440 can see with today's AI or incremental improvements on today's AI and all the other 719 01:06:45.480 --> 01:06:51.119 treatments that were being discussed at the Longevity Tubin event. In that case, 720 01:06:51.519 --> 01:06:58.000 I think maybe by twenty thirty we won't have rejuvenated people in all aspects, 721 01:06:58.079 --> 01:07:02.039 but we will have the ability homefully to rejuvenate people in many aspects, and 722 01:07:02.079 --> 01:07:08.159 that will buy all of us who are still alive then enough time to wait 723 01:07:08.400 --> 01:07:12.679 for more treatments to become available in the next ten years or so. Now 724 01:07:12.719 --> 01:07:15.599 I mentioned the funding for this, it comes from three sources. This one 725 01:07:15.679 --> 01:07:20.360 hundred and one million. There is a number of individuals who have put money 726 01:07:20.360 --> 01:07:25.360 in themselves, including Pizza de Amandis, who put five million dollars of his 727 01:07:25.400 --> 01:07:28.800 own money up as part of the prize, and many other people put up 728 01:07:28.840 --> 01:07:33.599 similar romance. There was one other successful businessman whose name unfortunately I can't remember. 729 01:07:34.360 --> 01:07:39.719 He did put up a significant amount of money too, in part because 730 01:07:39.800 --> 01:07:45.960 his son is suffering from a premiature aging disease, so that has partially motivated 731 01:07:45.039 --> 01:07:49.480 him. But the largest amount of money comes from evolution, and that's the 732 01:07:49.639 --> 01:07:53.559 last thing I'd like to talk to. And then maybe I will ask Victor 733 01:07:53.599 --> 01:07:57.679 to comment on evolution, because I know Victor has made a special study of 734 01:07:57.719 --> 01:08:02.800 what evolution are doing. Evolution is the fund set up from within Saudi Arabia 735 01:08:03.000 --> 01:08:10.360 dedicated to spending more and more money as time passes in support of longevity research. 736 01:08:10.960 --> 01:08:14.199 Actually they don't call it longevity research. They're always quite careful to say 737 01:08:14.639 --> 01:08:19.359 increased health span, that people who live longer will have much healthier times as 738 01:08:19.399 --> 01:08:24.840 they live longer. So they have set up two initiatives. One of them 739 01:08:25.199 --> 01:08:30.119 is an investment fund where they will invest with expectation that is, at least 740 01:08:30.159 --> 01:08:33.880 in some cases there will be a commercial return. But then there's also a 741 01:08:34.039 --> 01:08:42.000 grant side in which they make grants to academia and to other places such as 742 01:08:42.039 --> 01:08:46.000 the experize without any expectation of a commercial return. And they've taken a while 743 01:08:46.079 --> 01:08:49.640 to get up to the run rate that they said initially they'd hope to reach 744 01:08:49.720 --> 01:08:55.560 They haven't reached it yet, but increasingly they are spending more money and this 745 01:08:55.680 --> 01:09:02.840 could be tremendously significant. There were two speakers Dublin from the health Span sorry 746 01:09:02.960 --> 01:09:10.039 yes, from Evolution. The CEO men we Can at the last minute was 747 01:09:10.079 --> 01:09:15.359 called away on other personal business, but his chief of investment was there gave 748 01:09:15.399 --> 01:09:21.399 a very interesting talk and also separately another one of their scientific advisors who also 749 01:09:21.439 --> 01:09:27.159 works for one of the leading consultancies in the US. He gave a fascinating 750 01:09:27.199 --> 01:09:31.840 talk about the economics reasons why we should all be getting behind healthy longevity. 751 01:09:32.159 --> 01:09:35.359 So I'm encouraged by what Evolution are doing so far. I wish they would 752 01:09:35.399 --> 01:09:41.239 spend more money more quickly, but there are building up speed, I think, 753 01:09:41.319 --> 01:09:46.199 and the backing of the xprize is truly significant. Victor, I wonder 754 01:09:46.239 --> 01:09:50.600 if you anything you want to add, because you have been watching evolution from 755 01:09:50.720 --> 01:09:55.640 your own point of view. Yes, thank you, David. I don't 756 01:09:55.680 --> 01:09:59.760 think Victor is on the stream at this time, but if he does return, 757 01:10:00.239 --> 01:10:04.119 we can ask him this question. And I definitely appreciate your overview. 758 01:10:04.399 --> 01:10:12.359 Both of Peter Diamandis's comments on the X Prize health Span as well as the 759 01:10:12.479 --> 01:10:18.239 activities of evolution and the remarks by William Green who was present in person. 760 01:10:18.359 --> 01:10:27.359 He is the Chief Investment Officer of Evolution. So another theme that was addressed 761 01:10:27.479 --> 01:10:34.800 at the Longevity Summit is jurisdictional innovation. So as we know because we held 762 01:10:35.439 --> 01:10:45.039 our salon with Augmentation Limitless, who now have an affiliate in Roatan, the 763 01:10:45.039 --> 01:10:51.399 island of Roton in Honduras. There is now a special economic zone there called 764 01:10:51.760 --> 01:10:58.960 Prospera, and I had the occasion to interview to gentlemen. One of them 765 01:10:59.520 --> 01:11:04.760 is Trey Goff from Honduras Prospera, Inc. Which is the entity that's set 766 01:11:04.880 --> 01:11:15.359 up

Prospera as a special economic zone. And another individual is Pedro Henrik, 767 01:11:15.399 --> 01:11:21.319 who is one of the founders of Vitalia, which is a city, a 768 01:11:21.359 --> 01:11:29.920 pop up city and innovative community that is dedicated to life extension. And because 769 01:11:30.199 --> 01:11:35.119 of the longevity focus of the summit and our salon, I'm going to play 770 01:11:35.520 --> 01:11:42.800 the interview with Pedro first and then I will play part of the interview with 771 01:11:42.880 --> 01:11:46.399 Trey because it was actually quite extensive. We'll see what we can get to 772 01:11:47.119 --> 01:11:53.319 during this stream. But you will also be able to find the full interview 773 01:11:53.399 --> 01:12:00.920 with Trey on my YouTube channel afterward, but for now let us here from 774 01:12:01.119 --> 01:12:14.199 Pedro Henrik. He is quite an enthusiastic speaker and supporter of longevity. Pedro, 775 01:12:14.399 --> 01:12:19.199 could you please introduce yourself and tell us about your interest in longevity as 776 01:12:19.279 --> 01:12:25.000 well as how you became involved with Vitalia. All right, first of all, 777 01:12:25.000 --> 01:12:28.399 thanks so much for this opportunity to talk a little bit about Vitalia. 778 01:12:29.319 --> 01:12:32.960 My name is peed rennick. I am one of the pioneers in Vitalia, 779 01:12:33.520 --> 01:12:40.439 and we are creating the society that aims for the first time in history to 780 01:12:40.479 --> 01:12:44.159 get in the same spot, the same place people that want to shape the 781 01:12:44.199 --> 01:12:50.359 future of longevity of the human augmentation. So basically also getting this input on 782 01:12:50.399 --> 01:12:59.079 transhumanism. Our idea is by creating density of ali aligned people, we are 783 01:12:59.119 --> 01:13:02.439 able to push or the frontier of development. We work with biotechs, we 784 01:13:02.520 --> 01:13:06.239 work with the cybernetics, We work with a bunch of startups that wants to 785 01:13:06.279 --> 01:13:12.840 get things done and want to actually move the humanity and our capacity forward as 786 01:13:12.880 --> 01:13:15.800 fast as possible. Because this is pressing an insurgent and you are leaving these 787 01:13:16.880 --> 01:13:20.359 super interesting time in history that we have the knowledge, the technology and the 788 01:13:20.399 --> 01:13:24.920 willingness to make these things happen. So we're truly glad to be here talking 789 01:13:24.920 --> 01:13:27.960 with you a little bit about what you are doing. Yes, indeed, 790 01:13:28.000 --> 01:13:31.399 I'm pleased to be speaking with you as well. And indeed we live in 791 01:13:31.399 --> 01:13:39.960 interesting times, an era of jurisdictional experimentation. So, as many of us 792 01:13:40.039 --> 01:13:44.479 know, there was a pop up city called Zuzalou, which was a precursor 793 01:13:44.560 --> 01:13:49.880 to Vitalia. And could you perhaps tell our viewers a bit about

Zuzalu and 794 01:13:50.079 --> 01:13:56.279 also how Vitalia is different, how Vitallya is the next step from that. 795 01:13:56.640 --> 01:14:04.479 All right, So basically happened last year in Montenego. It was initiative spearheaded 796 01:14:04.560 --> 01:14:14.279 by Vital Gutriin, and it was what we call it city. It's within 797 01:14:14.359 --> 01:14:17.239 the lines of a concept called network states. It's to experiment how can we 798 01:14:17.319 --> 01:14:27.279 get Web three ideals, Web three governance tools and frameworks and implemented in the 799 01:14:27.319 --> 01:14:34.479 real world. Okay, And this was the initiative that happened for three months, 800 01:14:34.520 --> 01:14:40.920 if I'm not wrong, And from that initiative a bunch of enthusiasts also 801 01:14:41.239 --> 01:14:45.000 continue working on their own projects. Vitally is one of these projects. Susalu 802 01:14:45.199 --> 01:14:47.920 is mostly focused on REB three, even though that's alignment with a lot of 803 01:14:47.920 --> 01:14:55.079 interesting topics like that go beyond Web three, namely longevity and biotech. But 804 01:14:55.399 --> 01:15:01.239 Vitally itself specialized on this vertical on biotech and longevity and long bio and life 805 01:15:01.279 --> 01:15:05.199 extension. And our goal is to get some of the principles that were implemented 806 01:15:05.560 --> 01:15:13.479 in this pop up city and try it by plugging the concept in what we 807 01:15:13.560 --> 01:15:17.000 believe to be the best place in the world that allows us to create a 808 01:15:17.039 --> 01:15:25.159 network society, a startup society, a long bio society that is prospera in 809 01:15:25.479 --> 01:15:30.079 Latan. So it's a special economic zone that gives us well from the n 810 01:15:30.119 --> 01:15:38.319 During government, that gives us complete freedom when it comes to defining the most 811 01:15:38.399 --> 01:15:49.680 appropriate health legal regulations that leverage and expedite this goal of biotech development. And 812 01:15:49.760 --> 01:15:55.199 that's how so this year in January, for the first time, we had 813 01:15:55.840 --> 01:16:00.319 our own pop up city Vitalia that started the beginning of anyway. We had 814 01:16:00.359 --> 01:16:05.560 amazing thought leaders over there. We have the Aubrey that is hosting one of 815 01:16:05.600 --> 01:16:12.039 the most important presence heres in longevity Suvent in Dublin. We have the Naval 816 01:16:12.119 --> 01:16:15.520 Africa, we have Balaji, we have Brian Johnson. We had a lot 817 01:16:15.520 --> 01:16:19.199 of opinion and thought leaders worldwide that came to visit us that we did these 818 01:16:19.439 --> 01:16:27.119 experiments on what would be to live in a place, how to engineer the 819 01:16:27.119 --> 01:16:29.840 paradise that we want to see on Earth. I mean, we were lucky 820 01:16:29.920 --> 01:16:32.920 enough to have this amazing interaction that worked with us and made fut and not 821 01:16:32.960 --> 01:16:38.920 only a successful pop up city, but also allowed us to see the permanent 822 01:16:38.960 --> 01:16:45.000 basis for this permanent community that still exists and it's going to keep existing, 823 01:16:45.119 --> 01:16:53.159 we hope forever. That's been working on at least Yes, indeed, and 824 01:16:53.520 --> 01:16:59.199 one of the most important questions in my mind, apart from how to make 825 01:16:59.239 --> 01:17:08.039 individuals forever, is how to enable good organizations or good societies to endure forever 826 01:17:08.359 --> 01:17:15.439 or indefinitely, so that we don't have situations like violent revolutions or disintegrations of 827 01:17:15.520 --> 01:17:24.039 society or societies degenerating into tyranny, which has happened often throughout history. Great 828 01:17:24.039 --> 01:17:29.159 empires have collapsed, for example. So do you think Vitalia offers a proof 829 01:17:29.159 --> 01:17:36.479 of concept of a society that could endure where previous models have failed. So 830 01:17:36.720 --> 01:17:41.199 let me first clarify something. Our goal, of course is to work in 831 01:17:41.199 --> 01:17:44.720 life extension, but it goes beyond that. We think that life extension is 832 01:17:44.720 --> 01:17:48.279 a consequence of health. If we're able to mitigate things like aging BEFO, 833 01:17:48.279 --> 01:17:53.439 we're able to focus on being healthy, a side effect is going to be 834 01:17:53.479 --> 01:18:00.720 actually not dying or at least not dying through metal cause like aging diseases. 835 01:18:00.640 --> 01:18:09.279 So our goal is mostly to focus on life expansion in human augmentation, how 836 01:18:09.319 --> 01:18:14.199 can we go beyond our current limitations, so lete of extensions, it's something 837 01:18:14.199 --> 01:18:16.399 that we are focused on, but it's one of the side effects, one 838 01:18:16.399 --> 01:18:19.279 of the a lot of the side effects that can come. For example, 839 01:18:19.399 --> 01:18:27.680 intelligence in Greece can be also one of the consequences. And so answering if 840 01:18:27.720 --> 01:18:34.279 we are bulletproof regarding some of the vices that have been haunting societies for millennials 841 01:18:34.399 --> 01:18:40.439 or since human humans exist. Now we are not bulletproof, but we are 842 01:18:40.479 --> 01:18:45.359 open to experiment and to adapt the best practices that allow us to try to 843 01:18:45.399 --> 01:18:53.279 mitigate those possibilities. At the basic level. We so if you're able to 844 01:18:53.479 --> 01:18:58.640 engineer the new kinds of humans, maybe you're going to have the cognitive capacity 845 01:18:58.680 --> 01:19:02.359 to solve problems that we didn't we haven't done before. If we're able to 846 01:19:02.600 --> 01:19:10.039 invest in AI, the technology that allows us to leverage us our decision making 847 01:19:10.039 --> 01:19:14.000 capacities, we can also maybe find solutions that until now we haven't

seen before, 848 01:19:14.439 --> 01:19:17.159 but at a more basic level, assuming that ive things are still in 849 01:19:17.279 --> 01:19:27.039 process. We try to work with tools that are open to the community to 850 01:19:27.239 --> 01:19:32.399 engage and contribute in a speedy manner, because through iteration is the best way 851 01:19:32.399 --> 01:19:36.039 for it to evolve and to actually do something that is anti fragile and right 852 01:19:36.039 --> 01:19:40.479 now. We do that mostly by aligning with Prospera, and Prospera has been 853 01:19:40.479 --> 01:19:48.039 collecting the best practice in terms of the most successful legal structures worldwide economically, 854 01:19:48.279 --> 01:19:55.319 for example, especially economics zones like Hong Kong, like Dubai. But we 855 01:19:55.399 --> 01:20:00.359 go beyond that because we also focus on the human aspect of li TEA, 856 01:20:00.000 --> 01:20:08.359 and for that we have been including and even inviting prominent philosophers and economies to 857 01:20:08.439 --> 01:20:15.279 contribute on how to paradise engineer these places we want to build on the second 858 01:20:15.319 --> 01:20:20.640 hand, regarding this, besides Prospera, we also are employing open source solutions. 859 01:20:20.680 --> 01:20:29.159 A lot of them also based on Web three protocols, and that's something 860 01:20:29.159 --> 01:20:32.399 that you actually, we think is important to understand from everything that exists. 861 01:20:32.479 --> 01:20:36.199 So Web two, Web three, Web four, or web whatever is going 862 01:20:36.239 --> 01:20:44.000 to come. We are not stuck into a single philosophy when it comes to 863 01:20:44.079 --> 01:20:47.560 what are the best plays to create the best socie. We are open to 864 01:20:48.359 --> 01:20:57.039 the best solutions to optimize for the right and not optimize to an ideology. 865 01:20:57.119 --> 01:21:00.600 So anyone that wants to come, and one wants to come, one that 866 01:21:00.680 --> 01:21:03.399 believes that as an interesting solution, we invite for people to come. We 867 01:21:03.439 --> 01:21:11.640 have radical tolerance. We believe that only by exposing our current beliefs and our 868 01:21:11.680 --> 01:21:21.520 current ideals, our current basis of operation too. External challenges, external ways 869 01:21:21.560 --> 01:21:30.479 of thinking that may that may that may try to change and try to to 870 01:21:30.479 --> 01:21:35.520 to deconstruct some of our the things that we are creating right now is the 871 01:21:35.560 --> 01:21:40.520 only way that you actually can do something more sustainable. So by operating and 872 01:21:40.520 --> 01:21:44.960 integrating everyone that is willing to contribute, that's how we create an anti fragile 873 01:21:45.199 --> 01:21:47.680 society that tries to mitigate some of these issues that are trying to solve. 874 01:21:48.079 --> 01:21:55.760 Very interesting so it's possible that Vitalia will become a hub of new

political theory 875 01:21:56.079 --> 01:22:02.039 and experimentation, similar to what happened during the eighteenth century in Europe and in 876 01:22:02.079 --> 01:22:10.520 the United States, where essentially new republican or small de democratic forms of government 877 01:22:10.920 --> 01:22:16.199 were devised. And prior to that time much of the world was comprised of 878 01:22:16.279 --> 01:22:24.880 monarchies. So maybe still newer political structures and policy frameworks will be devised in 879 01:22:25.039 --> 01:22:30.920 Vitalia through these collaborations, through various thinkers coming over there and sharing their ideas. 880 01:22:31.039 --> 01:22:33.960 Now, I wonder, in your view, what are some of the 881 01:22:34.319 --> 01:22:42.319 policy reforms that Vitalia would be able to implement that could streamline, for instance, 882 01:22:42.359 --> 01:22:47.560 the discovery of new medical treatments or the deployment of those treatments to patients 883 01:22:47.560 --> 01:22:54.560 who might benefit them. So we believed in several things. We think that 884 01:22:54.640 --> 01:22:57.520 the best person for wait to talk a little bit about the legal innovations are 885 01:22:57.560 --> 01:23:01.880 going to be the one from prosper some of our partners. But we in 886 01:23:01.960 --> 01:23:05.960 Vitality, we are leveraging some of these legal frameworks, mostly those that allow 887 01:23:06.079 --> 01:23:11.560 us to, for example, expedite the go to market of biotechs from ten 888 01:23:11.640 --> 01:23:16.159 years and billions of dollars to less than one year and hundreds of thousands of 889 01:23:16.239 --> 01:23:20.640 dollars. That's a completely change of paradigm because what happens is, first of 890 01:23:20.680 --> 01:23:27.000 all, you allow for companies to start monetize in really early earlier stages. 891 01:23:27.359 --> 01:23:30.119 So for any kind of research or scientists or entrepreneurs that actually want to start 892 01:23:30.119 --> 01:23:33.399 doing something in this field, now they have an option. Because to become 893 01:23:33.439 --> 01:23:38.439 an entrepreneur on an industry that might require ten years to do something, well, 894 01:23:38.520 --> 01:23:42.319 that's not quite attractive. And we believe that by changing this paadiding, 895 01:23:42.560 --> 01:23:46.039 we are going to sentivise a potential revolution in terms of the creation of new 896 01:23:46.079 --> 01:23:50.720 biotechs, new cybernetics, new ideas in the realm of biology that can change 897 01:23:50.720 --> 01:24:00.119 completely the way we operate. We also regarding new regulations. Also, we 898 01:24:00.159 --> 01:24:03.920 believe that the no this is done and it is important for us to focus 899 01:24:03.920 --> 01:24:10.800 a little bit so we are able to shorten this process because we are most 900 01:24:11.239 --> 01:24:15.560 focused on safety. So the FCCY trials are not one of our main concerns 901 01:24:15.600 --> 01:24:20.000 because we believe that that's one of the main concerns of them of their companies 902 01:24:20.039 --> 01:24:26.520 providing the solutions, and they are liable for these solutions, and within the 903 01:24:26.560 --> 01:24:30.279 legal season that we create, they are, they can be litigated, they 904 01:24:30.279 --> 01:24:34.560 can be a target of being sued if they're not doing with what they are 905 01:24:34.600 --> 01:24:39.199 promising. Anyone from the community can do that. But our main focus in 906 01:24:39.399 --> 01:24:45.840 regarding government's entity is to get these safety So by focusing on the safety aspect 907 01:24:45.960 --> 01:24:49.640 of these trials, we allowed everything that we guarantee everything we're doing is actually 908 01:24:49.680 --> 01:24:57.279 safe for everyone to implement. And this allowed with also the possibility of the 909 01:24:57.399 --> 01:25:04.159 right to try well, enables us to eliminate One of the main causes of 910 01:25:04.199 --> 01:25:12.760 death right now is the slowness this space, this space of developments, that 911 01:25:13.760 --> 01:25:19.079 we don't see the effect on our deleted lives. Because everyone thinks about the 912 01:25:19.079 --> 01:25:25.840 people that are saved by a drug when it's wrongly administered. For example, 913 01:25:26.439 --> 01:25:30.560 if something that happens regarding a new treatment, we can see the effects of 914 01:25:30.640 --> 01:25:36.720 it being done in a poorly manner. What we don't see is the silent 915 01:25:36.840 --> 01:25:42.800 symmetry of people that die because a lot of these solutions didn't go to market 916 01:25:42.880 --> 01:25:49.479 so fast. So some studies says that in ten years, hundreds of thousands 917 01:25:49.720 --> 01:25:53.680 of people can be tens of thousands. Sorry, if people are saved by 918 01:25:54.279 --> 01:26:00.840 FDA regulations regarding safety, what we don't see is the hundreds of thousands or 919 01:26:00.880 --> 01:26:03.880 maybe even millions of people that try because a solution was not put into the 920 01:26:03.920 --> 01:26:15.319 market fast enough. And our goal is to create this system that fuels that 921 01:26:15.399 --> 01:26:18.680 allows for people that have problems that need to be solved urgently, because when 922 01:26:18.720 --> 01:26:25.520 you are diagnosed with something that may kill you, safety is important, of 923 01:26:25.520 --> 01:26:28.600 course is important, but we have something that you want to implement and try 924 01:26:28.880 --> 01:26:30.560 to save your life. That's the key thing that we're trying to solve over 925 01:26:30.600 --> 01:26:36.000 here. And our goal is not to replace the system completely or regarding safety, 926 01:26:36.039 --> 01:26:41.479 of course we are not. We believe that we need to find ways 927 01:26:41.520 --> 01:26:45.720 to collaborate with existing governing bodies. But what we're going to do is first 928 01:26:45.800 --> 01:26:49.520

allow for these solutions to go to market super fast, and then by providing 929 01:26:49.560 --> 01:26:56.079 these solutions that can be used by any kind of person, we're also producing 930 01:26:56.159 --> 01:27:01.199 data that they can then also expedite the process through the means by collecting data 931 01:27:01.279 --> 01:27:13.279 and improving what is being done is actually successful and well useful and can be 932 01:27:13.279 --> 01:27:17.279 implemented through a motivational mean of approval. Yes, indeed, and we and 933 01:27:17.439 --> 01:27:24.560 the US Transhumanist Party strongly support the broadest possible right to try, not only 934 01:27:25.119 --> 01:27:29.399 because of our strong support for patient autonomy, but also because of this data 935 01:27:29.439 --> 01:27:32.680 collection element that you mentioned. The best way to collect data about the efficacy 936 01:27:32.720 --> 01:27:40.000 of a treatment is to be it deployed in real world settings. Sometimes the 937 01:27:40.039 --> 01:27:44.960 Phase three clinical trials are too controlled to account for all of the variability that 938 01:27:45.039 --> 01:27:49.560 happens with actual patients. Now, for those who would like to get involved 939 01:27:49.840 --> 01:27:56.000 with Vitalia, what are some of the opportunities that are available? How can 940 01:27:56.079 --> 01:28:00.640 people do more to either collaborate with you or or even to come over there. 941 01:28:01.119 --> 01:28:06.640 So all the information is in Vitality lot city we are in, we 942 01:28:06.720 --> 01:28:13.199 have a website, we are on x You can also contact me through enrich 943 01:28:13.960 --> 01:28:18.520 dot ai. But the best way for you to get involved is get yourself 944 01:28:18.680 --> 01:28:23.239 there, come to visit us. And we're organizing events throughout the year. 945 01:28:24.279 --> 01:28:28.800 Usually we do summits with do workshops. Right now, in July we are 946 01:28:28.800 --> 01:28:31.760 going to have our Acceleration Sprints. We are going to organize three summits in 947 01:28:31.840 --> 01:28:36.600 one month, bio Accelerationism A surprise one there's going to be announced soon and 948 01:28:36.760 --> 01:28:41.840 Human Augmentation Summit. What happens is you're going to have experts from these areas 949 01:28:41.920 --> 01:28:47.560 coming contributing to this field and showing you how can you actually be a part 950 01:28:47.600 --> 01:28:53.159 of this movement and what are the amazing new developments emerging in the area. 951 01:28:53.680 --> 01:28:58.079 Besides that we have, while the summits are happening, we have this Acceleration 952 01:28:58.199 --> 01:29:03.720 Sprint program that brings starts that want to either they are in early stages. 953 01:29:03.760 --> 01:29:09.199 They don't want to get something from the ideation stage to something palpable, something 954 01:29:09.279 --> 01:29:13.520 physical, and they end to get an idea to a business plan, to

955 01:29:13.560 --> 01:29:16.000 an action plan to a fundraising plan, learn how to pitch it to get 956 01:29:16.039 --> 01:29:19.920 something rolling so the idea can start getting the attention that they're required to move 957 01:29:19.960 --> 01:29:23.600 forward. This is one of the targets that we can come over here, 958 01:29:23.680 --> 01:29:26.800 join us. We're going to have workshops with industry experts. We're going to 959 01:29:26.800 --> 01:29:32.439 get you ready to start your startup journey. Additionally, if you have our 960 01:29:32.560 --> 01:29:39.960 company going through clinical trials seat stage CITIZA, we're also going to use this 961 01:29:40.039 --> 01:29:46.079 acceleration period to help you employ the Mini Circle framework, the prospected framework that 962 01:29:46.159 --> 01:29:51.399 allows you to shorten these go to market from ten x so from ten years 963 01:29:51.399 --> 01:29:57.960 to an ear from billions to one hundreds of thousands. So these are it's 964 01:29:58.000 --> 01:30:01.079 amazing for startups. Also, if you just want to get things done while, 965 01:30:01.199 --> 01:30:04.399 just come and join us, because we are a society that aims at 966 01:30:04.680 --> 01:30:09.560 getting things done. So we film to get the work that you will do 967 01:30:09.600 --> 01:30:14.319 in three or four months in one month. While we have an amazing accountability, 968 01:30:14.359 --> 01:30:17.880 a deep work group that we do things together. And we're also implementing 969 01:30:17.920 --> 01:30:23.800 something we call the Bitalit protocol. Digital protocol aims to implement the best techniques 970 01:30:23.840 --> 01:30:28.399 of productivity and deep work, implement the best techniques for health, so working 971 01:30:28.439 --> 01:30:34.159 out, we're talking about nutrition, talking about sweet protocols. And we use 972 01:30:35.239 --> 01:30:39.920 a third pillar that it's based on technology to leverage all these kind of things 973 01:30:39.960 --> 01:30:45.800 from AIAS systems to second brains to a therapy tech to all these things and 974 01:30:45.800 --> 01:30:50.640 cybernetics that can enhance our capacity. So either if you are a startup, 975 01:30:51.079 --> 01:30:55.560 either if are curious, we are organizing any things all over the year, 976 01:30:56.000 --> 01:30:58.880 and in July it's going to be an amazing place to try all these things 977 01:31:00.119 --> 01:31:04.279 in a tropical island. So the second biggest corealist in the world where it 978 01:31:04.319 --> 01:31:10.720 can come, enjoy, get things done, and become a part of these 979 01:31:10.720 --> 01:31:16.159 movements things to push forward the frontier of human capabilities. Yes, this is 980 01:31:16.199 --> 01:31:24.079 all extremely intriguing, both from a broader standpoint of accelerating progress as well as 981 01:31:24.079 --> 01:31:30.920 from the standpoint of creating an environment that really catalyzes personal improvement

and productivity and 982 01:31:31.119 --> 01:31:35.920 good health, good habits. So Pedro, thank you very much for speaking 983 01:31:35.920 --> 01:31:41.000 with us today. One last question for you, since you've been here now 984 01:31:41.039 --> 01:31:45.359 for three days at Longevity sum at Dublin, what are your impressions of this 985 01:31:45.399 --> 01:31:49.479 event. Well, this event gives me a little of hope on an industry 986 01:31:50.359 --> 01:31:57.760 that I'm it's good to see that people are taking seriously the possibility to eliminate 987 01:31:57.960 --> 01:32:03.079 aging, that age aging is a disease, and we are getting our resource 988 01:32:03.119 --> 01:32:11.760 togethers and we are getting these amazing intellectual capacity align to well fight one of 989 01:32:11.800 --> 01:32:15.760 the main challenges of humanity. So for me, it's super grateful and super 990 01:32:15.800 --> 01:32:19.600 inspiring to be in this environment with such amazing people. So I'm really glad 991 01:32:19.680 --> 01:32:23.199 to do you read it, and I'm really glad to get to know you. 992 01:32:23.319 --> 01:32:27.439 Also. Yes, indeed, I'm very happy that you were able to 993 01:32:27.520 --> 01:32:31.600 attend and to have met you, because certainly our causes are quite aligned, 994 01:32:31.760 --> 01:32:35.359 and I wish you the best of success with Vitalia you too, Thank you 995 01:32:35.439 --> 01:32:44.319 so much. Thank you all right, So that was Pedro Henrik, and 996 01:32:44.560 --> 01:32:49.000 he did wish that we all live long and prosper at the end of that 997 01:32:49.119 --> 01:32:57.039 interview, which I appreciated, and he also referred me to Trey Goff of 998 01:32:57.399 --> 01:33:01.920 Prospero Honduras Inc. Today we are only going to have time to show a 999 01:33:01.960 --> 01:33:09.479 portion of our interview with Trey, but we do get into enough of the 1000 01:33:09.560 --> 01:33:15.359 details about how Prospera operates that I think this will motivate quite an interesting discussion, 1001 01:33:15.720 --> 01:33:20.640 and then the remainder of the interview will be accessible from my YouTube channel 1002 01:33:21.000 --> 01:33:29.359 soon. So now let us hear from Trey Goff. He is quite fascinating 1003 01:33:30.039 --> 01:33:35.960 as well. Hey, it's a pleasure to speak with you today, and 1004 01:33:36.439 --> 01:33:45.920 you just presented on Prospera. So for our US Transhumanist Party audience, could 1005 01:33:45.960 --> 01:33:53.119 you describe briefly the concept of a special economic zone in Honduras and some of 1006 01:33:53.159 --> 01:33:56.600 the history of Prospera. Absolutely no problem at all. Thank you so much 1007 01:33:56.600 --> 01:34:00.680 for the conversation. So Prospera is a specially e phenonomena zone off the co 1008 01:34:00.560 --> 01:34:03.319 on the island of Roatan. What that really means is you could think of 1009 01:34:03.319 --> 01:34:09.079 it kind of like municipality in the United States, except this particular municipality has 1010 01:34:09.119 --> 01:34:15.439 a number of degrees of freedom as a significant amena from the central government's legal 1011 01:34:15.479 --> 01:34:18.920 and regulatory environment. We're operating under a constitutional amendment that the Hunter and Congress 1012 01:34:18.920 --> 01:34:24.319 passed back in twenty twelve to twenty thirteen that effectively enables us to work closely 1013 01:34:24.359 --> 01:34:28.920 with the Hunduran government to form a brand new legal and regulatory system within this 1014 01:34:29.000 --> 01:34:33.039 special economic zone to rapidly catalyze economic development and create prosperity for hon durance and 1015 01:34:33.159 --> 01:34:39.199 unleash innovation from entrepreneurs that to operate in the jurisdiction. Prospero was founded back 1016 01:34:39.199 --> 01:34:43.520 in twenty seventeen. We were the first formally approved ze. We spent almost 1017 01:34:43.560 --> 01:34:46.640 two years working very closely with the Hunduran government and international legal and governance experts 1018 01:34:46.880 --> 01:34:51.760 to build our governance and regulatory environment to make sure it was based on best 1019 01:34:51.760 --> 01:34:57.159 practices from around the globe and that it would maximize prosperity and in economic freedom 1020 01:34:57.159 --> 01:35:00.039 and therefore the ability to operate businesses within the jurisdiction. We've been operating for 1021 01:35:00.079 --> 01:35:03.319 a few years now. We we're over a thousand acres in size now. 1022 01:35:03.399 --> 01:35:08.319 We have a number of the buildings and companies that are operating inside the jurisdiction 1023 01:35:08.399 --> 01:35:13.079 right now, especially focused on the cutting edge of biotech, longevity and things 1024 01:35:13.119 --> 01:35:15.800 that are very compatible with the kind of transhumanist movement as a whole. Yes, 1025 01:35:15.840 --> 01:35:21.159 indeed, and we am the Transhumanist Party, certainly welcome jurisdictional experimentation. 1026 01:35:21.680 --> 01:35:28.520 One of our interests, apart from making individuals live longer, is to enable 1027 01:35:28.600 --> 01:35:35.359 societies to last longer without descending into either chaos or tyranny. So what are 1028 01:35:35.359 --> 01:35:42.560 some of the ways in which prosper might help to fulfill that aim and hopefully 1029 01:35:42.840 --> 01:35:46.239 itself endure for an extremely long time. Absolutely, I'd love this question. 1030 01:35:46.439 --> 01:35:50.239 So let me start at the metal level for a second, kind of speaking 1031 01:35:50.239 --> 01:35:56.680 both kind of more personally here, one of the most important things about prospering 1032 01:35:56.800 --> 01:36:00.760 is that we are catalyzing competition in governance. Right. Governance is a service 1033 01:36:00.920 --> 01:36:04.760 that is currently provided by public entities. What we think of as political entities. 1034

01:36:04.920 --> 01:36:08.800 Right, But governance in and of itself is a service is simply setting 1035 01:36:08.800 --> 01:36:12.680 the rules of the game, enabling fair dispute resolution, and setting the rules 1036 01:36:12.680 --> 01:36:15.319 by which people interact within the jurisdiction. One of the most important things that 1037 01:36:15.359 --> 01:36:20.880 Prosperous catalyzing is a new competitive industry for governance as a service. Right, 1038 01:36:21.039 --> 01:36:24.239 we are one of the first movers in this industry. There are a number 1039 01:36:24.239 --> 01:36:26.880 of other companies that are doing it right now. But our end goal, 1040 01:36:27.039 --> 01:36:30.479 even if again at a metal level here, even if we don't survive, 1041 01:36:30.880 --> 01:36:35.039 but twenty years from now, there are one thousand new jurisdictions trying and experimenting 1042 01:36:35.039 --> 01:36:38.960 with new better forms of governance, that I will have considered us a wild 1043 01:36:39.039 --> 01:36:42.439 success in any case. Right, The objective here was to catalyze this entire 1044 01:36:42.520 --> 01:36:46.640 new industry of governance as a service, to create competition for governance such that 1045 01:36:46.680 --> 01:36:51.000 it improves rapidly over time, the same way any other industry that is exposed 1046 01:36:51.039 --> 01:36:56.520 to competition in the marketplace improves every time. Now, Prosperous specifically has been 1047 01:36:56.520 --> 01:37:00.039 structured to last effectively forever. This is because we have a kind of a 1048 01:37:00.039 --> 01:37:04.640 two our legal structures. If you will are two tiered. There's two separate 1049 01:37:04.680 --> 01:37:09.439 legal entities. We have the prosperous Zete, which is the political entity. 1050 01:37:09.439 --> 01:37:12.000 Again, this is the municipality I was thinking of that I was mentioning earlier. 1051 01:37:12.039 --> 01:37:15.640 It's the political legal jurisdiction, right. And then we have Honduras prosper 1052 01:37:15.680 --> 01:37:17.000 Ink, which is a Delaware se cour if it's an American company, and 1053 01:37:17.199 --> 01:37:20.359 it's the operating company. Right. We provide the capital and a lot of 1054 01:37:20.399 --> 01:37:25.520 the funding and the actual kind of work to start the jurisdiction. And that 1055 01:37:25.560 --> 01:37:29.520 means we kind of set the initial rules. Step over time, our governance 1056 01:37:29.560 --> 01:37:33.399 evolves to have more citizen input in such a way that we can ensure that 1057 01:37:33.479 --> 01:37:38.760 the short term interests of the jurisdiction balanced with the long term interest I'll give 1058 01:37:38.760 --> 01:37:41.439 you one like concrete example of this, because I know that's a little abstract. 1059 01:37:42.000 --> 01:37:45.439 The composition of the prosper Council is a nine member councils the governing entity 1060 01:37:45.520 --> 01:37:50.119 of the jurisdiction. Okay, five

of those council members democratically elected by the 1061 01:37:50.119 --> 01:37:55.079 residents, but four of them are appointed by the promoter and organizer of the 1062 01:37:55.159 --> 01:37:59.439 jurisdiction, which is Honduras prosper Ink. The reason for that is because almost 1063 01:37:59.520 --> 01:38:02.199 everything stantial, meaning any statute or regulation or anything like that, requires a 1064 01:38:02.239 --> 01:38:06.600 two thirds majority vote of the Council. What that means is you have the 1065 01:38:08.319 --> 01:38:13.039 frankly short term focus, which for good and for ill, democratically elected members 1066 01:38:13.079 --> 01:38:15.199 of the Council who are focused on kind of the short term benefits for their 1067 01:38:15.199 --> 01:38:21.560 residents and for their constituents, counterbalanced with the much longer term view of Hondura's 1068 01:38:21.560 --> 01:38:26.720 Prosperate Inc. As a private company which wants to grow as profitable as possible 1069 01:38:27.039 --> 01:38:30.199 at for as long as possible, right to be a multi century extant company. 1070 01:38:30.239 --> 01:38:33.920 Effectively, so you have a balance of forces on the Council where for 1071 01:38:34.600 --> 01:38:39.520 any given piece of legislation and an important act to be done at or passed, 1072 01:38:39.760 --> 01:38:42.079 you have to have a balance of these interests, of the short term 1073 01:38:42.079 --> 01:38:45.479 interests and of the long term interest but also the first jurisdiction to implement something 1074 01:38:45.479 --> 01:38:50.279 called double democracy, which effectively means the way this works mechanistically, anything the 1075 01:38:50.279 --> 01:38:57.319 Council passes, the residents have the right to immediately veto via referendum within the 1076 01:38:57.479 --> 01:39:00.359 sixty day window after that legislation has passed. They do this via a referendum 1077 01:39:00.359 --> 01:39:03.800 that has to have a certain vote threshold. However, this effectively gives them 1078 01:39:04.319 --> 01:39:09.279 a way to stop very badly, somehow, some way, the council becomes 1079 01:39:09.279 --> 01:39:12.319 misaligned with the interests of the residents. They had the ability to stop that 1080 01:39:12.399 --> 01:39:15.880 bad legislation in his tracks. However, they cannot create new legislation three referendum, 1081 01:39:15.920 --> 01:39:19.880 which is often a mechanism for the Jory rule in a very bad way. 1082 01:39:20.000 --> 01:39:24.960 Effectively, so were the first jurisdiction to implement this This innovative double democracy 1083 01:39:24.960 --> 01:39:28.279 model as just a few examples of how we've been shored the long term political 1084 01:39:28.279 --> 01:39:30.520 and legal stability of the jurisdiction. Yes, this is very interesting. So 1085 01:39:30.840 --> 01:39:39.560 it's kind of a mixed democratic model with small d democratic veto power. Usually 1086 01:39:40.039 --> 01:39:43.840 veto

power is held by an executive, but you've kind of inverted this, 1087 01:39:43.960 --> 01:39:48.319 which is quite interesting as well. And I can see essentially how this would 1088 01:39:48.399 --> 01:39:56.760 work from the standpoint of protecting individual rights because this democratic veto power would be 1089 01:39:57.159 --> 01:40:03.600 particularly inclined to be exer size the situations where a majority might perceive a certain 1090 01:40:03.720 --> 01:40:11.359 vital right as being infringed upon. However, the lack of ability to propose 1091 01:40:11.720 --> 01:40:17.079 positive legislation by referendum could prevent policies that, for instance, would redistribute wealth 1092 01:40:17.079 --> 01:40:20.520 from one group of people to another. Exactly, you hit the nail on 1093 01:40:20.520 --> 01:40:23.319 the head there. I mean, you can imagine, like, let's imagine 1094 01:40:23.359 --> 01:40:26.359 for a second a worst case scenario. Right, let's stay far in the 1095 01:40:26.359 --> 01:40:29.479 future. Let's imagine there's ten thousand on hundred thousand residents in prosper whatever the 1096 01:40:29.520 --> 01:40:32.479 case may be, and for whatever reason, say hundred's prosper ink is no 1097 01:40:32.560 --> 01:40:38.000 longer controlled by the current group of people is controlled by It's been taken over 1098 01:40:38.079 --> 01:40:41.960 by some hostile actor or whatever. And that hostile actor has somehow, some 1099 01:40:42.079 --> 01:40:45.560 way forced through some bad legislation. Right, they've gotten some bad legislation through 1100 01:40:45.760 --> 01:40:48.800 through the council. Well, because of this double democracy, you effectively have 1101 01:40:48.840 --> 01:40:54.680 a check against either Hunters prosper Inc Going rogue, or the democratic politicians going 1102 01:40:54.800 --> 01:40:59.199 rogue, or the entire group going roman. Effectively, you could stop anything 1103 01:40:59.239 --> 01:41:03.000 they do in its tracks very early on because you have this immediate democratic veto 1104 01:41:03.119 --> 01:41:08.039 power. It's one of the reasons I hate this so much. There's always 1105 01:41:08.039 --> 01:41:12.479 these There's been a few articles written by left leaning publications who call us authoritarian 1106 01:41:12.520 --> 01:41:15.720 colonialists or whatever, but they don't realize because they never actually read anything that 1107 01:41:15.760 --> 01:41:17.520 we do. That where if you just look at the raw facts, the 1108 01:41:17.520 --> 01:41:23.199 most democratic jurisdiction in the world just implemented in any much more thoughtful way to 1109 01:41:23.560 --> 01:41:27.359 ensure the individual rights are protected over the long term and that the citizens have 1110 01:41:27.399 --> 01:41:30.840 a say and how they are governed, but not in such a way that 1111 01:41:30.960 --> 01:41:36.920 mob rule and majority rule can cause wealth redistribution or other violations of property rights, 1112 01:41:36.920 --> 01:41:42.039 effectively in violations of individual rights over time. Yes, this is quite 1113 01:41:42.039 --> 01:41:46.119 fascinating. Thank you for that answer. Now, one of the biggest threats 1114 01:41:46.159 --> 01:41:55.199 to the longevity of an enterprise such as Prospera would be the intervention of the 1115 01:41:55.199 --> 01:42:00.479 Honduran government in particular, and we know that in twenty twenty two the new 1116 01:42:00.760 --> 01:42:08.319 administration of Shermara Castro essentially express deep opposition to the special economic zones and try 1117 01:42:08.399 --> 01:42:14.159 to shut them down. But you mentioned in your presentation that there was considerable 1118 01:42:14.159 --> 01:42:18.039 pushback against that, and you believe that you have been successful in preserving the 1119 01:42:18.079 --> 01:42:24.399 autonomy of prospers. So could you please discuss more of what happened and why 1120 01:42:24.479 --> 01:42:28.479 you believe that this threat has been averted for the time being. Absolutely, 1121 01:42:28.520 --> 01:42:30.319 And I'm going to go in the weeds a little bit here just because the 1122 01:42:30.359 --> 01:42:33.399 details are really so. The first thing to note is that the enabling legislation 1123 01:42:33.560 --> 01:42:38.840 allows the creation of Zetis is comprised of two carts, a constitutional amendment and 1124 01:42:39.079 --> 01:42:43.680 a statute of the Zeti organic Law. The constitutional amendment, the way the 1125 01:42:43.760 --> 01:42:46.920 Hunter and legal system works, requires a two thirds majority vote of Congress super 1126 01:42:46.920 --> 01:42:51.479 majority, effectively in two consecutive sessions of Congress to change the Hunter in constitution 1127 01:42:51.560 --> 01:42:55.840 to ensure there's not some short term kind of impulsive action. Now, the 1128 01:42:55.840 --> 01:42:58.359 statute, of course, just being a regular statue, can be repealed at 1129 01:42:58.359 --> 01:43:00.760 any time by a unilateral simple majority vote of Congress. Well, they almost 1130 01:43:00.760 --> 01:43:06.039 immediately repealed that enabling law, the organic law. But that, however, 1131 01:43:06.199 --> 01:43:11.079 the founders of the in the framers of this system were brilliant and this we 1132 01:43:11.119 --> 01:43:12.800 had nothing to do with this, to be clear, These were just a 1133 01:43:12.840 --> 01:43:17.680 few absolutely visionary hun Duran politicians and actors. They anticipated this, that this 1134 01:43:17.800 --> 01:43:21.399 something like this would happen in the legislation. So what happens is instead of 1135 01:43:21.600 --> 01:43:25.640 the repealing of the Organic Law causing US to no longer be able to operate. 1136 01:43:26.159 --> 01:43:28.960 All that means is no news eddas can be formed because all the real 1137 01:43:29.039 --> 01:43:31.720 all the Organic Law really did was set out the rules and the system by 1138

01:43:31.720 --> 01:43:35.319 which news eda's were formed. So no news eda's can be formed. Fine, 1139 01:43:35.359 --> 01:43:40.880 but the Constitutional Amendment remains intact. The second repeal vote failed, which 1140 01:43:40.920 --> 01:43:44.720 means it is protected effectively. It is still in is still part of the 1141 01:43:44.760 --> 01:43:47.079 hunter In Constitution, and as a result, US and the other two exit 1142 01:43:47.159 --> 01:43:50.119 ed as we're not the only one can continue to exist in definitely where we 1143 01:43:50.119 --> 01:43:54.039 could think of it as being grandfathered in effectively because we're already there and the 1144 01:43:54.039 --> 01:43:58.039 Constitutional Amendment still exist. So that's the first point. The second point is 1145 01:43:58.039 --> 01:44:02.439 that the Castro administration was also hostile to a number of other private enterprises in 1146 01:44:02.800 --> 01:44:05.000 Honduras. This is there's been a lot of news written about this. I'm 1147 01:44:05.000 --> 01:44:11.399 not sharing any private information here, and there was kind of a grassroots up 1148 01:44:11.520 --> 01:44:16.479 uprising effectively welling of support from companies unrelated to US, just other private companies 1149 01:44:16.479 --> 01:44:20.159 in Honduras, other American companies that have invested in Honduras. Because the Castro 1150 01:44:20.199 --> 01:44:24.600 administration was not friendly to not just US, but a bunch of other private 1151 01:44:24.680 --> 01:44:29.640 enterprise. So there was a pretty unified pushback by the business sector against many 1152 01:44:29.640 --> 01:44:31.720 of the things she was doing. That has resulted in her losing a considerable 1153 01:44:31.720 --> 01:44:33.960 amount of political power, and as a result, she's not even running for 1154 01:44:34.000 --> 01:44:38.039 reelection, and it looks like the opposition party, which is more market friendly, 1155 01:44:38.199 --> 01:44:43.399 will end up overtaking the presidency in the upcoming presidential election. The third 1156 01:44:43.399 --> 01:44:45.560 point I want to make is we also had a number of legal protections in 1157 01:44:45.600 --> 01:44:49.760 place because we were a US company were therefore we are a Party two and 1158 01:44:49.840 --> 01:44:55.600 protected by KAFTA and a number of other international trade agreements and treaties. And 1159 01:44:55.800 --> 01:45:00.199 an important part of that is there's a kind of established norm in this which 1160 01:45:00.239 --> 01:45:05.399 in case law, international law that says, basically, if a invites another 1161 01:45:05.439 --> 01:45:10.359 company from another country to invest in that country, and then based on a 1162 01:45:10.359 --> 01:45:14.119 certain law, and then they repeal that law, that amounts to and expropriation. 1163 01:45:14.640 --> 01:45:15.720 You can think of it if you think of the just company a little 1164 01:45:15.720 --> 01:45:18.800 more

sense. It's like me saying, hey, I will build you a 1165 01:45:18.800 --> 01:45:24.000 building with a bunch of specialized equipment in it, and then I build you 1166 01:45:24.039 --> 01:45:25.439 a building, and I don't put any of the equipment in it, right, 1167 01:45:25.479 --> 01:45:27.760 I just violate our contract, which is obviously wrong, and you could 1168 01:45:27.760 --> 01:45:30.920 sue me rightfully, So it's the same way. So we as a results 1169 01:45:30.920 --> 01:45:34.520 soon the hunter in government at exend the International Court of State and Investor dispute 1170 01:45:34.520 --> 01:45:39.039 at the World Bank for violating their treaty obligations under CAFTA and a few other 1171 01:45:39.079 --> 01:45:44.319 treaties, and that case is going swimmingly and we anticipate a favorable outcome from 1172 01:45:44.319 --> 01:45:46.079 that as well. I can't share any details there, but suffice to say 1173 01:45:46.119 --> 01:45:50.199 the combination of all of these things has resulted in US continuing to operate completely 1174 01:45:50.279 --> 01:45:55.399 unabated. And importantly, this is kind of our most vulnerable time right We're 1175 01:45:55.399 --> 01:45:58.079 the smallest we're ever going to be right now, so it is the easiest 1176 01:45:58.079 --> 01:46:00.960 to kind of try to push us over. The fact that we repel the 1177 01:46:00.960 --> 01:46:04.079 attack now means that any future attack will not be able to succeed effectively because 1178 01:46:04.880 --> 01:46:09.199 our growth is extremely rapid. There's a bunch of people in companies setting up 1179 01:46:09.239 --> 01:46:13.399 into jurisdiction, and importantly, our over ninety percent of the workforce and our 1180 01:46:13.439 --> 01:46:15.600 jurisdiction is Honduran and that will remain to be the case moving forward because again 1181 01:46:15.640 --> 01:46:20.439 we exist a catalyzed prosperity for endurance through innovation and entrepreneurship. And so because 1182 01:46:20.439 --> 01:46:25.000 our jurisdiction is majority hon Duram, as more company comes, more hondurance are 1183 01:46:25.039 --> 01:46:28.760 employed, that becomes a political and voting block of itself. Will that can 1184 01:46:28.800 --> 01:46:33.439 help to have again a grassroots upswelling of support to kind of stop such attacks 1185 01:46:33.479 --> 01:46:38.199 in the future before they even happy. Yes, indeed, and I agree 1186 01:46:38.199 --> 01:46:43.520 that with the passage of time, prosperous position will only become stronger. And 1187 01:46:43.600 --> 01:46:47.239 I'm glad that you have these multiple layers of protections in place, both from 1188 01:46:47.600 --> 01:46:53.640 a legal standpoints on the practical reality of the situation in Honduras, I do 1189 01:46:53.680 --> 01:46:58.920 hope the administration there changes now. As a follow up on that, do 1190 01:46:58.960 --> 01:47:02.960 you think the culture sure of the rule of law is strong enough in Honduras 1191 01:47:03.079 --> 01:47:11.520 that future administration would not just decide to disregard the law altogether and despite your 1192 01:47:11.760 --> 01:47:18.600 legal victories, just choose to evict prosper from the territory of Honduras because it 1193 01:47:18.680 --> 01:47:23.279 can sure. It's a great question. The short answer is no, I 1194 01:47:23.279 --> 01:47:27.319 don't see this happening. Basically, Ever, Honduran support for the role of 1195 01:47:27.399 --> 01:47:30.760 law, while not perfect, is better than you might suspect. And importantly, 1196 01:47:31.359 --> 01:47:35.560 if you think about this just from a raw kind of brute incentives perspective, 1197 01:47:35.640 --> 01:47:40.199 to be honest, doing so would caused them massive harm because it only 1198 01:47:40.239 --> 01:47:44.560 further strengthens any litigation we might bring against them an international court, which can 1199 01:47:44.600 --> 01:47:49.920 massively harm them economically if the exed our ARBITRII rules against them, and further 1200 01:47:50.279 --> 01:47:54.920 they because we are a US company, that means by default we effectively have 1201 01:47:55.000 --> 01:47:59.119 the backing of the US government. I'm not just saying anything that people are 1202 01:47:59.079 --> 01:48:01.439 already know, Like the State Department all the time helps companies in other countries 1203 01:48:01.920 --> 01:48:05.680 through diplomacy, stay craft, kind of just helping make sure that American companies 1204 01:48:05.680 --> 01:48:10.039 were able to operate as intended in countries where they're where they're working. The 1205 01:48:10.119 --> 01:48:14.399 Hunduran government is an enormous benefactor of US generosity and a number of things that 1206 01:48:14.439 --> 01:48:17.680 the United States does for them, So kind of attacking US frontally that way 1207 01:48:18.399 --> 01:48:26.840 would have again speculating here, some but I suspect would drastically Let's say worsen 1208 01:48:26.960 --> 01:48:30.039 diplomatic relations between the two countries, perhaps in some tangible ways. I can 1209 01:48:30.079 --> 01:48:34.560 give you some evidence for this already in that the United States actually revoked the 1210 01:48:34.640 --> 01:48:40.600 visas of a few Hunduran politicians because of some of the extremely inflammatory things they 1211 01:48:40.640 --> 01:48:43.600 said in actions they took against not just US, but other American companies. 1212 01:48:43.600 --> 01:48:45.680 And for example, Dole has a massive operations in Hunters for their fruit, 1213 01:48:45.720 --> 01:48:48.359 their fruit farms. So it's not just US here, to be clear. 1214 01:48:49.399 --> 01:48:54.920 So I suspect over the long term that this this becomes less of an option 1215 01:48:56.119 --> 01:49:01.840 as Hunters remains. The importance of Hundur in U s relation different. All 1216 01:49:01.960 --> 01:49:08.640 right, So I am going to stop the interview here for now, but

1217 01:49:08.800 --> 01:49:13.439 again the rest will be up on my YouTube channel. I wanted to provide 1218 01:49:13.439 --> 01:49:19.600 an opportunity for David especially to offer some thoughts in regard to what has been 1219 01:49:19.760 --> 01:49:24.920 said. I think we did cover a lot of ground with these interviews. 1220 01:49:25.840 --> 01:49:31.960 Well, it's absolutely fascinating and they are to be applauded for the serious thinking 1221 01:49:32.039 --> 01:49:40.680 seriously about options for organizing more effectively to bring solutions to market without some of 1222 01:49:40.720 --> 01:49:45.399 the hindrances that have grown up accidentally in some ways or sometimes purposefully, so 1223 01:49:46.000 --> 01:49:50.760 many people are thinking about alternatives. People can look online for something called longevity 1224 01:49:50.920 --> 01:49:58.000 network State or Longevity State conference, in which different people have got different ideas. 1225 01:49:58.560 --> 01:50:05.479 I know Trey is expression optimism that the sighting Prospera and Vitalia will persevere. 1226 01:50:05.880 --> 01:50:09.840 Other people saying, well, in case it fails, we can retry 1227 01:50:09.920 --> 01:50:14.720 some some indias elsewhere in the world. So Lawrence Iron, who is also 1228 01:50:14.760 --> 01:50:19.600 one of the thinkers and movers behind this particular aspect of longevity, he has 1229 01:50:19.720 --> 01:50:24.920 a number of other candidate places, some in America, some in Europe, 1230 01:50:25.000 --> 01:50:30.319 some in Africa and elsewhere. Possibly some of the people in the conference weren't 1231 01:50:30.479 --> 01:50:33.840 entirely convinced. They were saying, do you realize if you go too quickly 1232 01:50:33.920 --> 01:50:40.199 with approvals for new drugs, that can be terribly disruptive. Some doctors said 1233 01:50:40.199 --> 01:50:45.399 that many side effects from drugs that haven't been properly tried. Other people spoke 1234 01:50:45.439 --> 01:50:50.399 about stem cell treatments that they were outright dangerous and should be prosecuted. There 1235 01:50:50.439 --> 01:50:56.319 is a Netflix video series which I recommend, called Bad Surgeon, but a 1236 01:50:56.359 --> 01:51:00.159 notorious person who was very famous and very well respected for a while. It 1237 01:51:00.159 --> 01:51:03.680 turns out his stem cell treatments were nothing like what he claimed. So there 1238 01:51:03.840 --> 01:51:09.399 is a lot of discussion going on as how we can get the benefits of 1239 01:51:09.520 --> 01:51:15.359 innovation with that falling foul of free riders, bad actors, and just incompetence. 1240 01:51:15.680 --> 01:51:18.079 Well, I think this discussion is going to run and run, and 1241 01:51:18.079 --> 01:51:20.920 we should encourage it to run and run. We should be creative, and 1242 01:51:20.960 --> 01:51:27.279 we should be critically thoughtful as well. Yes, indeed, I think we 1243 01:51:27.359 --> 01:51:36.840 need to discuss the implications of each of these innovative proposals and brainstorm about possible 1244 01:51:36.920 --> 01:51:43.720 vulnerabilities, which I did with Trey, and actually the interview continues in this 1245 01:51:43.840 --> 01:51:50.960 fashion. We delved quite a bit into the regulatory insurance aspects of prosper that 1246 01:51:51.039 --> 01:51:58.119 Trey also briefly mentioned during his presentation at Longevity Some at Dublin, and I 1247 01:51:58.199 --> 01:52:00.800 think, yes, we need to be open to this kind of innovation, 1248 01:52:00.920 --> 01:52:08.840 but also thoughtful about possible risks and hopefully averting those risks. To begin with. 1249 01:52:09.239 --> 01:52:14.560 Now, in the last minute and a half or so of the salon, 1250 01:52:14.600 --> 01:52:18.880 I'd like to invite Ben Balweg to share any impressions, any feedback that 1251 01:52:18.960 --> 01:52:27.000 he might have as our director of Longevity outreach. I'm glad you guys heard 1252 01:52:27.000 --> 01:52:30.680 about that buffalo fish. That's kind of neat and that's a little bit in 1253 01:52:30.720 --> 01:52:39.439 my backyard up in northern Wisconsin border with Minnesota. But any reveal that happened 1254 01:52:39.479 --> 01:52:43.920 this year, I know last year was Dublin Longevity Declaration. Any any other 1255 01:52:45.199 --> 01:52:49.279 big, big splashes that happened this year at the summit, I would say 1256 01:52:49.640 --> 01:52:56.800 the RMR study update, the Robust Mouse Rejuvenation update, as well as the 1257 01:52:56.880 --> 01:53:04.039 discussion of Xprize health span constituted that I would say soft reveals because people didn't 1258 01:53:04.079 --> 01:53:12.800 know about them. But this wasn't as public of knowledge as it became after 1259 01:53:12.840 --> 01:53:16.319 the summit. But da, if you have some comments, please feel free 1260 01:53:16.359 --> 01:53:28.760 to share. Let's see I think we might so yeah, I couldn't find 1261 01:53:28.760 --> 01:53:32.640 the mic, so yes, So very short, I want to say that 1262 01:53:33.000 --> 01:53:40.199 concerning gin tap is there are quite a few things with clinical trials going on. 1263 01:53:40.800 --> 01:53:45.319 But also I wanted to make a few general comments before we stop. 1264 01:53:45.079 --> 01:53:49.159 The first one is there are many, many, many conferences going on, 1265 01:53:49.880 --> 01:53:55.600 and this is quite interesting, more conferences than ever. I have the impression 1266 01:53:55.680 --> 01:54:00.920 more energy and more intees than error. But on the other side, we 1267 01:54:00.079 --> 01:54:08.520 have to know that the longest person ever is not older than a few years 1268 01:54:08.520 --> 01:54:14.039 ago, and all those ever is also not older than a few years ago. 1269 01:54:14.199 --> 01:54:20.680 So things are there. There is more energy days, more knowledge, 1270 01:54:20.800 --> 01:54:25.960 day is more scientific research. But I think that if there is not a 1271 01:54:25.960 --> 01:54:31.720 big progress concerning artificial intelligence, we are going to wait a while before we 1272 01:54:31.760 --> 01:54:41.439 can really live longer. And for me on the let's say relatively short term, 1273 01:54:41.600 --> 01:54:46.000 what is really really important is that the IVF is one of the really, 1274 01:54:46.119 --> 01:54:51.000 really very important things. Is that LVF is getting money for the second 1275 01:54:51.600 --> 01:55:00.720 experiment on mice and all that other people are doing other experiments on on mice 1276 01:55:00.119 --> 01:55:04.479 and also humans. Of course, that's it for today. No, I 1277 01:55:04.520 --> 01:55:13.000 also wanted to general I'll comment that nobody was speaking about that, but maybe 1278 01:55:13.000 --> 01:55:17.720 some of you know. I was kind of especially pessimistic the last two years 1279 01:55:17.720 --> 01:55:25.760 because life expectancy was going down in Europe. Life expectancy is again going up, 1280 01:55:25.800 --> 01:55:29.439 Sourde. That's on the positive pride. Yes, well, thank you 1281 01:55:29.520 --> 01:55:34.840 for mentioning that positive development, But indeed we need to be concerned about life 1282 01:55:34.840 --> 01:55:40.800 expectancy not increasing faster. So I do hope Ray Kurtzweil is right that Jose's 1283 01:55:40.840 --> 01:55:45.159 optimism is justified that we get more AI progress, and that we absolutely get 1284 01:55:45.199 --> 01:55:51.439 more funding for Robust mouse rejuvenation and the Longevity Escape Velocity Foundation, so that 1285 01:55:51.520 --> 01:55:55.239 we could all live long and prosper