התמלול המלא של WS 516 All About PrEP

bye. Bye, bitch. So she got trimmed. Poovey 36 00:02:58.719 --> 00:03:06.129 pays a professional for their dog. So I got a 37 00:03:06.229 --> 00:03:09.770 tote bag and I cut five holes in it. Four 38 00:03:09.889 --> 00:03:12.710 in the corners for legs and one in the side. 39 00:03:13.530 --> 00:03:16.560 And I can put my little chihuahua. He's half chihuahua. 40 00:03:17.080 --> 00:03:20.099 I put him in the bag and then I dangle 41 00:03:20.139 --> 00:03:23.539 him from the shower curtain rod so I can do 42 00:03:23.620 --> 00:03:27.349 his toes. He hates it. He hates it. Hates it 43 00:03:27.439 --> 00:03:31.620 so much. I put him down in there and then 44 00:03:32.439 --> 00:03:35.560 he gets to go dangle because he's up in the 45 00:03:35.620 --> 00:03:42.840 air going, I can't run away. And then I do 46 00:03:42.900 --> 00:03:45.620 his toenails. I don't do that to the ancient dog. 47 00:03:46.400 --> 00:03:51.310 She's too old for that. Her, we go outside because 48 00:03:51.370 --> 00:03:56.289 then she's distracted by like being outside. She's very old. 49 00:03:57.500 --> 00:03:59.680 And then I can do her feets. And she's like, 50 00:03:59.759 --> 00:04:03.949 what just happened? I'm so confused. Oh, I smell something. 51 00:04:04.550 --> 00:04:08.030 I'm like, she's fine. If I tried to do that inside, 52 00:04:08.050 --> 00:04:14.949 it would not go nearly as well. She's very old 53 00:04:15.050 --> 00:04:23.779 and very senile. Very senile. And blind. Found that one out. 54 00:04:24.129 --> 00:04:27.670 Because she got a little confused on the way out 55 00:04:27.709 --> 00:04:34.970 the door yesterday. And walked into the wall. I shouldn't laugh, 56 00:04:35.110 --> 00:04:51.819 but also. So. My poor old lady. Poor critter. Alright. Ooh, 57 00:04:51.930 --> 00:04:55.389 somebody joined us. Addie! Addie joined us. Hi, girl. Hi. 58 00:04:56.410 --> 00:05:01.470 We're going to talk about prep tonight. P-R-E-P. What's prep? 59 00:05:01.790 --> 00:05:05.649 You may be asking yourself. Oh, boy, oh, boy. Prep 60 00:05:05.709 --> 00:05:09.970 is something that you should definitely be doing. Now, most 61 00:05:10.009 --> 00:05:11.829 of the time when it comes to stuff like sex, 62 00:05:12.600 --> 00:05:16.120 when somebody says, are you on prep? They're talking about 63 00:05:16.139 --> 00:05:19.660 a very specific thing. We're going to talk about that, too. 64 00:05:20.170 --> 00:05:22.829 But I'm going to start broad and then work down 65 00:05:22.990 --> 00:05:29.129 into that specific thing because it's neat. It's neat. PREP, 66 00:05:30.149 --> 00:05:36.360 as an acronym, stands for pre-exposure prophylaxis. And it's basically 67 00:05:36.660 --> 00:05:42.139 before you're exposed to an illness, you take a medication 68 00:05:42.279 --> 00:05:47.430 or do something in order to prevent the transmission of 69 00:05:47.490 --> 00:05:55.620 the illness. So, using condoms is a type of prep. 70 00:05:56.199 --> 00:06:01.360 It's preparatory. It's a pre-exposure prophylaxis. It's literally a prophylactic. 71 00:06:02.819 --> 00:06:08.519 It's in the fucking name. It is a medication or 72 00:06:09.060 --> 00:06:14.439 a thing that one does to help prevent or make 73 00:06:14.540 --> 00:06:23.199 less likely the transmission of illness. And this does mean 74 00:06:23.639 --> 00:06:27.879 that wearing a mask is a form of prep. It 75 00:06:27.939 --> 00:06:31.459 is a prophylaxis that helps to prevent the transmission of 76 00:06:31.490 --> 00:06:38.110 airborne illnesses. It's a condom for your nose and mouth. 77 00:06:39.430 --> 00:06:46.350 Your face holes. He says becoming a bubble boy is 78 00:06:46.490 --> 00:06:50.959 also the dream. Right? God. I want to be a 79 00:06:51.069 --> 00:06:53.959 bubble person. Then people would be able to touch me. 80 00:06:57.279 --> 00:07:01.100 Or come too close. Or breathe my air. Mott said, 81 00:07:01.139 --> 00:07:04.100 I'm bringing back the term Jimmy hat for a condom. 82 00:07:07.509 --> 00:07:18.769 Skin sleeve. So, um... Let's talk about viruses. Because... That's... 83 00:07:19.560 --> 00:07:22.160 The number one thing that most people, if you say, 84 00:07:23.139 --> 00:07:27.379 are you on PrEP? What they're asking about is specifically 85 00:07:28.769 --> 00:07:33.329 a drug regimen to help prevent the spread of HIV, 86 00:07:33.509 --> 00:07:43.730 which is human immunovirus. Which leads to AIDS, acquired immune 87 00:07:43.769 --> 00:07:52.519 deficiency syndrome. Mostly it's just HIV. The antiretroviral medications are 88 00:07:52.600 --> 00:08:00.370 so good nowadays that you... You'll probably be fine. Like, 89 00:08:00.430 --> 00:08:02.949 as long as you have insurance and can afford your 90 00:08:02.990 --> 00:08:08.050 medication and stay on your fucking medications, you'll be fine. 91 00:08:09.350 --> 00:08:12.449 Of course, an ounce of prevention is worth a pound 92 00:08:12.490 --> 00:08:17.500 of cure. And it is always better to prevent than 93 00:08:17.560 --> 00:08:20.509 it is to try to fix it. After the fact. 94 00:08:20.829 --> 00:08:29.000 Because no matter what, once you have an illness, you 95 00:08:29.040 --> 00:08:34.860 will have effects from that illness. They, nowadays, very mild. 96 00:08:36.360 --> 00:08:39.200 Extremely mild. Probably will not affect the rest of your life. 97 00:08:40.039 --> 00:08:42.470 Other than that whole, you should keep on taking your 98 00:08:42.509 --> 00:08:48.389 antiretroviral medications. So, let's talk about viruses. What's a virus? 99 00:08:51.299 --> 00:08:56.159 For most people, people don't really have to go through 100 00:08:56.720 --> 00:09:01.539 most of the time in your lived life knowing what 101 00:09:01.580 --> 00:09:09.240 a virus is. Right? Or a bacteria. Because unless you 102 00:09:09.440 --> 00:09:15.220 work in microbiology or are studying microbiology, why the fuck 103 00:09:15.259 --> 00:09:19.779 would you know that? I know that. I went to 104

00:09:19.840 --> 00:09:22.580 a very STEM-heavy school, and I was taking a very 105 00:09:22.659 --> 00:09:28.580 STEM-heavy course load. It's not what the advanced degrees are in, 106 00:09:28.659 --> 00:09:35.320 but it's what the bachelor's was in. So, Abby said, 107 00:09:35.720 --> 00:09:40.539 they're thingy-thingies. Not really dead, nor alive. Very no-no crowd. 108 00:09:42.710 --> 00:09:45.009 And Poovey says, I have to know about bacteria. Thank 109 00:09:45.029 --> 00:09:49.639 you very much. Temperature danger zone for the win. Right? Okay, 110 00:09:49.700 --> 00:09:55.830 so a virus, much like a bacteria, is a transmissible, 111 00:09:56.129 --> 00:09:58.389 meaning it can move from one person to the next 112 00:09:58.529 --> 00:10:07.639 through various mechanisms. Hacket of DNA. That's the fastest way 113 00:10:07.679 --> 00:10:11.450 to say that. It is a way for some DNA 114 00:10:11.570 --> 00:10:16.470 or RNA to move from one living organism to another. 115 00:10:21.610 --> 00:10:23.350 While it says viruses are on the top of the 116 00:10:23.389 --> 00:10:26.169 food chain on planet Earth, viruses eat us from the 117 00:10:26.250 --> 00:10:31.980 inside one by one. Kind of. The stuff that a 118 00:10:32.059 --> 00:10:36.600 virus does to us that we don't like, the negative 119 00:10:36.639 --> 00:10:40.950 side effects of a virus, the virus doesn't really give 120 00:10:40.990 --> 00:10:47.110 a shit about. By the time you experience the negative 121 00:10:47.169 --> 00:10:50.559 stuff from having caught a virus... You are now into 122 00:10:50.600 --> 00:10:54.059 the phase where you are spreading the virus to other people. 123 00:10:55.059 --> 00:10:58.000 The virus is done with you now. It's using your 124 00:10:58.059 --> 00:11:02.029 immune response and hijacking your immune response in order to 125 00:11:02.110 --> 00:11:04.049 travel from one to the other. It's not really that 126 00:11:04.090 --> 00:11:17.340 it's eating you. It's using you. So. A virus. Okay. 127 00:11:19.269 --> 00:11:25.789 Brace yourselves. A virus is a microscopic organism. It infects 128 00:11:26.200 --> 00:11:30.960 hosts like humans, plants, or animals. Pretty much if you 129 00:11:31.000 --> 00:11:34.399 have a cell, you can get a virus. They have 130 00:11:34.539 --> 00:11:38.639 a little piece of genetic information, either DNA or RNA, 131 00:11:38.919 --> 00:11:47.509 that is, deoxyribonucleic acid, or, uh, ribonucleic acid. They left 132 00:11:47.549 --> 00:11:52.210 off the deoxy. And they're inside a shell. And the 133 00:11:52.269 --> 00:11:55.610 shell is called a capsid. Remember that word. It's an 134 00:11:55.649 --> 00:12:01.159 important word. Some, but not all, viruses also have an 135 00:12:01.559 --> 00:12:09.120 envelope around the capsid. Viruses cannot reproduce without a host. 136 00:12:10.039 --> 00:12:14.610 If the virus is in your environment, but it never 137 00:12:14.659 --> 00:12:18.470 manages to infect you, the virus is shit out of luck. 138 00:12:20.259 --> 00:12:25.799 Common diseases are caused by viruses. The flu, the common cold, 139 00:12:26.120 --> 00:12:36.090 and a whole bunch more. Lots of things are caused 140 00:12:36.149 --> 00:12:40.309 by viruses. And you have definitely had a virus at 141 00:12:40.350 --> 00:12:46.679 some point in the past. Mott says, wash that ass. 142 00:12:47.320 --> 00:12:52.870 That would be bacterial. Addie said, that sounds mildly dehumanizing 143 00:12:52.929 --> 00:13:05.620 and objectifying and abusive. They use me? Just leave like that? Yeah. Sometimes. 144 00:13:05.840 --> 00:13:10.000 Sometimes they leave. Not all the time. Don't worry, I'm 145 00:13:10.019 --> 00:13:12.080 going to tell you about the types of viruses. You've 146 00:13:12.100 --> 00:13:20.200 got your influenza viruses. Orthomyoxyviridae. That's influenza A and B. 147 00:13:20.879 --> 00:13:24.159 That's the flu. So if you've ever heard somebody talking about, oh, no, 148 00:13:24.220 --> 00:13:29.750 the bird flu. Oh, swine flu. Oh, H1N1 is going 149 00:13:29.769 --> 00:13:42.820 to get you. Yeah. Those. That's a virus. That's one. 150 00:13:43.200 --> 00:13:47.860 It depends on the specific strain. So they're named after 151 00:13:47.899 --> 00:13:51.500 the species. the type of animal it was originally found in. 152 00:13:51.600 --> 00:13:58.700 So bird flus were first found in birds, like chickens. 153 00:13:59.159 --> 00:14:02.440 And the reason why bird flu is a problem, do 154 00:14:02.480 --> 00:14:05.110 you know how much of the food we eat in 155 00:14:05.139 --> 00:14:14.950 the United States is chicken? Where do eggs come from? Chickens. Eggs, chicken. 156 00:14:16.429 --> 00:14:20.340 So A farm that winds up with bird flu often 157 00:14:20.399 --> 00:14:25.330 has to put down all the birds, all of them, 158 00:14:26.090 --> 00:14:30.409 in order to stop the bird flu from spreading. Because 159 00:14:30.649 --> 00:14:34.509 if a human eats a piece of chicken that was 160 00:14:34.570 --> 00:14:39.100 infected with bird flu, it can make the jump from 161 00:14:39.120 --> 00:14:47.509 a bird flu into a human flu. hi Kylie, we're 162 00:14:47.559 --> 00:14:55.279 talking about viruses tonight. So, you don't want a virus 163 00:14:55.399 --> 00:14:59.299 that started originally in an animal to jump over into 164 00:14:59.759 --> 00:15:07.490 human-to-human transmission. Because it's mutated, something in it changed, now 165 00:15:07.549 --> 00:15:11.690 it likes people. Great. And we may or may not 166 00:15:11.889 --> 00:15:17.350 have an immune response to it. And so, um, Some 167 00:15:17.450 --> 00:15:24.169 influenzas can become extremely deadly. The Spanish influenza of 1912 168 00:15:24.169 --> 00:15:30.379 comes to mind. Uh-huh. Callie says the Spanish flu got 169 00:15:30.419 --> 00:15:34.220 wrongly named because countries didn't want to report their cases. Yep, 170 00:15:34.299 --> 00:15:38.500 and so they wound up

blaming it on, oh, Spanish influenza, 171 00:15:38.940 --> 00:15:42.210 the Spanish flu, because they were like, hey, we have 172 00:15:42.230 --> 00:15:46.860 a problem. And everybody else went, nuh-uh, that's all you. Ah, 173 00:15:46.899 --> 00:15:53.039 it's your fault. Jackasses. It was probably a bird flu. 174 00:15:54.500 --> 00:16:02.779 And it popped on over to human transmission. And then, whoops-de-doodle, 175 00:16:02.850 --> 00:16:06.129 probably came from Kansas. It probably did actually originate in 176 00:16:06.149 --> 00:16:15.990 the U.S. So, herpes viridae. Herpes viridae. Okay. Okay. I 177 00:16:16.009 --> 00:16:20.070 say that real nice and slow, but it's herpesviruses. There's 178 00:16:20.090 --> 00:16:26.460 a bunch in the herpes family. There's simplexes 1 through 9. 179 00:16:26.460 --> 00:16:28.080 I'm not going to go over all of them. You 180 00:16:28.120 --> 00:16:33.440 can refer back to the episode of Horse School about herpes. Oral, 181 00:16:33.779 --> 00:16:42.590 genital herpes, chickenpox, shingles, Epstein-Barr, and cytomegalovirus are all herpesviruses. 182 00:16:44.730 --> 00:16:50.120 Aren't those great? You get a funny bump. It's probably 183 00:16:50.129 --> 00:16:57.379 a herpes somewhere on you. Epstein-Barr gives you muscle tremors 184 00:16:58.600 --> 00:17:06.599 and like shingles. Shingles is a mutation of chicken pox. 185 00:17:06.680 --> 00:17:09.200 Chicken pox give you bumps and sores all over your skin. 186 00:17:09.740 --> 00:17:18.779 And then shingles gets into the muscle sheaths Yay. You 187 00:17:18.819 --> 00:17:21.680 can also, by the way, you can get any of 188 00:17:21.740 --> 00:17:26.000 these herpes viruses. They have where they like to be 189 00:17:26.359 --> 00:17:29.160 on the body. So genital herpes likes to be on 190 00:17:29.200 --> 00:17:32.599 the genitals and oral herpes likes to be on the mouth. 191 00:17:32.720 --> 00:17:36.500 They can show up anywhere, including on the lining of 192 00:17:36.539 --> 00:17:50.990 your organs. Isn't that neat? Vaguely terrifying. Horrifying. Chickenpox is 193 00:17:51.049 --> 00:17:57.029 no fun. They have a vaccination for chickenpox now. If 194 00:17:57.069 --> 00:18:02.710 you have not had chickenpox or the chickenpox vaccination, go 195 00:18:02.789 --> 00:18:06.210 fucking get it. Because it also prevents shingles. There's a 196 00:18:06.349 --> 00:18:10.210 shingles vaccination as well. But I think you have to 197 00:18:10.250 --> 00:18:13.730 be a certain age to get the shingles vaccination. I'm 198 00:18:13.779 --> 00:18:16.779 not sure about that. Talk to your healthcare provider and 199 00:18:16.799 --> 00:18:23.019 be like, what can you shoot me up with? So, 200 00:18:23.759 --> 00:18:35.079 get that. Coronaviruses. There are lots of coronaviruses. They cause 201 00:18:35.099 --> 00:18:40.259 the cold, just like the influenza viruses cause influenza, the 202 00:18:40.339 --> 00:18:44.259 flu virus. coronaviruses cause the common cold. There are a 203 00:18:44.640 --> 00:18:48.799 bunch of coronaviruses out there, but currently the most famous 204 00:18:48.920 --> 00:18:56.660 one is SARS-CoV-2, COVID-19. There's also vaccines for that one, 205 00:18:57.079 --> 00:18:59.109 which you should also go and get and make sure 206 00:18:59.119 --> 00:19:01.569 that you're up to date. You can get a flu virus, 207 00:19:01.609 --> 00:19:06.470 you can get a chickenpox flu vaccine, chickenpox vaccine, shingles vaccine, 208 00:19:06.690 --> 00:19:11.430 coronavirus vaccine, and you should Hey, prisoner, welcome to the 209 00:19:11.470 --> 00:19:17.309 show tonight. All of those are viruses. All of those 210 00:19:17.390 --> 00:19:23.670 can be steeply ameliorated. Or if you catch it, even 211 00:19:23.809 --> 00:19:27.970 if you have been vaccinated, you get less sick. It's 212 00:19:28.150 --> 00:19:32.359 less likely to knock you on your ass and liquefy 213 00:19:32.380 --> 00:19:41.579 your lungs. Poovey, I can't repeat that joke. That is 214 00:19:41.640 --> 00:19:50.970 really funny. Jerk. Okay, human papillomavirus. Hey, guess what? HPV. 215 00:19:52.089 --> 00:19:55.029 There's a vaccine for that one too. And you should 216 00:19:55.109 --> 00:19:59.250 get it if you have sex. The human papillomavirus. I've 217 00:19:59.309 --> 00:20:04.440 covered this one as well. It is a sexually transmitted illness. 218 00:20:05.059 --> 00:20:10.359 There are no symptoms for HPV in men. on account 219 00:20:10.390 --> 00:20:14.299 of you don't have a cervix. Okay, no, cis men. 220 00:20:14.799 --> 00:20:17.759 Let's be clear. Cis men who do not have a 221 00:20:17.819 --> 00:20:23.440 cervix cannot suffer the negative effects of having human papillomavirus. 222 00:20:25.779 --> 00:20:29.000 But if you stick your diseased dick in a woman 223 00:20:29.339 --> 00:20:33.119 or a person who does have a cervix, you can 224 00:20:33.240 --> 00:20:38.720 give her or them an STD that will eventually cause cancer. 225 00:20:39.849 --> 00:20:47.720 Cervical cancer. Don't fucking do that. Men should absolutely get 226 00:20:47.759 --> 00:20:52.279 the vaccination. Persons who have a cervix should definitely get 227 00:20:52.319 --> 00:20:55.640 the vaccine. It's recommended for people who are under 45 228 00:20:55.640 --> 00:21:00.089 years of age. If you are older and you are 229 00:21:00.119 --> 00:21:12.160 still having risky sex, get it anyway. Bitches. Enteroviruses! Oh, 230 00:21:12.200 --> 00:21:19.019 we love a good enterovirus. Ugh. Those are the ones 231 00:21:19.059 --> 00:21:23.859 that go after your intestinal tract. An enterovirus is one 232 00:21:23.900 --> 00:21:26.980 of the viral infections that will cause you to become 233 00:21:27.180 --> 00:21:33.930 very good bestie friends with your toilet. Hand, foot, and 234 00:21:34.130 --> 00:21:42.130 mouth disease is an enterovirus. Ew. So is polio. But 235 00:21:42.190 --> 00:21:48.569 enterovirus is also one of the hallmarks of

an enterovirus 236 00:21:48.670 --> 00:21:52.359 is you have to spend a lot of time sitting 237 00:21:52.440 --> 00:22:04.680 on the porcelain throne. Isn't that great? Flaviviruses. Flaviviruses. They're 238 00:22:04.700 --> 00:22:08.990 spread by mosquitoes most often. And isn't that just a 239 00:22:09.650 --> 00:22:17.380 fucked up bitch? That's some crap. We do not enjoy those. 240 00:22:17.819 --> 00:22:24.799 The flavivirus is fuck mosquitoes. Zika, West Nile, dengue fever, 241 00:22:25.440 --> 00:22:28.180 yellow fever. Again, you're going to be sick as shit. 242 00:22:28.220 --> 00:22:30.829 You're going to sweat a whole lot. For some people, 243 00:22:32.589 --> 00:22:37.150 compromised immune system, or if they're already weakened, it's real bad. 244 00:22:40.089 --> 00:22:41.569 Let's see if you can guess what this one is. 245 00:22:42.509 --> 00:22:50.799 Orthopox viruses. Ortho pox viruses. Can you figure out what 246 00:22:50.819 --> 00:22:58.859 those ones are? They're fun. Yup. Prisoner said if one 247 00:22:59.279 --> 00:23:03.309 cow or bull in England is diagnosed with hoof and mouth, 248 00:23:03.369 --> 00:23:05.690 the entire herd that cow or bull was a member 249 00:23:05.769 --> 00:23:10.619 of is slaughtered and cremated. Yup. Um, In the United States, 250 00:23:10.839 --> 00:23:13.329 if you have a herd of swine who wind up 251 00:23:13.430 --> 00:23:18.130 with swine flu, bye-bye piggies. All of your birds, if 252 00:23:18.170 --> 00:23:21.710 they wind up with bird flu, bye-bye birdies. Same thing. 253 00:23:22.950 --> 00:23:27.640 There's also, there's various things that aren't viral. So like 254 00:23:27.759 --> 00:23:32.740 prion disease. If you get prions in your cows, one, 255 00:23:35.380 --> 00:23:38.829 feed them a higher quality of feed. And two, Put 256 00:23:38.869 --> 00:23:45.049 them all down. Because prion disease, that's the one where 257 00:23:45.089 --> 00:23:48.990 you get holes in your brain. I don't like that. 258 00:23:50.299 --> 00:24:00.799 Orthopoxviruses cause blistering rashes. An orthopoxvirus would be monkeypox, smallpox, cowpox, 259 00:24:01.599 --> 00:24:04.740 those things. And again, cowpox refers to the fact that 260 00:24:04.759 --> 00:24:14.269 it was first found in cow's The hepatitis viruses. Hepatitis A, B, 261 00:24:14.349 --> 00:24:17.299 and C are the most common ones. Guess what part 262 00:24:17.339 --> 00:24:24.299 of your anatomy the hepatitis viruses attack? Your liver. You 263 00:24:24.380 --> 00:24:31.269 need that. You need a liver. You need that. Poovie 264 00:24:31.289 --> 00:24:33.509 says it happens to plants too. The T virus in 265 00:24:33.529 --> 00:24:38.220 bananas will mean entire orchard is destroyed. Yes. The tobacco 266 00:24:38.259 --> 00:24:41.759 mosaic virus, which started off in tobacco plants, but it 267 00:24:41.799 --> 00:24:45.799 can also show up in any nightshade. Would you like 268 00:24:45.839 --> 00:24:47.740 to know how much of the North American diet is 269 00:24:47.799 --> 00:24:56.059 composed of nightshades? Tomatoes, potatoes, all peppers, eggplants. All of 270 00:24:56.119 --> 00:25:03.640 those are nightshades. It's terrible. And then we have the retroviruses. 271 00:25:06.759 --> 00:25:11.099 A retrovirus is a virus that uses RNA and it 272 00:25:11.200 --> 00:25:15.339 has special proteins packaged in with it to make DNA. 273 00:25:17.059 --> 00:25:23.069 When you're infected with a retrovirus, it starts off as RNA. 274 00:25:24.490 --> 00:25:28.630 It uses part of your body's cells to make DNA. 275 00:25:29.069 --> 00:25:34.430 The DNA is inserted into your DNA and then your 276 00:25:34.490 --> 00:25:39.829 cells go, Okay, we make this stuff now? Great. And 277 00:25:39.849 --> 00:25:41.970 it will make whatever the viral DNA is said to do, 278 00:25:42.569 --> 00:25:49.369 which would be the parts of the virus. Yay. So 279 00:25:49.410 --> 00:25:52.809 then your body is making more of the virus. Just 280 00:25:53.329 --> 00:25:56.539 making it because now part of it has become part 281 00:25:56.579 --> 00:26:03.460 of you. HIV is a retrovirus. Human T lymphotropic virus 282 00:26:04.059 --> 00:26:08.160 is also a retrovirus. There are other retroviruses. which is 283 00:26:08.240 --> 00:26:18.069 why it's important to take antiretroviral medications. Oncoviruses. This is 284 00:26:18.109 --> 00:26:22.130 more of a broader group, and it encompasses several of 285 00:26:22.170 --> 00:26:27.930 the different types. The viruses that cause cancer, HPV, Epstein-Barr, HIV, 286 00:26:28.109 --> 00:26:36.150 hepatitis B and C, the human T lymphotropic virus, and 287 00:26:36.349 --> 00:26:43.849 human herpes virus, all can cause cancer. Which is why 288 00:26:43.910 --> 00:26:52.609 the fact that we have vaccines for HPV, hepatitis, and 289 00:26:52.690 --> 00:26:58.910 humans' herpes virus is kind of important. I think we have... No, 290 00:26:58.950 --> 00:27:09.769 we do not have a vaccine for herpes virus yet. So... Obvious. 291 00:27:10.390 --> 00:27:19.420 Mott said I'm taking a shower after horsecore. Mwahaha. Yeah. 292 00:27:22.420 --> 00:27:30.200 All of these viruses, they're not alive in the way that, like, 293 00:27:30.579 --> 00:27:37.640 you are alive. They are alive in that they exist. 294 00:27:38.880 --> 00:27:47.039 They consume resources. They replicate themselves. So they're kind of alive. 295 00:27:47.539 --> 00:27:49.359 They're kind of not alive. But they kind of are. 296 00:27:50.519 --> 00:27:58.109 They attach to cells. They have a mechanism built into. 297 00:27:58.200 --> 00:28:00.069 So it's got like these little legs that come off 298 00:28:00.109 --> 00:28:04.789 of the capsid. Think of the capsid as like a ball. 299 00:28:05.450 --> 00:28:08.349 And it's got this structure. looking off the side of 300 00:28:08.410 --> 00:28:14.109 it and it has legs and it hooks into your cells. 301 00:28:15.150 --> 00:28:18.710 Most of the time those little

legs have specific shapes 302 00:28:18.769 --> 00:28:22.529 to them and they attach to specific shapes on your cells. 303 00:28:23.130 --> 00:28:25.690 This is why we say that they like certain types 304 00:28:25.759 --> 00:28:30.700 of tissue. They're looking for specific cell types and specific 305 00:28:30.859 --> 00:28:33.359 proteins on the surfaces of the cells. That's how they 306 00:28:33.380 --> 00:28:38.210 can tell the difference between genital tissue and a liver. 307 00:28:40.150 --> 00:28:43.599 In a pinch, most of these viruses will take whatever 308 00:28:43.640 --> 00:28:47.059 they can fucking get. But some of them are highly 309 00:28:47.140 --> 00:28:52.960 specialized and will only attach to specific receptors on your cells. 310 00:28:53.000 --> 00:29:00.230 They go, ooh, there's that receptor. I'm in. They attach 311 00:29:00.549 --> 00:29:05.349 and then there's kind of a spring mechanism in there 312 00:29:05.759 --> 00:29:11.359 that kind of pucks through the lining of your cell, 313 00:29:12.480 --> 00:29:17.400 and it squirts the contents of the capsid into your cell, 314 00:29:18.619 --> 00:29:22.569 at which point it begins to replicate itself by using 315 00:29:23.609 --> 00:29:28.369 your cell's stuff. Your cell comes along and goes, ooh, 316 00:29:28.549 --> 00:29:32.170 here's some DNA. Oh, okay, I should make more of this? Great. 317 00:29:32.750 --> 00:29:35.009 And keep in mind, though, your cell isn't really thinking 318 00:29:35.869 --> 00:29:47.819 because it's just one cell. It's just... doing stuff. Eventually 319 00:29:47.859 --> 00:29:57.140 it puts all the pieces together, and then it... gets 320 00:29:57.380 --> 00:30:05.990 out of your cell. Sometimes you can be infected with 321 00:30:06.049 --> 00:30:11.690 a virus and show no symptoms whatsoever. It's because it 322 00:30:11.730 --> 00:30:14.369 can go dormant in your body or it can just 323 00:30:14.430 --> 00:30:19.180 be silent and not do anything in there. Eventually there 324 00:30:19.220 --> 00:30:22.500 will be a trigger and it causes the cells to burst. 325 00:30:23.339 --> 00:30:26.339 And it spreads the viral particles into your body and 326 00:30:26.380 --> 00:30:31.480 infects other cells inside. It could be stress. It could 327 00:30:31.500 --> 00:30:36.079 be chemical signals. It could be temperature changes. This is why, 328 00:30:36.220 --> 00:30:38.500 if you have herpes, for example, this is why it 329 00:30:38.539 --> 00:30:41.809 comes back. Why the sores on your mouth or the 330 00:30:41.869 --> 00:30:46.769 sores on your genitals come back, especially if you're stressed out. 331 00:30:47.289 --> 00:30:51.210 You get an outbreak, right? It's in there. It's just 332 00:30:51.250 --> 00:30:55.680 gone dormant until it's not. And then it's active again. 333 00:30:58.079 --> 00:31:02.819 Most of these... viruses, you're more likely to spread when 334 00:31:02.880 --> 00:31:06.259 it is active than when it is dormant. Most of 335 00:31:06.279 --> 00:31:09.369 the time when it's dormant, you do not spread it. 336 00:31:10.160 --> 00:31:15.759 When it is active, you do spread it. Yeah, does 337 00:31:15.779 --> 00:31:19.779 that make sense? Addie said herpes is the one that 338 00:31:19.819 --> 00:31:23.319 most humans have, right? Yes. In some populations, it's up 339 00:31:23.559 --> 00:31:28.200 to 80% of the population has herpes, usually oral herpes. 340 00:31:28.829 --> 00:31:33.150 But keep in mind, there are nine versions, like nine 341 00:31:33.410 --> 00:31:39.180 herpes simplexes. And number eight is the one that causes cancer. Actually, 342 00:31:39.200 --> 00:31:42.039 Epstein-Barr is also a herpes virus, so two of them 343 00:31:42.099 --> 00:31:51.380 cause cancer. They're bad for you. Addie says, she's frantically 344 00:31:51.440 --> 00:31:55.619 raising her hand. Have I watched Cells at work? If 345 00:31:55.680 --> 00:32:01.369 I did, it was a while ago? Not recently. Okay. 346 00:32:05.069 --> 00:32:11.630 Tons of different shapes for viruses. Tons of different things 347 00:32:11.730 --> 00:32:15.950 that they do. But if you don't want a virus, 348 00:32:16.829 --> 00:32:22.470 how do you stop it? Right? That is kind of 349 00:32:22.569 --> 00:32:26.769 the quintessential human question. How do you stop something that 350 00:32:26.809 --> 00:32:30.900 you can't see and you can't smell it And you 351 00:32:30.940 --> 00:32:36.079 can't hear it. And it's just kind of there. How 352 00:32:36.099 --> 00:32:40.279 do you stop it? I'm so glad you asked. Through 353 00:32:40.299 --> 00:32:46.069 this process that we like to call prep. Pre-exposure prophylaxis. Basically, 354 00:32:46.329 --> 00:32:51.109 remember that that is any medication or process that you 355 00:32:51.150 --> 00:32:57.769 undergo to try to prevent or reduce the odds of 356 00:32:58.289 --> 00:33:14.079 catching or transmitting and illness, including viruses. Wash your hands 357 00:33:15.039 --> 00:33:20.720 with soap and water. Sing yourself happy birthday while you 358 00:33:20.759 --> 00:33:22.819 do it to make sure that you have soap on 359 00:33:22.859 --> 00:33:28.269 your skin for long enough. Real soap. Soap, soap. in 360 00:33:28.309 --> 00:33:31.059 this harbor. Why do I have to use soap? Ah, 361 00:33:31.099 --> 00:33:33.599 you remember the capsid? I told you to remember that word. 362 00:33:36.160 --> 00:33:40.079 An awful lot of viruses have a capsid. In fact, 363 00:33:40.240 --> 00:33:42.420 all of them do. Some of them have an envelope 364 00:33:42.960 --> 00:33:47.450 to protect the capsid around it. The vast majority of them, 365 00:33:48.250 --> 00:33:54.789 the capsid is made of fat. Basically, I am so 366 00:33:54.869 --> 00:34:03.220 simplifying things. Soap breaks the bonds in fat. So before 367 00:34:03.519 --> 00:34:07.220 your virus has a chance to hook into your cell 368 00:34:07.279 --> 00:34:12.719 and squirt its guts inside of you, you can use 369

00:34:12.929 --> 00:34:18.150 soap to pop it like a bubble. Isn't that great? 370 00:34:21.030 --> 00:34:29.530 Addie said, what about just a bit of spit? no 371 00:34:30.289 --> 00:34:37.679 soap soap and water for fuck's sake not spit no 372 00:34:38.409 --> 00:34:42.599 please do not lick things it doesn't get them clean 373 00:34:45.619 --> 00:34:47.840 would you like to know all about the enzymes that 374 00:34:47.880 --> 00:34:52.940 exist in spit because i will tell you it's a 375 00:34:53.260 --> 00:34:56.909 threat Okay, do you want me to make you feel 376 00:34:56.969 --> 00:35:00.090 vaguely grossed out about what's in your mouth? Because I 377 00:35:00.130 --> 00:35:10.590 can do it. I took way too many microbiology classes, okay? 378 00:35:11.550 --> 00:35:19.900 Organic chemistry, microbiology, and genetics. It's all about viruses. I 379 00:35:19.940 --> 00:35:31.860 know what's in spit. Mm-mm. Nope. He said, why not? 380 00:35:32.420 --> 00:35:34.619 You've made us grossed out about the rest of our 381 00:35:34.639 --> 00:35:44.429 bodies so far. I would say, I'm sorry for that, 382 00:35:44.630 --> 00:35:54.730 but I'm not. It would be a lie. Prisoners, it 383 00:35:54.769 --> 00:35:57.190 was the microbiology class to learn how to brew beer. 384 00:35:58.010 --> 00:36:00.750 I mean, we did talk about yeast because yeast is 385 00:36:00.809 --> 00:36:06.130 a single cellular organism that is definitely alive in all 386 00:36:06.170 --> 00:36:08.070 the ways that we think of things as being alive. 387 00:36:09.210 --> 00:36:15.559 Yeast is fascinating stuff. But no. We did talk about 388 00:36:15.599 --> 00:36:23.449 brewing beer and making other alcohols. But no, that's not 389 00:36:23.489 --> 00:36:28.900 why I took the class. It was really fun. They 390 00:36:28.920 --> 00:36:35.119 had us go and swab our bathrooms. And as a result, 391 00:36:35.539 --> 00:36:40.670 I have developed a lifelong habit. Always, no matter what, 392 00:36:41.889 --> 00:36:49.250 before you flush the toilet, put the lid down. For 393 00:36:49.309 --> 00:36:59.510 the love of fuck, that's Disgusting. So. Bud says, hey, 394 00:36:59.570 --> 00:37:03.840 for no reason, fuck John Calvin. Hell yeah, fuck John Calvin, 395 00:37:03.880 --> 00:37:16.219 that asshole. We still hate him. Screw that dick monkey. Uh-oh. 396 00:37:16.800 --> 00:37:26.570 I broke something. Oops. It's fine. The computer will respond 397 00:37:26.590 --> 00:37:36.059 in a minute. Poovey said, you don't like making aerosol 398 00:37:36.119 --> 00:37:39.860 clouds of biomatter? Look, as soon as I learned what 399 00:37:40.000 --> 00:37:44.559 microspray is, I was like, oh, you're right. Note to self. 400 00:37:48.079 --> 00:38:03.139 That's disgusting. My toothbrush lives here. There it is. Found it. Uh-uh. 401 00:38:13.369 --> 00:38:20.559 So prep. Pre-exposure prophylaxis. Wearing gloves. A mask when you 402 00:38:20.639 --> 00:38:25.280 are around strangers is a form of pre-exposure prophylaxis, and 403 00:38:25.320 --> 00:38:33.349 it can prevent or ameliorate the transmission of influenzas and coronaviruses. 404 00:38:34.010 --> 00:38:35.969 And the reason I call those out is because those 405 00:38:36.010 --> 00:38:39.190 are the ones that are most likely to be spread 406 00:38:41.860 --> 00:38:46.639 by aerosolized droplets in the air aka you ever get 407 00:38:46.760 --> 00:38:49.570 really really into talking about something and discover that you've 408 00:38:49.619 --> 00:38:53.869 accidentally been spitting the whole time yep those are aerosolized 409 00:38:53.909 --> 00:39:08.829 droplets ew wear a mask wear a mask Because other 410 00:39:08.869 --> 00:39:20.739 people's exhalations are gross. Okay, well, it's just nasty. My 411 00:39:20.780 --> 00:39:32.260 dog's stomach is gurgling behind me. Holy crap. Okay. If 412 00:39:32.340 --> 00:39:44.869 you are interested in engaging in risky sex, and that 413 00:39:44.909 --> 00:39:50.920 can include sex with strangers, Sex with people who themselves 414 00:39:51.079 --> 00:39:58.539 engage in risky sex, including sex with strangers. You should 415 00:39:59.000 --> 00:40:03.059 probably speak to your primary health care provider about getting 416 00:40:03.440 --> 00:40:10.130 on one of any number of different types of PrEP, 417 00:40:10.969 --> 00:40:16.489 pre-exposure prophylaxis for HIV. You don't want HIV. You really 418 00:40:16.530 --> 00:40:24.000 do not want it. It causes several cancers and is 419 00:40:24.340 --> 00:40:28.780 bad for you. Like, it's not a fun one. This 420 00:40:28.909 --> 00:40:34.570 is not bragging rights. You want not to ever catch this. So, 421 00:40:35.090 --> 00:40:40.929 the first one, Truvada, was approved in 2012. If this 422 00:40:41.010 --> 00:40:45.389 is the first that you're hearing, Addie says, it causes cancers. Yes, 423 00:40:45.550 --> 00:40:49.900 several cancers. AIDS was such a big deal because people 424 00:40:49.920 --> 00:40:51.900 were like, what the fuck? Why are these people getting 425 00:40:52.079 --> 00:41:00.909 really weird, obscure, unusual cancers in clusters? Like weird cancer clusters. 426 00:41:00.929 --> 00:41:02.949 And they could not figure out what was causing this. 427 00:41:03.710 --> 00:41:09.829 It was HIV. It causes cancers. Like skin lesions that 428 00:41:09.869 --> 00:41:14.579 turn into cancers. Cancer of the like bits of your 429 00:41:14.599 --> 00:41:18.679 body that normally don't get cancer. Your liver usually doesn't 430 00:41:18.780 --> 00:41:27.610 really get cancer. Addie said, I thought it was just 431 00:41:27.650 --> 00:41:30.030 like your immune system and people were dying because of 432 00:41:30.590 --> 00:41:33.550 really basic diseases like the flu. I mean, that definitely 433 00:41:33.630 --> 00:41:40.670 did not help. It does. So HIV... They call it 434 00:41:40.730 --> 00:41:47.570 acquired immune deficiency because it does weaken your immune system drastically,

435 00:41:48.050 --> 00:41:50.320 which means you are more likely to catch anything that 436 00:41:50.340 --> 00:41:53.099 walks past. And as a result of that, you can 437 00:41:53.139 --> 00:41:58.099 wind up kicking off because you've caught everything. Would you 438 00:41:58.119 --> 00:42:00.079 like to catch two or three strains of the flu 439 00:42:00.340 --> 00:42:03.510 at the same time? Because that's possible. You can do that. 440 00:42:04.329 --> 00:42:09.170 But it also would give people cancer. weird cancers that 441 00:42:09.190 --> 00:42:10.869 they were like we don't have a cure for that 442 00:42:10.989 --> 00:42:17.480 because it's so rare so people would die from and 443 00:42:17.519 --> 00:42:21.900 it would like would you like blood cancer we can 444 00:42:21.920 --> 00:42:31.630 give you some of that like weird fucking cancers well 445 00:42:33.530 --> 00:42:38.360 the dogs are moving around mott said nightmare It was terrible, 446 00:42:38.659 --> 00:42:41.780 and in the 80s, late 70s, early 80s, all the 447 00:42:41.800 --> 00:42:46.840 way through the 90s, it was considered God's punishment for gays. 448 00:42:51.079 --> 00:42:54.739 It's terrible. Like, the history around AIDS is just awful. 449 00:42:55.360 --> 00:43:01.789 In 2012, Truvada was finally approved to use as pre-exposure prophylaxis. 450 00:43:02.789 --> 00:43:05.650 Most of you, if you have insurance, your insurance probably 451 00:43:05.690 --> 00:43:09.309 covers it. Because it is far cheaper in the long 452 00:43:09.349 --> 00:43:18.769 run to prevent an illness than to treat the illness. So, 453 00:43:19.289 --> 00:43:28.230 Truvada was the first one. It is... Let me make 454 00:43:28.250 --> 00:43:43.690 sure I can pronounce this. Impricitabine. tenofovir, tenofovir, brand name Truvada. Um, 455 00:43:43.869 --> 00:43:48.730 there's other names that it's also sold under. It is 456 00:43:48.949 --> 00:43:55.949 used for HIV prevention, HIV treatment, and hepatitis B treatment. Um, 457 00:43:58.449 --> 00:44:02.670 and if you have both hep B and HIV, hey, 458 00:44:02.690 --> 00:44:09.530 it works on both at the same time. Um, It's 459 00:44:13.210 --> 00:44:25.639 an antiretroviral medication. If you are not currently infected with HIV, 460 00:44:25.880 --> 00:44:35.179 you can take Truvada before exposure and it reduces your 461 00:44:35.360 --> 00:44:40.889 risk by at least 54%. on average, which is really 462 00:44:40.989 --> 00:44:49.300 fucking good, because without it, your risk, it's not super high. 463 00:44:49.880 --> 00:44:53.460 It's not like you're definitely going to get HIV if 464 00:44:53.480 --> 00:44:56.539 you fuck a man. It's only 1 in 200, but 465 00:44:56.599 --> 00:44:59.139 on Truvada, it's 1 in 400, which is better. Right? 466 00:45:08.929 --> 00:45:20.099 So that's that one. There is also... Where did it go? 467 00:45:20.119 --> 00:45:24.030 I have so many things open. You don't even know. 468 00:45:33.369 --> 00:45:40.329 There

is... So that was the... amtricitabine and tenofovir. And 469 00:45:40.349 --> 00:45:44.289 then there's one that is the same thing, but it 470 00:45:44.369 --> 00:45:52.699 is tenofovir alafenamide, which is Descovy, which can also be 471 00:45:52.780 --> 00:46:02.369 used as PrEP. It is... Truvada is for everybody. Descovy 472 00:46:02.570 --> 00:46:07.010 is for cis men and trans women. because they have 473 00:46:07.070 --> 00:46:13.320 not assessed it for women doing receptive vaginal sex. So 474 00:46:14.320 --> 00:46:27.230 that's the difference between those. In 21, cabotegravir, abotegravir, aperitude, 475 00:46:29.150 --> 00:46:35.670 was approved. It is an injectable form of pre-exposure prophylaxis. 476 00:46:47.300 --> 00:46:52.420 whereas Truvada and Descovy are pills that you have to 477 00:46:52.500 --> 00:46:57.340 take every day, preferably for like a month before you 478 00:46:57.380 --> 00:46:59.340 engage in risky sex. So if you're thinking you might 479 00:46:59.420 --> 00:47:02.590 want to, you should probably go and get on it now. 480 00:47:02.610 --> 00:47:07.510 Aperitude is injectable, and you only have to have an 481 00:47:07.570 --> 00:47:13.570 injection once every two months. They were hoping that Aperitude 482 00:47:13.590 --> 00:47:16.789 would be more popular because it's just one shot every 483 00:47:16.829 --> 00:47:21.710 two months. So you're more likely to have people follow 484 00:47:21.789 --> 00:47:28.219 through with it and not forget or lose their pills 485 00:47:28.280 --> 00:47:38.880 or stop taking them for whatever reason. And then there is... 486 00:47:40.929 --> 00:47:48.369 Another one. This one's really super duper new. And again, 487 00:47:48.389 --> 00:47:54.909 we get a really wild fucking name. It is an 488 00:47:54.989 --> 00:48:10.230 extended release injectable Lenacapavir. Lenacapavir. It's branded as Yeztugo. Now, currently, 489 00:48:10.820 --> 00:48:12.880 This is the one that I was talking about for 490 00:48:12.940 --> 00:48:16.690 Femdom Fridays, because they've managed to get my attention and 491 00:48:16.809 --> 00:48:22.809 piss me off at the same time. Yezd Hugo is 492 00:48:25.710 --> 00:48:30.769 through Gilead Sciences. Pointing. What's with that name? Why is 493 00:48:30.829 --> 00:48:46.940 it called Gilead? What the shit? Hi, Chicago. We're talking about, uh... Viruses. Tonight. Okay. 494 00:48:47.440 --> 00:48:52.460 So Yez Tugo. From Gilead Sciences. They're in the process 495 00:48:52.500 --> 00:48:56.159 of going through. And getting full approval. For global release 496 00:48:56.199 --> 00:48:59.860 of this medication. And they've made deals. So that in 497 00:49:00.139 --> 00:49:03.880 lower income countries. They will release the shot. And it's 498 00:49:04.219 --> 00:49:06.840 two shots per year. So it's one shot every six months. 499 00:49:08.460 --> 00:49:14.309 that they will release it for $ 40 per shot in 500 00:49:14.429 --> 00:49:27.659 low-income countries. Fabulous, right? Yes, to go as PrEP before 501 00:49:28.039 --> 00:49:33.199 one is infected with anything, that sounds absolutely fabulous. A 502 00:49:33.320 --> 00:49:36.400 shot every six months, and it reduces your risk of 503 00:49:36.440 --> 00:49:42.119 catching HIV. We love that. Yes, please. It's also used 504 00:49:42.159 --> 00:49:46.139 for people who have HIV, but their strain of HIV 505 00:49:46.179 --> 00:49:53.570 has become medication resistant. And the trials for this medication 506 00:49:54.469 --> 00:50:00.239 for people who have a resistant strain of HIV, it's 507 00:50:00.300 --> 00:50:03.940 working very, very well. The problem is in first world 508 00:50:03.980 --> 00:50:10.050 countries like the United States, it's 42%. thousand dollars per 509 00:50:10.300 --> 00:50:21.190 year for treatment your money or your life and that 510 00:50:21.550 --> 00:50:26.429 is why medicines and frontiers or doctors without borders has 511 00:50:26.510 --> 00:50:35.250 launched a campaign to attempt to push um where did 512 00:50:35.269 --> 00:50:39.059 it go i have a link for this Here it is. 513 00:50:41.460 --> 00:50:48.409 Gilead Sciences into releasing the medication. Yes to go. Boom. 514 00:50:48.449 --> 00:50:54.050 Told you I had a link. For $ 40 per shot. Globally. Everywhere. 515 00:50:58.329 --> 00:51:00.949 Because that would be so much better. And you can 516 00:51:00.989 --> 00:51:08.389 see it's very simple. Lenacapavir. Two shots. $ 40. Everywhere. Everywhere. So, 517 00:51:09.019 --> 00:51:12.260 they're trying to put pressure onto Gilead Sciences to lower 518 00:51:12.300 --> 00:51:21.420 the fucking price. Lower the cost, you bitches. So, if 519 00:51:21.989 --> 00:51:23.650 they can manage to put pressure on them for that, 520 00:51:24.230 --> 00:51:33.369 that is huge. That's massive. That's so good. So, if 521 00:51:33.429 --> 00:51:36.360 you are about to go forth and engage in risky sex... 522 00:51:38.840 --> 00:51:43.800 Step one. Make sure that you have gone to your 523 00:51:43.860 --> 00:51:47.199 local health department and gotten tested recently so you can 524 00:51:47.260 --> 00:51:50.780 prove that you're clean. Demand that anybody you're about to 525 00:51:50.840 --> 00:51:56.860 do anything sexy with can also prove that they are clean. 526 00:52:01.949 --> 00:52:05.909 Have you been tested? How long ago? Have you had 527 00:52:05.969 --> 00:52:09.699 risky sex since then? Those are the questions you want 528 00:52:09.719 --> 00:52:12.280 to ask and then judge for yourself. Do you feel 529 00:52:12.420 --> 00:52:17.630 safe doing sexy stuff with this person? If yes, great. 530 00:52:18.230 --> 00:52:26.389 If no, examine what you're about to put inside of 531 00:52:26.429 --> 00:52:28.880 your body before you do so. If it looks like 532 00:52:29.239 --> 00:52:35.260 it's got a rash, don't fuck it. Funny bumps, funny smells. 533 00:52:36.519 --> 00:52:39.610 If it just the vibe's not right. You

can say 534 00:52:39.670 --> 00:52:41.659 no at any point and say, you know what? I 535 00:52:41.699 --> 00:52:46.400 changed my mind. Why is your dick green? You know, 536 00:52:46.519 --> 00:52:48.340 you're allowed to do that. You're allowed to back out 537 00:52:48.480 --> 00:52:59.099 and just no. And if you know ahead of time 538 00:52:59.139 --> 00:53:01.449 that you're about to be engaging in risky sex, you 539 00:53:01.489 --> 00:53:06.280 can always, always go to your primary care physician, And 540 00:53:06.510 --> 00:53:12.360 ask for PrEP. It'll probably be Truvada. It is a pill. 541 00:53:13.679 --> 00:53:20.920 Oh no. Take it every day. And you'll drastically reduce 542 00:53:21.619 --> 00:53:25.719 the chances that if you do manage to accidentally have 543 00:53:25.780 --> 00:53:28.940 sex with somebody who happens to be positive, you won't 544 00:53:28.980 --> 00:53:39.949 catch it. It's like wearing a mask or your genitalia. Oh, 545 00:53:41.130 --> 00:53:48.710 and sign that campaign. Back them and be like, hey, 546 00:53:49.710 --> 00:53:54.039 lower that price because $ 42, 000 for the first year's treatment 547 00:53:54.119 --> 00:54:15.869 is a ridiculous price. Oh my god. Those greedy shits. Mm-mm. God. Pissed. Oh, how? Why? 548 00:54:16.730 --> 00:54:21.889 Why is it so expensive? It's the difference in the price, too, 549 00:54:22.070 --> 00:54:24.909 between it's one price in one country and a different 550 00:54:24.949 --> 00:54:31.590 price in another country, and that's just... I'm not a 551 00:54:31.650 --> 00:54:36.090 fan of that. I don't like that. Oh, by the way, 552 00:54:36.150 --> 00:54:40.690 would you like to know how Lenacapivir works? This is 553 00:54:40.750 --> 00:54:49.800 the cool shit. It's also Senluka, Yes2Go, and Yay2O. The 554 00:54:49.860 --> 00:54:53.599 way that it works. Okay, so remember I said capsid 555 00:54:53.699 --> 00:55:00.019 earlier and how capsid was an important word. Lenacapivir binds 556 00:55:00.119 --> 00:55:06.789 to the capsid protein subunits in... the HIV. So think 557 00:55:06.849 --> 00:55:09.590 of the subunits as like the building blocks of the capsid, 558 00:55:09.730 --> 00:55:13.690 and they are in rows, like ribs all the way around. 559 00:55:14.409 --> 00:55:19.610 When it's time, the HIV virus hooks into your cells, injects, 560 00:55:20.280 --> 00:55:23.719 and then kind of crunches down in order to inject 561 00:55:23.760 --> 00:55:28.139 what was in the capsid into you. Lenacapivir binds to 562 00:55:28.179 --> 00:55:33.059 the capsid and stiffens it and makes it so that 563 00:55:33.119 --> 00:55:40.409 it cannot eject a It can't. It can, it can 564 00:55:40.670 --> 00:55:43.030 hold onto your cells and it's like, okay, I'm ready 565 00:55:43.070 --> 00:55:49.309 to go. It's like, um, it's a ruined orgasm for 566 00:55:49.329 --> 00:55:54.449 the whole virus. It can't come. It can't. It's, it's 567 00:55:54.530 --> 00:55:58.440 too stiff. The capsid itself is so stiff it cannot 568 00:55:58.579 --> 00:56:05.480 collapse down and thus squirt into your cells. I kind 569 00:56:05.539 --> 00:56:14.949 of love that. I'm like, oh, good. Addie says, if 570 00:56:14.989 --> 00:56:17.530 I don't have sex, how often should I be getting tested? 571 00:56:17.670 --> 00:56:24.780 Just in case. Every six months. Easy answer. Every six months. 572 00:56:25.739 --> 00:56:29.300 The reason for that one is because you do want 573 00:56:29.340 --> 00:56:34.900 to have fairly recent test results. And some illnesses, remember, 574 00:56:35.320 --> 00:56:38.949 some of those viruses will go dormant. Some of them, 575 00:56:39.090 --> 00:56:43.150 if they're dormant in your body, they cannot be tested 576 00:56:43.250 --> 00:56:47.710 for because the viral bodies are so low, they're undetectable. 577 00:56:49.130 --> 00:56:51.869 And so you test every six months in case something 578 00:56:51.909 --> 00:56:55.929 has gone active and then it will catch. So every 579 00:56:55.969 --> 00:57:05.679 six months, test it. Boom. At least these all sound 580 00:57:05.699 --> 00:57:11.909 like names for Kanye West. Yeah, yeah. a little bit 581 00:57:16.050 --> 00:57:23.900 and it's yes to go y-e-z-t-u-g-o yes to go you 582 00:57:23.920 --> 00:57:27.019 just know eventually you're going to see an ad somewhere 583 00:57:27.840 --> 00:57:30.739 on something and it's gonna be some sassy person going 584 00:57:30.880 --> 00:57:35.929 yes to go And just so you know, that's what 585 00:57:35.969 --> 00:57:40.909 this is. It's an anti-HIV medication. It's an antiretroviral that 586 00:57:40.969 --> 00:57:46.670 is highly effective on HIV and hepatitis B. So that's 587 00:57:48.110 --> 00:57:54.090 all about PrEP. You have learned about viruses tonight. You 588 00:57:54.110 --> 00:57:58.530 learned about the types of viruses. You've learned about the 589 00:57:58.570 --> 00:58:06.289 importance of pre-exposure prophylaxis. Wear a mask when you're in public. Also, 590 00:58:06.309 --> 00:58:09.750 a common problem that I've heard people talk about is 591 00:58:09.809 --> 00:58:11.630 the fact that they think if the mask is good 592 00:58:11.670 --> 00:58:17.130 enough to prevent a virus from getting through it and 593 00:58:17.190 --> 00:58:21.570 into your lungs, then it must also prevent oxygen from 594 00:58:21.610 --> 00:58:23.780 getting through it and into your lungs. To which I 595 00:58:23.800 --> 00:58:27.340 can say, with authority, because I looked it up special 596 00:58:27.420 --> 00:58:36.190 just before the show, viruses are 300... to 1,300 times 597 00:58:36.570 --> 00:58:47.179 larger than oxygen. Just to be clear about size. Okay? 598 00:58:50.039 --> 00:58:53.900 Oxygen can get through the mask. Viruses cannot. Thank you. 599 00:58:55.340 --> 00:58:59.630 Wash your hands with soap. Stay six feet away from people, 600 00:59:00.250 --> 00:59:01.690 unless you want to fuck them, in which case get 601 00:59:01.730 --> 00:59:04.960 on PrEP. Wear a mask when you are in crowded 602 00:59:05.019 --> 00:59:09.360 locations surrounded by dirty, dirty people We're coming into cold 603 00:59:09.449 --> 00:59:13.710 and flu season. Make sure that your vaccinations are up 604 00:59:13.789 --> 00:59:18.289 to date. Go get your autism shots. Come on. That 605 00:59:18.349 --> 00:59:23.869 was sarcasm, by the way. CoreSchool will be back again 606 00:59:24.550 --> 00:59:30.639 next week with more... horrifying sex facts that you need 607 00:59:30.659 --> 00:59:37.969 to know. Thank you all for listening. I'll be back. 608 00:59:38.929 --> 00:59:39.389 Good night.