Jakson Thyroid Masterclass with Big Paul Barnett - Optimizing Thyroid For Bodybuilders (PART II) täydellinen litterointi

00:03:36.080 --> 00:03:43.599 So you also have to remember the free T4 is going to protect, the free version is going to be protected, like we talked about with uh TBG on the previous episode. 00:03:43.840 --> 00:03:46.000 So that uh free fraction is gonna stay there. 00:03:46.080 --> 00:03:50.560 So a lot of people they say, like, hey, my TSH is elevated, but my free T4 and my free T3 look fine. 00:03:50.639 --> 00:03:51.520 What's going on? 00:03:51.840 --> 00:03:53.120 My doctor doesn't know what to do. 00:03:53.199 --> 00:04:00.240 And I'm like, well, your doctor didn't really understand that the issue is that the the pituitary is literally screaming for more thyroid production. 00:04:01.360 --> 00:04:03.599 At one point, the gland is gonna fail. 00:04:03.759 --> 00:04:07.759 And once the gland fails, then you're like, oh, now I see the TSH was screaming for that. 00:04:07.840 --> 00:04:09.759 No, the TSH was screaming for that all along. 00:04:09.919 --> 00:04:11.840 So it's very good to catch a failing gland. 00:04:11.919 --> 00:04:13.439 Now, what if your issue is conversion? 00:04:13.520 --> 00:04:16.240 What if it's the T the T4 is not converting to T3? 00:04:16.399 --> 00:04:18.560 Well, your TSH gland is gonna be fine. 00:04:18.639 --> 00:04:22.639 So the TSH stays normal, but the free T4 is gonna start dropping. 00:04:22.720 --> 00:04:28.959 The free T3 still stays elevated for a little bit of time because of the protection of the free fraction, but that is a sign that the conversion is failing. 00:04:29.120 --> 00:04:34.399 You have plenty of T4, the T3 is not not being like uh presented, so to speak, is not being activated. 00:04:34.560 --> 00:04:37.439 And that's because the gland mostly produces the storage hormone. 00:04:37.600 --> 00:04:43.680 Every single organ in your body pretty much produces the active form of a hormone, the thyroid, it just produces the storage form of it. 00:04:43.759 --> 00:04:44.800 And then you need to activate it. 00:04:44.879 --> 00:04:47.680 So I just want to say that to say the TSH is not useless. 00:04:47.839 --> 00:04:53.040 Also, when people talk about the TSH, like the TSH is important because it is measuring things as a proxy. 00:04:53.120 --> 00:04:55.839 So it's kind of like a waist measurement for a bodybuilder. 00:04:56.000 --> 00:04:59.759 It's not the most important thing in the world, but come on, it's a pretty good proxy. 00:04:59.839 --> 00:05:08.319 Like if you say that someone has, you know, fucking 60, like fucking 70 inch circumference on the shoulders, but a 32-inch waist, you know they're ripped. 00:05:08.399 --> 00:05:09.920 You know they look really fucking good. 00:05:10.079 --> 00:05:18.079 So, in the same way with the with the tests, it becomes uh similar in that direction where the the TSH is generally gonna be talking about the gland. 00:05:18.240 --> 00:05:24.800 The problem is, like we talked about before, the brain actually has its own supply of thyroid hormone. 00:05:25.040 --> 00:05:36.000 So D2, which is the enzyme that's gonna convert T4 into active T3 in the tissues, it exists in brown fat tissue, it exists in skeletal muscle, and it also exists in the pituitary specifically. 00:05:36.399 --> 00:05:48.800 It's different in the pituitary from the rest of your body because in the pituitary, as soon as the enzyme D2 transforms T4 into T3, it clips itself for destruction so that you don't end up with too much T3. 00:05:48.879 --> 00:05:50.319 So it's a protective mechanism. 00:05:50.480 --> 00:05:53.519 The problem is the pituitary doesn't have that clipping mechanism. 00:05:53.759 --> 00:06:04.000 So your D2 stays active, which means you always have plenty of hormone in the pituitary before you start not having plenty of hormone in the rest of your body. 00:06:04.240 --> 00:06:07.600 So for that issue, the TSH becomes extremely limiting. 00:06:07.839 --> 00:06:14.879 Also, TSH is uh basically a shout, it's a screen saying, hey, thyroid, make more hormone, right? 00:06:15.680 --> 00:06:19.759 It's the test that we measure measures the quantity of TSH. 00:06:19.920 --> 00:06:22.720 It does not measure the quality of TSH. 00:06:23.040 --> 00:06:25.759 And within quality, there's also substructures of that. 00:06:25.920 --> 00:06:27.680 So TSH is very, very complex. 00:06:27.839 --> 00:06:30.240 You actually have TSH receptors all over your body. 00:06:30.319 --> 00:06:32.079 You have TSH receptors in your bones. 00:06:32.240 --> 00:06:34.160 Most people think it's just in the pituitary. 00:06:34.240 --> 00:06:34.720 It's not. 00:06:34.879 --> 00:06:36.800 But like I said before, it's a radio. 00:06:36.959 --> 00:06:38.480 So it doesn't transmit information back. 00:06:38.639 --> 00:06:40.240 It doesn't say, hey, tissues are starving. 00:06:40.399 --> 00:06:42.959 Pituitary, yell to the thyroid to produce more T4. 00:06:43.040 --> 00:06:43.680 It doesn't do that. 00:06:43.759 --> 00:06:44.639 So it's only a radio. 00:06:44.720 --> 00:06:47.439 It only sends signal from the pituitary down to the bones, right? 00:06:47.519 --> 00:07:01.920 So there's some limitations, there's some good things, but I've I've seen certain you know this person, and everybody knows, so I'm not gonna say who it is, but they literally said in a in a post in April, I believe, because I I'm talking about this post, they said TSH is completely fucking useless. 00:07:02.079 --> 00:07:02.480 It's not. 00:07:02.560 --> 00:07:04.399 Uh, it's it's it it can't be. 00:07:04.480 --> 00:07:12.240 It is a piece of information, especially when you get to like older people, especially when you're dealing with women or with children, TSH becomes very, very, very important. 00:07:12.399 --> 00:07:12.720 Okay. 00:07:12.959 --> 00:07:14.079 So there's there's that thing. 00:07:14.240 --> 00:07:17.199 Now, the the issue with like guiding TSH is the test. 00:07:17.279 --> 00:07:22.319 To to understand how the TSH became the test, you kind of have to

understand the history, right? 00:07:22.399 --> 00:07:25.279 Like we talked a little bit about the history of my sedema, right? 00:07:25.439 --> 00:07:30.399 You have in in the 1800s, if you have hypothyroidism, you're gonna you're gonna be gone. 00:07:30.560 --> 00:07:31.439 Like you're gonna die. 00:07:31.519 --> 00:07:32.879 There's no other solution for you. 00:07:33.120 --> 00:07:38.319 Doctors, they can watch it happen, but they can't do a single thing about what is happening, okay? 00:07:38.639 --> 00:07:51.920 1891, after a bunch of other people, this guy comes on and he has this brilliant idea, based off of other people's ideas, of getting a sheep gland, killing a sheep, getting that gland, mushing it up, and then injecting in that woman. 00:07:52.079 --> 00:07:53.600 That woman ended up to live. 00:07:53.680 --> 00:08:00.079 So in the in in 1800s, 1891 was the last time that my cedema was terminal disease. 00:08:00.240 --> 00:08:02.639 Now, when you look at like, okay, what did they give that person? 00:08:02.720 --> 00:08:04.240 They gave it the gland. 00:08:04.879 --> 00:08:08.319 So, okay, now this is tied into the question that you asked here. 00:08:08.560 --> 00:08:10.399 Because what is in the gland, Paul? 00:08:10.560 --> 00:08:11.839 The gland has it all. 00:08:12.079 --> 00:08:14.000 It has T4 and it has T3. 00:08:14.399 --> 00:08:23.600 So, for people to remember, I said in the previous episode, and it's true, the first instance of hormonal replacement therapy in history actually comes from the thyroid. 00:08:23.759 --> 00:08:30.879 And when you look at the first sentence of hormonal replacement therapy, the one that saved people from dying, it was combination therapy from day one. 00:08:31.120 --> 00:08:32.639 T3 was in the picture. 00:08:32.799 --> 00:08:34.720 Now, look at what happens, right? 00:08:34.960 --> 00:08:39.360 The desiccated thyroid, it ran for pretty much about a century, right? 00:08:39.440 --> 00:08:41.039 On desiccated pig glands. 00:08:41.279 --> 00:08:45.039 Armor was actually not a pharmaceutical company, it was a slaughterhouse. 00:08:45.200 --> 00:08:47.840 They just had access to lots of animals, lots of glands. 00:08:47.919 --> 00:08:50.960 So they just saw the quick money and they just decided to do that, right? 00:08:51.039 --> 00:08:55.440 No, nobody studied the thyroid of these animals to know if this was a good idea, by the way. 00:08:55.600 --> 00:08:59.360 It's just that we saw it working, people were dying, let's fucking stop the bleed, right? 00:08:59.440 --> 00:09:00.480 It's it's kind of like the idea. 00:09:00.639 --> 00:09:05.440 If you do a tactical emergency casualty course, you know the phrase stop the bleed, that's the same idea here. 00:09:05.519 --> 00:09:10.399 You just pack the holes, seal the wounds, tourniquet the limbs, and just move on, right? 00:09:10.720 --> 00:09:14.480 Now, there is there are certain flaws with the desiccated, right? 00:09:14.720 --> 00:09:22.000 First, first thing, in in 1914, Edward Kendall he synthesizes uh T4 for the first time. 00:09:22.399 --> 00:09:30.720 So uh Harrington had synthesized it in 1926 after that, but the early forms they absorbed very, very poorly. 00:09:30.960 --> 00:09:32.399 So we had to change that. 00:09:32.559 --> 00:09:41.519 We had the the the molecule was basically available on the shelf, just like a bunch of of other drugs that we know that exist and are promising, but you can't buy them, you can't actually use them. 00:09:41.759 --> 00:09:48.320 So, in from like 1949 to like 1955, levothyroxine literally does arrive, right? 00:09:48.480 --> 00:09:50.000 So now you have T4. 00:09:50.320 --> 00:09:52.240 It's great, it's a subtraction, right? 00:09:52.320 --> 00:09:58.480 And the the the the in in in 1956, right, the year right after that, that's when cytomel became a thing. 00:09:58.639 --> 00:09:59.759 That's when C3 became a thing. 00:09:59.840 --> 00:10:00.879 So literally a year after. 00:10:01.039 --> 00:10:03.919 So the question is like, why did the TSH became the test then? 00:10:04.080 --> 00:10:04.399 Okay. 00:10:04.559 --> 00:10:09.200 Well, the person that created the TSH test actually won a Nobel Prize because of how important the test is. 00:10:09.279 --> 00:10:12.559 So again, like the people that say the TSH is useless, it's really not. 00:10:12.799 --> 00:10:16.240 The the in in 1970, uh, there's two things that happened. 00:10:16.399 --> 00:10:19.360 One, there was a discovery of conversion. 00:10:19.759 --> 00:10:29.120 So the finding was uh that you can read this in a paper by Beyond in 2012, but the finding was that basically like the body's gonna convert T4 into T3. 00:10:29.279 --> 00:10:30.720 So why do we need a T3? 00:10:30.799 --> 00:10:32.960 Plus, Kendall just synthesized T4. 00:10:33.039 --> 00:10:35.039 Like, we don't need to add Cytomel to the picture. 00:10:35.200 --> 00:10:37.360 Cytomel, you need to take it multiple times a day. 00:10:37.519 --> 00:10:40.080 It's very complicated, like it's just it doesn't make any sense. 00:10:40.240 --> 00:10:44.240 Plus, at this time in 1970, the TSH test became a thing. 00:10:44.399 --> 00:10:45.279 It was available. 00:10:45.440 --> 00:10:50.879 So until 1970, all of the dosing of desiccated thyroid was made off of vibes, pretty much. 00:10:51.039 --> 00:10:52.960 It was body temperature, reflex test. 00:10:53.039 --> 00:10:54.960 You know the reflex test that they hit your knee? 00:10:55.120 --> 00:11:01.840 It's actually to see like your thyroid function and whether the calcium uh is actually channeling through and everything, like one of the things that it measures it, right? 00:11:02.080 --> 00:11:05.519 But the problem is like the the the you you basically have two generations. 00:11:05.600 --> 00:11:07.120 The first two generations are very, very bad. 00:11:07.279 --> 00:11:10.000 They can't tell you whether you are hypothyroid or hyper. 00:11:10.080 --> 00:11:11.279 That's how

insensitive they are. 00:11:11.440 --> 00:11:13.279 So it was a fraction of like two points. 00:11:13.440 --> 00:11:19.440 Whereas right now, the fourth generation is actually at a fraction of point in terms of uh sensitivity, really, really good. 00:11:19.759 --> 00:11:21.519 Problem is you have one test now. 00:11:21.600 --> 00:11:26.559 So what happens when you get all of those people in 1970 that were taking desiccated thyroid and you do the test? 00:11:26.960 --> 00:11:30.879 Holy shit, a bunch of these people were literally hyperthyroid. 00:11:30.960 --> 00:11:32.639 So we over-treated these people. 00:11:32.879 --> 00:11:35.200 So that is the problem with desiccated. 00:11:35.279 --> 00:11:36.559 What is the problem with desiccated? 00:11:36.639 --> 00:11:38.799 Okay, specifically to just be very, very clear. 00:11:39.039 --> 00:11:42.240 Number one, it's standardized on iodine. 00:11:42.879 --> 00:11:46.000 So it's it's not standardized by hormone content. 00:11:46.240 --> 00:11:49.039 So that's not what they're measuring inside of the pill. 00:11:49.200 --> 00:11:56.720 It it it it it it's uh the potency is going to swing batch to batch because it is measured of it is a measured of iodine. 00:11:56.879 --> 00:12:00.639 Number two, the the biggest one, it actually comes from a fixed pig ratio. 00:12:00.720 --> 00:12:08.559 So a pig's thyroid is going to produce four four to one as a ratio of T4 to T3, whereas a human is 14 to 1. 00:12:08.720 --> 00:12:26.399 So a human taking desiccated thyroid not only is unable to like figure out which potency they're using because it's just measured on iodine, but also they are not able to uh actually have something that looks like human replacement because you are using an animal fixed gland form. 00:12:26.639 --> 00:12:30.240 And the problem is that people were assuming they're like, oh, but it has T3, right? 00:12:30.320 --> 00:12:32.240 It's it's armor, it's fucking awesome, right? 00:12:32.399 --> 00:12:33.120 Yeah, bro. 00:12:33.200 --> 00:12:39.919 Yeah, but like the the the armor and thyroid, they are they are literally unapproved medications. 00:12:40.080 --> 00:12:55.200 I don't know if people know that, but they got we are allowed to use them given a 1938 grandfather clause that lithium also passed with that, that doesn't require us to basically prove that these medications are safe and effective. 00:12:55.360 --> 00:12:57.200 So uh armor thyroid doesn't need to. 00:12:57.279 --> 00:13:00.480 That's why you can buy it outside of medical settings uh because of that. 00:13:00.639 --> 00:13:01.919 Now, what's the problem with that? 00:13:02.000 --> 00:13:03.679 The problem is you can't dose it correctly. 00:13:03.759 --> 00:13:06.559 You're like, oh, but I measured it and when I did my blood work, it was fine. 00:13:06.720 --> 00:13:08.080 Yeah, but you just got a new batch. 00:13:08.159 --> 00:13:09.519 Did you do blood work again? 00:13:09.759 --> 00:13:10.960 Like, no, you didn't. 00:13:11.120 --> 00:13:12.480 Plus, you have a bunch of T4. 00:13:12.559 --> 00:13:15.200 Remember that excess of T4 is gonna downregulate D2. 00:13:15.360 --> 00:13:19.200 So it why would you, if you want conversion, why would you put a fuck ton of T4 in there? 00:13:19.279 --> 00:13:21.039 It's just gonna bottleneck the whole thing. 00:13:21.200 --> 00:13:28.000 So for you to understand how bad desiccated is, in 2025, the FDA actually moved to pull desiccated thyroid off the market. 00:13:28.159 --> 00:13:35.360 So that's like 1.5 million Americans that are on desiccated thyroid right now as of 2024, but you can't precisely dose it. 00:13:35.519 --> 00:13:42.639 Plus, it has been uh it has been uh uh recalled so many freaking times that it's just it's just absurd. 00:13:42.799 --> 00:13:43.759 It's just absurd. 00:13:43.919 --> 00:13:51.360 But it but it also does tell us that, like, hey, this whole story, like T3, like how did T3 become exiled because it started with T3? 00:13:51.519 --> 00:13:56.879 Well, it's it's just that T3 got a bad name for for the for the for the potency of it. 00:13:57.039 --> 00:14:07.200 So given that some people would take it and their heart rates would go up, they assumed, they didn't test this until 2025, but they assumed that because the heart rate is going up, that this is causing heart damage. 00:14:07.360 --> 00:14:12.000 And it's also from the standpoint of like, hey, why would you just tell people to take drugs one way or another? 00:14:12.159 --> 00:14:15.759 Yes, it's pharmacokinetics and pharmacodynamics, but also adherence. 00:14:15.919 --> 00:14:19.919 So it's much easier to have someone take one T4 pill and then just move on, right? 00:14:20.080 --> 00:14:26.000 Problem is, as we know, as we come finding out later on with Bionico and his group, is that conversion doesn't happen naturally. 00:14:26.240 --> 00:14:30.480 So that's the issue that like desiccated solves, but the problem is it's very improper dosing. 00:14:30.559 --> 00:14:31.759 It still hasn't been fixed. 00:14:31.840 --> 00:14:37.759 Uh, the the the the ratio that it did that it exists and it cannot be fixed because it's coming from an animal that has a fixed dosing. 00:14:37.919 --> 00:14:47.039 So if you wanted to do combo therapy, the best way to do it would be to do actual T4 plus actual T3 and then do that in a ratio of four to one. 00:14:47.279 --> 00:14:51.200 That would be the most similar to a human uh uh replacement dose right there. 00:14:51.600 --> 00:14:53.200 Yeah, so the four to one ratio. 00:14:53.360 --> 00:14:54.879 Yeah, sorry if I misquoted you earlier. 00:14:54.960 --> 00:15:00.080 I just no, no, you're talking about I I hear constantly from people that TSH is a useless. 00:15:00.559 --> 00:15:08.000 I don't normally check TSH, but there are, like I said, there are certain instances in which it's very important in the same way that I don't propose that you should use T4, right? 00:15:08.080 --> 00:15:09.840 This

whole time I'm telling you you shouldn't use C4. 00:15:10.080 --> 00:15:16.960 There's three instances in the literature in which you have to use C4, and if you use C3, you're gonna fuck something up pretty badly to the point of costing someone their life. 00:15:17.200 --> 00:15:19.360 So it it just depends. 00:15:20.080 --> 00:15:21.759 Yeah, so so that makes total sense. 00:15:21.840 --> 00:15:27.600 So it it is one of the pieces of data that we need to look at, but it's better to look at all the data. 00:15:27.840 --> 00:15:31.519 Exact, exactly, exactly that, which is which is like how I was talking about blood work. 00:15:31.600 --> 00:15:36.960 I don't I don't remember if we went really deep on blood work here, but like when I'm reading blood work, I'm reading it as a story. 00:15:37.039 --> 00:15:38.080 I'm just asking questions. 00:15:38.159 --> 00:15:38.960 I'm just a listener. 00:15:39.039 --> 00:15:40.960 I'm just asking what, like, hey, what are you telling me? 00:15:41.039 --> 00:15:42.399 Like, oh, the gland is doing this. 00:15:42.720 --> 00:15:44.000 I wonder what iron is doing. 00:15:44.080 --> 00:15:46.960 And then I look at your fertility and it's like, whoa, fertility is also messed up. 00:15:47.039 --> 00:15:50.960 Okay, fertility, LDL, and your sleep are messed up, and you also don't have energy. 00:15:51.039 --> 00:15:51.919 That's really fucking weird. 00:15:52.000 --> 00:15:53.440 Like, there must be something going on here. 00:15:53.600 --> 00:15:54.720 Just asking, asking questions. 00:15:54.799 --> 00:16:05.600 I feel like this is one of the ways that I'm teaching people in the academy in these live lectures because I feel like most people they just look at the sheet and it's like if there's a red value, they Google, how do I make the red value green? 00:16:05.759 --> 00:16:08.080 And that's how you make people pursue reverse T3. 00:16:08.240 --> 00:16:13.679 So reverse T3 is super fucking interesting because it's a marker of what your body has decided. 00:16:13.840 --> 00:16:15.679 But people treat it as a verdict. 00:16:15.840 --> 00:16:18.639 So, like, I see people asking, like, hey, my reverse T3 is too high. 00:16:18.720 --> 00:16:20.000 Should I bump on my T3? 00:16:20.159 --> 00:16:22.639 And I'm like, that won't do anything. 00:16:22.879 --> 00:16:28.320 As a matter of fact, all of the thyroid courses that I've taken, they teach reverse T3 wrong, every single one of them. 00:16:28.399 --> 00:16:34.559 And I actually went back on every single one of them and I found the quotes on every single slide of every single one of them, and we're gonna be pulling these apart. 00:16:34.639 --> 00:16:40.240 But people say that reverse T3 is an inactive isoform that blocks T3 at the entrance of the receptor. 00:16:41.919 --> 00:16:46.960 How can an inactive thing perform an action blocking? 00:16:47.279 --> 00:16:50.080 How can that's that's contradictory? 00:16:50.320 --> 00:16:50.559 Exactly. 00:16:50.639 --> 00:16:51.360

It's contradictory. 00:16:51.679 --> 00:16:59.519 The problem is like with the you can see this in Huberman's podcast on the episode that he did on the thyroid, 281 lines on a transcript. 00:16:59.679 --> 00:17:04.480 He breaks down multiple physiological patterns, and every time he breaks out physiological patterns, he cites people. 00:17:04.640 --> 00:17:10.079 As a matter of fact, when he gets to the growth hormone person, he cites the paper, the date, and he spells out the name of the author. 00:17:10.240 --> 00:17:12.480 You know how many citations he does for the thyroid? 00:17:12.640 --> 00:17:13.119 Zero. 00:17:13.279 --> 00:17:13.920 No one does. 00:17:14.079 --> 00:17:17.200 You look at people's courses on the thyroid, people have zero citations. 00:17:17.359 --> 00:17:20.960 Just on this first lecture, we're covering 16 papers that we're doing on Thursday. 00:17:21.039 --> 00:17:26.480 And that's because people are not asking questions to validate whether what they know is true or not. 00:17:26.640 --> 00:17:28.880 And that's why we're finding a bunch of these mistakes. 00:17:29.119 --> 00:17:32.240 So with reverse T3, it's inactive. 00:17:32.400 --> 00:17:33.119 It can't do anything. 00:17:33.200 --> 00:17:37.920 It doesn't sit at the base of the receptor mimicking T3 and then blocking the T3 from getting there. 00:17:38.079 --> 00:17:39.599 As a mat, how do we know that? 00:17:39.839 --> 00:17:43.680 Well, we did a study in which we injected people with reverse T3. 00:17:43.839 --> 00:17:45.599 Guess what happened to their free T3? 00:17:46.160 --> 00:17:46.960 Nothing. 00:17:47.359 --> 00:17:54.640 Because reverse T3 is just a measure of your stress, your cortisol, your temperature, your your recovery, right? 00:17:54.880 --> 00:17:56.960 It's it's it's a it's a measurement of multiple things. 00:17:57.039 --> 00:17:59.279 It's not, it's a measurement of your environment. 00:17:59.440 --> 00:18:13.119 It's literally telling if your reverse T3 is high, is literally just your body telling us, like, hey, given the environment, I think that the best solution for you right now, the best course of action is to downshift everything to make sure that we're gonna have enough energy to survive this for longer. 00:18:13.279 --> 00:18:15.759 So that's why your reverse T3 goes up when you start dieting, right? 00:18:15.839 --> 00:18:22.640 And it's uh when people start chasing the marker as opposed to chasing understanding what the marker is actually telling you, that's when you create a problem, right? 00:18:22.720 --> 00:18:24.160 And that's the same thing with TSH. 00:18:24.240 --> 00:18:27.440 When you're looking at like, oh, the TSH is screaming, but the thing Glenn is not doing anything. 00:18:27.519 --> 00:18:28.799 I'm like, what can't you see? 00:18:28.960 --> 00:18:30.799 You can't see the quality of the TSH. 00:18:31.119 --> 00:18:35.119 So that's when we need to start thinking beyond what the papers are telling us. 00:18:35.359 --> 00:18:52.960 Edward, like fucking Edward uh Murray, he didn't discover uh uh uh that you could inject uh desiccated thyroid into a person because there was a paper or an academic uh convention in London, which there was one a few years before that he drew some things from, but he didn't wait until there was a paper to make a decision. 00:18:53.119 --> 00:18:54.960 He just went there and fucking did it. 00:18:55.119 --> 00:18:56.400 What's the worst that's gonna happen? 00:18:56.559 --> 00:18:58.960 The woman is gonna die, she's gonna die anyways. 00:18:59.200 --> 00:19:06.160 So I find that in in my courses, what I try to do is to teach people what I call a healthy extrapolation, which is what I try to do here. 00:19:06.240 --> 00:19:12.000 It's like, hey, don't be don't be like the doctor that like if there isn't a guideline, oh my hands are tied, there's nothing I can do. 00:19:12.160 --> 00:19:14.079 You're dying, oh, you have a hole in your chest. 00:19:14.240 --> 00:19:15.599 Let me look at the guidelines. 00:19:15.759 --> 00:19:16.480 There's nothing here. 00:19:16.559 --> 00:19:17.839 I'm sorry, you're gonna die. 00:19:18.000 --> 00:19:19.279 And the person is like, what the fuck? 00:19:19.359 --> 00:19:21.599 Just fucking spitting blood and just dying and all this shit. 00:19:21.680 --> 00:19:23.920 Um, it's it's it's it's it's the same situation, right? 00:19:24.000 --> 00:19:29.519 So I just think it's when it comes to blood work, the way that we teach blood work is very wrong. 00:19:29.680 --> 00:19:34.720 We teach it as just like, here are 20 markers, memorize what they are, what they do, and go ahead. 00:19:34.799 --> 00:19:36.799 And I'm like, no, I want to know about the historical context. 00:19:36.880 --> 00:19:48.960 I want to know about why the fuck does Quest and Lab Corp use different TSHs and why can I send the same client to both of these locations on the same day, which is a test that I did, and on one lab they're hypothyroid and in the other lab they're normal. 00:19:49.200 --> 00:19:56.160 Why is it that I can send an uh an anti-TG test and get a positive antibody and then do it another day and get a negative one? 00:19:56.319 --> 00:19:58.000 Like that is something that I'm interested in, right? 00:19:58.079 --> 00:20:06.160 And I feel like those are the questions that Paul, you you, you know these questions because you're you're staring at blood work all day long and you're like, this doesn't make any fucking sense. 00:20:06.319 --> 00:20:07.039 This is crazy. 00:20:07.200 --> 00:20:12.799 And I I feel like maybe, Paul, maybe what we should start doing is posting on Instagram, you know, just being like, hey guys, what what is the solution? 00:20:12.880 --> 00:20:16.799 This because there's always gonna be one or two smart bands that are gonna say, Oh, this is super easy. 00:20:16.880 --> 00:20:19.359 I know exactly what it is without any context whatsoever. 00:20:19.440 --> 00:20:37.119 But yeah, that's just a I, you

know, I I you know my background, but I worked years in computer science, and this is a problem I see a lot of times, and it it seems to be a problem in the medical industry, is and you hit the nail on the head, is nobody stops to ask why, and there's no critical thought. 00:20:37.200 --> 00:20:39.759 They're just reciting something they read in a text. 00:20:39.839 --> 00:20:43.839 They don't they don't there's no critical thought applied to anything. 00:20:44.079 --> 00:20:44.480 Yep. 00:20:45.039 --> 00:20:45.599 Yeah, yeah. 00:20:45.759 --> 00:20:56.160 And you know, look, I'm you're way ahead of me on this shit, but it's uh I think it's just a general thought process that you need to apply to everything you do in in life. 00:20:56.319 --> 00:20:58.319 You know, just don't take things at face value. 00:20:58.480 --> 00:21:05.759 That first level thinking is what you know, what what I you know, what they call it, but you d dig a little deeper, ask why. 00:21:06.079 --> 00:21:06.559 Yeah. 00:21:06.799 --> 00:21:07.839 Yeah, no, absolutely. 00:21:07.920 --> 00:21:09.200 I I I agree with that a lot. 00:21:09.359 --> 00:21:18.720 I think especially with the thyroid, is because it's uh it's it seems to be a very simple story that you can just break down as like, oh, hypothalamus, pituitary, gland, blood, good to go. 00:21:18.880 --> 00:21:20.960 And it's like it's not even a chain, y'all. 00:21:21.039 --> 00:21:25.039 Like we teach people as is being a chain, but we already covered this in the first uh episode with you. 00:21:25.200 --> 00:21:28.160 Like it's like the hypothalamus is the middle of the equation. 00:21:28.319 --> 00:21:29.440 It's literally a loop. 00:21:29.599 --> 00:21:31.039 Like you can't have a starting point. 00:21:31.119 --> 00:21:38.160 We can teach, we pedagogically we can have a starting point, but we can't teach it as the physiological starting point, which is what we do, you know. 00:21:38.319 --> 00:21:40.480 And these these things they have consequences, Paul. 00:21:40.559 --> 00:21:49.119 Like people are telling to and fro this is a big myth that I'm gonna lay uh that I'm gonna destroy on next week on this lecture. 00:21:49.200 --> 00:21:52.319 But people talk about you know the gut doing a big chunk of the conversion. 00:21:52.720 --> 00:21:54.720 Problem is the gut doesn't have diodenasis, right? 00:21:54.799 --> 00:21:56.240 Like we talked about in the first episode. 00:21:56.400 --> 00:21:59.279 Now, what happens if you believe that the gut has diodenasis? 00:21:59.359 --> 00:22:02.720 You get some Someone who's hypothyroid, their gut is also messed up. 00:22:02.799 --> 00:22:06.400 And now you believe that you need to treat the gut first before treating the thyroid. 00:22:06.480 --> 00:22:10.160 And when you treat the gut, the thyroid is gonna fix on its own because it's gonna fix the conversion. 00:22:10.319 --> 00:22:12.799 So you spend six months to a year fixing that person's gut. 00:22:12.960 --> 00:22:16.160

You know it takes a long time to fix someone's gut and make sure that the issues don't come back. 00:22:16.319 --> 00:22:17.839 So you take six months to a year, and guess what? 00:22:17.920 --> 00:22:18.960 Their thyroid is still the same. 00:22:19.039 --> 00:22:19.279 Why? 00:22:19.440 --> 00:22:21.440 Because you believe the wrong physiological story. 00:22:21.599 --> 00:22:28.880 You made that person lose a year of their lives because you bought a course that didn't read the fucking paper that they were talking about. 00:22:29.039 --> 00:22:31.519 It's like fuck, ideas do really have consequence. 00:22:31.599 --> 00:22:34.400 And that's one of the things that I feel like we need to do better in this space here. 00:22:34.799 --> 00:22:41.119 Going back to what you were saying before, I mean, I guess logically it makes sense that it would be a loop because it needs feedback, right? 00:22:41.359 --> 00:22:41.680 Exactly. 00:22:41.759 --> 00:22:42.480 It does need feedback. 00:22:42.559 --> 00:22:42.720 Yeah. 00:22:42.799 --> 00:22:42.880 Yeah. 00:22:43.039 --> 00:22:45.680 The tissues, the tissues need to uh uh relay their status. 00:22:45.839 --> 00:22:48.000 You that they need to read the status of the body. 00:22:48.079 --> 00:22:59.279 And like I said, with with regards to like cross like hormone crosstalk, this is where I feel like it gets really, really interesting because the the hormones they actually like talk to talk to another. 00:22:59.599 --> 00:23:08.240 So like if you think about like there there's there's three levels of crosstalk with uh with your hormones with regards to like sex hormones, for instance, right? 00:23:08.319 --> 00:23:17.920 You have your your your uh conversion, you have your transport, and you have your fucking uh like the axis is all like wired up together, right? 00:23:18.160 --> 00:23:22.559 So, for instance, like we talked about with with estrogen, uh raising your TBG, right? 00:23:22.720 --> 00:23:26.799 Your estrogen is literally affecting what is happening to your thyroid. 00:23:27.200 --> 00:23:30.000 Pregnancy nearly doubles your TBG, right? 00:23:30.079 --> 00:23:35.359 So it's just like a normal thing that happens with life, it's gonna change your thyroid as uh scenario for like a really, really long time. 00:23:35.519 --> 00:23:38.079 But also, estrogen also speeds up conversion. 00:23:38.240 --> 00:23:43.440 So D1 is about like 30, like higher up is like mixed with that uh TBG effect. 00:23:43.519 --> 00:23:45.279 So your D1 also goes up. 00:23:45.440 --> 00:23:50.400 But then like you think about outside of estrogen, well, testosterone also supports conversion, right? 00:23:50.720 --> 00:23:55.440 Because when you inject castrated rats with testosterone, their D1 activity in the liver goes up. 00:23:55.519 --> 00:24:01.599 So you know that it's like actually like talking back to the hormones as opposed to just like talking to them, right? 00:24:01.759 --> 00:24:04.799 You you also have things with

like pregnenolone and all these things, right? 00:24:04.880 --> 00:24:11.200 Because with with you you just you just think like with the if you have a low thyroid, you're basically slowing down the entirety of the system, right? 00:24:11.359 --> 00:24:16.880 So you have a slow clearance, which a slow clearance is gonna raise your uh your estrogen, right? 00:24:17.039 --> 00:24:23.119 So when you raise your estrogen, you're gonna raise your TBG, which if you have an impaired gland is gonna lower your free thyroid. 00:24:23.200 --> 00:24:25.759 If you don't have an impaired gland, you're gonna be fine, just like the pregnant women. 00:24:26.079 --> 00:24:30.559 But it just it really does depend on the the hormones, they're literally talking to themselves. 00:24:30.720 --> 00:24:34.799 And like we like we talked about the the gh and the the IGF-1 loop, right? 00:24:34.880 --> 00:24:41.359 They're both coming from pit one, which is that cell that's gonna be the TSH-making cells and the GH-making cells is pit one. 00:24:41.599 --> 00:24:44.640 It's literally coming out of the same cell, so they're literally intertwined there. 00:24:44.720 --> 00:24:51.039 And the thyroid is literally permissive for the GH because, well, we know that a hypothyroid kid, they literally stop growing. 00:24:51.200 --> 00:24:56.720 One of the signs of a kid that has hypothyroidism is that their weight continues expanding, but their growth rate actually stagnates. 00:24:56.799 --> 00:24:57.759 So that's a a good sign. 00:24:58.000 --> 00:25:00.880 You get that plus bad grades, your kid has a thyroid problem. 00:25:01.039 --> 00:25:03.680 And then, like we said, the GH is gonna unmask a thyroid problem, right? 00:25:03.759 --> 00:25:07.759 Like 36% of people needing to hop on replacement or raise their doses after that. 00:25:07.839 --> 00:25:16.240 It's not because the gh caused the problem, it's just it revealed that the conversion was an issue before it and it just like pressed the uh the the pedal to the metal, so to speak, right? 00:25:16.400 --> 00:25:22.880 But like the the the reality is that like all these, these things are they're they're talking to each other, right? 00:25:22.960 --> 00:25:28.319 So like when you think of the uh T3 and the and the bone, right? 00:25:28.400 --> 00:25:33.119 Like your bone has its own, like it's it's bone is not like a the like a skeleton dead. 00:25:33.200 --> 00:25:37.839 We associate bone with dead tissue, but it's actually living tissue, and there's two crews in your bones. 00:25:38.000 --> 00:25:46.480 One of them is gonna be uh basically it's gonna be uh this uh like the osteoblasts are gonna build, very easy to remember, osteoblast build with a B. 00:25:46.720 --> 00:25:50.400 And then you're also gonna have osteoclasts, which are gonna crash everything. 00:25:50.480 --> 00:25:52.640 They're gonna destroy all of this shit, right? 00:25:53.039 --> 00:25:56.720 Health is literally the balance between osteoclasts and osteoblasts.

00:25:56.880 --> 00:26:00.799 The thyroid sets the remodeling tempo of these two, right? 00:26:00.960 --> 00:26:04.480 And then if you run it out, it's literally an inverted U U curve, right? 00:26:04.559 --> 00:26:08.799 Whereas like too little thyroid, you have bad remodeling, too much you have bad remodeling. 00:26:08.960 --> 00:26:15.680 But the excess thyroid is gonna speed up the osteoclasts, lack of it is gonna uh basically give you more osteoblasts, right? 00:26:15.759 --> 00:26:18.160 So the hormones are all talking to one another. 00:26:18.319 --> 00:26:23.119 It's not like the brain just sends a signal to to your muscle and just says, make more T3. 00:26:23.359 --> 00:26:25.359 Create a contract, like it that's it's not how it works. 00:26:25.519 --> 00:26:29.599 It's literally a communication that's happening with with all of these uh at the same time, you know. 00:26:30.400 --> 00:26:34.000 The body is amazing how it how it regulates things. 00:26:34.799 --> 00:26:35.519 It's crazy. 00:26:36.240 --> 00:26:45.519 Yeah, it's really cool because like with certain one of these things, like you expect the TSH to go up and the T3 to go down, but it doesn't immediately because the body has a way to protect that. 00:26:45.680 --> 00:26:47.440 Because remember, your body has a reservoir. 00:26:47.599 --> 00:26:50.000 People are saying, like, oh, the gland is stupid, it just makes T4. 00:26:50.079 --> 00:26:52.000 No, the GLAN is stupid because it just follows order. 00:26:52.079 --> 00:26:54.559 But in making T4 is actually the smart thing about it. 00:26:54.720 --> 00:27:03.680 Making T4 is what allows you to not piss off all of your T3 as soon as it's conjugated, as soon as it's transformed into T3, because otherwise it would be too small, right? 00:27:03.759 --> 00:27:06.480 So you have T4 and it's gonna stay there for longer. 00:27:06.640 --> 00:27:08.400 Also, it's a reservoir of months. 00:27:08.559 --> 00:27:13.279 Like you you use about like one unit, I think of about a hundred or a thousand. 00:27:13.440 --> 00:27:20.000 So it takes like it takes like half a year or some shit, like crazy numbers to like go over all of your supply. 00:27:20.160 --> 00:27:25.200 So it's literally like you see the TSH going up, it's gonna take about like six months for the T4 to start coming down. 00:27:25.279 --> 00:27:27.839 So there's all of these like regulatory patterns and stuff. 00:27:28.000 --> 00:27:36.799 And it's really interesting because we talked about like iodine and selenium and how you can have iodine and poisoning, selenium poisoning, but the body has a fantastic way of protecting against those, man. 00:27:36.880 --> 00:27:41.599 It's uh it's one of the reasons why for iodine and selenium now I pretty much just do food. 00:27:41.759 --> 00:27:47.440 I don't do supplementation for those pretty much because the body has a way to protect against the supplementation overload. 00:27:47.519 --> 00:27:56.799 I mean, I mean against the food overload, which is why you can eat a fuck ton of oysters and not get selenosis, which is why you can eat a bunch of fucking sushi and not get kelp poisoning from the iodine, right? 00:27:57.039 --> 00:28:02.000 Problem is if you actually do that in supplementation, you're not doing like six times the recommended range. 00:28:02.160 --> 00:28:07.039 Like when selenium was recalled, it was over 200 times the reference range. 00:28:07.279 --> 00:28:09.680 So, like that is gonna fuck you up, right? 00:28:10.640 --> 00:28:19.200 The only instance in which this happened was in our far northern region in China that there was a flood that transported the selenium contents from one part of the soil into the rice. 00:28:19.279 --> 00:28:24.720 And then once they started eating rice, the the incidence of uh thyroid disease went up like sevenfold. 00:28:25.279 --> 00:28:26.559 Yeah, it went up like sevenfold. 00:28:26.640 --> 00:28:27.839 It was fucking crazy. 00:28:28.160 --> 00:28:43.519 There's something I wanted to ask you about, and I paraphrase here, so I apologize if I've got this wrong, but I recall seeing some of your content in the past and you talking about people in the bodybuilding community who are performance and enhanced. 00:28:43.839 --> 00:28:50.400 If if I recall what you were saying, that you were advocating for most of them using some sort of T3 supplementation. 00:28:50.880 --> 00:28:51.920 Yes, yes, I am. 00:28:52.079 --> 00:29:01.519 I am because okay, so so the first thing that we gotta understand is the the the the the the issue that people have is that they don't want to use T3 because they think T3 burns muscle. 00:29:01.680 --> 00:29:10.640 So if I'm gonna stand up here and I'm gonna say you should take T3 in the offseason where they're trying to build muscle, I have some some uphill battlehead that I need to that I need to do here. 00:29:10.720 --> 00:29:20.640 So the three- I'm probably guilty of saying that because I had a poor experience with T3 on contest prep, but I was using 100 micrograms in my defense, so it was way too much. 00:29:20.880 --> 00:29:22.240 Did you feel like shit? 00:29:22.640 --> 00:29:25.279 I lost a shit ton of muscle and felt like shit. 00:29:25.599 --> 00:29:30.559 There's a lot a lot of that actually comes from substrates and cofactors that you can prevent that from happening with that. 00:29:30.720 --> 00:29:35.279 But like people don't really consider the what changes in the environment once you add T3 in a picture. 00:29:35.359 --> 00:29:39.599 So like T3 is gonna burn your CoQ10 reserves more frequently and more often. 00:29:39.759 --> 00:29:49.279 So like for a guy who's on like regular stuff or like just mitochondria uh biogenesis, um, something like fucking a little bit of like 100 milligrams of CoQ10 is gonna be fine. 00:29:49.440 --> 00:29:51.359 200 if you also want the hard stuff. 00:29:51.599 --> 00:29:56.319 By the way, the hard stuff is mostly like just really, really like low grade

evidence. 00:29:56.400 --> 00:29:58.720 Like that's the stuff that we praise CoQ10 for. 00:29:58.799 --> 00:30:01.359 It's literally the lowest leverage of like where that shit is coming from. 00:30:01.519 --> 00:30:06.319 I think we have better evidence even on like PQQ and cognitive enhancement than we have for that. 00:30:06.640 --> 00:30:08.559 But we do we do a lot of myths in our space, right? 00:30:08.640 --> 00:30:16.799 Like we have the whole like KK vitamin K to route the calcium out of the arteries, but then when we try that in studies, we see that it has no effect whatsoever. 00:30:16.960 --> 00:30:19.359 So it's like there are certain interesting things here. 00:30:19.440 --> 00:30:21.920 Now, I'm not saying that we shouldn't take vitamin K, right? 00:30:22.000 --> 00:30:22.799 I'm not saying that at all. 00:30:22.880 --> 00:30:26.400 I think it's a great insurance policy and it does make sense mechanistically, so let's fucking do it. 00:30:26.480 --> 00:30:30.400 Nobody's fucking trialing bodybuilders, they're trialing people eating fast food three times a week. 00:30:30.559 --> 00:30:34.160 Not the same thing as doing two grams of gear uh every week for 10 years. 00:30:34.240 --> 00:30:36.720 I I I would uh I would think so, you know. 00:30:36.880 --> 00:30:41.440 But so so we think that the the the issue is that T3 burns muscle, right? 00:30:42.000 --> 00:30:49.359 I need to say that the the the risk is real, but the risk is called thyrotoxic myopathy. 00:30:49.519 --> 00:30:56.720 So thyrotoxic myopathy is just full-blown hyper thyroidism, which does waste muscle. 00:30:56.880 --> 00:30:58.079 You can measure that, okay? 00:30:58.240 --> 00:31:04.000 It's gonna be hitting your big fibers the first and the fastest and the hardest, which is why like it hurts so much. 00:31:04.079 --> 00:31:08.160 That like you can literally watch muscle being melted off if you have if you're in thyrotoxic territory. 00:31:08.400 --> 00:31:11.039 So uh you have turnover rate, right? 00:31:11.200 --> 00:31:13.039 That's that's one thing here with muscle, right? 00:31:13.119 --> 00:31:15.119 You have a breakdown and buildup. 00:31:15.279 --> 00:31:19.759 And if you add T3, you're you could potentially be speeding up that breakdown thing, right? 00:31:19.920 --> 00:31:22.000 Uh T3 is gonna be speeding up that breakdown. 00:31:22.160 --> 00:31:24.720 T3 is also gonna flip the that destruction machinery. 00:31:24.880 --> 00:31:31.599 So the more T3 you add in the picture, the more you're gonna have the destruction of the muscle cells of the the crude that's gonna break the tear down as well. 00:31:31.839 --> 00:31:35.039 And you're you're you're gonna have like hyperthyroid wasting. 00:31:35.200 --> 00:31:37.519 So the the the assumption here, it actually works. 00:31:37.680 --> 00:31:40.799 The assumption that T3 burns through muscle, I think it works. 00:31:40.960 --> 00:31:46.000 Uh, you can read this in a paper, Sabatino, Sanbatino, something like that, in like the 2020s. 00:31:46.240 --> 00:31:48.000 You wrote a paper breaking all of this down. 00:31:48.160 --> 00:31:50.880 But okay, there's a couple of issues with the premises. 00:31:51.279 --> 00:32:00.720 So the when you add T3, the the the the breakdown it nearly tripled in one of the studies that we have, but it's a dose-dependent fashion. 00:32:01.359 --> 00:32:04.720 Up to 50 micrograms, you see no markers of breakdown at all. 00:32:05.119 --> 00:32:09.519 Once you get to 60, you see some, 75, you see some, 100, you definitely see some. 00:32:10.559 --> 00:32:19.200 Paul, this is in an untrained person who doesn't train at all, who doesn't eat enough protein, and doesn't take fucking loads of anabolics. 00:32:19.599 --> 00:32:23.279 Okay, so like, yes, in that context, it does tear about muscle. 00:32:23.440 --> 00:32:25.599 The other issue is that uh it's called FOXO3. 00:32:25.759 --> 00:32:29.119 We're very familiar with FOXO4, but FOXO3 is a demolition crew. 00:32:29.279 --> 00:32:31.440 T3 induces FOXO3, right? 00:32:31.599 --> 00:32:38.960 So when that uh T3, when that goes up, it's gonna bump a bunch of other proteins, and uh this is going to drive autophagy. 00:32:39.200 --> 00:32:46.000 So you literally create that whole like cycling of like the the the autophagy, the AMPK, all of that side of things, right? 00:32:46.240 --> 00:32:51.680 The problem is here, people are smuggling a couple of things under the premise here, and that's the issue, right? 00:32:51.759 --> 00:32:54.319 So the first is the dose smuggle that's going on. 00:32:54.480 --> 00:32:58.880 Every scary point that I talked about is true, but it's also about thyrotoxic territory. 00:33:00.000 --> 00:33:01.359 What's the thyroid range? 00:33:01.440 --> 00:33:02.319 Like three to four? 00:33:02.640 --> 00:33:03.599 What's my proposal? 00:33:03.759 --> 00:33:04.480 Four to five? 00:33:04.559 --> 00:33:06.799 If you're in prep, you can bump like six to seven. 00:33:07.119 --> 00:33:08.880 What is thyrotoxic territory? 00:33:09.599 --> 00:33:10.240 Twenty-eight? 00:33:11.359 --> 00:33:14.319 Like, we're nowhere fucking near that territory at all. 00:33:14.559 --> 00:33:15.039 Like what? 00:33:15.200 --> 00:33:18.000 And it's totally based by person, it's not based by the dose. 00:33:18.160 --> 00:33:21.920 So I, when I'm taking 50 micrograms of T3, I'm at five. 00:33:22.640 --> 00:33:29.119 I have other people that when they're like Todd Lee, he takes six micrograms of T3 and he's like 4.3 or some shit. 00:33:29.359 --> 00:33:31.680 Like six micrograms doesn't do anything for me, you know? 00:33:31.759 --> 00:33:33.200 So it's really, really person dependent. 00:33:33.359 --> 00:33:34.960 The other one is the numbers, right? 00:33:35.119 --> 00:33:36.960 That that that that I told you, like that's the burn, right? 00:33:37.279 --> 00:33:39.759 I'm proposing like five to six, not like fucking 28. 00:33:40.079 --> 00:33:50.240 But there's also a fasting trick here,

which when you when you measure uh a fasting uh athlete, you measure their free T3 levels, their free T3 levels go up, uh go go up. 00:33:50.480 --> 00:33:55.359 T3 plus starvation, you actually don't see muscle loss in the presence of exercise. 00:33:55.519 --> 00:33:56.480 So that is interesting. 00:33:56.640 --> 00:33:58.240 Also, this is not one arm. 00:33:58.400 --> 00:34:03.519 When we say that uh T3 speeds up the cycling, it sets the tempo of this stuff. 00:34:03.680 --> 00:34:08.079 We are saying that it sets up the tempo of breakdown, yes, but also buildup. 00:34:08.239 --> 00:34:11.280 So you can't say that it's going to just cause the buildup of this. 00:34:11.440 --> 00:34:11.840 Why? 00:34:12.000 --> 00:34:18.239 What would what about the T3 molecule have you modified that now makes it so that it only attaches one side of your mitochondria? 00:34:18.320 --> 00:34:19.360 That doesn't make any fucking sense. 00:34:19.440 --> 00:34:22.719 It doesn't work like that in bone, in brain, in anything. 00:34:22.800 --> 00:34:24.079 Why would it work like that in muscle? 00:34:24.159 --> 00:34:26.960 So you have to make an argument as to why it would work like that in muscle. 00:34:27.199 --> 00:34:32.079 Now, hypothyroid also falsifies the own argument, right? 00:34:32.239 --> 00:34:36.559 Because if low T3 spared muscle, hypothyroid people would be jacked. 00:34:36.639 --> 00:34:39.760 Uh, but it turns out they actually waste a bunch of type two fibers. 00:34:39.840 --> 00:34:41.599 This is seeing that same sabotino study. 00:34:41.679 --> 00:34:42.719 I wish I remembered a date. 00:34:42.800 --> 00:34:46.079 Um, but it's uh you you you you you just don't see that happening. 00:34:46.320 --> 00:34:49.679 Also, we know that T3 is required to build muscle. 00:34:49.840 --> 00:34:58.719 Like we we we literally know that the satellite cell commitment in hypothyroid people, like it needs the induction of that myo D protein that we talked about. 00:34:58.880 --> 00:35:06.000 If you have no T3 signaling, you literally have no satellite cell saying build up from this damage signal that we have. 00:35:06.159 --> 00:35:18.719 In other words, you are not gonna build muscle, which is why hypothyroid people have very little muscle, similar to hyper, but for a completely different cause, in the same way that you have extreme fatigue in hypothyroidism and also hyperthyroidism, but for different reasons. 00:35:18.880 --> 00:35:22.800 One, you're burning the end of the week, the other one, you don't have anything left to burn, right? 00:35:22.880 --> 00:35:25.199 So it's it's it's it's it's working kind of like that. 00:35:25.280 --> 00:35:29.360 And then like even the damage of T3, like that's the other thing that people don't realize. 00:35:29.440 --> 00:35:36.719 Like, one, okay, let's say you went on T3, let's say that all of the research that I've been talking about, hundreds of papers, they're all fucking wrong, and you're the only person that's right.

00:35:36.880 --> 00:35:38.079 And you lost muscle. 00:35:38.239 --> 00:35:40.239 Okay, you're gonna gain that muscle in like fucking a month. 00:35:40.320 --> 00:35:43.280 So it's it's uh it's a limited trial that you can run, it's not gonna be anything. 00:35:43.440 --> 00:35:44.559 Uh also, how long did you think? 00:35:44.719 --> 00:35:45.840 That's what happened to me, man. 00:35:46.000 --> 00:35:48.239 I I overdid it on contest prep. 00:35:48.320 --> 00:35:53.280 I got down to like 190 pounds, which is crazy for me. 00:35:53.519 --> 00:36:01.440 I was 100 micrograms of T3, and then like within eight weeks of being back after the show, I gained like 60 pounds back. 00:36:01.519 --> 00:36:02.159 It was crazy. 00:36:02.400 --> 00:36:02.880 Yeah, yeah. 00:36:02.960 --> 00:36:18.239 But if you had the thyroid dialed in, you would have an additive effect because we know the like growth hormone bumps up that like amino acid uptake from that study that they did, uh injecting of IGF 1 into an arm, and you see that IGF 1 go, well, sorry, um, amino acid uptake goes up like 71%. 00:36:18.719 --> 00:36:22.239 You know that testosterone bumps muscle protein synthesis by 27%. 00:36:22.800 --> 00:36:25.360 The question then is how much does T3 contribute here? 00:36:25.519 --> 00:36:28.559 T3 actually bumps up muscle protein synthesis higher than testosterone. 00:36:28.639 --> 00:36:29.199 It's 29%. 00:36:29.920 --> 00:36:32.400 Yeah, it increases protein metabolism, correct? 00:36:32.719 --> 00:36:34.480 Yeah, yeah, exactly, exactly. 00:36:34.639 --> 00:36:46.559 So it's uh when you when you when you look into like uh the the the context of an of an enhanced person, all of the benefits that you get from the T3, which we can we can we can talk about it, but we already talked about so many of them. 00:36:46.639 --> 00:36:54.719 But it's like if there is no risk, if the argument is actually smuggling a premise that doesn't really fucking work, if we tested this and it doesn't really happen, like what what the fuck is the point? 00:36:54.800 --> 00:36:55.679 Like what is actually happening? 00:36:56.480 --> 00:36:58.639 Completely changing my perspectives on all of this. 00:36:58.880 --> 00:36:59.280 I love it. 00:36:59.360 --> 00:36:59.599 I love it. 00:36:59.679 --> 00:37:00.960 That's that's what we're here for, right? 00:37:01.039 --> 00:37:04.079 We're here to challenge one another and and and and grow out of that. 00:37:04.239 --> 00:37:16.079 But it's just it's one of the few things that you can run an experiment on because like I decided that I I uh I'm gonna I was gonna run 50 micrograms for my offseason and I'm I'm running 36 micrograms right now. 00:37:16.159 --> 00:37:18.960 I want to see if I gain more muscle on 36 versus 50. 00:37:19.039 --> 00:37:20.159 I don't think it's gonna happen. 00:37:20.320 --> 00:37:21.840 I really don't, but I'm gonna try out. 00:37:21.920 --> 00:37:28.239 Like, I'm gonna lose fucking half a year trying this experiment

for other people to see, and it's just an end uh equals one. 00:37:28.400 --> 00:37:34.719 But I do think that, like, hey, if it takes like two to five weeks for your access to bounce back, why don't you just give it a try? 00:37:34.960 --> 00:37:44.880 I have so many fucking testimonials in a folder just about T3 that people are like, they literally started, and the next day or same day, they're literally like, what the fuck is going on? 00:37:44.960 --> 00:37:48.320 I had someone hop on one of my calls a few days ago with all my clients. 00:37:48.400 --> 00:37:51.840 We do like these office hours every week, and then the clients just hop in and talk. 00:37:52.000 --> 00:38:01.440 And one of my clients hopped in, Brian Trinari, and he was like, Nathan, I don't know if this is placebo, but I I just uh I feel like my whole life I've been living in like slow motion. 00:38:01.599 --> 00:38:05.519 Kind of like the the the handbrake is on and now shit just works. 00:38:05.599 --> 00:38:20.079 And I'm like, Yeah, the first time that you with ADHD that are taking 70 milligrams of amphetamines and you take T3 and you realize that you can get away with two milligrams, holy shit, that's a completely fucking different game changer, man. 00:38:20.159 --> 00:38:26.880 It's uh yeah, it's uh which is which is why like since all of these they are like uh they are related, right? 00:38:26.960 --> 00:38:41.679 Like since the the T3 is permissive for the IGF one, since the T3 bumps muscle protein since it's additive on top of and more than testosterone does, my HRT is actually testosterone, growth hormone, and T3. 00:38:42.159 --> 00:38:48.639 So when I say that someone got, you know, gained 30 pounds on that, they're gained 30 pounds on testosterone, growth hormone, and TRT. 00:38:48.800 --> 00:38:50.000 Um, that's that's what we're doing. 00:38:50.079 --> 00:38:59.840 So uh usually that's gonna be something like 25 milligrams of tests a day to start with, uh 12 micrograms of T3 twice a day to start with, and about two to three units of growth hormone max. 00:39:00.000 --> 00:39:02.239 Most of my guys are using under six units, man. 00:39:02.320 --> 00:39:04.400 I I I'm the only one that can use a fuck ton. 00:39:04.480 --> 00:39:09.360 And even I decided to stop using or using significantly less just because I can't fucking find it. 00:39:09.440 --> 00:39:12.639 So uh that's uh well I can't find it for a price that is reasonable. 00:39:12.800 --> 00:39:16.639 I can find it for a dollar a unit, which I'm not gonna do, but yeah. 00:39:16.800 --> 00:39:28.960 Yeah, there's uh yeah, for for for T3, I feel like we we just don't understand how T3 does the things that it does directly in the muscle, which is if we did, it would just be so clear that it's permissive for muscle growth. 00:39:29.119 --> 00:39:31.519 And when I talk to bodybuilders, I get messages like this every day. 00:39:31.599 --> 00:39:37.199 They're like, dude, I was working with a coach, they put me

on T3, I wanted to continue on because I felt so good and they took me out. 00:39:37.280 --> 00:39:39.920 Uh, I felt like shit, and now I'm doing it things on my own. 00:39:40.000 --> 00:39:41.920 I listened to you, I started taking T3, bro. 00:39:42.000 --> 00:39:42.559 I feel so good. 00:39:42.639 --> 00:39:43.679 Thank you so much for that. 00:39:43.920 --> 00:40:00.000 Like, it's if thyroid disease is such a such a tricky thing that you can't really tell just by blood work because your blood work could be perfect and you could be hypothyroid in the tissues, then giving it a fair try is one of the most like reasonable things you can do. 00:40:00.159 --> 00:40:02.480 Because it's just like you can't just go by blood work. 00:40:02.559 --> 00:40:11.920 You can't just go by feelings alone, because when you measure people that are just symptomatic, the majority of people that are hypothyroid, they only have one symptom or two on one of the studies that we measured. 00:40:12.000 --> 00:40:15.199 And people that are not hypothyroid, they have more symptoms. 00:40:15.360 --> 00:40:20.400 So, like when you think about fatigue, hair loss, cognitive issues, mood issues, it's very vague. 00:40:20.480 --> 00:40:24.400 Like you go to a TRT clinic, they're talking about testosterone having the same benefits there as well. 00:40:24.639 --> 00:40:26.800 The problem is that all of those are indirect. 00:40:27.039 --> 00:40:28.960 These are all direct, right? 00:40:29.039 --> 00:40:31.119 So that's that's the difference here on what we're doing. 00:40:31.280 --> 00:40:40.800 Also, D's are gonna travel like in terms of like you're picking a certain number off a list, and if it matches more than what the guidelines say, then you're eligible for hopping on TRT. 00:40:40.960 --> 00:40:42.960 Here, it's significantly more complicated. 00:40:43.039 --> 00:40:48.159 You you need the symptomatic picture, you need the history of the person, you also need their labs to be able to figure something else. 00:40:48.320 --> 00:40:54.800 And sometimes, in some cases, you also need a biopsy, you also need a which is just a needle, people scare because they hear the word biopsy. 00:40:55.039 --> 00:41:01.920 Like if you have a cancer, a thyroid cancer, which by the way, it's not like in general, like majority of people, it's literally nothing. 00:41:02.079 --> 00:41:09.199 So much so that in Korea, they started scanning people's thyroids, everyone, uh the entire nation, in order to prevent thyroid cancer. 00:41:09.360 --> 00:41:11.760 And guess how much they were able to prevent thyroid cancer? 00:41:11.920 --> 00:41:14.000 Nothing, because the cancer is mostly benign. 00:41:14.159 --> 00:41:20.559 So there's a lot of context involved in the thyroid conversation that I feel like we just don't have and we don't take uh into consideration. 00:41:20.639 --> 00:41:28.559 But like even with TRT, like my TRT is not just taking testosterone, it's also estrogen management, lipids, and and blood pressure and hematocrate and prolactin, right? 00:41:28.639 --> 00:41:32.559 And and TBG and free T3 and all free T4 and all of these things, right? 00:41:32.639 --> 00:41:35.599 So it's all it's all connected, and that's what I wish that people understood. 00:41:35.679 --> 00:41:43.199 But again, like that is why I created the academy, because I can't teach you all of that in a two-hour lecture about the thyroid or a one-hour lecture. 00:41:43.280 --> 00:41:45.760 Like you do most courses, 15 minutes to two hours. 00:41:45.920 --> 00:41:48.079 Like you can't, I can't teach you all of this stuff there, right? 00:41:48.159 --> 00:41:49.679 So we need to like go week over week. 00:41:49.760 --> 00:41:51.360 I'll give you one or two papers to read. 00:41:51.440 --> 00:41:57.760 We're gonna break those papers out, actually read them, actually understand, and start thinking in terms of what we can do beyond the research. 00:41:57.920 --> 00:42:07.360 And the cool thing is that once you get to the end of the curriculum, we're gonna do a tracing of the history of the thyroid, and you're gonna notice that the whole field is moving towards where we already are, which is a really cool thing to find out. 00:42:07.519 --> 00:42:10.000 It's like, oh fuck, they're coming back to T3 monotherapy. 00:42:10.079 --> 00:42:11.119 That's really fucking cool. 00:42:11.199 --> 00:42:13.679 Because it's uh it was kind of there from the beginning, you know. 00:42:13.920 --> 00:42:15.840 So you don't use T4 at all? 00:42:16.639 --> 00:42:20.719 No, because T4 is gonna the a large amount of T4 is gonna uh it's there for what? 00:42:20.880 --> 00:42:22.480 Like, what do I need a log for? 00:42:22.559 --> 00:42:26.000 Like, why do I need to take Tonga Ali if I'm injecting testosterone? 00:42:26.239 --> 00:42:26.880 Right. 00:42:27.440 --> 00:42:27.920 Yeah, right. 00:42:28.239 --> 00:42:30.639 Now, some people are like, well, but the body produces, so you need it. 00:42:30.719 --> 00:42:35.440 It was like, well, you are then the same crowd that is gonna inject HCG alongside your TRT, uh, which is fine. 00:42:35.519 --> 00:42:38.239 But you gotta remember HCG also only takes care of one arm. 00:42:38.320 --> 00:42:41.519 You actually need AGMG to get Sertoli and Litex cells, right? 00:42:41.599 --> 00:42:44.559 So uh it's also wrong in how people do it, but it's costs. 00:42:44.639 --> 00:42:51.760 It's it's so fucked up how people do it, because it's like they're not doing HCG to maintain the most natural way to do it, they're doing it to maintain fertility because they're afraid of it. 00:42:51.840 --> 00:42:55.119 But when you just add HMG, it just comes back like a fucking 72 days. 00:42:55.199 --> 00:42:56.719 It's it's fucking it's crazy. 00:42:56.800 --> 00:42:59.920 I've never had uh to take someone off of uh TRT to get them pregnant. 00:43:00.000 --> 00:43:02.400 I I I think it's super uh I never have either. 00:43:02.559 --> 00:43:03.360 Yeah, it's super

rare. 00:43:03.440 --> 00:43:09.039 And I always find it interesting when I when I'm talking to someone and they're like, Man, I've been off for like eight months, I feel like shit, and we're still not pregnant, and everything. 00:43:09.119 --> 00:43:11.199 And I'm like, why didn't you just talk to me first? 00:43:11.360 --> 00:43:16.159 Like, I've not one I've run I think we run similar fertility protocols. 00:43:16.239 --> 00:43:22.000 I've never once had somebody who couldn't get their their girl pregnant while on even on blast. 00:43:22.400 --> 00:43:23.360 Yeah, yeah, 100%. 00:43:23.679 --> 00:43:26.000 Dude, my my motility and my markers are fucking great. 00:43:26.079 --> 00:43:29.360 I have 300% above what's needed to get someone pregnant. 00:43:29.599 --> 00:43:31.280 I measured them mid-blast. 00:43:32.239 --> 00:43:32.559 Yeah. 00:43:32.800 --> 00:43:34.480 Yeah, even on blast, I've had that. 00:43:34.639 --> 00:43:36.159 Man, this is this is fascinating. 00:43:36.239 --> 00:43:38.400 I really appreciate you sharing all this with me. 00:43:38.480 --> 00:43:42.079 This is uh makes me realize how how many blind spots I have. 00:43:42.320 --> 00:43:43.360 And I, you know, I knew it. 00:43:43.440 --> 00:43:46.159 I'm not I'm not like a a thorough expert by any means. 00:43:46.320 --> 00:43:47.039 I know enough. 00:43:47.199 --> 00:43:48.400 Just the bare minimum. 00:43:48.719 --> 00:43:50.559 I think like most coaches out here. 00:43:50.800 --> 00:43:53.199 This is uh fantastic information that you're doing. 00:43:53.440 --> 00:43:56.559 You're the only person I know of actually in the community that's doing this. 00:43:56.880 --> 00:43:59.760 Yeah, there are certain people on there who are talking about it a little bit. 00:44:00.159 --> 00:44:00.559 Bit more now. 00:44:00.639 --> 00:44:02.559 The thing that I'm That's why I wanted to talk to you. 00:44:02.800 --> 00:44:07.440 Yeah, the thing that I'm noticing a lot is one, okay, this is a public form, right? 00:44:07.519 --> 00:44:10.239 So uh whatever I put out there is now belongs to everybody else. 00:44:10.400 --> 00:44:11.599 Now it doesn't belong to me anymore. 00:44:11.679 --> 00:44:12.719 That's how art works. 00:44:12.960 --> 00:44:26.400 People are taking a lot of the things that I'm saying and they're making it into something that I didn't say, uh, which is normal whenever you start talking about a subject, but like I never told people to just start taking T3, and I never said that everybody needs T3, and I never said that T4 is useless, I never said TSH is useless. 00:44:26.480 --> 00:44:28.400 Like it there's a little bit of nuance, right? 00:44:28.480 --> 00:44:31.840 Like I have a whole stack of supporting T3 action inside of the cell. 00:44:32.000 --> 00:44:34.320 That is the important part, not just the T3, right? 00:44:34.400 --> 00:44:36.960 Because if it can't be active inside of the cell, what the fuck is the point? 00:44:37.199 --> 00:44:38.880 So um that is one of the issues. 00:44:39.039 --> 00:44:41.920 The other issue is that people are still regurgitating. 00:44:42.000 --> 00:44:47.119 I I find people saying the same exact lines, quoting the same exact figures when those figures don't exist in the literature. 00:44:47.360 --> 00:45:04.639 Any person that tells you 60% of conversion happens in the liver, 20% happens in the gut, and the other 20% happens in the tissues, not only is that wrong, but that clean number doesn't exist because the number actually varies, it fluctuates depending on which tissue you're talking about and which phase of the year and how that person's environment is, right? 00:45:04.719 --> 00:45:05.920 So you can't even say that. 00:45:06.159 --> 00:45:09.760 It's uh Well, that's what you get from a Chad GPT search. 00:45:10.000 --> 00:45:21.760 Yeah, yeah, and all but but it but but also and that's the most concerning part because a lot of these people they are they are actually doing courses, they're actually doing mentorships, they're actually paying people for this information, and the information is not up to date in any way, shape, or form. 00:45:21.840 --> 00:45:24.960 Like there's some information that hasn't been updated since fucking 1950. 00:45:25.119 --> 00:45:41.440 But like when you look at when you look at the citation of uh suck, I don't remember which specific part of the thyroid is, but you look at uh you look at Dom Cooza, you look at uh uh J3U, you look at Pro IQ, you look at ECA, Justin Mahaley, uh physique, you look at all everybody. 00:45:41.599 --> 00:45:44.880 The only people that cite uh something is J3U. 00:45:45.039 --> 00:45:49.599 And when they cite it, they actually cite a book, which is like an airport book, it's not even an academic book. 00:45:49.760 --> 00:45:51.920 And I'm like, fuck, that's the problem right there. 00:45:52.079 --> 00:45:56.000 We don't think we need to check the evidence because we assume that we already know where we're gonna find. 00:45:56.400 --> 00:46:08.000 Because we're so like I feel like we're so interested in learning about peptides and and and PEDs and all this type of stuff, that I'm like, guys, the primary tool that you have is the human body, right? 00:46:08.079 --> 00:46:13.280 Like, wouldn't we want to leverage that first and foremost before uh playing with anything else? 00:46:13.440 --> 00:46:23.280 Plus, like I said in the first episode, you have a compound for your for your insulin, one for your GH, one for your testosterone, one for your cortisol, one for your cognition, one for your sleep, one for your mood. 00:46:23.360 --> 00:46:25.119 And I'm like, T3 touches all of them. 00:46:25.199 --> 00:46:28.320 Why didn't you start with T3 and then just see what remained? 00:46:28.480 --> 00:46:31.840 Because that is telling you that the issue was not the T3, it was something else, right? 00:46:31.920 --> 00:46:33.119 It's just the process of elimination. 00:46:33.199 --> 00:46:34.000 It's super easy. 00:46:34.159

--> 00:46:38.480 So having T3 first is very important, but I do encourage people to read the papers. 00:46:38.559 --> 00:46:41.519 Like when I'm putting a post on Instagram, I actually read the papers that I'm putting out. 00:46:41.679 --> 00:46:43.360 I make mistakes, people make mistakes all the time. 00:46:43.440 --> 00:46:45.199 I posted a mistake that I made a few days ago. 00:46:45.280 --> 00:46:48.079 I talked to Anthony Castor about him when I was talking about senescent cells. 00:46:48.159 --> 00:46:52.000 I made the mistake of telling specific uh numbers on where things come from in the thyroid. 00:46:52.079 --> 00:46:56.400 I even, I even found something, uh T3 acetoglucurinide, glucuronide. 00:46:56.639 --> 00:46:57.440 That doesn't exist. 00:46:57.519 --> 00:47:06.800 I actually have that in one of my notes as learning uh what happens in the conjugation and the tagming of the sulfatase of T3 in the in the in the gut. 00:47:07.039 --> 00:47:09.679 And I just found out that that number doesn't exist, it doesn't come from anywhere. 00:47:09.760 --> 00:47:11.440 I literally hallucinated myself. 00:47:11.599 --> 00:47:21.119 I was probably listening to the lecture and I listened to a number and they start if they continue talking, and I just wrote the number of the thing that they were talking about under that same point, like without realize. 00:47:21.360 --> 00:47:25.760 Like these mistakes, these things happen, but it's why we need to check ourselves or have someone who's checking. 00:47:25.920 --> 00:47:29.280 I'm doing the checking Thursday, the 27th, 12 p.m. 00:47:29.440 --> 00:47:32.480 EST, you guys can show up to the check and we're gonna be answering two questions. 00:47:32.639 --> 00:47:36.239 On Thursday, the first question we're gonna be answering is should we even give a shit? 00:47:36.320 --> 00:47:37.599 Like, how big is this problem? 00:47:37.760 --> 00:47:39.519 Like, how big is the thyroid thing, even? 00:47:39.599 --> 00:47:43.760 Because it is this is not just a minority, like the majority of our people are just like drug users, bodybuilders, whatever. 00:47:43.840 --> 00:47:44.800 And it's like, how big is the thing? 00:47:44.880 --> 00:47:48.719 And what we're gonna find out is that that question is not easy to be answered at all. 00:47:48.880 --> 00:47:54.320 Counting people with thyroid problems is not the same as counting how many people have broken tibias out there. 00:47:54.480 --> 00:47:57.360 It's not a clear fact that you can hold with your hands, right? 00:47:57.440 --> 00:48:09.840 So that's the first thing that we're gonna do, but we're gonna see how massive this issue is, especially in terms of the grade of like how big the problem is globally in the US and specifically in our population that we deal with because it starts becoming significantly higher. 00:48:10.000 --> 00:48:13.840 On the next week, we're gonna look at the problem of the scale and how we manage this. 00:48:14.079 --> 00:48:16.960 So when we're thinking about thyroid, what is the story that we tell? 00:48:17.039 --> 00:48:21.199 What is the, oh, it goes on the hypothalamus, the pituitary, the thyroid, the blood, and then it goes on, right? 00:48:21.360 --> 00:48:27.440 None of these people mention a single thing about conversion, none of these people mention a single thing about activation, transport, binding, and all these types of things. 00:48:27.599 --> 00:48:28.960 That is all of the shit that's missing. 00:48:29.039 --> 00:48:31.119 That is what we're gonna be telling on the next week. 00:48:31.199 --> 00:48:34.559 We're gonna be putting all people's names on the board, including myself, because I fucked up plenty. 00:48:34.639 --> 00:48:44.880 Uh, and uh, we're gonna be seeing where I fucked up so that you don't have to fuck up and going over every single one of those and what is the good that comes out of the stories that we learn, what is potentially harmful, and what is actually really fucking bad. 00:48:44.960 --> 00:48:48.320 Like you're gonna get someone in trouble from believing the normal stories. 00:48:48.480 --> 00:48:51.039 And if you want to learn the right story, you're gonna join the Academy. 00:48:51.119 --> 00:48:52.800 The link is on my website, the link is down below. 00:48:52.960 --> 00:48:54.639 Paul, thank you so much for your time. 00:48:54.800 --> 00:49:00.880 I really appreciate the opportunity to talk to you and uh, you know, give a little bit back to our communities here when it comes to the thyroid and everything. 00:49:01.039 --> 00:49:03.360 Guys, if you wanna, if you wanna find us, you already know. 00:49:03.440 --> 00:49:05.119 Well, it's uh it's gonna be on Instagram. 00:49:05.280 --> 00:49:08.639 Myself, OptimalAthan, Paul Paul Burnett on Instagram. 00:49:08.880 --> 00:49:10.719 Go to his community, take his course. 00:49:10.800 --> 00:49:12.239 I've taken his course, I can vouch for it. 00:49:12.400 --> 00:49:16.639 Great course if you're starting out wanting to learn a little bit more about PDs and the the foundation of everything. 00:49:16.800 --> 00:49:17.920 Great opportunity right there. 00:49:18.000 --> 00:49:21.119 And I'll see all of you guys on Thursday for a masterclass. 00:49:21.199 --> 00:49:35.840 And I'm super fucking excited to get you guys inside of the Academy, which is the brand new, brand new branch of the Opti Lab, completely different from the engine one-on-one education, actual papers, sitting down, going back and forth, and actually seeing what the evidence really says compared to what is everybody else saying. 00:49:36.000 --> 00:49:37.199 I'll catch you guys in the next one. 00:49:37.360 --> 00:49:40.880 Tomorrow, QA video, Friday, new interview, Thursday, the Academy. 00:49:40.960 --> 00:49:42.000 I'll catch you guys in the next one. 00:49:42.079 --> 00:49:42.800 Peace out.