WEBVTT
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[SPEAKER_01]: So if you think of the human body as a building, before the smoke comes out, was there fire?
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[SPEAKER_01]: There was fire going on, right?
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[SPEAKER_01]: And it was smoldering.
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[SPEAKER_01]: And that is the aging process, the whole smoldering process.
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[SPEAKER_01]: By the time the fire, the smoke comes out, that's a disease.
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[SPEAKER_01]: Then your doctor can diagnose you.
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[SPEAKER_01]: But before the disease is showing up, the aging is doing its work.
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[SPEAKER_01]: So what we wanna do,
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[SPEAKER_01]: is to prevent the aging process to or at least slow it down, so that's why the inflammation aging is so tied in together as this word, you know, inflammation.
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[SPEAKER_01]: Welcome to the Dr. Duay Kong podcast.
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[SPEAKER_01]: This is where I have a chance to share with you some of the latest developments in the space of holistic health, longevity, and wellness.
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[SPEAKER_01]: I've always honored intellectual curiosity and scientific rigor, combined with real world practicality.
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[SPEAKER_01]: My goal is that what you learn here will help you live longer and live better.
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[SPEAKER_01]: Hope you enjoy the journey with me.
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[SPEAKER_00]: We'll come back to the Dr. Joy Kong podcast.
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[SPEAKER_00]: A lot of you have questions about what stems out there you can do when it comes to reducing the rate of aging or slowing down our decline that comes with age.
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[SPEAKER_00]: So I actually have given a lecture that delve.
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[SPEAKER_00]: in detail as to the theory and the evidence behind what stands out there if you can do.
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[SPEAKER_00]: So I hope you enjoy this lecture and that it answers a lot of your questions.
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[SPEAKER_01]: So stem cell therapy has been a passion of mine.
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[SPEAKER_01]: It hasn't been that long.
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[SPEAKER_01]: It's been for the last six years.
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[SPEAKER_01]: I specialize in psychiatry because I love the brain and then addiction medicine.
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[SPEAKER_01]: And then I've always wanted to incorporate.
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[SPEAKER_01]: holistic approach to medicine and I can't imagine anything that's more holistic and more integrative than then stem cell therapy because if you look at stem cells is really who we were right we we were all one single cell from that one single cell what isn't that single cell
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[SPEAKER_01]: that got us to be what we are today, that kind of power that's in that one cell.
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[SPEAKER_01]: So, never discount a single cell.
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[SPEAKER_01]: And what's in that cell is DNA.
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[SPEAKER_01]: The DNA contains the intelligence that can make us.
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[SPEAKER_01]: And it's that intelligence that I'm tapping into when I do stem cell therapy.
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[SPEAKER_01]: So this is the first time in human history that we're not using a molecule or a group of molecules which are, you know, herbs or other kind of medications.
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[SPEAKER_01]: We're using intelligence, right?
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[SPEAKER_01]: We're tapping into DNA and DNA is the most energy-thens substance in the universe.
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[SPEAKER_01]: And so when I do stem cell therapy, I consider myself doing
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[SPEAKER_01]: I mean, infusing energy into people's body, and that kind of intelligence that's in the cells are able to have mechanisms that can get to the areas where you need healing and then produce this vast array of benefits, and I'll show you what how they work.
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[SPEAKER_01]: So I know this group is all about longevity and anti-aging, so the topic I have today is
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[SPEAKER_01]: sense out therapy as an antiaging tool.
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[SPEAKER_01]: I'm very excited about this because I am a direct product of this antiaging experiment because six years ago when I found out about stem cell therapy knowing what it does.
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[SPEAKER_01]: I was like, well, I've got to put in my body.
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[SPEAKER_01]: I'm going to do this.
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[SPEAKER_01]: So I started doing it every three months.
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[SPEAKER_01]: So in a week, I'm turning 51.
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[SPEAKER_01]: And if you look at my picture now comparing to when I was 43, you could literally see the age reversal.
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[SPEAKER_01]: So that was not something I was looking for.
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[SPEAKER_01]: I just wanted to stay healthy in my brain.
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[SPEAKER_01]: I didn't even know I was aging.
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[SPEAKER_01]: I thought I was looking great.
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[SPEAKER_01]: But now when I was looking, now I look at, you know, Facebook start to remind me, happy anniversaries, look at you six years ago, and I was like, oh no.
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[SPEAKER_01]: Why did I post that?
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[SPEAKER_01]: I don't know, because we look at yourself every day.
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[SPEAKER_01]: You don't even see that you're aging.
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[SPEAKER_01]: So if you got better, and then you can compare.
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[SPEAKER_01]: So I think the thing is, when people look at themselves, I think people need to realize, when you look at yourself in the mirror, and you think, oh, gosh, I think I look a little older.
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[SPEAKER_01]: You know, I got wrinkles.
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[SPEAKER_01]: Just think about the wrinkling on your face is happening everywhere inside of your body.
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[SPEAKER_01]: All your organs are wrinkling up.
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[SPEAKER_01]: Our reduce, reduce regenerative potential.
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[SPEAKER_01]: So that's something we want to address.
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[SPEAKER_01]: And this is the first time that we have, we have a lot of tools.
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[SPEAKER_01]: But there's something fundamental about stem cells and what it can do for you.
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[SPEAKER_01]: So I'm, you know, because we're
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[SPEAKER_01]: the engine behind regeneration, because I'll talk about why.
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[SPEAKER_01]: So I should just get started.
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[SPEAKER_01]: So let's just talk about how we all seek the optimal.
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[SPEAKER_01]: That's why we're here.
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[SPEAKER_01]: We don't want to just live forever, but we want to live optimally forever, right?
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[SPEAKER_01]: So what causes our decline?
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[SPEAKER_01]: The root cause is really the aging process.
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[SPEAKER_01]: And so for example, when you look at osteoarthritis,
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[SPEAKER_01]: People think, oh, it's an wear and tear disease.
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[SPEAKER_01]: No, it's actually at an inflammatory disease.
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[SPEAKER_01]: As your body's lagging in this ability to regenerate.
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[SPEAKER_01]: Because if you look at us as little kids, you know, eight, ten years old, were we wearing and tearing our body?
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[SPEAKER_01]: We're doing a lot more damage to our bodies than what we're doing now, and what we're doing in our 70s, 80s, right?
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[SPEAKER_01]: We're not trying to wear and tear it.
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[SPEAKER_01]: your body couldn't repair.
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[SPEAKER_01]: So one example is when they try to put a knee construct, right, artificial piece of cartilage into the knee joint of, oh, osteoarthritis, knee, that construct will be eaten away by the joint itself because the joint is so inflammatory.
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[SPEAKER_01]: It doesn't allow it to stay.
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[SPEAKER_01]: It doesn't even allow the continuance of this healthy tissue.
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[SPEAKER_01]: So it's really because we have reduced capacity for regeneration.
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[SPEAKER_01]: That's causing, you know, this condition, also a lot of conditions.
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[SPEAKER_01]: You know, what causes aging?
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[SPEAKER_01]: So we're talking a little bit about the causes of aging.
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[SPEAKER_01]: If you look at different mechanisms, I'm sure this group is familiar with all these different mechanisms, mitochondrial dysfunction, genomic changes, and degradation, epigenetic changes,
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[SPEAKER_01]: So everything leads back to stem cell exhaustion because okay, so if you any of these problems or any tissue damage you have you have enough stem cells and the stem cells are good then you're replacing the damage tissue you're new again, right, but if you don't have the stem cells to come up and really get you to regenerate then the damage stays the inflammation stays and there's degradation.
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[SPEAKER_01]: all these potentials, all these problems can lead to stem cell exhaustion and an impaired cellular communication.
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[SPEAKER_01]: So the health of the stem cells eventually is going to determine the health of this entire organism and how long it's going to live and how well.
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[SPEAKER_01]: And so what I look at,
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[SPEAKER_01]: is what I consider disease and aging and really how one analogy is a burning building.
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[SPEAKER_01]: So if you think of the human body as a building, before the smoke comes out, was there fire?
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[SPEAKER_01]: There was fire going on, right?
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[SPEAKER_01]: And it was smoldering.
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[SPEAKER_01]: And that is the aging process, the whole smoldering process.
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[SPEAKER_01]: By the time the fire, the smoke comes out, that's a disease, then your doctor can diagnose you.
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[SPEAKER_01]: But before the disease is showing up, the aging is doing its work.
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[SPEAKER_01]: So what we want to do is to prevent the aging process
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[SPEAKER_01]: to where at least slow it down.
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[SPEAKER_01]: So that's why the inflammation aging is so tight in together as this word, you know, inflammation.
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[SPEAKER_01]: And so to show you why
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[SPEAKER_01]: uh, inflammation is such a driving force for aging, you know, some of the important aspects to even think about.
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[SPEAKER_01]: So you look at this gentleman, you know, he's, you know, probably his early 60s, his, you know, his vibrant, his boxing every day, but even for him, who's super healthy, his inflammation level is higher than a younger.
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[SPEAKER_01]: you know, younger guys, you know, in the 40s.
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[SPEAKER_01]: So, it doesn't matter if he didn't, he wasn't sick or anything, just by living to that age, his inflammation level is higher.
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[SPEAKER_01]: The inflammation markers are elevated.
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[SPEAKER_01]: And inflammation has been shown to be the driving force almost of all age-related diseases.
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[SPEAKER_01]: And these elevated levels can predict disease, diseases, and disability in the aging population.
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[SPEAKER_01]: and then increase the two love markers LL6 and CRP are strongly linked to poor physical performance, decreased muscle strength, cognitive decline, and early death.
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[SPEAKER_01]: Um, so here's this study that, um, that talks about how STEM cells can be a strategy for to target inflammation, that's acted as an anti-aging method.
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[SPEAKER_01]: So in this, um, rat TBI study, they infuse MSC.
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[SPEAKER_01]: So messing climate stem cells, this is kind of like one of the holy grails that we are using right now.
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[SPEAKER_01]: I don't think this end all be all forever, but this stage in STEM
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[SPEAKER_01]: the most important cells.
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[SPEAKER_01]: So they infuse MSCs into these rats with, you know, brain injuries.
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[SPEAKER_01]: And they showed decreased brain inflammatory cell infiltration, decreased microglias on type of immune cells, and apoptotic cell number.
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[SPEAKER_01]: So cells decrease number of cells that go on program cell death.
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[SPEAKER_01]: And another study, 172 rheumatoid arthritis patients,
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[SPEAKER_01]: And 16 loop is patient, they were giving them allergenic, so that's from another person, from somebody else, MSCs, they infuse these MSCs.
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[SPEAKER_01]: And that helped reestablish the balance in the immune system.
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[SPEAKER_01]: So it changes the immune system from a very pro-inflammatory to a more anti-inflammatory state.
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[SPEAKER_01]: And that could be traced by significant decrease in these inflammation markers, LS6,
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[SPEAKER_01]: TNF alpha and CRP levels, and another example is in patients with enclosing sponolitis, they're severe disease condition, they were also using allergenic MSCs, so these mesenchymos does decrease CRP levels and decrease disease activity.
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[SPEAKER_01]: In Crohn's disease, who these people were refractory to all these therapies that are available, they used MSCs and that correlated
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[SPEAKER_01]: with improved quality of life and improved CRP level.
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[SPEAKER_01]: So you see the going hand in hand between decreasing formation and decreased disease condition.
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[SPEAKER_01]: And, you know, I talked about, you know, this is when resimps so passionate is because, you know, looking tracing our origin and tracing the source of intelligence and these are, you know, that's who we came from.
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[SPEAKER_01]: And the reason that we do age or a significant part is because we're running out of stem cells.
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[SPEAKER_01]: So if you're just looking at us when we're born, everyone in 10,000 cells,
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[SPEAKER_01]: is an MSC.
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[SPEAKER_01]: So these mesenchymos themselves.
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[SPEAKER_01]: I'll talk just a little bit about what they are.
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[SPEAKER_01]: And but when we reach our teenage years is already one in 100,000.
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[SPEAKER_01]: So 10th vote less.
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[SPEAKER_01]: And then when we reach our 40s, it becomes one in 400,000, you're in our 80s, one in 2 million.
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[SPEAKER_01]: So you're literally running out of these engines that's helping you to regenerate.
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[SPEAKER_01]: And so this is graph of the drastic decline as we age.
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[SPEAKER_01]: So even though you're just reaching teenage years, but your body has dramatically less regenerative capabilities.
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[SPEAKER_01]: So these are MICs.
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[SPEAKER_01]: When they are, so what they are is that these cells are,
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[SPEAKER_01]: everywhere along your blood vessels.
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[SPEAKER_01]: Anywhere you have blood supply, which is everywhere, you will have these cells that are huddling around the blood vessels.
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[SPEAKER_01]: So you're looking at them, I think of them like geckles, you know, they're hugging the blood vessels.
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[SPEAKER_01]: So what they're doing, you see all those tentacles, all these feet, they are sensing what's going on in the blood.
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[SPEAKER_01]: So they're able to sense if there's inflammation going on somewhere, is immune system trying to send signals hormones, they're trying to figure out having the pulse on your systemic condition.
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[SPEAKER_01]: But they also have all these, you know, this, you know, I guess 10 calls they can also sense what's going on in the neighborhood.
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[SPEAKER_01]: So they have communication with neighboring cells, with neighboring stem cells, they can talk to local stem cells.
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[SPEAKER_01]: If needed, they can tell the local stem cells, hey, you need to divide, you need to make me new tissue.
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[SPEAKER_01]: So they don't themselves rarely.
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[SPEAKER_01]: to become new tissue.
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[SPEAKER_01]: This is why it's fundamental difference in this stem cell therapy that we're not relying on these cells ability to form new cells and new tissue.
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[SPEAKER_01]: We're counting their ability to coordinate this regeneration.
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[SPEAKER_01]: So that's why, you know, I call them the master regeneration that they're
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[SPEAKER_01]: kind of the conductor and the symphony of regeneration.
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[SPEAKER_01]: And these are just what they look like.
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[SPEAKER_01]: The fact that they are so important in the whole signaling of regeneration.
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[SPEAKER_01]: This is why the doctor who discovered these cells, Dr. Arnold Kaplan, he wanted to
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[SPEAKER_01]: change the name of these cells.
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[SPEAKER_01]: He was like stop calling them stem cells.
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[SPEAKER_01]: You know these are these are whole different category.
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[SPEAKER_01]: He wants to change them to be medicinal signaling cells because we've seen that's how they conduct their work is by monitoring and sending signals.
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[SPEAKER_01]: So how do they work?
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[SPEAKER_01]: So these MSCs, first of all, they're highly anti-inflammatory.
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[SPEAKER_01]: That's one of the benefits, not only the support about a lot of research, but also for me, just seeing patients and me have drastic anti-inflammatory effects sometimes really fast.
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[SPEAKER_01]: Just give you a couple of examples.
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[SPEAKER_01]: For example, one time I treated a liver cirrhosis patient and he wasn't in hospital.
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[SPEAKER_01]: So he didn't have much longer to live.
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[SPEAKER_01]: And I give him one injection on his way back to Sacramento on the drive back.
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[SPEAKER_01]: His brother told us, oh my god, my brother's that's swelling in the abdomen has gone down a lot.
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[SPEAKER_01]: This is just on the drive back, right, within hours.
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[SPEAKER_01]: These are the fast and time inflammatory effect.
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[SPEAKER_01]: Another patient who had rheumatoid arthritis, you know, wonderful lady, surgical technician and she couldn't work because she couldn't even make a fist.
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[SPEAKER_01]: And when I was giving her stem cell infusion in the middle of the infusion, you know, because infusion probably takes about 40, 45 minutes in the middle of the infusion.
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[SPEAKER_01]: And she did this.
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[SPEAKER_01]: She did this.
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[SPEAKER_01]: And she started crying.
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[SPEAKER_01]: She said, I haven't been able to make a fit for two months.
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[SPEAKER_01]: And she just started crying.
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[SPEAKER_01]: And and there's another patient is really interesting.
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[SPEAKER_01]: She had Alzheimer's in her 60s.
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[SPEAKER_01]: She's very severely, you know,
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[SPEAKER_01]: even who her husband was and so she stopped feeding herself for a couple months.
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[SPEAKER_01]: So she may be hungry, but she would just sit in front of plate of food and she wouldn't touch a knife and fork to just she couldn't feed herself.
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[SPEAKER_01]: And I gave her a stem salt treatment the next day.
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[SPEAKER_01]: So the husband told me later that they put the plate of food in front of her and she picked up a knife and fork and just ate.
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[SPEAKER_01]: And her husband was like, looking at her like this and she would be like,
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[SPEAKER_01]: you know, what's your problem?
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[SPEAKER_01]: And that to me is this quick, anti-inflammatory action of the cells because what I think of her brain is so inflamed and so jammed up that the cell cannot, one cell cannot communicate with another cell.
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[SPEAKER_01]: So the, the, the signals just doesn't pass through, she may be hungry, but there's absolutely no way to communicate.
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[SPEAKER_01]: All of a sudden when you can clear the pathway,
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[SPEAKER_01]: And you call the inflammation, the cells are actually able to communicate.
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[SPEAKER_01]: So it's just anti-inflammatory effect.
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[SPEAKER_01]: It's really wonderful.
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[SPEAKER_01]: And then a new modulatory, which is shifting on immune system from a more inflammatory anti-inflammatory condition, state, that's why the, for autoimmune conditions is so powerful.
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[SPEAKER_01]: I've seen, I mean, I used to have cat allergies.
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[SPEAKER_01]: And you know, I was, you know, hacking and coughing
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[SPEAKER_01]: And taking medications and after stem cell treatment, you know, it's been, yeah, this has been six years.
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[SPEAKER_01]: I don't need any any medications.
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[SPEAKER_01]: So I've seen, you know, the immune system getting to a more healthy state the regenerative potential.
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[SPEAKER_01]: That's the talking with the local stem cells and telling them to regenerate.
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[SPEAKER_01]: So this local effect and the endogenic benefits is that it does help you to regenerate and grow new blood vessels because you've
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[SPEAKER_01]: We regenerate cells tissue if there's no blood supply, it doesn't help you any right you need to supply nutrients and remove waste.
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[SPEAKER_01]: So the antiogenic potential is very powerful and another potential way that these cells work is mitochondria transfer so we all know about mitochondria decline and what's fascinating.
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[SPEAKER_01]: is that these stem cells actually can deliver fresh new mitochondria to your cells.
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[SPEAKER_01]: It's able to tell that your cells mitochondria is not doing well, and either it can shoot off mitochondria into the space and the mitochondria can enter or put mitochondria in a vesicle, and the vesicle will fuse within, you know, your own cell that may need the mitochondria.
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[SPEAKER_01]: Or establish this nanotubial and mitochondria can
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[SPEAKER_01]: can walk across the tubio.
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[SPEAKER_01]: So they call these on intellectual microscopy, can walk across the tubio and get to the recipient's cell.
18:24.469 --> 18:27.734
[SPEAKER_01]: So you're rescuing the mitochondria, the energy level of the cells.
18:28.215 --> 18:30.298
[SPEAKER_01]: So it's really powerful.
18:30.358 --> 18:33.243
[SPEAKER_01]: I, you know, some people have mitochondria disorders.
18:34.064 --> 18:36.147
[SPEAKER_01]: They've actually shown using
18:36.363 --> 18:41.190
[SPEAKER_01]: stem cells through mitochondria transfer that these people are doing better.
18:42.071 --> 19:03.282
[SPEAKER_01]: Anti-faburotic property is very important because when I'm treating people, like the liver cirrhosis patients, so that patient I treated within two months, he's liver function became normal, which was shocking because I just given one infusion, I did not anticipate that because I told him to come back in a couple of weeks and he didn't come back and I didn't know what happened to him and then I found out
19:03.262 --> 19:04.663
[SPEAKER_01]: that he was doing fantastic.
19:05.764 --> 19:09.167
[SPEAKER_01]: So sometimes, just have these amazing, amazing results.
19:09.868 --> 19:13.792
[SPEAKER_01]: And liver ciruses is a fibroctic disease, regular liver is a sturorosing.
19:13.872 --> 19:17.315
[SPEAKER_01]: It's heartening and losing cells.
19:17.735 --> 19:25.383
[SPEAKER_01]: So it's able to break down the scar tissue and same for COPD, I love treating COPD patients because it's so easy.
19:25.403 --> 19:31.328
[SPEAKER_01]: The first, when I give people stem cells through intravenous route, the first place they go to is the lungs.
19:31.679 --> 19:37.526
[SPEAKER_01]: And if you have a lung problems and a lot of inflammation going on, a lot of cells are going to stay there and try to fix it for you.
19:38.007 --> 19:56.050
[SPEAKER_01]: So this is another reason that, you know, we meet, we may need different waves of cells because you have a lot of inflammation, all your body, you know, if you have a, this number of cells, and you get into the body to fix that amount of inflammation, that amount of inflammation may end up killed some of the cells, because inflammation is toxic.
19:56.502 --> 19:59.565
[SPEAKER_01]: to not only your own cells but also to stem cells that's given to you.
20:00.085 --> 20:07.833
[SPEAKER_01]: So you may end up fighting the condition but you're losing some of the cells and the process right there sacrifice and the fight for you.
20:08.414 --> 20:16.061
[SPEAKER_01]: So there's so only so much, you know, you're only giving so many cells in one infusion and you may need a second wave for further repair.
20:16.782 --> 20:20.485
[SPEAKER_01]: And then anti-apoptotic properties really interesting.
20:20.545 --> 20:25.210
[SPEAKER_01]: So let's say somebody has a stroke
20:25.190 --> 20:28.977
[SPEAKER_01]: blood is cut off that becomes dead tissue, right?
20:28.997 --> 20:30.059
[SPEAKER_01]: That's the stroke center.
20:30.500 --> 20:43.384
[SPEAKER_01]: But the neighboring cells somehow are going on and become dead pretty soon because of this cascade of, you know, a chemical reaction is calcium cascade and these cells ended up,
20:43.702 --> 20:44.743
[SPEAKER_01]: dying.
20:45.004 --> 20:59.063
[SPEAKER_01]: So they're going on program cell death, even though they don't have to, but stem cells can come in rescue, so you can imagine radiation therapy or crush injuries, things of that nature when neighboring cells may die, the stem cells that they able to rescue them.
20:59.664 --> 21:01.727
[SPEAKER_01]: On the other hand, they also have, um,
21:02.298 --> 21:03.640
[SPEAKER_01]: pro-apoptotic.
21:03.660 --> 21:05.864
[SPEAKER_01]: So apoptosis is program self-death.
21:05.904 --> 21:09.149
[SPEAKER_01]: So pro-apoptotic, that means pro-death.
21:09.590 --> 21:14.859
[SPEAKER_01]: So these happens when you have senescent cells or cancer cells.
21:15.260 --> 21:22.011
[SPEAKER_01]: So when the cells are dysfunctional when they don't belong, these
21:21.991 --> 21:29.102
[SPEAKER_01]: mesenchymos themselves are able to tell that they shouldn't be there, and they will send the signal to trigger them into program self-death.
21:29.563 --> 21:34.290
[SPEAKER_01]: So senescent cells is not just not working, not doing anything good for you.
21:34.591 --> 21:36.013
[SPEAKER_01]: They're actively toxic.
21:36.073 --> 21:39.579
[SPEAKER_01]: They secret things that cause damage to your neighboring cells.
21:39.959 --> 21:48.673
[SPEAKER_01]: So when you remove them, that's why, you know, people can have such great recovery is because you're removing the dysfunctional cells.
21:48.653 --> 21:50.155
[SPEAKER_01]: and of course the cancer cells.
21:50.856 --> 21:55.962
[SPEAKER_01]: So stem cells have been used in cancer treatment and has been shown good results, but I'll talk a little bit about that later.
21:56.002 --> 21:58.845
[SPEAKER_01]: There's some nuances in the anti-microbial.
21:58.865 --> 22:09.598
[SPEAKER_01]: So these MICs have been shown to have direct anti-microbial properties so they can actually secrete anti-microbial peptides and directly kill off microbes.
22:10.557 --> 22:11.459
[SPEAKER_01]: So that's the range.
22:11.479 --> 22:12.843
[SPEAKER_01]: That's a lot of functions, right?
22:15.088 --> 22:18.055
[SPEAKER_01]: So one word about young versus old MSCs.
22:18.075 --> 22:25.233
[SPEAKER_01]: So part of my mission is to find out what's the best source of stem cell for patients because there's so many things out there.
22:25.273 --> 22:26.035
[SPEAKER_01]: There's so many,
22:26.015 --> 22:32.122
[SPEAKER_01]: claims and people use fadderive, you know, bone marrow derived and, you know, unblockal core derived.
22:32.623 --> 22:38.229
[SPEAKER_01]: So when I came on the scene, I was like, all I wanted to know which one works the best.
22:38.349 --> 22:41.974
[SPEAKER_01]: That's what I want to do because whichever one works the best, that's what I'm going to do.
22:42.494 --> 22:44.016
[SPEAKER_01]: So I went on a mission to find out.
22:44.477 --> 22:53.307
[SPEAKER_01]: And some of this information is accumulated in what I was trying to find out what's the research all around the world about the differences between different kinds of stem cells.
22:53.327 --> 22:55.009
[SPEAKER_01]: So I actually have a lecture on YouTube.
22:54.989 --> 23:01.580
[SPEAKER_01]: is called our OMSC's created equal, where I went into great depth about these different sources and comparisons.
23:02.021 --> 23:12.338
[SPEAKER_01]: But just the words on young versus old MSC, so you know all of us here, you know, when mature adults, you know, our MSC's are a lot older than what's in a local court, right?
23:13.119 --> 23:14.261
[SPEAKER_01]: The virtual reward.
23:14.802 --> 23:16.525
[SPEAKER_01]: So that's age matter.
23:16.505 --> 23:25.573
[SPEAKER_01]: The fact that these MSEs are in us, our entire lifetime, makes them very susceptible to accumulation of cellular damages.
23:26.014 --> 23:28.977
[SPEAKER_01]: So the longer we live, the more we accumulate these damages.
23:28.997 --> 23:37.605
[SPEAKER_01]: So that can lead to cell deaths, cinescence, laws of magenta functions, or even cancers, changes, neoplastic transformations.
23:38.305 --> 23:45.432
[SPEAKER_01]: But neonatal MSEs, so these are very young, birth tissue.
23:45.749 --> 23:50.716
[SPEAKER_01]: by as a part of the and local court and their spared of these pro-aging factors.
23:52.378 --> 23:57.445
[SPEAKER_01]: So some other evidence when they looked at aged, out of post-derived MSEs.
23:57.465 --> 23:59.407
[SPEAKER_01]: So these are fact-derived MSEs.
23:59.488 --> 24:04.074
[SPEAKER_01]: What they do is when they extract the fat is not that the fat has any MSEs.
24:04.174 --> 24:07.058
[SPEAKER_01]: It's the blood vessels that are supplying the fat everywhere.
24:07.338 --> 24:09.882
[SPEAKER_01]: They're getting the MSEs out of there.
24:10.542 --> 24:15.469
[SPEAKER_01]: And so these are significantly compromised when a person is older.
24:15.449 --> 24:26.418
[SPEAKER_01]: So, they were looking at when they used these, they were unable to support repair.
24:26.498 --> 24:28.443
[SPEAKER_01]: So, age associated impairment.
24:28.463 --> 24:29.526
[SPEAKER_01]: So, when we get older,
24:29.894 --> 24:46.013
[SPEAKER_01]: We have less ability for wound healing and so they were not able to to improve wound healing any further because they are just that that's all they can do and when they use bone marrow drive that my sees they also show that they have less.
24:46.280 --> 25:04.339
[SPEAKER_01]: Myogenic potential, so less ability to form muscles and less capable to engraft, staying in the in the in the donor, I mean in the recipient, then developmentally early MSC so they you know older MSC's have less differentiation potential.
25:04.724 --> 25:24.150
[SPEAKER_01]: and less ability to stay where, you know, they're, they're transplanted and bone marrow derived MICs also exhibit age related decline in inflammatory response and other type of responses that are important for the MIC's migration and activation and their capabilities.
25:24.485 --> 25:31.914
[SPEAKER_01]: When you look at genetic material in adipose direct stem cells, they do decline when we age.
25:32.155 --> 25:43.088
[SPEAKER_01]: So there's senescence, genes that express that the cells are becoming older and, you know, senescing, and that increases with age in these adipose direct stem cells.
25:43.609 --> 25:53.361
[SPEAKER_01]: And aging also alters capabilities of these cells of adipose direct stem cells to form blood vessels.
25:56.733 --> 26:06.325
[SPEAKER_01]: There's also increased level of reactive oxygen species in bone marrow-derived MICs in aging bone marrow-derived MICs.
26:06.745 --> 26:19.140
[SPEAKER_01]: So not only they have increased level of these reactive oxygen species that can cause damages, they're also more sensitive to the reactive oxygen species that's in the environment, so it's double whammy.
26:19.581 --> 26:24.867
[SPEAKER_01]: So they have increased levels and they're more sensitive, but they're more prone to damages.
26:26.652 --> 26:36.815
[SPEAKER_01]: And young MSCs from year one to five, all performed older MSCs from somebody that's aged 50 to 70 in improving cardiac parameters.
26:37.016 --> 26:42.889
[SPEAKER_01]: So after heart attack, if they try to treat the patient,
26:42.869 --> 26:47.281
[SPEAKER_01]: the younger stem cells will lead to better results, better improvements.
26:48.003 --> 26:54.381
[SPEAKER_01]: And then MSC's from young individuals can't undergo neural and actual dermal differentiation.
26:54.421 --> 26:57.891
[SPEAKER_01]: So that's the, you know, basically all the neuronal.
26:57.871 --> 27:05.425
[SPEAKER_01]: lineage differentiation, but when you use bone marrow stem cells from an elderly patient, they loss that capability.
27:05.445 --> 27:11.516
[SPEAKER_01]: So their ability to form maybe neurons that has been lost when you get older.
27:11.536 --> 27:18.850
[SPEAKER_01]: And from another study, adult MSCs are exposed to a lifetime of
27:18.830 --> 27:25.118
[SPEAKER_01]: factors of things we do to our body, including something as benign, as insects, you know, on time flammatures we take.
27:25.659 --> 27:32.588
[SPEAKER_01]: And that the insects can inhibit MSC's capability to form cartilage and bones.
27:33.409 --> 27:39.257
[SPEAKER_01]: So, you know, we are, you know, we're all exposed to a lot of toxic factors, you know, whether or not we like it.
27:40.559 --> 27:46.086
[SPEAKER_01]: Lifestyle factors also affect MSC something like a high-fat diet,
27:46.353 --> 27:59.882
[SPEAKER_01]: So they showed high fat, fed mice, had the higher, so these cells tend to differentiate more to work fat, rather than more toward endothelio, so the interlining of the blood vessels.
28:00.303 --> 28:04.632
[SPEAKER_01]: So it changes where they wanna go and who they can become.
28:04.612 --> 28:11.868
[SPEAKER_01]: And when you look at a bee's patients, their ability to form bones, the osteogenic potential are impaired.
28:11.948 --> 28:20.848
[SPEAKER_01]: So when you look at their MICs, they're able to the nodules and mineralization they can form is fewer and smaller.
28:20.828 --> 28:27.797
[SPEAKER_01]: and metabolic diseases changes environment that adipose direct stem cells are in.
28:28.157 --> 28:37.189
[SPEAKER_01]: So these cells can lose their capabilities to form vascular network that they've shown that both in the future dish and live animals.
28:37.349 --> 28:44.759
[SPEAKER_01]: So, you know, we all know the BCD rate and how diabetes 8% with diabetes in the country.
28:44.779 --> 28:49.485
[SPEAKER_01]: So, all these are factors when we consider using stem cells from our own body.
28:50.782 --> 28:57.592
[SPEAKER_01]: And aging also can lead to decreased bone marrow mesenchymos stem cells.
28:57.932 --> 29:02.359
[SPEAKER_01]: So bone marrow have about 0.1 to 0.01% of mesenchymos stem cells.
29:02.379 --> 29:04.282
[SPEAKER_01]: So not that much to begin with.
29:04.942 --> 29:08.327
[SPEAKER_01]: But when you age, you start to lose more.
29:09.048 --> 29:11.913
[SPEAKER_01]: You just have less and less mesenchymos stem cells in your bone.
29:12.934 --> 29:15.017
[SPEAKER_01]: And that could be one of the reasons
29:14.997 --> 29:24.713
[SPEAKER_01]: for osteoporosis because these mesenchymal stem cells tend to more tend to differentiate more into fat cells rather than bone cells.
29:26.416 --> 29:35.250
[SPEAKER_01]: And when you transplant young MSCs into the bone marrow of old mice, not only rescues the bone loss, but it also delays aging.
29:35.990 --> 29:47.919
[SPEAKER_01]: And even if you do it subcutaneously, so even if you just put it in the skill layers, inject into the skill layers, that can also suppress age-related degeneration of various organs.
29:48.380 --> 29:52.851
[SPEAKER_01]: So Michael is to put the cells somewhere in the body, because once it's in the body,
29:52.831 --> 30:03.787
[SPEAKER_01]: Yes, if you put locally, we're treating local problems more will stay in that area, but some will also, you know, always end up somewhere else because, you know, this is a fluid dynamic system.
30:04.347 --> 30:13.461
[SPEAKER_01]: So as long as you put, you know, even for, you know, what I do stem cell facial inject stem cells into the skin layer, the key is to get it in there and then the cells can do his own work.
30:14.742 --> 30:22.213
[SPEAKER_01]: So like they say, you know, you can hear even subcutaneous, it can delay some other degeneration associated with aging.
30:22.885 --> 30:31.540
[SPEAKER_01]: And so aging of MICs is also detrimental to things like your hematopoatic systems or your whole blood forming system.
30:32.181 --> 30:43.260
[SPEAKER_01]: And aging compromises therapeutic potential at these MICs, including the cells from not only people who are older, but also when you expand the cells for many generations.
30:43.541 --> 30:47.728
[SPEAKER_01]: So you age them when you grow them in the incubator and let them keep dividing.
30:49.615 --> 31:05.119
[SPEAKER_01]: Um, so stem cells, this study showed that stem cells from older donors have defective functions, including their impaired capability to proliferate and differentiate when compared to cells from younger individuals.
31:05.800 --> 31:15.876
[SPEAKER_01]: And when you look at, uh, function of bone marrow direct stem cells isolated from young, uh, mice,
31:15.856 --> 31:22.847
[SPEAKER_01]: The bone marrow stem cells from old animals are significantly less capability for differentiation.
31:22.887 --> 31:39.433
[SPEAKER_01]: And when you transplant young bone marrow stem cells, it delays the decrease in bone densities, but what's really fascinating is that if you transplant old bone marrow drips stem cells, it can actually accelerate the decline in bone density.
31:39.413 --> 31:43.318
[SPEAKER_01]: So what are some of the evidence of anti-aging benefits from stem cell therapy?
31:43.879 --> 31:46.642
[SPEAKER_01]: So there are some studies I want to show you, which are really interesting.
31:47.143 --> 31:50.327
[SPEAKER_01]: So this is general background information.
31:50.367 --> 31:56.956
[SPEAKER_01]: H does lead to progressive deterioration of a colonurgic and doconurgic systems.
31:57.256 --> 31:59.559
[SPEAKER_01]: So that's in both our muscles and our brain.
31:59.920 --> 32:05.387
[SPEAKER_01]: You know, muscle mass is important, of course, you know, maintaining brain capacity is important as we age.
32:05.654 --> 32:18.309
[SPEAKER_01]: So the concentration of neurotopens in the brain and muscles decline leading to reduced neurogenesis, accelerated muscular atrophy, and that can lead to impairment both cognitively and in your physically.
32:19.190 --> 32:24.837
[SPEAKER_01]: Aging can lead to exhaustion of stem cell population as we've seen in the statistics.
32:25.498 --> 32:34.328
[SPEAKER_01]: And various stem cells can exert neural protective effects and enhance functional recovery by secreting neurotopic factors.
32:34.308 --> 32:41.081
[SPEAKER_01]: and concentration of this tow bar at T-bars is by product of lipid prostration.
32:41.101 --> 32:52.823
[SPEAKER_01]: So just kind of waste product that increases significantly in the brain, muscle, heart, liver and lungs of aging rats and along with a decreased blood vessel density.
32:52.803 --> 32:55.647
[SPEAKER_01]: So these are just signs of aging.
32:56.448 --> 33:16.034
[SPEAKER_01]: And what they did, well, first of all, they have seen the Adapose Drive MICs can increase the concentration of neurotransmitter, acetylcholine, and also some growth factors, brain-derived neurotropic factor, and nerve growth factor, and those can improve cognitive physical function of aging mice.
33:16.835 --> 33:21.882
[SPEAKER_01]: And Adapose Devote Drive MICs can also
33:21.862 --> 33:28.211
[SPEAKER_01]: So, helping with blood formation and extending lifespan in an ALS mouse model.
33:28.993 --> 33:37.485
[SPEAKER_01]: And even this muscle derived progenitor cells can extend health span and lifespan of progeria mice.
33:37.505 --> 33:39.849
[SPEAKER_01]: So, these are prematurely aging mice.
33:41.051 --> 33:48.021
[SPEAKER_01]: They do this by restoring micro vessels and muscle fibers by creating different factors.
33:49.300 --> 33:59.194
[SPEAKER_01]: So in this experiment, which is very interesting, they started at age 10, which is kind of middle age for mice that rats.
33:59.254 --> 34:08.246
[SPEAKER_01]: So these rats, they give them either control or any hunting membrane derived MICs or adipose derived MICs.
34:09.088 --> 34:17.299
[SPEAKER_01]: And they give these cells intravenously through the main and the tail, once a month, throughout the rest of their lives.
34:17.448 --> 34:24.496
[SPEAKER_01]: And the stem cell group showed improved cognitive and physical function of these naturally aging rats.
34:25.477 --> 34:29.022
[SPEAKER_01]: Life span extended by between 23 to 31%.
34:31.064 --> 34:39.414
[SPEAKER_01]: And by the time these rats, right, they were 10 months old, by the time they reached 20 months of age in the control group, only 30% of rats are still alive.
34:40.055 --> 34:47.083
[SPEAKER_01]: But in the ones that got stem cells, there's between 70 to 100% of them, the rats are still alive.
34:47.249 --> 34:52.037
[SPEAKER_01]: So there's a big difference, and by 23 months, all the rats in the control group have died.
34:52.699 --> 34:57.667
[SPEAKER_01]: But between 60 to 72 percent of the stem cell group are still alive.
34:59.851 --> 35:05.541
[SPEAKER_01]: And some of the transplant cells were able to, they found them to differentiate even into neurons.
35:06.583 --> 35:11.552
[SPEAKER_01]: So there's a significant differentiation rate, so we're just fascinating.
35:13.068 --> 35:16.718
[SPEAKER_01]: And when they looked at the different factors that we talked about.
35:16.738 --> 35:18.965
[SPEAKER_01]: So there's brain neurotropic factors.
35:20.208 --> 35:26.245
[SPEAKER_01]: They were restored to a level higher than when they were, you know, a younger rats.
35:26.646 --> 35:28.090
[SPEAKER_01]: And muscular.
35:28.559 --> 35:45.994
[SPEAKER_01]: New Archbishop of Factors were also restored, you know, back to levels younger than the younger rats, and they looked at the blood vessels, and their density also have increased comparable to the level of the young rat, so the restored and geogenesis.
35:47.425 --> 35:51.851
[SPEAKER_01]: And the tissue injury was almost fully restored.
35:51.871 --> 36:01.184
[SPEAKER_01]: And the monthly transplantation of these stem cells have markedly increased the rats, stamina, and cognitive functions.
36:01.264 --> 36:03.748
[SPEAKER_01]: So that's talking about vitality, right?
36:04.249 --> 36:06.592
[SPEAKER_01]: So cognitively and physically.
36:07.513 --> 36:14.563
[SPEAKER_01]: And then acetylcholine concentration in both the cerebellum spinal fluid and the muscles have been restored.
36:15.117 --> 36:16.881
[SPEAKER_01]: back to the younger state.
36:17.642 --> 36:29.446
[SPEAKER_01]: And the genus version that which changes, right, genes start to degrade as we get older, and those changes were also reversed.
36:29.466 --> 36:35.438
[SPEAKER_01]: So they were able to measure all these different, you know, tangible outcomes.
36:35.992 --> 36:42.044
[SPEAKER_01]: And the number of the host stem cells in age rats is a lot less, right?
36:42.084 --> 36:54.709
[SPEAKER_01]: It's only 28, 27.8% of the younger rats, but when we infuse these new stem cells, they increase the number of these host stem cells to the level that's comparable to younger time.
36:54.689 --> 37:05.146
[SPEAKER_01]: and the expression of certain things as suppresses neurogenesis of this particular molecule that has been fully reversed.
37:05.707 --> 37:18.828
[SPEAKER_01]: So then you can restore neurogenesis and stem cell therapy so in conclusion, you know, can restore colonurgic and dopanturgic nervous system and microbezzles and muscle mass and anti-oxidative capabilities.
37:19.890 --> 37:21.793
[SPEAKER_01]: And then I want to show you another study
37:23.360 --> 37:27.024
[SPEAKER_01]: which is really interesting because this that we started a little later.
37:27.044 --> 37:32.571
[SPEAKER_01]: So they started these rats, these are mice at age 15 months.
37:32.831 --> 37:35.574
[SPEAKER_01]: So this is human equivalent age of 75.
37:36.155 --> 37:41.341
[SPEAKER_01]: So these are much older mice and 50% of their peers have died.
37:41.681 --> 37:43.783
[SPEAKER_01]: That's how they determine the time.
37:44.804 --> 37:51.392
[SPEAKER_01]: And they were giving them intravenous bone marrow transplantation from bone marrow cells of the younger
37:51.878 --> 38:04.521
[SPEAKER_01]: So they give them also through IV route six times within three months, so every two weeks and the mice that's only three to 15 weeks were the donors.
38:07.049 --> 38:13.459
[SPEAKER_01]: And the result is that the maximum lifespan of the transplanted mice were increased by over 30%.
38:14.080 --> 38:15.422
[SPEAKER_01]: So that has been pretty consistent.
38:15.442 --> 38:18.427
[SPEAKER_01]: This extending of lifespan by 30% has been consistent.
38:18.927 --> 38:30.846
[SPEAKER_01]: And the survival time from the beginning of the experiment was increased by 3.2% a fold, which means that is that having one month left, if you got the stem cells, you could have three months left.
38:30.826 --> 38:41.906
[SPEAKER_01]: So at age 19.3 months, it's kind of funny, but the last mouse of the control group died sedentary, almost a mobile, a hunchbacked with poor hair.
38:42.467 --> 38:46.916
[SPEAKER_01]: The transplanted mice were active, had even spine, and shiny even hair.
38:47.136 --> 38:49.961
[SPEAKER_01]: So their vibrant is not just living longer.
38:49.981 --> 38:51.484
[SPEAKER_01]: They're living well.
38:51.852 --> 38:58.583
[SPEAKER_01]: And these observed lifespan, definitely was a company by the healthy life period.
38:59.084 --> 39:03.892
[SPEAKER_01]: And there's chimerism, which means that one individual have two sets of genetic material.
39:04.293 --> 39:10.944
[SPEAKER_01]: So there's these new cells dis-stay in the mice and a lot of them dis-stay the chimerism was 28%.
39:12.066 --> 39:15.852
[SPEAKER_01]: So this is very encouraging for us as humans.
39:15.832 --> 39:19.917
[SPEAKER_01]: And this is just a study on humans.
39:20.037 --> 39:24.582
[SPEAKER_01]: It's not a big study, but there's still we still need more human studies.
39:25.483 --> 39:27.906
[SPEAKER_01]: This is 20 patients with chronic inflammation.
39:27.926 --> 39:34.033
[SPEAKER_01]: And they were just getting one IV infusion of a local core blood derived stem cells for anti-aging purposes.
39:35.574 --> 39:39.679
[SPEAKER_01]: So half of them showed improvement in CBC, so in their blood count, their
39:40.132 --> 39:45.404
[SPEAKER_01]: chemistry, comprehensive, you know, a panel, their liver function, and their cholesterol.
39:46.486 --> 39:59.575
[SPEAKER_01]: And they evaluate the changes in their for antiaging benefits, you know, at 24 hours, two weeks, and three months, and showed improvement in skin hair, nail growth, energy level, libido, mood, sleep, and pain levels.
40:01.225 --> 40:02.066
[SPEAKER_01]: Yeah.
40:02.346 --> 40:07.370
[SPEAKER_01]: So just this, just the last study, just going to show a little about frailty.
40:07.431 --> 40:10.153
[SPEAKER_01]: So frailty is actually a big problem when we age.
40:10.894 --> 40:17.700
[SPEAKER_01]: People get very frail and that's correlated with you know, hospitalization, institutionalization, disability and death.
40:19.221 --> 40:22.924
[SPEAKER_01]: So you, you know, there's huge percentage.
40:23.024 --> 40:29.410
[SPEAKER_01]: Well, there's seven to 12 percent of adults over age 65
40:29.390 --> 40:38.532
[SPEAKER_01]: fit the definition of frailty, but there's free frailty, which means they fit partial criteria as large as 35 to 50%.
40:38.592 --> 40:47.213
[SPEAKER_01]: So there's a lot of frailty, which is associated with comorbidities with all your organ systems and neurological and psychiatric issues.
40:47.682 --> 41:01.099
[SPEAKER_01]: So, and they show that there's strong link between frailty, inflammation, and the imparitability to repair injuries to the fact that there's not enough stem cells.
41:01.780 --> 41:05.324
[SPEAKER_01]: And aging induces a quiescent to senescent switch.
41:05.825 --> 41:08.188
[SPEAKER_01]: So, you may have stem cells that are
41:08.168 --> 41:12.678
[SPEAKER_01]: they're just, you know, hibernating, they're not doing anything they're waiting.
41:13.219 --> 41:15.924
[SPEAKER_01]: And then aging made them switch to senescence.
41:15.945 --> 41:20.895
[SPEAKER_01]: So before they even can get to work, they're already aged, they're old, and they're causing problems.
41:21.719 --> 41:27.588
[SPEAKER_01]: And they have shown that MICs can undergo synestens.
41:27.749 --> 41:33.898
[SPEAKER_01]: So as we go older, they can become older and become less effective.
41:34.619 --> 41:37.464
[SPEAKER_01]: And their capability is gradually disappear.
41:38.005 --> 41:47.119
[SPEAKER_01]: And intravenous delivered allergenic MICs, so from somebody else, are safe and can produce significant improvement in physical performance.
41:47.099 --> 41:49.891
[SPEAKER_01]: and as well as inflammation markers.
41:50.333 --> 41:57.463
[SPEAKER_01]: So that's the size, you know, a little bit of examples and the anti-aging protocol that I use is
41:57.815 --> 42:04.085
[SPEAKER_01]: that I, in my clinic, only used birth tissue derived MSCs and these are minimally manipulated.
42:04.105 --> 42:13.140
[SPEAKER_01]: I don't, you know, in the US, if you expand the cells, you do any manipulation, then you have to participate in a IND study.
42:13.461 --> 42:15.945
[SPEAKER_01]: This is why so many companies are going overseas.
42:15.985 --> 42:17.848
[SPEAKER_01]: They're in Mexico, Panama,
42:18.132 --> 42:25.981
[SPEAKER_01]: They're doing, you know, that these expanded cell treatments is sounds great, that they're giving you 100 million, 200 million, 300 million cells.
42:26.461 --> 42:31.567
[SPEAKER_01]: But when they grow cells in multiple generations, there could be deleterious changes.
42:32.028 --> 42:40.377
[SPEAKER_01]: They could decrease in potency and also gain more differentiation because oftentimes when they divide, they don't divide evenly.
42:41.150 --> 42:43.333
[SPEAKER_01]: into two stem cells.
42:43.654 --> 42:47.680
[SPEAKER_01]: A lot of times, stem cells, when in culture, they would divide into one stem cell, one daughter cell.
42:48.100 --> 42:49.883
[SPEAKER_01]: The daughter cell is more differentiated.
42:50.364 --> 42:55.491
[SPEAKER_01]: And when it's more differentiated, then it has more surface receptors that can mark the mes Jane or Joan.
42:55.551 --> 42:57.835
[SPEAKER_01]: You know, they have their own characteristics.
42:58.215 --> 43:04.805
[SPEAKER_01]: So your immune systems can destroy them, but they also can trigger this immune rejection response.
43:04.865 --> 43:10.954
[SPEAKER_01]: And this is probably why I've seen more side effects when people getting these large dose of stem cells
43:10.934 --> 43:22.632
[SPEAKER_01]: Um, they often have to divide the doses, but, um, because of the side effects, but even when you divide it, the problem is that you could be priming somebody.
43:22.983 --> 43:24.905
[SPEAKER_01]: of these immune rejection, right?
43:24.945 --> 43:26.968
[SPEAKER_01]: So we all know if you sensitize the body.
43:27.188 --> 43:31.934
[SPEAKER_01]: So first infusion, your body just recognized, oh, oh my god, you've got to give me something for it.
43:31.954 --> 43:34.537
[SPEAKER_01]: So I'm gonna build up these antibodies.
43:34.837 --> 43:37.080
[SPEAKER_01]: And then a few days later, you give them a second injection.
43:37.160 --> 43:38.982
[SPEAKER_01]: All of a sudden, the body's like, I am ready to fight.
43:39.383 --> 43:45.430
[SPEAKER_01]: So they're getting worse and worse rejection reactions, getting sicker, is either your body trying to fight it off.
43:45.410 --> 43:54.940
[SPEAKER_01]: And I've seen that using much less doses that's minimally manipulated can achieve just as good if not better results than what they're doing overseas.
43:55.020 --> 44:00.766
[SPEAKER_01]: But it's certainly a sound sexy that I'm giving you 200 million cells, right, then giving you 10 million.
44:01.107 --> 44:03.509
[SPEAKER_01]: So a lot of people buy into the hype.
44:03.750 --> 44:15.282
[SPEAKER_01]: Anyhow, so what I do is that generally, you know, the product I use
44:15.515 --> 44:16.751
[SPEAKER_01]: And then I add another
44:17.219 --> 44:24.309
[SPEAKER_01]: CC in somebody's over the age of 65 to 70 because they're more depleted than I add more if they have severe health issues.
44:24.929 --> 44:30.937
[SPEAKER_01]: And for anti-aging treatments, usually we do it, you know, between every three to six months.
44:31.879 --> 44:38.167
[SPEAKER_01]: You know, sometimes some people may want to do it every 12 months, but generally these cells will live in your body for about three months.
44:38.468 --> 44:42.092
[SPEAKER_01]: So if I give you some stem cells, their lifespan in your body is about three months.
44:42.533 --> 44:46.298
[SPEAKER_01]: And then their effect may last
44:46.278 --> 44:51.645
[SPEAKER_01]: So that's why we have the protocol of at least every six months when you want to do it for anti-aging purposes.
44:52.105 --> 44:59.014
[SPEAKER_01]: So, you know, some of my patients are more aggressive, I do it every three months, some my patients do it every two months, and I had, you know, some I want to do every month.
44:59.074 --> 45:09.467
[SPEAKER_01]: So, um, at these kind of doses, you know, it's going to be pretty hard to overdose, um, you know, I think it's just a matter of hitting a point of no extra benefit.
45:09.447 --> 45:12.011
[SPEAKER_01]: So you don't really need drastic doses.
45:12.192 --> 45:14.976
[SPEAKER_01]: I prefer smaller doses, multiple treatments.
45:15.016 --> 45:17.220
[SPEAKER_01]: I think that's going to give you waves or regeneration.
45:17.641 --> 45:23.671
[SPEAKER_01]: So that's my talk, you know, may you all live more years with vitality, right?
45:23.691 --> 45:25.414
[SPEAKER_01]: We just want to live good years.
45:27.014 --> 45:37.653
[SPEAKER_01]: Thank you for listening to this episode, hope you enjoy the content, and if so, please rate and follow this podcast.
45:37.673 --> 45:43.524
[SPEAKER_01]: To reach me, you can contact uplift longevity center, and that is uplift with a lot.
45:43.784 --> 45:47.551
[SPEAKER_01]: You can also subscribe to my YouTube channel, Joy Kong, MD.
45:47.971 --> 45:48.853
[SPEAKER_01]: See you next time!
00:01.718 --> 00:07.307
[SPEAKER_01]: So if you think of the human body as a building, before the smoke comes out, was there fire?
00:07.687 --> 00:08.929
[SPEAKER_01]: There was fire going on, right?
00:09.390 --> 00:10.311
[SPEAKER_01]: And it was smoldering.
00:10.992 --> 00:14.598
[SPEAKER_01]: And that is the aging process, the whole smoldering process.
00:14.638 --> 00:19.385
[SPEAKER_01]: By the time the fire, the smoke comes out, that's a disease.
00:19.846 --> 00:21.589
[SPEAKER_01]: Then your doctor can diagnose you.
00:22.110 --> 00:26.657
[SPEAKER_01]: But before the disease is showing up, the aging is doing its work.
00:27.157 --> 00:28.840
[SPEAKER_01]: So what we wanna do,
00:28.820 --> 00:38.259
[SPEAKER_01]: is to prevent the aging process to or at least slow it down, so that's why the inflammation aging is so tied in together as this word, you know, inflammation.
00:38.840 --> 00:41.485
[SPEAKER_01]: Welcome to the Dr. Duay Kong podcast.
00:41.505 --> 00:48.820
[SPEAKER_01]: This is where I have a chance to share with you some of the latest developments in the space of holistic health, longevity, and wellness.
00:48.800 --> 00:55.761
[SPEAKER_01]: I've always honored intellectual curiosity and scientific rigor, combined with real world practicality.
00:56.062 --> 01:00.475
[SPEAKER_01]: My goal is that what you learn here will help you live longer and live better.
01:00.775 --> 01:02.320
[SPEAKER_01]: Hope you enjoy the journey with me.
01:02.738 --> 01:05.163
[SPEAKER_00]: We'll come back to the Dr. Joy Kong podcast.
01:05.645 --> 01:16.910
[SPEAKER_00]: A lot of you have questions about what stems out there you can do when it comes to reducing the rate of aging or slowing down our decline that comes with age.
01:17.491 --> 01:22.182
[SPEAKER_00]: So I actually have given a lecture that delve.
01:22.162 --> 01:30.078
[SPEAKER_00]: in detail as to the theory and the evidence behind what stands out there if you can do.
01:30.519 --> 01:35.850
[SPEAKER_00]: So I hope you enjoy this lecture and that it answers a lot of your questions.
01:35.982 --> 01:39.010
[SPEAKER_01]: So stem cell therapy has been a passion of mine.
01:39.351 --> 01:41.336
[SPEAKER_01]: It hasn't been that long.
01:41.356 --> 01:42.799
[SPEAKER_01]: It's been for the last six years.
01:43.000 --> 01:48.454
[SPEAKER_01]: I specialize in psychiatry because I love the brain and then addiction medicine.
01:48.474 --> 01:52.624
[SPEAKER_01]: And then I've always wanted to incorporate.
01:52.604 --> 02:12.334
[SPEAKER_01]: holistic approach to medicine and I can't imagine anything that's more holistic and more integrative than then stem cell therapy because if you look at stem cells is really who we were right we we were all one single cell from that one single cell what isn't that single cell
02:12.314 --> 02:17.805
[SPEAKER_01]: that got us to be what we are today, that kind of power that's in that one cell.
02:17.825 --> 02:19.969
[SPEAKER_01]: So, never discount a single cell.
02:20.370 --> 02:22.174
[SPEAKER_01]: And what's in that cell is DNA.
02:22.655 --> 02:26.863
[SPEAKER_01]: The DNA contains the intelligence that can make us.
02:27.232 --> 02:31.899
[SPEAKER_01]: And it's that intelligence that I'm tapping into when I do stem cell therapy.
02:32.199 --> 02:42.253
[SPEAKER_01]: So this is the first time in human history that we're not using a molecule or a group of molecules which are, you know, herbs or other kind of medications.
02:42.734 --> 02:45.498
[SPEAKER_01]: We're using intelligence, right?
02:45.518 --> 02:50.044
[SPEAKER_01]: We're tapping into DNA and DNA is the most energy-thens substance in the universe.
02:50.765 --> 02:55.011
[SPEAKER_01]: And so when I do stem cell therapy, I consider myself doing
02:54.991 --> 03:13.351
[SPEAKER_01]: I mean, infusing energy into people's body, and that kind of intelligence that's in the cells are able to have mechanisms that can get to the areas where you need healing and then produce this vast array of benefits, and I'll show you what how they work.
03:13.771 --> 03:20.779
[SPEAKER_01]: So I know this group is all about longevity and anti-aging, so the topic I have today is
03:20.759 --> 03:22.942
[SPEAKER_01]: sense out therapy as an antiaging tool.
03:23.002 --> 03:34.819
[SPEAKER_01]: I'm very excited about this because I am a direct product of this antiaging experiment because six years ago when I found out about stem cell therapy knowing what it does.
03:34.959 --> 03:36.622
[SPEAKER_01]: I was like, well, I've got to put in my body.
03:36.942 --> 03:37.683
[SPEAKER_01]: I'm going to do this.
03:38.024 --> 03:39.786
[SPEAKER_01]: So I started doing it every three months.
03:40.748 --> 03:43.071
[SPEAKER_01]: So in a week, I'm turning 51.
03:43.051 --> 03:50.621
[SPEAKER_01]: And if you look at my picture now comparing to when I was 43, you could literally see the age reversal.
03:50.981 --> 03:53.484
[SPEAKER_01]: So that was not something I was looking for.
03:53.585 --> 03:55.347
[SPEAKER_01]: I just wanted to stay healthy in my brain.
03:55.367 --> 03:56.528
[SPEAKER_01]: I didn't even know I was aging.
03:56.889 --> 03:58.731
[SPEAKER_01]: I thought I was looking great.
03:59.032 --> 04:07.202
[SPEAKER_01]: But now when I was looking, now I look at, you know, Facebook start to remind me, happy anniversaries, look at you six years ago, and I was like, oh no.
04:07.182 --> 04:08.304
[SPEAKER_01]: Why did I post that?
04:08.324 --> 04:11.469
[SPEAKER_01]: I don't know, because we look at yourself every day.
04:11.509 --> 04:13.152
[SPEAKER_01]: You don't even see that you're aging.
04:13.653 --> 04:17.880
[SPEAKER_01]: So if you got better, and then you can compare.
04:17.920 --> 04:27.696
[SPEAKER_01]: So I think the thing is, when people look at themselves, I think people need to realize, when you look at yourself in the mirror, and you think, oh, gosh, I think I look a little older.
04:27.736 --> 04:29.359
[SPEAKER_01]: You know, I got wrinkles.
04:29.339 --> 04:35.768
[SPEAKER_01]: Just think about the wrinkling on your face is happening everywhere inside of your body.
04:35.888 --> 04:37.450
[SPEAKER_01]: All your organs are wrinkling up.
04:38.051 --> 04:41.215
[SPEAKER_01]: Our reduce, reduce regenerative potential.
04:41.636 --> 04:43.458
[SPEAKER_01]: So that's something we want to address.
04:43.879 --> 04:46.562
[SPEAKER_01]: And this is the first time that we have, we have a lot of tools.
04:46.923 --> 04:52.150
[SPEAKER_01]: But there's something fundamental about stem cells and what it can do for you.
04:52.490 --> 04:57.557
[SPEAKER_01]: So I'm, you know, because we're
04:59.225 --> 05:04.894
[SPEAKER_01]: the engine behind regeneration, because I'll talk about why.
05:04.974 --> 05:06.917
[SPEAKER_01]: So I should just get started.
05:07.979 --> 05:11.044
[SPEAKER_01]: So let's just talk about how we all seek the optimal.
05:11.124 --> 05:11.965
[SPEAKER_01]: That's why we're here.
05:11.985 --> 05:16.633
[SPEAKER_01]: We don't want to just live forever, but we want to live optimally forever, right?
05:16.653 --> 05:18.716
[SPEAKER_01]: So what causes our decline?
05:19.037 --> 05:21.480
[SPEAKER_01]: The root cause is really the aging process.
05:22.302 --> 05:26.228
[SPEAKER_01]: And so for example, when you look at osteoarthritis,
05:26.731 --> 05:28.634
[SPEAKER_01]: People think, oh, it's an wear and tear disease.
05:28.774 --> 05:31.679
[SPEAKER_01]: No, it's actually at an inflammatory disease.
05:32.240 --> 05:36.867
[SPEAKER_01]: As your body's lagging in this ability to regenerate.
05:36.967 --> 05:43.277
[SPEAKER_01]: Because if you look at us as little kids, you know, eight, ten years old, were we wearing and tearing our body?
05:43.798 --> 05:51.349
[SPEAKER_01]: We're doing a lot more damage to our bodies than what we're doing now, and what we're doing in our 70s, 80s, right?
05:51.430 --> 05:52.992
[SPEAKER_01]: We're not trying to wear and tear it.
05:52.972 --> 05:54.294
[SPEAKER_01]: your body couldn't repair.
05:54.374 --> 06:09.793
[SPEAKER_01]: So one example is when they try to put a knee construct, right, artificial piece of cartilage into the knee joint of, oh, osteoarthritis, knee, that construct will be eaten away by the joint itself because the joint is so inflammatory.
06:10.234 --> 06:12.657
[SPEAKER_01]: It doesn't allow it to stay.
06:12.757 --> 06:18.945
[SPEAKER_01]: It doesn't even allow the continuance of this healthy tissue.
06:18.925 --> 06:23.111
[SPEAKER_01]: So it's really because we have reduced capacity for regeneration.
06:23.511 --> 06:26.215
[SPEAKER_01]: That's causing, you know, this condition, also a lot of conditions.
06:26.536 --> 06:27.657
[SPEAKER_01]: You know, what causes aging?
06:27.677 --> 06:31.062
[SPEAKER_01]: So we're talking a little bit about the causes of aging.
06:31.102 --> 06:46.063
[SPEAKER_01]: If you look at different mechanisms, I'm sure this group is familiar with all these different mechanisms, mitochondrial dysfunction, genomic changes, and degradation, epigenetic changes,
06:46.043 --> 07:13.738
[SPEAKER_01]: So everything leads back to stem cell exhaustion because okay, so if you any of these problems or any tissue damage you have you have enough stem cells and the stem cells are good then you're replacing the damage tissue you're new again, right, but if you don't have the stem cells to come up and really get you to regenerate then the damage stays the inflammation stays and there's degradation.
07:14.309 --> 07:23.004
[SPEAKER_01]: all these potentials, all these problems can lead to stem cell exhaustion and an impaired cellular communication.
07:23.044 --> 07:31.358
[SPEAKER_01]: So the health of the stem cells eventually is going to determine the health of this entire organism and how long it's going to live and how well.
07:32.420 --> 07:34.984
[SPEAKER_01]: And so what I look at,
07:35.690 --> 07:42.947
[SPEAKER_01]: is what I consider disease and aging and really how one analogy is a burning building.
07:43.228 --> 07:48.780
[SPEAKER_01]: So if you think of the human body as a building, before the smoke comes out, was there fire?
07:49.181 --> 07:50.404
[SPEAKER_01]: There was fire going on, right?
07:50.865 --> 07:52.028
[SPEAKER_01]: And it was smoldering.
07:52.345 --> 07:56.050
[SPEAKER_01]: And that is the aging process, the whole smoldering process.
07:56.070 --> 08:03.038
[SPEAKER_01]: By the time the fire, the smoke comes out, that's a disease, then your doctor can diagnose you.
08:03.559 --> 08:08.105
[SPEAKER_01]: But before the disease is showing up, the aging is doing its work.
08:08.585 --> 08:13.932
[SPEAKER_01]: So what we want to do is to prevent the aging process
08:13.912 --> 08:15.798
[SPEAKER_01]: to where at least slow it down.
08:15.878 --> 08:20.854
[SPEAKER_01]: So that's why the inflammation aging is so tight in together as this word, you know, inflammation.
08:21.737 --> 08:24.445
[SPEAKER_01]: And so to show you why
08:25.572 --> 08:32.342
[SPEAKER_01]: uh, inflammation is such a driving force for aging, you know, some of the important aspects to even think about.
08:32.362 --> 08:47.125
[SPEAKER_01]: So you look at this gentleman, you know, he's, you know, probably his early 60s, his, you know, his vibrant, his boxing every day, but even for him, who's super healthy, his inflammation level is higher than a younger.
08:48.117 --> 08:50.860
[SPEAKER_01]: you know, younger guys, you know, in the 40s.
08:51.361 --> 08:58.770
[SPEAKER_01]: So, it doesn't matter if he didn't, he wasn't sick or anything, just by living to that age, his inflammation level is higher.
08:58.930 --> 09:00.972
[SPEAKER_01]: The inflammation markers are elevated.
09:01.853 --> 09:07.000
[SPEAKER_01]: And inflammation has been shown to be the driving force almost of all age-related diseases.
09:07.660 --> 09:15.610
[SPEAKER_01]: And these elevated levels can predict disease, diseases, and disability in the aging population.
09:16.147 --> 09:27.743
[SPEAKER_01]: and then increase the two love markers LL6 and CRP are strongly linked to poor physical performance, decreased muscle strength, cognitive decline, and early death.
09:29.495 --> 09:41.150
[SPEAKER_01]: Um, so here's this study that, um, that talks about how STEM cells can be a strategy for to target inflammation, that's acted as an anti-aging method.
09:41.491 --> 09:46.337
[SPEAKER_01]: So in this, um, rat TBI study, they infuse MSC.
09:46.357 --> 09:51.064
[SPEAKER_01]: So messing climate stem cells, this is kind of like one of the holy grails that we are using right now.
09:51.104 --> 09:56.751
[SPEAKER_01]: I don't think this end all be all forever, but this stage in STEM
09:56.731 --> 09:58.214
[SPEAKER_01]: the most important cells.
09:58.655 --> 10:03.904
[SPEAKER_01]: So they infuse MSCs into these rats with, you know, brain injuries.
10:04.265 --> 10:12.721
[SPEAKER_01]: And they showed decreased brain inflammatory cell infiltration, decreased microglias on type of immune cells, and apoptotic cell number.
10:12.761 --> 10:15.807
[SPEAKER_01]: So cells decrease number of cells that go on program cell death.
10:16.468 --> 10:20.275
[SPEAKER_01]: And another study, 172 rheumatoid arthritis patients,
10:20.255 --> 10:29.708
[SPEAKER_01]: And 16 loop is patient, they were giving them allergenic, so that's from another person, from somebody else, MSCs, they infuse these MSCs.
10:29.768 --> 10:32.752
[SPEAKER_01]: And that helped reestablish the balance in the immune system.
10:33.292 --> 10:38.740
[SPEAKER_01]: So it changes the immune system from a very pro-inflammatory to a more anti-inflammatory state.
10:39.200 --> 10:46.650
[SPEAKER_01]: And that could be traced by significant decrease in these inflammation markers, LS6,
10:46.883 --> 11:04.252
[SPEAKER_01]: TNF alpha and CRP levels, and another example is in patients with enclosing sponolitis, they're severe disease condition, they were also using allergenic MSCs, so these mesenchymos does decrease CRP levels and decrease disease activity.
11:04.752 --> 11:13.667
[SPEAKER_01]: In Crohn's disease, who these people were refractory to all these therapies that are available, they used MSCs and that correlated
11:13.647 --> 11:16.739
[SPEAKER_01]: with improved quality of life and improved CRP level.
11:16.779 --> 11:21.497
[SPEAKER_01]: So you see the going hand in hand between decreasing formation and decreased disease condition.
11:23.047 --> 11:34.066
[SPEAKER_01]: And, you know, I talked about, you know, this is when resimps so passionate is because, you know, looking tracing our origin and tracing the source of intelligence and these are, you know, that's who we came from.
11:34.086 --> 11:41.379
[SPEAKER_01]: And the reason that we do age or a significant part is because we're running out of stem cells.
11:41.760 --> 11:45.747
[SPEAKER_01]: So if you're just looking at us when we're born, everyone in 10,000 cells,
11:46.064 --> 11:47.025
[SPEAKER_01]: is an MSC.
11:47.045 --> 11:48.447
[SPEAKER_01]: So these mesenchymos themselves.
11:48.487 --> 11:50.150
[SPEAKER_01]: I'll talk just a little bit about what they are.
11:51.031 --> 11:54.996
[SPEAKER_01]: And but when we reach our teenage years is already one in 100,000.
11:55.156 --> 11:56.999
[SPEAKER_01]: So 10th vote less.
11:57.419 --> 12:03.247
[SPEAKER_01]: And then when we reach our 40s, it becomes one in 400,000, you're in our 80s, one in 2 million.
12:03.648 --> 12:08.815
[SPEAKER_01]: So you're literally running out of these engines that's helping you to regenerate.
12:09.605 --> 12:13.373
[SPEAKER_01]: And so this is graph of the drastic decline as we age.
12:13.434 --> 12:19.808
[SPEAKER_01]: So even though you're just reaching teenage years, but your body has dramatically less regenerative capabilities.
12:20.089 --> 12:21.251
[SPEAKER_01]: So these are MICs.
12:22.554 --> 12:26.483
[SPEAKER_01]: When they are, so what they are is that these cells are,
12:26.463 --> 12:28.486
[SPEAKER_01]: everywhere along your blood vessels.
12:29.026 --> 12:35.755
[SPEAKER_01]: Anywhere you have blood supply, which is everywhere, you will have these cells that are huddling around the blood vessels.
12:35.775 --> 12:40.402
[SPEAKER_01]: So you're looking at them, I think of them like geckles, you know, they're hugging the blood vessels.
12:40.782 --> 12:47.391
[SPEAKER_01]: So what they're doing, you see all those tentacles, all these feet, they are sensing what's going on in the blood.
12:47.371 --> 12:57.348
[SPEAKER_01]: So they're able to sense if there's inflammation going on somewhere, is immune system trying to send signals hormones, they're trying to figure out having the pulse on your systemic condition.
12:57.849 --> 13:06.544
[SPEAKER_01]: But they also have all these, you know, this, you know, I guess 10 calls they can also sense what's going on in the neighborhood.
13:06.524 --> 13:14.224
[SPEAKER_01]: So they have communication with neighboring cells, with neighboring stem cells, they can talk to local stem cells.
13:14.485 --> 13:19.498
[SPEAKER_01]: If needed, they can tell the local stem cells, hey, you need to divide, you need to make me new tissue.
13:19.839 --> 13:22.305
[SPEAKER_01]: So they don't themselves rarely.
13:22.285 --> 13:23.568
[SPEAKER_01]: to become new tissue.
13:23.608 --> 13:31.667
[SPEAKER_01]: This is why it's fundamental difference in this stem cell therapy that we're not relying on these cells ability to form new cells and new tissue.
13:32.008 --> 13:35.416
[SPEAKER_01]: We're counting their ability to coordinate this regeneration.
13:35.837 --> 13:40.328
[SPEAKER_01]: So that's why, you know, I call them the master regeneration that they're
13:40.308 --> 13:43.455
[SPEAKER_01]: kind of the conductor and the symphony of regeneration.
13:44.177 --> 13:45.741
[SPEAKER_01]: And these are just what they look like.
13:46.723 --> 13:53.178
[SPEAKER_01]: The fact that they are so important in the whole signaling of regeneration.
13:53.198 --> 13:58.350
[SPEAKER_01]: This is why the doctor who discovered these cells, Dr. Arnold Kaplan, he wanted to
13:58.330 --> 13:59.733
[SPEAKER_01]: change the name of these cells.
14:00.054 --> 14:01.717
[SPEAKER_01]: He was like stop calling them stem cells.
14:01.757 --> 14:04.583
[SPEAKER_01]: You know these are these are whole different category.
14:04.603 --> 14:16.609
[SPEAKER_01]: He wants to change them to be medicinal signaling cells because we've seen that's how they conduct their work is by monitoring and sending signals.
14:17.905 --> 14:18.846
[SPEAKER_01]: So how do they work?
14:19.106 --> 14:22.589
[SPEAKER_01]: So these MSCs, first of all, they're highly anti-inflammatory.
14:22.609 --> 14:35.721
[SPEAKER_01]: That's one of the benefits, not only the support about a lot of research, but also for me, just seeing patients and me have drastic anti-inflammatory effects sometimes really fast.
14:35.741 --> 14:36.922
[SPEAKER_01]: Just give you a couple of examples.
14:37.963 --> 14:43.388
[SPEAKER_01]: For example, one time I treated a liver cirrhosis patient and he wasn't in hospital.
14:43.408 --> 14:47.592
[SPEAKER_01]: So he didn't have much longer to live.
14:47.943 --> 14:53.992
[SPEAKER_01]: And I give him one injection on his way back to Sacramento on the drive back.
14:54.052 --> 14:59.660
[SPEAKER_01]: His brother told us, oh my god, my brother's that's swelling in the abdomen has gone down a lot.
15:00.040 --> 15:02.844
[SPEAKER_01]: This is just on the drive back, right, within hours.
15:03.745 --> 15:05.508
[SPEAKER_01]: These are the fast and time inflammatory effect.
15:05.548 --> 15:14.220
[SPEAKER_01]: Another patient who had rheumatoid arthritis, you know, wonderful lady, surgical technician and she couldn't work because she couldn't even make a fist.
15:14.200 --> 15:21.827
[SPEAKER_01]: And when I was giving her stem cell infusion in the middle of the infusion, you know, because infusion probably takes about 40, 45 minutes in the middle of the infusion.
15:21.967 --> 15:22.668
[SPEAKER_01]: And she did this.
15:23.228 --> 15:23.729
[SPEAKER_01]: She did this.
15:24.650 --> 15:25.631
[SPEAKER_01]: And she started crying.
15:26.251 --> 15:28.553
[SPEAKER_01]: She said, I haven't been able to make a fit for two months.
15:29.214 --> 15:30.415
[SPEAKER_01]: And she just started crying.
15:30.435 --> 15:34.879
[SPEAKER_01]: And and there's another patient is really interesting.
15:34.959 --> 15:37.562
[SPEAKER_01]: She had Alzheimer's in her 60s.
15:37.602 --> 15:41.946
[SPEAKER_01]: She's very severely, you know,
15:41.926 --> 15:46.211
[SPEAKER_01]: even who her husband was and so she stopped feeding herself for a couple months.
15:46.271 --> 15:53.238
[SPEAKER_01]: So she may be hungry, but she would just sit in front of plate of food and she wouldn't touch a knife and fork to just she couldn't feed herself.
15:53.819 --> 15:56.141
[SPEAKER_01]: And I gave her a stem salt treatment the next day.
15:56.161 --> 16:02.949
[SPEAKER_01]: So the husband told me later that they put the plate of food in front of her and she picked up a knife and fork and just ate.
16:03.349 --> 16:06.853
[SPEAKER_01]: And her husband was like, looking at her like this and she would be like,
16:06.833 --> 16:07.855
[SPEAKER_01]: you know, what's your problem?
16:08.335 --> 16:24.001
[SPEAKER_01]: And that to me is this quick, anti-inflammatory action of the cells because what I think of her brain is so inflamed and so jammed up that the cell cannot, one cell cannot communicate with another cell.
16:24.382 --> 16:30.051
[SPEAKER_01]: So the, the, the signals just doesn't pass through, she may be hungry, but there's absolutely no way to communicate.
16:30.411 --> 16:32.655
[SPEAKER_01]: All of a sudden when you can clear the pathway,
16:32.922 --> 16:36.086
[SPEAKER_01]: And you call the inflammation, the cells are actually able to communicate.
16:36.146 --> 16:38.169
[SPEAKER_01]: So it's just anti-inflammatory effect.
16:38.189 --> 16:39.030
[SPEAKER_01]: It's really wonderful.
16:39.090 --> 16:52.508
[SPEAKER_01]: And then a new modulatory, which is shifting on immune system from a more inflammatory anti-inflammatory condition, state, that's why the, for autoimmune conditions is so powerful.
16:53.750 --> 16:56.073
[SPEAKER_01]: I've seen, I mean, I used to have cat allergies.
16:56.334 --> 17:01.140
[SPEAKER_01]: And you know, I was, you know, hacking and coughing
17:01.407 --> 17:06.594
[SPEAKER_01]: And taking medications and after stem cell treatment, you know, it's been, yeah, this has been six years.
17:06.674 --> 17:09.258
[SPEAKER_01]: I don't need any any medications.
17:09.658 --> 17:16.668
[SPEAKER_01]: So I've seen, you know, the immune system getting to a more healthy state the regenerative potential.
17:16.728 --> 17:21.794
[SPEAKER_01]: That's the talking with the local stem cells and telling them to regenerate.
17:21.855 --> 17:31.127
[SPEAKER_01]: So this local effect and the endogenic benefits is that it does help you to regenerate and grow new blood vessels because you've
17:31.107 --> 17:39.982
[SPEAKER_01]: We regenerate cells tissue if there's no blood supply, it doesn't help you any right you need to supply nutrients and remove waste.
17:40.883 --> 17:52.322
[SPEAKER_01]: So the antiogenic potential is very powerful and another potential way that these cells work is mitochondria transfer so we all know about mitochondria decline and what's fascinating.
17:52.606 --> 17:58.213
[SPEAKER_01]: is that these stem cells actually can deliver fresh new mitochondria to your cells.
17:58.233 --> 18:12.913
[SPEAKER_01]: It's able to tell that your cells mitochondria is not doing well, and either it can shoot off mitochondria into the space and the mitochondria can enter or put mitochondria in a vesicle, and the vesicle will fuse within, you know, your own cell that may need the mitochondria.
18:13.433 --> 18:17.078
[SPEAKER_01]: Or establish this nanotubial and mitochondria can
18:17.058 --> 18:18.620
[SPEAKER_01]: can walk across the tubio.
18:18.640 --> 18:24.189
[SPEAKER_01]: So they call these on intellectual microscopy, can walk across the tubio and get to the recipient's cell.
18:24.469 --> 18:27.734
[SPEAKER_01]: So you're rescuing the mitochondria, the energy level of the cells.
18:28.215 --> 18:30.298
[SPEAKER_01]: So it's really powerful.
18:30.358 --> 18:33.243
[SPEAKER_01]: I, you know, some people have mitochondria disorders.
18:34.064 --> 18:36.147
[SPEAKER_01]: They've actually shown using
18:36.363 --> 18:41.190
[SPEAKER_01]: stem cells through mitochondria transfer that these people are doing better.
18:42.071 --> 19:03.282
[SPEAKER_01]: Anti-faburotic property is very important because when I'm treating people, like the liver cirrhosis patients, so that patient I treated within two months, he's liver function became normal, which was shocking because I just given one infusion, I did not anticipate that because I told him to come back in a couple of weeks and he didn't come back and I didn't know what happened to him and then I found out
19:03.262 --> 19:04.663
[SPEAKER_01]: that he was doing fantastic.
19:05.764 --> 19:09.167
[SPEAKER_01]: So sometimes, just have these amazing, amazing results.
19:09.868 --> 19:13.792
[SPEAKER_01]: And liver ciruses is a fibroctic disease, regular liver is a sturorosing.
19:13.872 --> 19:17.315
[SPEAKER_01]: It's heartening and losing cells.
19:17.735 --> 19:25.383
[SPEAKER_01]: So it's able to break down the scar tissue and same for COPD, I love treating COPD patients because it's so easy.
19:25.403 --> 19:31.328
[SPEAKER_01]: The first, when I give people stem cells through intravenous route, the first place they go to is the lungs.
19:31.679 --> 19:37.526
[SPEAKER_01]: And if you have a lung problems and a lot of inflammation going on, a lot of cells are going to stay there and try to fix it for you.
19:38.007 --> 19:56.050
[SPEAKER_01]: So this is another reason that, you know, we meet, we may need different waves of cells because you have a lot of inflammation, all your body, you know, if you have a, this number of cells, and you get into the body to fix that amount of inflammation, that amount of inflammation may end up killed some of the cells, because inflammation is toxic.
19:56.502 --> 19:59.565
[SPEAKER_01]: to not only your own cells but also to stem cells that's given to you.
20:00.085 --> 20:07.833
[SPEAKER_01]: So you may end up fighting the condition but you're losing some of the cells and the process right there sacrifice and the fight for you.
20:08.414 --> 20:16.061
[SPEAKER_01]: So there's so only so much, you know, you're only giving so many cells in one infusion and you may need a second wave for further repair.
20:16.782 --> 20:20.485
[SPEAKER_01]: And then anti-apoptotic properties really interesting.
20:20.545 --> 20:25.210
[SPEAKER_01]: So let's say somebody has a stroke
20:25.190 --> 20:28.977
[SPEAKER_01]: blood is cut off that becomes dead tissue, right?
20:28.997 --> 20:30.059
[SPEAKER_01]: That's the stroke center.
20:30.500 --> 20:43.384
[SPEAKER_01]: But the neighboring cells somehow are going on and become dead pretty soon because of this cascade of, you know, a chemical reaction is calcium cascade and these cells ended up,
20:43.702 --> 20:44.743
[SPEAKER_01]: dying.
20:45.004 --> 20:59.063
[SPEAKER_01]: So they're going on program cell death, even though they don't have to, but stem cells can come in rescue, so you can imagine radiation therapy or crush injuries, things of that nature when neighboring cells may die, the stem cells that they able to rescue them.
20:59.664 --> 21:01.727
[SPEAKER_01]: On the other hand, they also have, um,
21:02.298 --> 21:03.640
[SPEAKER_01]: pro-apoptotic.
21:03.660 --> 21:05.864
[SPEAKER_01]: So apoptosis is program self-death.
21:05.904 --> 21:09.149
[SPEAKER_01]: So pro-apoptotic, that means pro-death.
21:09.590 --> 21:14.859
[SPEAKER_01]: So these happens when you have senescent cells or cancer cells.
21:15.260 --> 21:22.011
[SPEAKER_01]: So when the cells are dysfunctional when they don't belong, these
21:21.991 --> 21:29.102
[SPEAKER_01]: mesenchymos themselves are able to tell that they shouldn't be there, and they will send the signal to trigger them into program self-death.
21:29.563 --> 21:34.290
[SPEAKER_01]: So senescent cells is not just not working, not doing anything good for you.
21:34.591 --> 21:36.013
[SPEAKER_01]: They're actively toxic.
21:36.073 --> 21:39.579
[SPEAKER_01]: They secret things that cause damage to your neighboring cells.
21:39.959 --> 21:48.673
[SPEAKER_01]: So when you remove them, that's why, you know, people can have such great recovery is because you're removing the dysfunctional cells.
21:48.653 --> 21:50.155
[SPEAKER_01]: and of course the cancer cells.
21:50.856 --> 21:55.962
[SPEAKER_01]: So stem cells have been used in cancer treatment and has been shown good results, but I'll talk a little bit about that later.
21:56.002 --> 21:58.845
[SPEAKER_01]: There's some nuances in the anti-microbial.
21:58.865 --> 22:09.598
[SPEAKER_01]: So these MICs have been shown to have direct anti-microbial properties so they can actually secrete anti-microbial peptides and directly kill off microbes.
22:10.557 --> 22:11.459
[SPEAKER_01]: So that's the range.
22:11.479 --> 22:12.843
[SPEAKER_01]: That's a lot of functions, right?
22:15.088 --> 22:18.055
[SPEAKER_01]: So one word about young versus old MSCs.
22:18.075 --> 22:25.233
[SPEAKER_01]: So part of my mission is to find out what's the best source of stem cell for patients because there's so many things out there.
22:25.273 --> 22:26.035
[SPEAKER_01]: There's so many,
22:26.015 --> 22:32.122
[SPEAKER_01]: claims and people use fadderive, you know, bone marrow derived and, you know, unblockal core derived.
22:32.623 --> 22:38.229
[SPEAKER_01]: So when I came on the scene, I was like, all I wanted to know which one works the best.
22:38.349 --> 22:41.974
[SPEAKER_01]: That's what I want to do because whichever one works the best, that's what I'm going to do.
22:42.494 --> 22:44.016
[SPEAKER_01]: So I went on a mission to find out.
22:44.477 --> 22:53.307
[SPEAKER_01]: And some of this information is accumulated in what I was trying to find out what's the research all around the world about the differences between different kinds of stem cells.
22:53.327 --> 22:55.009
[SPEAKER_01]: So I actually have a lecture on YouTube.
22:54.989 --> 23:01.580
[SPEAKER_01]: is called our OMSC's created equal, where I went into great depth about these different sources and comparisons.
23:02.021 --> 23:12.338
[SPEAKER_01]: But just the words on young versus old MSC, so you know all of us here, you know, when mature adults, you know, our MSC's are a lot older than what's in a local court, right?
23:13.119 --> 23:14.261
[SPEAKER_01]: The virtual reward.
23:14.802 --> 23:16.525
[SPEAKER_01]: So that's age matter.
23:16.505 --> 23:25.573
[SPEAKER_01]: The fact that these MSEs are in us, our entire lifetime, makes them very susceptible to accumulation of cellular damages.
23:26.014 --> 23:28.977
[SPEAKER_01]: So the longer we live, the more we accumulate these damages.
23:28.997 --> 23:37.605
[SPEAKER_01]: So that can lead to cell deaths, cinescence, laws of magenta functions, or even cancers, changes, neoplastic transformations.
23:38.305 --> 23:45.432
[SPEAKER_01]: But neonatal MSEs, so these are very young, birth tissue.
23:45.749 --> 23:50.716
[SPEAKER_01]: by as a part of the and local court and their spared of these pro-aging factors.
23:52.378 --> 23:57.445
[SPEAKER_01]: So some other evidence when they looked at aged, out of post-derived MSEs.
23:57.465 --> 23:59.407
[SPEAKER_01]: So these are fact-derived MSEs.
23:59.488 --> 24:04.074
[SPEAKER_01]: What they do is when they extract the fat is not that the fat has any MSEs.
24:04.174 --> 24:07.058
[SPEAKER_01]: It's the blood vessels that are supplying the fat everywhere.
24:07.338 --> 24:09.882
[SPEAKER_01]: They're getting the MSEs out of there.
24:10.542 --> 24:15.469
[SPEAKER_01]: And so these are significantly compromised when a person is older.
24:15.449 --> 24:26.418
[SPEAKER_01]: So, they were looking at when they used these, they were unable to support repair.
24:26.498 --> 24:28.443
[SPEAKER_01]: So, age associated impairment.
24:28.463 --> 24:29.526
[SPEAKER_01]: So, when we get older,
24:29.894 --> 24:46.013
[SPEAKER_01]: We have less ability for wound healing and so they were not able to to improve wound healing any further because they are just that that's all they can do and when they use bone marrow drive that my sees they also show that they have less.
24:46.280 --> 25:04.339
[SPEAKER_01]: Myogenic potential, so less ability to form muscles and less capable to engraft, staying in the in the in the donor, I mean in the recipient, then developmentally early MSC so they you know older MSC's have less differentiation potential.
25:04.724 --> 25:24.150
[SPEAKER_01]: and less ability to stay where, you know, they're, they're transplanted and bone marrow derived MICs also exhibit age related decline in inflammatory response and other type of responses that are important for the MIC's migration and activation and their capabilities.
25:24.485 --> 25:31.914
[SPEAKER_01]: When you look at genetic material in adipose direct stem cells, they do decline when we age.
25:32.155 --> 25:43.088
[SPEAKER_01]: So there's senescence, genes that express that the cells are becoming older and, you know, senescing, and that increases with age in these adipose direct stem cells.
25:43.609 --> 25:53.361
[SPEAKER_01]: And aging also alters capabilities of these cells of adipose direct stem cells to form blood vessels.
25:56.733 --> 26:06.325
[SPEAKER_01]: There's also increased level of reactive oxygen species in bone marrow-derived MICs in aging bone marrow-derived MICs.
26:06.745 --> 26:19.140
[SPEAKER_01]: So not only they have increased level of these reactive oxygen species that can cause damages, they're also more sensitive to the reactive oxygen species that's in the environment, so it's double whammy.
26:19.581 --> 26:24.867
[SPEAKER_01]: So they have increased levels and they're more sensitive, but they're more prone to damages.
26:26.652 --> 26:36.815
[SPEAKER_01]: And young MSCs from year one to five, all performed older MSCs from somebody that's aged 50 to 70 in improving cardiac parameters.
26:37.016 --> 26:42.889
[SPEAKER_01]: So after heart attack, if they try to treat the patient,
26:42.869 --> 26:47.281
[SPEAKER_01]: the younger stem cells will lead to better results, better improvements.
26:48.003 --> 26:54.381
[SPEAKER_01]: And then MSC's from young individuals can't undergo neural and actual dermal differentiation.
26:54.421 --> 26:57.891
[SPEAKER_01]: So that's the, you know, basically all the neuronal.
26:57.871 --> 27:05.425
[SPEAKER_01]: lineage differentiation, but when you use bone marrow stem cells from an elderly patient, they loss that capability.
27:05.445 --> 27:11.516
[SPEAKER_01]: So their ability to form maybe neurons that has been lost when you get older.
27:11.536 --> 27:18.850
[SPEAKER_01]: And from another study, adult MSCs are exposed to a lifetime of
27:18.830 --> 27:25.118
[SPEAKER_01]: factors of things we do to our body, including something as benign, as insects, you know, on time flammatures we take.
27:25.659 --> 27:32.588
[SPEAKER_01]: And that the insects can inhibit MSC's capability to form cartilage and bones.
27:33.409 --> 27:39.257
[SPEAKER_01]: So, you know, we are, you know, we're all exposed to a lot of toxic factors, you know, whether or not we like it.
27:40.559 --> 27:46.086
[SPEAKER_01]: Lifestyle factors also affect MSC something like a high-fat diet,
27:46.353 --> 27:59.882
[SPEAKER_01]: So they showed high fat, fed mice, had the higher, so these cells tend to differentiate more to work fat, rather than more toward endothelio, so the interlining of the blood vessels.
28:00.303 --> 28:04.632
[SPEAKER_01]: So it changes where they wanna go and who they can become.
28:04.612 --> 28:11.868
[SPEAKER_01]: And when you look at a bee's patients, their ability to form bones, the osteogenic potential are impaired.
28:11.948 --> 28:20.848
[SPEAKER_01]: So when you look at their MICs, they're able to the nodules and mineralization they can form is fewer and smaller.
28:20.828 --> 28:27.797
[SPEAKER_01]: and metabolic diseases changes environment that adipose direct stem cells are in.
28:28.157 --> 28:37.189
[SPEAKER_01]: So these cells can lose their capabilities to form vascular network that they've shown that both in the future dish and live animals.
28:37.349 --> 28:44.759
[SPEAKER_01]: So, you know, we all know the BCD rate and how diabetes 8% with diabetes in the country.
28:44.779 --> 28:49.485
[SPEAKER_01]: So, all these are factors when we consider using stem cells from our own body.
28:50.782 --> 28:57.592
[SPEAKER_01]: And aging also can lead to decreased bone marrow mesenchymos stem cells.
28:57.932 --> 29:02.359
[SPEAKER_01]: So bone marrow have about 0.1 to 0.01% of mesenchymos stem cells.
29:02.379 --> 29:04.282
[SPEAKER_01]: So not that much to begin with.
29:04.942 --> 29:08.327
[SPEAKER_01]: But when you age, you start to lose more.
29:09.048 --> 29:11.913
[SPEAKER_01]: You just have less and less mesenchymos stem cells in your bone.
29:12.934 --> 29:15.017
[SPEAKER_01]: And that could be one of the reasons
29:14.997 --> 29:24.713
[SPEAKER_01]: for osteoporosis because these mesenchymal stem cells tend to more tend to differentiate more into fat cells rather than bone cells.
29:26.416 --> 29:35.250
[SPEAKER_01]: And when you transplant young MSCs into the bone marrow of old mice, not only rescues the bone loss, but it also delays aging.
29:35.990 --> 29:47.919
[SPEAKER_01]: And even if you do it subcutaneously, so even if you just put it in the skill layers, inject into the skill layers, that can also suppress age-related degeneration of various organs.
29:48.380 --> 29:52.851
[SPEAKER_01]: So Michael is to put the cells somewhere in the body, because once it's in the body,
29:52.831 --> 30:03.787
[SPEAKER_01]: Yes, if you put locally, we're treating local problems more will stay in that area, but some will also, you know, always end up somewhere else because, you know, this is a fluid dynamic system.
30:04.347 --> 30:13.461
[SPEAKER_01]: So as long as you put, you know, even for, you know, what I do stem cell facial inject stem cells into the skin layer, the key is to get it in there and then the cells can do his own work.
30:14.742 --> 30:22.213
[SPEAKER_01]: So like they say, you know, you can hear even subcutaneous, it can delay some other degeneration associated with aging.
30:22.885 --> 30:31.540
[SPEAKER_01]: And so aging of MICs is also detrimental to things like your hematopoatic systems or your whole blood forming system.
30:32.181 --> 30:43.260
[SPEAKER_01]: And aging compromises therapeutic potential at these MICs, including the cells from not only people who are older, but also when you expand the cells for many generations.
30:43.541 --> 30:47.728
[SPEAKER_01]: So you age them when you grow them in the incubator and let them keep dividing.
30:49.615 --> 31:05.119
[SPEAKER_01]: Um, so stem cells, this study showed that stem cells from older donors have defective functions, including their impaired capability to proliferate and differentiate when compared to cells from younger individuals.
31:05.800 --> 31:15.876
[SPEAKER_01]: And when you look at, uh, function of bone marrow direct stem cells isolated from young, uh, mice,
31:15.856 --> 31:22.847
[SPEAKER_01]: The bone marrow stem cells from old animals are significantly less capability for differentiation.
31:22.887 --> 31:39.433
[SPEAKER_01]: And when you transplant young bone marrow stem cells, it delays the decrease in bone densities, but what's really fascinating is that if you transplant old bone marrow drips stem cells, it can actually accelerate the decline in bone density.
31:39.413 --> 31:43.318
[SPEAKER_01]: So what are some of the evidence of anti-aging benefits from stem cell therapy?
31:43.879 --> 31:46.642
[SPEAKER_01]: So there are some studies I want to show you, which are really interesting.
31:47.143 --> 31:50.327
[SPEAKER_01]: So this is general background information.
31:50.367 --> 31:56.956
[SPEAKER_01]: H does lead to progressive deterioration of a colonurgic and doconurgic systems.
31:57.256 --> 31:59.559
[SPEAKER_01]: So that's in both our muscles and our brain.
31:59.920 --> 32:05.387
[SPEAKER_01]: You know, muscle mass is important, of course, you know, maintaining brain capacity is important as we age.
32:05.654 --> 32:18.309
[SPEAKER_01]: So the concentration of neurotopens in the brain and muscles decline leading to reduced neurogenesis, accelerated muscular atrophy, and that can lead to impairment both cognitively and in your physically.
32:19.190 --> 32:24.837
[SPEAKER_01]: Aging can lead to exhaustion of stem cell population as we've seen in the statistics.
32:25.498 --> 32:34.328
[SPEAKER_01]: And various stem cells can exert neural protective effects and enhance functional recovery by secreting neurotopic factors.
32:34.308 --> 32:41.081
[SPEAKER_01]: and concentration of this tow bar at T-bars is by product of lipid prostration.
32:41.101 --> 32:52.823
[SPEAKER_01]: So just kind of waste product that increases significantly in the brain, muscle, heart, liver and lungs of aging rats and along with a decreased blood vessel density.
32:52.803 --> 32:55.647
[SPEAKER_01]: So these are just signs of aging.
32:56.448 --> 33:16.034
[SPEAKER_01]: And what they did, well, first of all, they have seen the Adapose Drive MICs can increase the concentration of neurotransmitter, acetylcholine, and also some growth factors, brain-derived neurotropic factor, and nerve growth factor, and those can improve cognitive physical function of aging mice.
33:16.835 --> 33:21.882
[SPEAKER_01]: And Adapose Devote Drive MICs can also
33:21.862 --> 33:28.211
[SPEAKER_01]: So, helping with blood formation and extending lifespan in an ALS mouse model.
33:28.993 --> 33:37.485
[SPEAKER_01]: And even this muscle derived progenitor cells can extend health span and lifespan of progeria mice.
33:37.505 --> 33:39.849
[SPEAKER_01]: So, these are prematurely aging mice.
33:41.051 --> 33:48.021
[SPEAKER_01]: They do this by restoring micro vessels and muscle fibers by creating different factors.
33:49.300 --> 33:59.194
[SPEAKER_01]: So in this experiment, which is very interesting, they started at age 10, which is kind of middle age for mice that rats.
33:59.254 --> 34:08.246
[SPEAKER_01]: So these rats, they give them either control or any hunting membrane derived MICs or adipose derived MICs.
34:09.088 --> 34:17.299
[SPEAKER_01]: And they give these cells intravenously through the main and the tail, once a month, throughout the rest of their lives.
34:17.448 --> 34:24.496
[SPEAKER_01]: And the stem cell group showed improved cognitive and physical function of these naturally aging rats.
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[SPEAKER_01]: Life span extended by between 23 to 31%.
34:31.064 --> 34:39.414
[SPEAKER_01]: And by the time these rats, right, they were 10 months old, by the time they reached 20 months of age in the control group, only 30% of rats are still alive.
34:40.055 --> 34:47.083
[SPEAKER_01]: But in the ones that got stem cells, there's between 70 to 100% of them, the rats are still alive.
34:47.249 --> 34:52.037
[SPEAKER_01]: So there's a big difference, and by 23 months, all the rats in the control group have died.
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[SPEAKER_01]: But between 60 to 72 percent of the stem cell group are still alive.
34:59.851 --> 35:05.541
[SPEAKER_01]: And some of the transplant cells were able to, they found them to differentiate even into neurons.
35:06.583 --> 35:11.552
[SPEAKER_01]: So there's a significant differentiation rate, so we're just fascinating.
35:13.068 --> 35:16.718
[SPEAKER_01]: And when they looked at the different factors that we talked about.
35:16.738 --> 35:18.965
[SPEAKER_01]: So there's brain neurotropic factors.
35:20.208 --> 35:26.245
[SPEAKER_01]: They were restored to a level higher than when they were, you know, a younger rats.
35:26.646 --> 35:28.090
[SPEAKER_01]: And muscular.
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[SPEAKER_01]: New Archbishop of Factors were also restored, you know, back to levels younger than the younger rats, and they looked at the blood vessels, and their density also have increased comparable to the level of the young rat, so the restored and geogenesis.
35:47.425 --> 35:51.851
[SPEAKER_01]: And the tissue injury was almost fully restored.
35:51.871 --> 36:01.184
[SPEAKER_01]: And the monthly transplantation of these stem cells have markedly increased the rats, stamina, and cognitive functions.
36:01.264 --> 36:03.748
[SPEAKER_01]: So that's talking about vitality, right?
36:04.249 --> 36:06.592
[SPEAKER_01]: So cognitively and physically.
36:07.513 --> 36:14.563
[SPEAKER_01]: And then acetylcholine concentration in both the cerebellum spinal fluid and the muscles have been restored.
36:15.117 --> 36:16.881
[SPEAKER_01]: back to the younger state.
36:17.642 --> 36:29.446
[SPEAKER_01]: And the genus version that which changes, right, genes start to degrade as we get older, and those changes were also reversed.
36:29.466 --> 36:35.438
[SPEAKER_01]: So they were able to measure all these different, you know, tangible outcomes.
36:35.992 --> 36:42.044
[SPEAKER_01]: And the number of the host stem cells in age rats is a lot less, right?
36:42.084 --> 36:54.709
[SPEAKER_01]: It's only 28, 27.8% of the younger rats, but when we infuse these new stem cells, they increase the number of these host stem cells to the level that's comparable to younger time.
36:54.689 --> 37:05.146
[SPEAKER_01]: and the expression of certain things as suppresses neurogenesis of this particular molecule that has been fully reversed.
37:05.707 --> 37:18.828
[SPEAKER_01]: So then you can restore neurogenesis and stem cell therapy so in conclusion, you know, can restore colonurgic and dopanturgic nervous system and microbezzles and muscle mass and anti-oxidative capabilities.
37:19.890 --> 37:21.793
[SPEAKER_01]: And then I want to show you another study
37:23.360 --> 37:27.024
[SPEAKER_01]: which is really interesting because this that we started a little later.
37:27.044 --> 37:32.571
[SPEAKER_01]: So they started these rats, these are mice at age 15 months.
37:32.831 --> 37:35.574
[SPEAKER_01]: So this is human equivalent age of 75.
37:36.155 --> 37:41.341
[SPEAKER_01]: So these are much older mice and 50% of their peers have died.
37:41.681 --> 37:43.783
[SPEAKER_01]: That's how they determine the time.
37:44.804 --> 37:51.392
[SPEAKER_01]: And they were giving them intravenous bone marrow transplantation from bone marrow cells of the younger
37:51.878 --> 38:04.521
[SPEAKER_01]: So they give them also through IV route six times within three months, so every two weeks and the mice that's only three to 15 weeks were the donors.
38:07.049 --> 38:13.459
[SPEAKER_01]: And the result is that the maximum lifespan of the transplanted mice were increased by over 30%.
38:14.080 --> 38:15.422
[SPEAKER_01]: So that has been pretty consistent.
38:15.442 --> 38:18.427
[SPEAKER_01]: This extending of lifespan by 30% has been consistent.
38:18.927 --> 38:30.846
[SPEAKER_01]: And the survival time from the beginning of the experiment was increased by 3.2% a fold, which means that is that having one month left, if you got the stem cells, you could have three months left.
38:30.826 --> 38:41.906
[SPEAKER_01]: So at age 19.3 months, it's kind of funny, but the last mouse of the control group died sedentary, almost a mobile, a hunchbacked with poor hair.
38:42.467 --> 38:46.916
[SPEAKER_01]: The transplanted mice were active, had even spine, and shiny even hair.
38:47.136 --> 38:49.961
[SPEAKER_01]: So their vibrant is not just living longer.
38:49.981 --> 38:51.484
[SPEAKER_01]: They're living well.
38:51.852 --> 38:58.583
[SPEAKER_01]: And these observed lifespan, definitely was a company by the healthy life period.
38:59.084 --> 39:03.892
[SPEAKER_01]: And there's chimerism, which means that one individual have two sets of genetic material.
39:04.293 --> 39:10.944
[SPEAKER_01]: So there's these new cells dis-stay in the mice and a lot of them dis-stay the chimerism was 28%.
39:12.066 --> 39:15.852
[SPEAKER_01]: So this is very encouraging for us as humans.
39:15.832 --> 39:19.917
[SPEAKER_01]: And this is just a study on humans.
39:20.037 --> 39:24.582
[SPEAKER_01]: It's not a big study, but there's still we still need more human studies.
39:25.483 --> 39:27.906
[SPEAKER_01]: This is 20 patients with chronic inflammation.
39:27.926 --> 39:34.033
[SPEAKER_01]: And they were just getting one IV infusion of a local core blood derived stem cells for anti-aging purposes.
39:35.574 --> 39:39.679
[SPEAKER_01]: So half of them showed improvement in CBC, so in their blood count, their
39:40.132 --> 39:45.404
[SPEAKER_01]: chemistry, comprehensive, you know, a panel, their liver function, and their cholesterol.
39:46.486 --> 39:59.575
[SPEAKER_01]: And they evaluate the changes in their for antiaging benefits, you know, at 24 hours, two weeks, and three months, and showed improvement in skin hair, nail growth, energy level, libido, mood, sleep, and pain levels.
40:01.225 --> 40:02.066
[SPEAKER_01]: Yeah.
40:02.346 --> 40:07.370
[SPEAKER_01]: So just this, just the last study, just going to show a little about frailty.
40:07.431 --> 40:10.153
[SPEAKER_01]: So frailty is actually a big problem when we age.
40:10.894 --> 40:17.700
[SPEAKER_01]: People get very frail and that's correlated with you know, hospitalization, institutionalization, disability and death.
40:19.221 --> 40:22.924
[SPEAKER_01]: So you, you know, there's huge percentage.
40:23.024 --> 40:29.410
[SPEAKER_01]: Well, there's seven to 12 percent of adults over age 65
40:29.390 --> 40:38.532
[SPEAKER_01]: fit the definition of frailty, but there's free frailty, which means they fit partial criteria as large as 35 to 50%.
40:38.592 --> 40:47.213
[SPEAKER_01]: So there's a lot of frailty, which is associated with comorbidities with all your organ systems and neurological and psychiatric issues.
40:47.682 --> 41:01.099
[SPEAKER_01]: So, and they show that there's strong link between frailty, inflammation, and the imparitability to repair injuries to the fact that there's not enough stem cells.
41:01.780 --> 41:05.324
[SPEAKER_01]: And aging induces a quiescent to senescent switch.
41:05.825 --> 41:08.188
[SPEAKER_01]: So, you may have stem cells that are
41:08.168 --> 41:12.678
[SPEAKER_01]: they're just, you know, hibernating, they're not doing anything they're waiting.
41:13.219 --> 41:15.924
[SPEAKER_01]: And then aging made them switch to senescence.
41:15.945 --> 41:20.895
[SPEAKER_01]: So before they even can get to work, they're already aged, they're old, and they're causing problems.
41:21.719 --> 41:27.588
[SPEAKER_01]: And they have shown that MICs can undergo synestens.
41:27.749 --> 41:33.898
[SPEAKER_01]: So as we go older, they can become older and become less effective.
41:34.619 --> 41:37.464
[SPEAKER_01]: And their capability is gradually disappear.
41:38.005 --> 41:47.119
[SPEAKER_01]: And intravenous delivered allergenic MICs, so from somebody else, are safe and can produce significant improvement in physical performance.
41:47.099 --> 41:49.891
[SPEAKER_01]: and as well as inflammation markers.
41:50.333 --> 41:57.463
[SPEAKER_01]: So that's the size, you know, a little bit of examples and the anti-aging protocol that I use is
41:57.815 --> 42:04.085
[SPEAKER_01]: that I, in my clinic, only used birth tissue derived MSCs and these are minimally manipulated.
42:04.105 --> 42:13.140
[SPEAKER_01]: I don't, you know, in the US, if you expand the cells, you do any manipulation, then you have to participate in a IND study.
42:13.461 --> 42:15.945
[SPEAKER_01]: This is why so many companies are going overseas.
42:15.985 --> 42:17.848
[SPEAKER_01]: They're in Mexico, Panama,
42:18.132 --> 42:25.981
[SPEAKER_01]: They're doing, you know, that these expanded cell treatments is sounds great, that they're giving you 100 million, 200 million, 300 million cells.
42:26.461 --> 42:31.567
[SPEAKER_01]: But when they grow cells in multiple generations, there could be deleterious changes.
42:32.028 --> 42:40.377
[SPEAKER_01]: They could decrease in potency and also gain more differentiation because oftentimes when they divide, they don't divide evenly.
42:41.150 --> 42:43.333
[SPEAKER_01]: into two stem cells.
42:43.654 --> 42:47.680
[SPEAKER_01]: A lot of times, stem cells, when in culture, they would divide into one stem cell, one daughter cell.
42:48.100 --> 42:49.883
[SPEAKER_01]: The daughter cell is more differentiated.
42:50.364 --> 42:55.491
[SPEAKER_01]: And when it's more differentiated, then it has more surface receptors that can mark the mes Jane or Joan.
42:55.551 --> 42:57.835
[SPEAKER_01]: You know, they have their own characteristics.
42:58.215 --> 43:04.805
[SPEAKER_01]: So your immune systems can destroy them, but they also can trigger this immune rejection response.
43:04.865 --> 43:10.954
[SPEAKER_01]: And this is probably why I've seen more side effects when people getting these large dose of stem cells
43:10.934 --> 43:22.632
[SPEAKER_01]: Um, they often have to divide the doses, but, um, because of the side effects, but even when you divide it, the problem is that you could be priming somebody.
43:22.983 --> 43:24.905
[SPEAKER_01]: of these immune rejection, right?
43:24.945 --> 43:26.968
[SPEAKER_01]: So we all know if you sensitize the body.
43:27.188 --> 43:31.934
[SPEAKER_01]: So first infusion, your body just recognized, oh, oh my god, you've got to give me something for it.
43:31.954 --> 43:34.537
[SPEAKER_01]: So I'm gonna build up these antibodies.
43:34.837 --> 43:37.080
[SPEAKER_01]: And then a few days later, you give them a second injection.
43:37.160 --> 43:38.982
[SPEAKER_01]: All of a sudden, the body's like, I am ready to fight.
43:39.383 --> 43:45.430
[SPEAKER_01]: So they're getting worse and worse rejection reactions, getting sicker, is either your body trying to fight it off.
43:45.410 --> 43:54.940
[SPEAKER_01]: And I've seen that using much less doses that's minimally manipulated can achieve just as good if not better results than what they're doing overseas.
43:55.020 --> 44:00.766
[SPEAKER_01]: But it's certainly a sound sexy that I'm giving you 200 million cells, right, then giving you 10 million.
44:01.107 --> 44:03.509
[SPEAKER_01]: So a lot of people buy into the hype.
44:03.750 --> 44:15.282
[SPEAKER_01]: Anyhow, so what I do is that generally, you know, the product I use
44:15.515 --> 44:16.751
[SPEAKER_01]: And then I add another
44:17.219 --> 44:24.309
[SPEAKER_01]: CC in somebody's over the age of 65 to 70 because they're more depleted than I add more if they have severe health issues.
44:24.929 --> 44:30.937
[SPEAKER_01]: And for anti-aging treatments, usually we do it, you know, between every three to six months.
44:31.879 --> 44:38.167
[SPEAKER_01]: You know, sometimes some people may want to do it every 12 months, but generally these cells will live in your body for about three months.
44:38.468 --> 44:42.092
[SPEAKER_01]: So if I give you some stem cells, their lifespan in your body is about three months.
44:42.533 --> 44:46.298
[SPEAKER_01]: And then their effect may last
44:46.278 --> 44:51.645
[SPEAKER_01]: So that's why we have the protocol of at least every six months when you want to do it for anti-aging purposes.
44:52.105 --> 44:59.014
[SPEAKER_01]: So, you know, some of my patients are more aggressive, I do it every three months, some my patients do it every two months, and I had, you know, some I want to do every month.
44:59.074 --> 45:09.467
[SPEAKER_01]: So, um, at these kind of doses, you know, it's going to be pretty hard to overdose, um, you know, I think it's just a matter of hitting a point of no extra benefit.
45:09.447 --> 45:12.011
[SPEAKER_01]: So you don't really need drastic doses.
45:12.192 --> 45:14.976
[SPEAKER_01]: I prefer smaller doses, multiple treatments.
45:15.016 --> 45:17.220
[SPEAKER_01]: I think that's going to give you waves or regeneration.
45:17.641 --> 45:23.671
[SPEAKER_01]: So that's my talk, you know, may you all live more years with vitality, right?
45:23.691 --> 45:25.414
[SPEAKER_01]: We just want to live good years.
45:27.014 --> 45:37.653
[SPEAKER_01]: Thank you for listening to this episode, hope you enjoy the content, and if so, please rate and follow this podcast.
45:37.673 --> 45:43.524
[SPEAKER_01]: To reach me, you can contact uplift longevity center, and that is uplift with a lot.
45:43.784 --> 45:47.551
[SPEAKER_01]: You can also subscribe to my YouTube channel, Joy Kong, MD.
45:47.971 --> 45:48.853
[SPEAKER_01]: See you next time!
