WEBVTT
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[SPEAKER_00]: We do know that systemic inflammation plays a major role in aging.
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[SPEAKER_00]: That's the word inflamaging.
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[SPEAKER_00]: Ethlamaging therapeutic plasmics change can remove this inflammatory factors very effectively.
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[SPEAKER_00]: Attacks inflammation on many different levels.
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[SPEAKER_02]: So, inflammation markers will keep rising even if person looks perfectly healthy.
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[SPEAKER_02]: But still, they are in a state of decline.
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[SPEAKER_02]: And that's one thing I think that's exciting about using plasma freezes for longevity purposes is how to reverse that aging process and actually revert the body into a younger state.
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[SPEAKER_03]: Welcome to the Dr. Joy Kong podcast.
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[SPEAKER_03]: This is why I have a chance to share with you some of the latest developments in the space of holistic health
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[SPEAKER_03]: longevity and wellness.
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[SPEAKER_03]: I've always honored intellectual curiosity and scientific rigor combined with real world practicality.
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[SPEAKER_03]: My goal is that what you learn here will help you live longer and live better.
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[SPEAKER_03]: Hope you enjoy the journey with me.
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[SPEAKER_02]: Dr. Kiproth, I am so excited to be interviewing you.
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[SPEAKER_02]: You are a pioneer in the longevity field and you have been contributing to the world of health with particularly when it comes to plasma for races, which has gaining popularity.
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[SPEAKER_02]: People are just beginning to really understand what a powerful modality this is at rejuvenating their body, not to mention combatting illnesses.
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[SPEAKER_02]: So,
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[SPEAKER_00]: The pleasure and honor to be with you.
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[SPEAKER_02]: Oh, thank you.
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[SPEAKER_02]: So of course, I had just gotten treatment from you.
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[SPEAKER_02]: My bad just vulnerable.
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[SPEAKER_02]: Of course, the blood comes out one side, and then it comes back in the other side.
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[SPEAKER_00]: How do you feel?
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[SPEAKER_02]: I feel amazing.
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[SPEAKER_02]: Yeah, it's fantastic.
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[SPEAKER_02]: It was easy.
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[SPEAKER_02]: You know, my veins usually are not corroborating, but you know, today actually did quite well.
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[SPEAKER_02]: I saw my full bag.
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[SPEAKER_02]: So one and a half liters of my own plasma.
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[SPEAKER_02]: Well, I held in my hand.
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[SPEAKER_02]: So that was amazing.
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[SPEAKER_02]: And now we're replenishing with something that doesn't have harmful elements, you know, that's correct.
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[SPEAKER_02]: And then you can, yeah, so tell us a little bit about plasma freezes and the history of it.
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[SPEAKER_02]: Like what what even got you interested in plasma freezes and what is it first of all?
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[SPEAKER_00]: As you described it, it's the removal of all plasma and replacing it in your case with 5% albumin, which is about 65% of human plasma.
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[SPEAKER_00]: So we clean up the old plasma, which accumulates a variety of substances that contribute to a variety of diseases and also aging.
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[SPEAKER_00]: and by removing them and substituting with human plasma, with human now-be-me, we accomplish a variety of different things, including fighting inflammation, which is very important.
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[SPEAKER_00]: It's basically the major contributor to aging, and the major contributor to most age-related diseases.
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[SPEAKER_00]: So, how do we do that?
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[SPEAKER_00]: We do it with a machine, which is capable of separating your whole blood into cells and plasma.
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[SPEAKER_00]: We give you the cells back, with the 5% aluminum, and we throw your whole plasma away.
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[SPEAKER_00]: How does simple as that?
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[SPEAKER_02]: Right.
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[SPEAKER_02]: And somehow, you mean what we have is not good?
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[SPEAKER_02]: People are trying very hard to protect, was inside a body, rather, always afraid to let go.
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[SPEAKER_02]: So, what's going on in the blood?
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[SPEAKER_00]: Well, blood is obviously very important for life because it creates the environment, the milieu of every single cell in the body, from stem cells to your brain cells, heart and so forth.
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[SPEAKER_00]: So it's critical.
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[SPEAKER_00]: In addition to that, a lot of distributes all the food and hormones and everything that the body needs and the cells need.
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[SPEAKER_00]: So it's a very important organ to have.
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[SPEAKER_00]: The problem becomes later in life for most people and sometimes in younger people as well.
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[SPEAKER_00]: And that is that there is some sort of imbalance that happens in the content of the plasma.
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[SPEAKER_00]: So the plasma has hundreds and hundreds, probably thousands of different molecules, different proteins.
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[SPEAKER_00]: that circulate in the plasma, and in normal situation called homostasis, these are all imbalance and infection pretty well.
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[SPEAKER_00]: In some diseases, there is an imbalance of plasma components,
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[SPEAKER_00]: or some other proteins, they may cause diseases and some of these diseases are really, very, very rough to deal with.
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[SPEAKER_00]: They are really deadly.
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[SPEAKER_00]: So in these cases, we do plasma for disease or plasma exchange to remove these substances that cause these horrible diseases.
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[SPEAKER_02]: And how long ago did this treatment even start a plasma phrase as when did we start to use them?
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[SPEAKER_00]: Probably the first plasma exchange treatment started in the 1950s in the skin of Sweden I believe for a disease called Waldenstroms, where the blood gets thick from the accumulation of abnormal immunoglobulins.
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[SPEAKER_00]: That's where it started in general.
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[SPEAKER_00]: I think the late late 70s, it started to getting more and more popular with equipment becoming more available.
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[SPEAKER_00]: Some of the early cases came from England and from the United States, Peter Dao, who was my teacher, is the pioneer of Plasma Exchange in the United States.
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[SPEAKER_00]: So, I would say,
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[SPEAKER_02]: late 70s and this is an FDA-approved treatment for a variety of diseases.
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[SPEAKER_00]: Well, actually no, the FDA approves the equipment we use.
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[SPEAKER_00]: The machines that we use to separate blood.
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[SPEAKER_00]: Okay.
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[SPEAKER_00]: Our approved by the FDA.
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[SPEAKER_00]: There are a number of machines approved in the United States.
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[SPEAKER_00]: Many more approved in other countries.
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[SPEAKER_00]: We don't have all the equipment.
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[SPEAKER_00]: that's available.
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[SPEAKER_00]: In other countries, we have only limited number and FDA-approved machines.
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[SPEAKER_00]: But again, FDA approves the equipment.
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[SPEAKER_00]: They don't approve the disease, it's head.
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[SPEAKER_02]: Right, but does it approve the equipment for treating a certain condition?
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[SPEAKER_00]: Right, so if you're a physician, you have the ability of label to use FDA approved equipment.
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[SPEAKER_00]: So, how do we get to the diseases?
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[SPEAKER_00]: We get to the diseases through medical associations.
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[SPEAKER_00]: So, American Society for A for Disease is a medical association that
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[SPEAKER_00]: represents A for Ezekiel in general, cosmic change is part of that.
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[SPEAKER_00]: This society called Asua publishes every three years a special edition of the Journal of Pentecostal A for Ezekiel, where they publish recommendations, recommendations, not approvals, just recommendations for the use of different A for Ezekiel's procedures for different diseases.
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[SPEAKER_00]: and they are categorized depending on scientifically published documentation that there is benefit of cosmic change or other FRIZs procedures in certain diseases.
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[SPEAKER_02]: is interesting.
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[SPEAKER_02]: Okay, it reminds me of a little bit of a different therapies, maybe even something like stem cell therapy, and maybe there's no FDA approval for certain conditions.
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[SPEAKER_02]: A lot of devices, they do seek indications, but it some may just be approved for
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[SPEAKER_02]: you know for certain function I guess and then it's up to the medical organizations to recommend whether or not it's or it's fits certain criteria whether or not something has enough scientific evidence to be basically recommended.
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[SPEAKER_02]: Yeah so a lot of people may be confused with the different words so Plasma Furious is as the same as Plasma Exchange are they exactly the same thing.
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[SPEAKER_00]: Actually, they are not, but they are used interchangeable interchangeably in some way.
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[SPEAKER_00]: Plasma for resist is actually the act of the separation of whole blood into plasma and cells.
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[SPEAKER_00]: That's what plasma for resist is.
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[SPEAKER_00]: I see.
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[SPEAKER_00]: Plasma exchange is the fact that we will
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[SPEAKER_00]: perform plasma for is this, but in addition to that, we're going to throw the old plasma away and it creates it, exchange it with a new, a new fluid in our situation, 5% of it.
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[SPEAKER_02]: I see.
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[SPEAKER_02]: And then A for ises, because you have a company called global A for ises, what is A for ises?
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[SPEAKER_00]: Well, if this is a general term, it comes from the Greek and means to take away.
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[SPEAKER_00]: Oh.
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[SPEAKER_00]: However, we use it today, medicine to indicate a field of medicine, which involves the separation of blood in its different components.
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[SPEAKER_00]: and the removal of each individual component separately as you need it or your patients need it and it could be done in blood banking.
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[SPEAKER_00]: We collect red cells, platelets, plasma, could be done in plasma centers while they collect plasma for variety of products and it could be used to collect themselves for transplantation usually
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[SPEAKER_00]: in oncology and hematologic diseases and more recently something that's very popular now and I think will become even more popular is called CART therapy.
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[SPEAKER_00]: These are specialized procedures to treat really bad cancers.
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[SPEAKER_00]: And it also will become more and more popular, I believe, in genetic engineering.
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[SPEAKER_00]: So in order to perform genetic engineering, you need cells and these cells circulate in the blood and we collect these cells and give them to labs where they are genetically manipulated and then brought back to the patient.
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[SPEAKER_02]: that's so interesting.
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[SPEAKER_02]: Thank you for making that clear because I've been not not sure in my head or how to connect the dots.
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[SPEAKER_02]: So as far as the plasma, you know, plasma for uses, that's the decepiration of different components.
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[SPEAKER_02]: And I think it implies plasma exchange as well, right?
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[SPEAKER_02]: Right.
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[SPEAKER_02]: That as a procedure.
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[SPEAKER_03]: Yeah.
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[SPEAKER_02]: And what has, has it been recommended for?
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[SPEAKER_02]: What type of conditions?
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[SPEAKER_02]: has been helpful for.
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[SPEAKER_00]: Plasma exchange has been used in probably over 80 different diseases.
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[SPEAKER_00]: The majority of these diseases are all immune diseases, how we call them, all immune diseases.
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[SPEAKER_00]: So basically it is something that your own immune system attacks itself and other organs.
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[SPEAKER_00]: So the immune system is the protective army of the body.
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[SPEAKER_00]: So it protects us from infections, it protects us from cancer, and other outside invaders, if you will.
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[SPEAKER_00]: So, in the autoimmune conditions, the immune system fails to recognize and differentiate itself from now self and it starts attacking self and it may attack the kidneys, it may attack the brain, it may attack the heart and other tissues.
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[SPEAKER_00]: And it does that by creating auto antibodies, which are proteins that attack self-tissue, that's why they're auto antibodies.
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[SPEAKER_00]: So these autoimmune diseases, there's a bunch of them in neurology, in the phrology, in variety of different specialties.
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[SPEAKER_00]: And by removing these auto antibodies from the blood, we help treat these diseases, usually in combination with other medications.
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[SPEAKER_01]: And how well does it work in your practice?
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[SPEAKER_00]: It depends.
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[SPEAKER_00]: It depends on many, on many things.
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[SPEAKER_00]: It depends on the disease.
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[SPEAKER_00]: It depends on how advanced the disease is, how much damage has already been created in different organs.
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[SPEAKER_00]: So the earlier you start in any treatment, until any disease is the better.
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[SPEAKER_00]: What happens with plasmic change, unfortunately, is that people don't know much about it, it's an obscure take.
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[SPEAKER_00]: Although it's approved and it's being available, it's a procedure that even well-educated physicians don't understand.
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[SPEAKER_00]: So, they ask for plasma for easy-sim-difficult cases, usually they're all last resort.
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[SPEAKER_00]: And by that time, it is difficult to achieve great results.
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[SPEAKER_00]: Nonetheless, we see some dramatic improvement in very difficult conditions where everything else is failed.
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[SPEAKER_00]: So it's very rewarding, and that's why I'm here practicing this for four years, is because we have success, not in every single case, but in many cases, and many times this success is very dramatic.
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[SPEAKER_00]: As I said, people have tried everything on earth, they didn't work, and they
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[SPEAKER_00]: finally come to us and all of a sudden they opened their eyes, they start talking again, they start moving, it's very rewarding.
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[SPEAKER_02]: And you were just showing me just a few things in your office, a related to patients you've treated, one of them was an athlete, right?
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[SPEAKER_02]: He yes, he was an eye condition that he couldn't see and he was a dark player, right?
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[SPEAKER_02]: And then with how many
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[SPEAKER_00]: Well, he had a condition called Myestina Grabis and I've been treating him for years.
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[SPEAKER_00]: But lately, as the pictures that you showed, he's been coming periodically to get three cleanses doing well.
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[SPEAKER_02]: Yeah, another picture you showed me was lots of kids that were born because you helped a mother to improve their condition.
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[SPEAKER_00]: It's a difficult question and I'm not sure I know the answer, but we have seen quite a few number of women who experience forced trimester miscarriages.
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[SPEAKER_00]: So, first-stream master miscarriages, he's characterized by somebody who has more than three or more miscarriages in the first-stream master.
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[SPEAKER_00]: And the women that we see have three or more, some have five, six, 11 miscarriages.
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[SPEAKER_00]: So the majority of these ladies, we have identified auto antibories.
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[SPEAKER_00]: So they have an all-emion condition, which is poorly defined, but they have a variety of antibories circulating in their blood.
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[SPEAKER_00]: And we believe that these antibories contribute to the miscarriages.
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[SPEAKER_00]: By removing them, either by plasma-freezes, or by attacking them with medications, such as intravenous immunoglobulin, we can solve the problem.
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[SPEAKER_00]: Unfortunately for all these women and to us,
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[SPEAKER_00]: We have this successful in the majority of these cases to to scale this women and have children.
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[SPEAKER_00]: And what is on the picture are the kids.
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[SPEAKER_00]: I call them my kids.
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[SPEAKER_00]: They're not, but I feel proud that I contributed.
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[SPEAKER_02]: Yeah, that's amazing, so autoimmune condition is really the mainstay of what Plasma Exchange is kind of indicated for right correct any inflammation and and just general inflammation right okay so how do you decide that how who comes to you for inflammation like it
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[SPEAKER_00]: Well, there are many tests today that indicate systemic inflammation.
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[SPEAKER_00]: I'm not talking about inflammation where you cut yourself and you have swelling of the fingers and all that.
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[SPEAKER_00]: But systemic inflammation leads to a variety of diseases from type to diabetes, to stroke, to cardiovascular disease, cancer and so forth.
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[SPEAKER_00]: So systemic inflammation can be measured with the variety of laboratory tests, blood tests, usually, biopsies, if needed, and all that.
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[SPEAKER_00]: So we do know that systemic inflammation plays a major role in ageing.
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[SPEAKER_00]: Yeah, that's the word inflamaging, inflamaging.
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[SPEAKER_00]: They're hand in hand.
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[SPEAKER_00]: Exactly, inflammation and aging.
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[SPEAKER_00]: And I think that this is the so-called longevity medicine attacks that inflamaging.
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[SPEAKER_00]: So how do we attack inflamaging?
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[SPEAKER_00]: Usually a single drug doesn't do the job because it's a very complex physiologic process or pathophysiologic process.
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[SPEAKER_00]: And we know that therapeutic plasma exchange can remove this inflammatory factors very effectively and attack inflammation on many different levels.
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[SPEAKER_02]: Yeah.
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[SPEAKER_02]: Right.
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[SPEAKER_02]: So inflammation is accumulating as we age whether or not the person has any disease.
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[SPEAKER_02]: So inflammation markers would keep a rising even if person looks perfectly healthy.
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[SPEAKER_02]: Sure.
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[SPEAKER_02]: But still, they are in a state of decline.
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[SPEAKER_02]: And that's one thing I think that's exciting
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[SPEAKER_02]: reverse that aging process and actually revert the the body into a younger state, right?
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[SPEAKER_00]: Correct, that's the goal, and by doing so, we expand the health span of people.
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[SPEAKER_00]: People in general are healthy over many years, until certain age comes, and then they start developing diseases.
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[SPEAKER_00]: In the United States, this border of health and disease is around 65, 70 years old.
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[SPEAKER_00]: Maybe a little earlier.
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[SPEAKER_00]: the health span is interrupted that people start getting diseases and fortunately or unfortunately we keep them alive because medicine has made tremendous progress over the last 50, 70 years.
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[SPEAKER_00]: So we know how to treat these diseases.
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[SPEAKER_00]: We don't know how to cure them, but we know how to treat them.
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[SPEAKER_00]: Unfortunately, we prolong the life of people with these diseases, but they're not healthy.
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[SPEAKER_00]: They're non-productive, they're not very happy.
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[SPEAKER_00]: They are suffering, and it takes an enormous amount of money to keep them alive.
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[SPEAKER_00]: So it is a problem.
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[SPEAKER_00]: So the goal of the so-called longevity medicine, it's a word that I don't like at all, but the goal here is to extend the health span.
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[SPEAKER_00]: To have people develop this disease is if at all, or longer health span.
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[SPEAKER_00]: If we can prolong the shell span of people with 2, 3 or 5 years, it will add tremendously to their productivity and life happiness and living a good life because people with injuries and diseases that they don't live a good life.
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[SPEAKER_00]: It's suffering with 72 pills every morning, so that's the goal.
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[SPEAKER_02]: Yeah, yeah, fantastic.
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[SPEAKER_02]: And that's, you know, most people I talk to, they say, I don't care how long I live, I just want to be healthy.
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[SPEAKER_02]: So that's really the goal.
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[SPEAKER_02]: That's what I'm trying to achieve.
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[SPEAKER_02]: Yeah.
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[SPEAKER_02]: So I'm curious, you're a Harvard trained immunologist, right?
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[SPEAKER_02]: And you are treating people with all kinds of
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[SPEAKER_02]: got into the longevity space, the word you'd like, but the promoting health rather than curing diseases.
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[SPEAKER_02]: So what promoted that shift in and as I mentioned, I don't like this word.
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[SPEAKER_00]: The longevity word is, I know it's getting now popularity and I'm beneficiary of the popularity, but the truth is that it is healthspot.
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[SPEAKER_00]: I have been a proponent of
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[SPEAKER_00]: healthy living, and there are the four plasma ferries that were two scientifically proven approaches to healthy living.
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[SPEAKER_00]: One is the Mediterranean diet and the other one is exercise.
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[SPEAKER_00]: These are all scientifically proven with clinical control clinical trials.
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[SPEAKER_00]: Now, we can add plasma ferrisis to that because we just finished a controlled placebo-controlled clinical trial in plasma ferrisis.
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[SPEAKER_00]: So we know that these contributes to extending life's path.
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[SPEAKER_00]: What did you get to show?
22:28.763 --> 22:30.623
[SPEAKER_00]: Study showed variety of different things.
22:30.683 --> 22:33.324
[SPEAKER_02]: Is it an animal study or human study, okay?
22:34.864 --> 22:37.605
[SPEAKER_00]: It's the only human study in Poulonjavit.
22:38.105 --> 22:41.166
[SPEAKER_00]: I see that it's clinically controlled, okay?
22:41.426 --> 22:55.290
[SPEAKER_00]: So I think that the most significant finding was that the biologic age of the patients who were treated as opposed to the non-treated one, the placebo control, their biologic age,
22:56.672 --> 23:14.484
[SPEAKER_00]: was much younger did that than their chronologic age and actually we have the ability to identify the biological age of different organs, not only the total body, but the different organs, you know, brain ages differently than the kidneys.
23:15.405 --> 23:36.385
[SPEAKER_00]: in the heart and so forth, so we can clarify every organ by a logic age, and we show that the immune system rejuvenates rejuvenates 7 to 9 years better than the non-treated group, you know, the placebo group, which did not get the treatment.
23:37.091 --> 23:39.233
[SPEAKER_00]: So the results are very encouraging.
23:39.293 --> 23:43.617
[SPEAKER_00]: We'll continue to do more research, but this so far the results are encouraging.
23:44.218 --> 23:56.510
[SPEAKER_00]: And overall, now we have the Mediterranean diet, exercise and plasma ferries that can really extend your lifespan, not necessarily, but you certainly, your health span.
23:56.750 --> 24:06.418
[SPEAKER_02]: Yeah, I was actually so I guess the nurse who was conducting the therapy for me, she actually went through to study herself.
24:06.699 --> 24:08.340
[SPEAKER_00]: She's the best nurse in the world.
24:09.401 --> 24:10.101
[SPEAKER_02]: She's amazing.
24:10.442 --> 24:13.284
[SPEAKER_02]: Yeah, but she was telling me, she had the frozen shoulder.
24:13.304 --> 24:13.805
[SPEAKER_00]: Right.
24:14.225 --> 24:21.151
[SPEAKER_02]: And that one away and she had thinning hair and she was really worried about that and that started to get better and better.
24:21.351 --> 24:21.571
[SPEAKER_00]: Right.
24:21.651 --> 24:37.700
[SPEAKER_00]: There are a variety of symptoms that come with aging, not necessarily a determined disease that are influenced, due to inflammation for sure, and they respond right away to the plasma exchange.
24:38.701 --> 24:44.004
[SPEAKER_00]: Usually, either arthritis that you had, other people have that, we had,
24:44.804 --> 24:51.210
[SPEAKER_00]: patients with all the immunolopeia, which is out to the immune conditions that leads to loss of hair.
24:51.890 --> 24:53.231
[SPEAKER_00]: The effect is dramatic.
24:53.732 --> 24:58.536
[SPEAKER_00]: They lose pieces of hair and all of a sudden it grows back.
24:58.556 --> 24:59.517
[SPEAKER_00]: It's amazing.
24:59.557 --> 25:00.638
[SPEAKER_00]: That's beautiful.
25:00.898 --> 25:03.020
[SPEAKER_02]: And how many sessions would that usually take?
25:04.213 --> 25:05.514
[SPEAKER_00]: We're still working on that.
25:05.574 --> 25:12.776
[SPEAKER_00]: I think that different diseases, different people require different number of sessions, usually between three and six.
25:13.237 --> 25:13.657
[SPEAKER_02]: I see.
25:14.337 --> 25:16.978
[SPEAKER_02]: What if someone just comes to you for a rejuvenation?
25:17.058 --> 25:20.880
[SPEAKER_02]: Just want to stay ahead of the game, maybe get a little younger.
25:20.900 --> 25:24.461
[SPEAKER_02]: So how many sessions would you recommend?
25:25.300 --> 25:29.383
[SPEAKER_00]: In the clinical study that are just described, we use six sessions.
25:30.483 --> 25:41.310
[SPEAKER_00]: This was based on preliminary studies that we did with the University of California in Berkeley, that indicated that there is a cumulative effect of hospital diseases.
25:41.831 --> 25:43.131
[SPEAKER_00]: The more treatments we did,
25:44.432 --> 25:50.037
[SPEAKER_00]: The more changes we saw in the different parameters that we measured.
25:50.898 --> 25:55.482
[SPEAKER_00]: So, six treatments is what is generally recommended.
25:55.682 --> 26:03.348
[SPEAKER_00]: I think that what we found in the current study is that the first two or three treatments are the most effective.
26:03.869 --> 26:06.431
[SPEAKER_02]: Okay, and these treatments are usually a matter of part.
26:07.673 --> 26:16.188
[SPEAKER_00]: Yes, we had three different treatment groups, one was a month apart, the other groups were two treatments per month for three months.
26:17.153 --> 26:22.655
[SPEAKER_01]: Okay, okay, so which one did better, the one that's farther apart or closer together?
26:22.775 --> 26:35.579
[SPEAKER_00]: Well, interestingly enough, it was not, they all improved, they all improved, but the group that received in addition to the Blazberg's change, intravenous immunoglobulin, which is part of the normal plasma.
26:36.259 --> 26:40.321
[SPEAKER_00]: So we added the small amount of heart-to-school IVIG
26:44.588 --> 26:48.230
[SPEAKER_00]: after each procedure had this made a big difference.
26:48.591 --> 26:53.333
[SPEAKER_02]: Okay, can you explain the IVIG people talk about that a lot these days?
26:53.794 --> 27:02.419
[SPEAKER_02]: What do you think made it so popular and can you tell us a little bit about that and the difference between that and the plasma produces or are they often given together?
27:03.148 --> 27:07.533
[SPEAKER_00]: So intravenous immunoglobulin is made from plasma.
27:08.654 --> 27:20.567
[SPEAKER_00]: Immunoglobulins are major component of human plasma and they are very important for the immune system, that's why they're called immunoglobulings.
27:21.388 --> 27:40.682
[SPEAKER_00]: There are four different kinds and the one called IGG is the most prominent one and I don't know if it's the most important but certainly a lot of the all-remune conditions are associated with all the antibodies of IGG class.
27:41.062 --> 27:46.006
[SPEAKER_00]: If we want to get deeper into this, this IGG one, this IGG two, this IGG three.
27:47.407 --> 27:51.772
[SPEAKER_00]: So people tell I VIG therapy which one are they using?
27:51.792 --> 27:58.959
[SPEAKER_00]: So the intravenous immunoglobulin is a preparation pharmaceutical preparation from Plasma.
27:59.620 --> 28:06.067
[SPEAKER_00]: It predominantly has IGG in it, but it has small amounts of IGA and IGM, right?
28:06.648 --> 28:08.229
[SPEAKER_00]: The other, the other immunoglobulin.
28:09.234 --> 28:16.767
[SPEAKER_00]: So initially I started using small amounts of IVRG as a replacement.
28:17.128 --> 28:18.450
[SPEAKER_00]: So we remove plasma.
28:20.166 --> 28:21.767
[SPEAKER_00]: And we remove everything that's in it.
28:22.827 --> 28:25.608
[SPEAKER_00]: We use the replacement fluid 5% out of it.
28:25.648 --> 28:28.790
[SPEAKER_00]: That's 65%, so we accomplished that.
28:29.510 --> 28:35.933
[SPEAKER_00]: But the immunoglobin is very, very important for your protection from infections and so forth.
28:36.753 --> 28:38.094
[SPEAKER_00]: We are not replacing those.
28:38.174 --> 28:46.158
[SPEAKER_00]: So I said, well, if we infuse a little bit of IVAG, this gets closer to normal plus.
28:47.458 --> 28:49.860
[SPEAKER_00]: So that was the initial idea.
28:50.041 --> 28:58.348
[SPEAKER_00]: I didn't know that it will have such a profound effect on DNA methylation.
28:58.368 --> 29:01.411
[SPEAKER_00]: That's how this biological cage clocks work.
29:02.172 --> 29:02.672
[SPEAKER_00]: But it did.
29:03.353 --> 29:08.457
[SPEAKER_00]: And I don't have the exact explanation of how this works.
29:09.658 --> 29:25.505
[SPEAKER_00]: But there is something, and we could get a little off-label here, but there is a study that was published from Johns Hopkins, Dr. Bob Montgomery, or famous nephrologist and the renal transplants, physicians.
29:26.165 --> 29:29.067
[SPEAKER_00]: He used plasma for disease.
29:30.367 --> 29:39.631
[SPEAKER_00]: followed by relatively small dose of IVIG to treat vinyl kidney rejection, very successful.
29:40.492 --> 29:44.914
[SPEAKER_00]: So, again, I don't think we know exactly the mechanism.
29:46.014 --> 29:50.676
[SPEAKER_00]: The idea is to suppress the immune system.
29:51.677 --> 29:54.798
[SPEAKER_00]: That's why people use a very high dose of IVIG.
29:55.218 --> 30:10.414
[SPEAKER_00]: So that's another different mechanism and it's very complicated and I'm not going to go into it, but there are different ways to use IVIG1 is to use very high doses to attack or immunity.
30:10.875 --> 30:12.537
[SPEAKER_00]: So it causes immunosuppression.
30:13.338 --> 30:18.402
[SPEAKER_00]: I believe it's more immunomodulation rather than a suppression, but these are semantics.
30:19.503 --> 30:31.334
[SPEAKER_00]: And the way we use it in combination with Plasma Exchange, with much smaller doses, which is obviously much less expensive, works really very well, both for renal transplantation.
30:32.094 --> 30:34.497
[SPEAKER_00]: rejection as well as in longevity.
30:35.158 --> 30:37.640
[SPEAKER_00]: I wish I knew the exact mechanism of action.
30:38.301 --> 30:47.931
[SPEAKER_00]: There is definitely influence on the different immunocompetence cells, they are cells in the body, in the blood.
30:48.672 --> 30:51.276
[SPEAKER_00]: that you have a lot to do with the immune system.
30:51.917 --> 31:02.251
[SPEAKER_00]: So we know that we influence those in a positive way and there is the replacement of antibodies, but that's as much as I know in the moment.
31:02.511 --> 31:05.035
[SPEAKER_02]: Does it help with fighting acute infections?
31:05.848 --> 31:07.709
[SPEAKER_00]: Well, it theoretically does.
31:08.130 --> 31:12.013
[SPEAKER_00]: I don't think it's being used universally to do that.
31:12.133 --> 31:18.638
[SPEAKER_00]: It's being used in patients who are born, immunodeficient, who are born with very low or absent high CG.
31:19.058 --> 31:19.418
[SPEAKER_02]: Okay.
31:19.959 --> 31:27.144
[SPEAKER_02]: And you've also used a plasma exchange to help people that's recovering from long haul colded, right?
31:27.545 --> 31:31.828
[SPEAKER_02]: So is that something you want to talk about?
31:32.348 --> 31:45.413
[SPEAKER_00]: I'm blamed for being the first to use plasma ferries for a long COVID and publish it with published that and we did extensive studies of why plasma ferries is helps in this condition.
31:46.874 --> 31:57.078
[SPEAKER_00]: Having said that, a long COVID is a very complicated disease and I don't think we know much about it.
31:57.859 --> 32:00.940
[SPEAKER_00]: And the reason for that is that long COVID is
32:02.775 --> 32:15.481
[SPEAKER_00]: political disease to a certain extent, and there isn't much much information about it because it's not being studied because there is no financial support for the studies that are necessary.
32:16.181 --> 32:20.543
[SPEAKER_00]: There are people who believe that long COVID is not a single disease, but...
32:22.695 --> 32:26.258
[SPEAKER_00]: It's a very complex matter.
32:27.098 --> 32:33.223
[SPEAKER_00]: Unfortunately, there are around 30 million people that suffer from this disease around the world.
32:34.084 --> 32:35.405
[SPEAKER_00]: There is no treatment for it.
32:35.445 --> 32:38.147
[SPEAKER_00]: The therapeutic plasma exchange helps some of them.
32:38.208 --> 32:40.469
[SPEAKER_00]: We have published our results.
32:41.350 --> 32:48.961
[SPEAKER_00]: in small group of patients about 65% success rate, which is better than nothing, but still it's an issue.
32:49.582 --> 32:56.653
[SPEAKER_00]: One of the problems that we see, especially today, as opposed to three years ago, is that people got infected.
32:58.142 --> 33:04.988
[SPEAKER_00]: three years ago and had symptoms and calm and show up three years after the disease started.
33:05.608 --> 33:13.375
[SPEAKER_00]: So there is already so much damage that the disease has caused that is difficult to predict where they are going to respond at all.
33:14.636 --> 33:21.001
[SPEAKER_00]: One thing we know is that it's certainly there is an autoimmunity in Lankovic.
33:21.802 --> 33:25.446
[SPEAKER_00]: kind of one common symptom is affecting peripheral nerves.
33:26.507 --> 33:35.676
[SPEAKER_00]: It affects the brain as well, but peripheral nerves is common and we are fairly successful in treating that part of the problem.
33:36.322 --> 33:45.807
[SPEAKER_02]: Okay, yeah, so I remember you said you had significant success for people who come to you for these long COVID symptoms.
33:46.347 --> 33:48.568
[SPEAKER_00]: They are dearly dearly the better.
33:48.588 --> 33:57.753
[SPEAKER_00]: They come up to years after they started, her chances, their chances are markedly diminished.
33:58.213 --> 34:03.796
[SPEAKER_02]: I see, and usually how many sessions does usually take for people to start noticing a difference?
34:04.636 --> 34:05.136
[SPEAKER_00]: It varies.
34:05.617 --> 34:06.037
[SPEAKER_00]: It varies.
34:06.077 --> 34:13.401
[SPEAKER_00]: Some people will respond right away with maybe 2-3 treatments, others will take 6 treatments.
34:15.162 --> 34:20.245
[SPEAKER_00]: Some will respond and they will come back because the disease exacerbates again.
34:20.826 --> 34:28.570
[SPEAKER_00]: It's definitely not a cure, it's a treatment and until we know more about the disease,
34:33.714 --> 34:39.518
[SPEAKER_02]: And I want to come back to the subject of longevity, the happy subject, keeping people healthy.
34:39.878 --> 34:52.687
[SPEAKER_02]: So I know you worked with very well-known researcher, Dr. Irina Combois, who was the one that was first designed the famous experiment of sewing two mice together, the young and old.
34:53.187 --> 35:00.392
[SPEAKER_02]: The younger mice started to manifest, of been symptoms of being a, old, and the older mice start to seem younger.
35:03.194 --> 35:20.688
[SPEAKER_02]: And so you also, you know, a lot of people thought that it was because the younger mice has something in the blood that's magical, that's helping the older mice, but we're just discussing that that's not the new perspective on the phenomenon.
35:20.748 --> 35:26.192
[SPEAKER_02]: So can you talk a little bit about what you think happened when these two mice are sewn together?
35:27.459 --> 35:39.549
[SPEAKER_02]: Well, there are a lot of things that happen when Yes, I don't really like, you know, yeah, I love animals and, you know, mice, you know, still, but anyhow, so the experiment happened.
35:40.269 --> 35:41.951
[SPEAKER_02]: The two animals that had direct.
35:42.411 --> 35:47.555
[SPEAKER_00]: The first thing when I discussed this, the first thing that I mentioned when I discussed this is
35:50.018 --> 35:51.699
[SPEAKER_00]: Remind people, you're not a mouse.
35:52.319 --> 36:04.603
[SPEAKER_00]: So everything that happens in experimental animals may teach us a lot of different basic science things, but they're not immediately applicable to humans.
36:05.123 --> 36:10.305
[SPEAKER_00]: The human body is unmasked, it's complexity.
36:10.765 --> 36:15.847
[SPEAKER_00]: There's no mouse that can come close to what the human body is in the complexity.
36:15.887 --> 36:16.667
[SPEAKER_00]: So a lot of things,
36:17.327 --> 36:26.874
[SPEAKER_00]: that happen in mice can lead us to certain conclusions and to try to mimic that in humans but it's not going to be the same.
36:27.454 --> 36:32.197
[SPEAKER_00]: And the same with the experiment you're referring to is called parabiasics.
36:32.858 --> 36:36.140
[SPEAKER_00]: And parabiasics is obviously impossible in humans.
36:37.221 --> 36:38.061
[SPEAKER_00]: You can do that.
36:46.367 --> 36:50.895
[SPEAKER_00]: On the subject, I publish a hypothesis that plasma exchange.
36:52.558 --> 36:56.740
[SPEAKER_00]: can be as close as we can get to a part of the Aussies he was.
36:58.140 --> 37:05.303
[SPEAKER_00]: Again, I had to get back to your question of finding the silver bullet in your blood.
37:06.163 --> 37:10.865
[SPEAKER_00]: I think I mentioned that the earlier there were millions of dollars spent.
37:12.165 --> 37:21.149
[SPEAKER_00]: And a lot of very capable and brilliant scientists have been looking to find this silver bullet.
37:22.009 --> 37:28.396
[SPEAKER_00]: And now it's 20 years later, and there is zero evidence that this exists.
37:28.736 --> 37:34.942
[SPEAKER_00]: I'm not saying it doesn't exist, but I'm saying that so far nobody has been able to identify them.
37:35.903 --> 37:42.810
[SPEAKER_00]: What we have been able to identify are substances that contribute to aging and inflammation.
37:44.712 --> 37:49.357
[SPEAKER_00]: in other people and in our experiments with humans and a certain age.
37:50.078 --> 38:06.434
[SPEAKER_00]: So we know now that if you compare the plasma components in people at age 20, 30, 40, 15, 60, there is a difference and by age 40, 45, the plasma components keep changing.
38:07.075 --> 38:19.545
[SPEAKER_00]: There is more accumulation of certain factors than we can identify plenty of them that contribute to a variety of diseases primarily by inflammation.
38:20.286 --> 38:27.472
[SPEAKER_00]: And other accumulation of other factors that contribute most prominently to Alzheimer's disease.
38:27.973 --> 38:33.797
[SPEAKER_00]: If you look at the plasma of patients with Alzheimer's disease, you will find all kinds of bad stuff.
38:34.698 --> 38:40.781
[SPEAKER_00]: So removing this best stuff with a ferries, which the word means to take away, is helpful.
38:41.481 --> 38:42.601
[SPEAKER_00]: Is that the whole answer?
38:42.681 --> 38:43.362
[SPEAKER_00]: No, it's not.
38:44.062 --> 38:48.584
[SPEAKER_00]: But as an arena, a label this process is dilution.
38:49.604 --> 38:55.667
[SPEAKER_00]: So when you connect to mice, their blood is diluted.
38:57.079 --> 38:59.141
[SPEAKER_00]: either way, both for both mice.
38:59.602 --> 39:02.505
[SPEAKER_00]: So these dilution diminishes the bad factors.
39:03.726 --> 39:08.611
[SPEAKER_02]: And some people also... And in the older mice, it carries the bad fact.
39:08.631 --> 39:14.757
[SPEAKER_00]: Yes, well, with the idea, is we had something to that process to rejuvenate.
39:15.118 --> 39:17.060
[SPEAKER_00]: We haven't been able to identify that.
39:17.720 --> 39:19.122
[SPEAKER_00]: At this point, it's mythology.
39:19.622 --> 39:28.789
[SPEAKER_00]: And what we do know, and people ignore the fact that the Yann Mouse became older.
39:30.350 --> 39:33.952
[SPEAKER_00]: Nobody talks about this, because it's not a pleasant subject.
39:34.373 --> 39:35.333
[SPEAKER_00]: Everybody goes out there.
39:35.774 --> 39:37.295
[SPEAKER_00]: The old mouse became younger.
39:37.895 --> 39:39.056
[SPEAKER_00]: Well, how about the other way?
39:39.316 --> 39:39.496
[SPEAKER_02]: Yeah.
39:40.580 --> 39:41.301
[SPEAKER_02]: Yeah, right.
39:41.821 --> 39:47.825
[SPEAKER_02]: So what is in the older mouse blood that's making life so much more unpleasant.
39:47.865 --> 39:57.892
[SPEAKER_00]: Well, and we do know we have been able to identify over the last 20 years a bunch of molecules that cause aging and cause inflammation.
39:58.993 --> 40:04.295
[SPEAKER_02]: So, can you give an idea of approaching how many molecules that are pro-aging and are dead?
40:04.475 --> 40:06.396
[SPEAKER_00]: Well, probably more than we know.
40:06.476 --> 40:11.938
[SPEAKER_00]: I mean, we, we, we discover all kinds of molecules that cause aging all the time.
40:12.558 --> 40:14.679
[SPEAKER_00]: The most recent one is I'll leave 11.
40:15.439 --> 40:23.062
[SPEAKER_00]: I'm not going to get into this, but now it's a conversational subject.
40:24.002 --> 40:27.363
[SPEAKER_00]: people want to make a more colonial antibody to kill hell.
40:27.563 --> 40:29.543
[SPEAKER_00]: I only learned how about the rest of them.
40:29.803 --> 40:30.023
[SPEAKER_02]: Right.
40:30.243 --> 40:32.104
[SPEAKER_00]: So it's complicated.
40:32.224 --> 40:32.524
[SPEAKER_02]: Right.
40:32.684 --> 40:34.104
[SPEAKER_02]: It's like a whack-a-mo most.
40:34.224 --> 40:34.544
[SPEAKER_02]: Yeah.
40:35.365 --> 40:39.446
[SPEAKER_02]: So Alina from Generation Lab actually gave a really nice analogy.
40:39.506 --> 40:43.046
[SPEAKER_02]: She was like, she said, well, think about a truckload of tomatoes.
40:43.907 --> 40:45.647
[SPEAKER_02]: And some are rotten and bad.
40:46.207 --> 40:51.748
[SPEAKER_02]: So do you want to make the whole truckload better by throwing more fresh tomatoes in there?
40:54.149 --> 40:56.951
[SPEAKER_02]: So the so the truck will can be better, right?
40:57.051 --> 40:59.092
[SPEAKER_02]: So that was a great analogy.
40:59.152 --> 41:00.032
[SPEAKER_00]: It was an analogy, yes.
41:00.252 --> 41:01.093
[SPEAKER_02]: Yeah, yeah.
41:01.153 --> 41:17.201
[SPEAKER_02]: So with the plasma ferrisis process that, you know, what I saw was that my blood was going through the machine and the plasma was separate out and was taken away and then you were giving me fresh albumin and then that got, you know,
41:21.083 --> 41:23.365
[SPEAKER_02]: blood cells and they get them back to me.
41:24.026 --> 41:28.170
[SPEAKER_02]: So I got this whole bag of just my own plasma.
41:28.790 --> 41:33.955
[SPEAKER_02]: So just that simple act of self has profound rejuvenation effects.
41:34.816 --> 41:44.564
[SPEAKER_02]: And the research, when it comes longevity, what parameters did it show as far as people improving and benefiting?
41:45.305 --> 41:52.993
[SPEAKER_00]: So, we mentioned the biological cage, so this was the main parameter that we found in Provee.
41:53.073 --> 42:01.221
[SPEAKER_00]: In addition to that we had clinical parameters that we followed, and the one was strength can strengthen.
42:01.841 --> 42:10.667
[SPEAKER_00]: The other one was Peter walking, and there are, you know, approved methodologies to do these things.
42:11.547 --> 42:17.751
[SPEAKER_00]: Balance, we measure balance, balance is extremely important for all the age.
42:17.771 --> 42:23.595
[SPEAKER_00]: There's a lot of debts and problems come from falls, injuries and so forth.
42:24.555 --> 42:27.277
[SPEAKER_00]: And we used a variety of...
42:29.265 --> 42:33.907
[SPEAKER_00]: question years that are given to AI to examine.
42:33.927 --> 42:44.451
[SPEAKER_00]: So we did a variety of clinical parameters, and we showed statistically significant difference in the treated versus the placebo patients.
42:46.592 --> 42:50.314
[SPEAKER_02]: Wow, this is such an incredible discussion, so have to learn from you.
42:50.554 --> 42:59.277
[SPEAKER_02]: You're such a pioneer and have trained a lot of providers and then a lot of lectures internationally.
42:59.797 --> 43:03.699
[SPEAKER_02]: So it's amazing to be sitting next to you and learn from you.
43:04.299 --> 43:11.002
[SPEAKER_02]: Any parting words of wisdom that you can share with the people who have followed the conversation this far.
43:12.401 --> 43:15.843
[SPEAKER_00]: stick to the Mediterranean diet and exercise every day.
43:16.263 --> 43:20.226
[SPEAKER_00]: Doesn't matter what exercise, not at all, whatever you like.
43:20.446 --> 43:29.111
[SPEAKER_00]: Like tennis, pickleball, we had a Chinese lady last week, and she's been coming here.
43:29.872 --> 43:34.054
[SPEAKER_00]: And after each treatment, she asked me, can I go and play pickleball now?
43:34.314 --> 43:37.876
[SPEAKER_00]: And she's 83 as all the looks, you know, little fragile in the middle.
43:38.297 --> 43:39.938
[SPEAKER_00]: And she goes and plays every day.
43:40.558 --> 43:41.939
[SPEAKER_00]: So if you like that, do it.
43:42.039 --> 43:43.239
[SPEAKER_00]: If not, just walk.
43:43.719 --> 43:43.980
[SPEAKER_02]: Uh-huh.
43:44.380 --> 43:44.920
[SPEAKER_02]: Wonderful.
43:45.500 --> 43:46.941
[SPEAKER_02]: Thank you, Dr. Kiprov.
43:47.141 --> 43:47.981
[SPEAKER_00]: You're very welcome.
43:48.242 --> 43:49.722
[SPEAKER_02]: Oh, so how do people find you?
43:49.822 --> 43:52.724
[SPEAKER_02]: Because you're in the Bay Area, right?
43:53.224 --> 43:55.565
[SPEAKER_02]: I guess, is this in San Francisco?
43:55.625 --> 43:56.545
[SPEAKER_02]: Are we in San Francisco?
43:56.585 --> 43:57.766
[SPEAKER_00]: No, we are in Milwaukee.
43:57.866 --> 43:59.166
[SPEAKER_00]: Oh, yes, sorry.
43:59.607 --> 44:00.507
[SPEAKER_02]: A gorgeous place.
44:00.907 --> 44:03.889
[SPEAKER_02]: Yeah, incredible view from your office.
44:04.269 --> 44:06.810
[SPEAKER_02]: So, and what's the best place where people can find you?
44:07.673 --> 44:10.455
[SPEAKER_00]: global afrizes.com.
44:11.295 --> 44:13.697
[SPEAKER_02]: Yes, waterfall, thank you so much.
44:13.737 --> 44:15.278
[SPEAKER_00]: You're very well, pleasure.
44:15.758 --> 44:22.323
[SPEAKER_03]: Thank you for listening to this episode, hope you enjoy the content, and if so, please rate and follow this podcast.
44:22.623 --> 44:28.467
[SPEAKER_03]: To reach me, you can contact uplift longevity center, and that is uplift with a why.
44:28.707 --> 44:30.908
[SPEAKER_03]: You can also subscribe to my YouTube channel,
00:00.071 --> 00:05.795
[SPEAKER_00]: We do know that systemic inflammation plays a major role in aging.
00:06.075 --> 00:07.556
[SPEAKER_00]: That's the word inflamaging.
00:07.676 --> 00:13.640
[SPEAKER_00]: Ethlamaging therapeutic plasmics change can remove this inflammatory factors very effectively.
00:13.940 --> 00:16.422
[SPEAKER_00]: Attacks inflammation on many different levels.
00:16.742 --> 00:21.264
[SPEAKER_02]: So, inflammation markers will keep rising even if person looks perfectly healthy.
00:21.484 --> 00:23.725
[SPEAKER_02]: But still, they are in a state of decline.
00:24.165 --> 00:37.451
[SPEAKER_02]: And that's one thing I think that's exciting about using plasma freezes for longevity purposes is how to reverse that aging process and actually revert the body into a younger state.
00:37.751 --> 00:40.113
[SPEAKER_03]: Welcome to the Dr. Joy Kong podcast.
00:40.413 --> 00:45.455
[SPEAKER_03]: This is why I have a chance to share with you some of the latest developments in the space of holistic health
00:45.775 --> 00:47.417
[SPEAKER_03]: longevity and wellness.
00:47.838 --> 00:54.667
[SPEAKER_03]: I've always honored intellectual curiosity and scientific rigor combined with real world practicality.
00:54.987 --> 00:59.373
[SPEAKER_03]: My goal is that what you learn here will help you live longer and live better.
00:59.694 --> 01:01.015
[SPEAKER_03]: Hope you enjoy the journey with me.
01:01.556 --> 01:04.338
[SPEAKER_02]: Dr. Kiproth, I am so excited to be interviewing you.
01:04.858 --> 01:17.446
[SPEAKER_02]: You are a pioneer in the longevity field and you have been contributing to the world of health with particularly when it comes to plasma for races, which has gaining popularity.
01:17.526 --> 01:28.193
[SPEAKER_02]: People are just beginning to really understand what a powerful modality this is at rejuvenating their body, not to mention combatting illnesses.
01:28.554 --> 01:28.674
[SPEAKER_02]: So,
01:31.027 --> 01:32.895
[SPEAKER_00]: The pleasure and honor to be with you.
01:33.375 --> 01:34.035
[SPEAKER_02]: Oh, thank you.
01:34.395 --> 01:37.116
[SPEAKER_02]: So of course, I had just gotten treatment from you.
01:37.376 --> 01:38.296
[SPEAKER_02]: My bad just vulnerable.
01:38.676 --> 01:43.958
[SPEAKER_02]: Of course, the blood comes out one side, and then it comes back in the other side.
01:44.218 --> 01:44.758
[SPEAKER_00]: How do you feel?
01:45.238 --> 01:46.138
[SPEAKER_02]: I feel amazing.
01:46.318 --> 01:47.558
[SPEAKER_02]: Yeah, it's fantastic.
01:47.638 --> 01:48.339
[SPEAKER_02]: It was easy.
01:48.619 --> 01:53.000
[SPEAKER_02]: You know, my veins usually are not corroborating, but you know, today actually did quite well.
01:53.440 --> 01:55.080
[SPEAKER_02]: I saw my full bag.
01:55.560 --> 01:58.321
[SPEAKER_02]: So one and a half liters of my own plasma.
01:58.661 --> 02:00.041
[SPEAKER_02]: Well, I held in my hand.
02:00.401 --> 02:01.522
[SPEAKER_02]: So that was amazing.
02:03.582 --> 02:08.869
[SPEAKER_02]: And now we're replenishing with something that doesn't have harmful elements, you know, that's correct.
02:08.949 --> 02:15.176
[SPEAKER_02]: And then you can, yeah, so tell us a little bit about plasma freezes and the history of it.
02:15.336 --> 02:19.421
[SPEAKER_02]: Like what what even got you interested in plasma freezes and what is it first of all?
02:19.943 --> 02:32.287
[SPEAKER_00]: As you described it, it's the removal of all plasma and replacing it in your case with 5% albumin, which is about 65% of human plasma.
02:32.307 --> 02:43.430
[SPEAKER_00]: So we clean up the old plasma, which accumulates a variety of substances that contribute to a variety of diseases and also aging.
02:44.690 --> 02:58.673
[SPEAKER_00]: and by removing them and substituting with human plasma, with human now-be-me, we accomplish a variety of different things, including fighting inflammation, which is very important.
02:58.773 --> 03:07.535
[SPEAKER_00]: It's basically the major contributor to aging, and the major contributor to most age-related diseases.
03:08.843 --> 03:10.324
[SPEAKER_00]: So, how do we do that?
03:10.404 --> 03:17.727
[SPEAKER_00]: We do it with a machine, which is capable of separating your whole blood into cells and plasma.
03:18.428 --> 03:23.970
[SPEAKER_00]: We give you the cells back, with the 5% aluminum, and we throw your whole plasma away.
03:24.330 --> 03:25.211
[SPEAKER_00]: How does simple as that?
03:25.431 --> 03:25.731
[SPEAKER_02]: Right.
03:25.931 --> 03:28.492
[SPEAKER_02]: And somehow, you mean what we have is not good?
03:29.533 --> 03:34.435
[SPEAKER_02]: People are trying very hard to protect, was inside a body, rather, always afraid to let go.
03:34.775 --> 03:36.776
[SPEAKER_02]: So, what's going on in the blood?
03:39.260 --> 03:54.830
[SPEAKER_00]: Well, blood is obviously very important for life because it creates the environment, the milieu of every single cell in the body, from stem cells to your brain cells, heart and so forth.
03:55.470 --> 03:56.631
[SPEAKER_00]: So it's critical.
03:56.791 --> 04:08.178
[SPEAKER_00]: In addition to that, a lot of distributes all the food and hormones and everything that the body needs and the cells need.
04:08.678 --> 04:12.440
[SPEAKER_00]: So it's a very important organ to have.
04:12.901 --> 04:21.686
[SPEAKER_00]: The problem becomes later in life for most people and sometimes in younger people as well.
04:22.326 --> 04:29.496
[SPEAKER_00]: And that is that there is some sort of imbalance that happens in the content of the plasma.
04:29.516 --> 04:36.706
[SPEAKER_00]: So the plasma has hundreds and hundreds, probably thousands of different molecules, different proteins.
04:38.656 --> 04:47.264
[SPEAKER_00]: that circulate in the plasma, and in normal situation called homostasis, these are all imbalance and infection pretty well.
04:48.024 --> 04:54.130
[SPEAKER_00]: In some diseases, there is an imbalance of plasma components,
04:58.093 --> 05:05.502
[SPEAKER_00]: or some other proteins, they may cause diseases and some of these diseases are really, very, very rough to deal with.
05:06.223 --> 05:07.365
[SPEAKER_00]: They are really deadly.
05:08.386 --> 05:17.317
[SPEAKER_00]: So in these cases, we do plasma for disease or plasma exchange to remove these substances that cause these horrible diseases.
05:18.100 --> 05:23.742
[SPEAKER_02]: And how long ago did this treatment even start a plasma phrase as when did we start to use them?
05:25.423 --> 05:45.011
[SPEAKER_00]: Probably the first plasma exchange treatment started in the 1950s in the skin of Sweden I believe for a disease called Waldenstroms, where the blood gets thick from the accumulation of abnormal immunoglobulins.
05:45.751 --> 05:48.572
[SPEAKER_00]: That's where it started in general.
05:48.592 --> 05:58.577
[SPEAKER_00]: I think the late late 70s, it started to getting more and more popular with equipment becoming more available.
05:59.637 --> 06:09.442
[SPEAKER_00]: Some of the early cases came from England and from the United States, Peter Dao, who was my teacher, is the pioneer of Plasma Exchange in the United States.
06:10.382 --> 06:11.503
[SPEAKER_00]: So, I would say,
06:12.981 --> 06:19.422
[SPEAKER_02]: late 70s and this is an FDA-approved treatment for a variety of diseases.
06:20.363 --> 06:26.524
[SPEAKER_00]: Well, actually no, the FDA approves the equipment we use.
06:26.984 --> 06:29.465
[SPEAKER_00]: The machines that we use to separate blood.
06:29.585 --> 06:29.925
[SPEAKER_00]: Okay.
06:30.505 --> 06:32.085
[SPEAKER_00]: Our approved by the FDA.
06:32.145 --> 06:35.386
[SPEAKER_00]: There are a number of machines approved in the United States.
06:36.006 --> 06:38.066
[SPEAKER_00]: Many more approved in other countries.
06:38.167 --> 06:39.987
[SPEAKER_00]: We don't have all the equipment.
06:40.627 --> 06:41.467
[SPEAKER_00]: that's available.
06:41.527 --> 06:46.029
[SPEAKER_00]: In other countries, we have only limited number and FDA-approved machines.
06:46.129 --> 06:48.690
[SPEAKER_00]: But again, FDA approves the equipment.
06:49.290 --> 06:51.391
[SPEAKER_00]: They don't approve the disease, it's head.
06:51.411 --> 06:55.452
[SPEAKER_02]: Right, but does it approve the equipment for treating a certain condition?
06:55.732 --> 07:02.955
[SPEAKER_00]: Right, so if you're a physician, you have the ability of label to use FDA approved equipment.
07:03.836 --> 07:06.097
[SPEAKER_00]: So, how do we get to the diseases?
07:06.217 --> 07:10.759
[SPEAKER_00]: We get to the diseases through medical associations.
07:10.979 --> 07:17.421
[SPEAKER_00]: So, American Society for A for Disease is a medical association that
07:19.102 --> 07:23.486
[SPEAKER_00]: represents A for Ezekiel in general, cosmic change is part of that.
07:24.127 --> 07:44.025
[SPEAKER_00]: This society called Asua publishes every three years a special edition of the Journal of Pentecostal A for Ezekiel, where they publish recommendations, recommendations, not approvals, just recommendations for the use of different A for Ezekiel's procedures for different diseases.
07:44.645 --> 08:00.603
[SPEAKER_00]: and they are categorized depending on scientifically published documentation that there is benefit of cosmic change or other FRIZs procedures in certain diseases.
08:00.917 --> 08:01.558
[SPEAKER_02]: is interesting.
08:02.479 --> 08:13.311
[SPEAKER_02]: Okay, it reminds me of a little bit of a different therapies, maybe even something like stem cell therapy, and maybe there's no FDA approval for certain conditions.
08:13.811 --> 08:19.097
[SPEAKER_02]: A lot of devices, they do seek indications, but it some may just be approved for
08:20.238 --> 08:36.663
[SPEAKER_02]: you know for certain function I guess and then it's up to the medical organizations to recommend whether or not it's or it's fits certain criteria whether or not something has enough scientific evidence to be basically recommended.
08:37.464 --> 08:47.047
[SPEAKER_02]: Yeah so a lot of people may be confused with the different words so Plasma Furious is as the same as Plasma Exchange are they exactly the same thing.
08:47.869 --> 08:54.652
[SPEAKER_00]: Actually, they are not, but they are used interchangeable interchangeably in some way.
08:54.712 --> 09:02.796
[SPEAKER_00]: Plasma for resist is actually the act of the separation of whole blood into plasma and cells.
09:02.897 --> 09:04.677
[SPEAKER_00]: That's what plasma for resist is.
09:04.837 --> 09:05.418
[SPEAKER_00]: I see.
09:06.198 --> 09:09.420
[SPEAKER_00]: Plasma exchange is the fact that we will
09:10.020 --> 09:23.955
[SPEAKER_00]: perform plasma for is this, but in addition to that, we're going to throw the old plasma away and it creates it, exchange it with a new, a new fluid in our situation, 5% of it.
09:24.295 --> 09:24.756
[SPEAKER_02]: I see.
09:25.156 --> 09:31.103
[SPEAKER_02]: And then A for ises, because you have a company called global A for ises, what is A for ises?
09:31.343 --> 09:36.365
[SPEAKER_00]: Well, if this is a general term, it comes from the Greek and means to take away.
09:36.385 --> 09:37.166
[SPEAKER_00]: Oh.
09:37.506 --> 09:48.331
[SPEAKER_00]: However, we use it today, medicine to indicate a field of medicine, which involves the separation of blood in its different components.
09:49.011 --> 09:57.594
[SPEAKER_00]: and the removal of each individual component separately as you need it or your patients need it and it could be done in blood banking.
09:58.114 --> 10:15.380
[SPEAKER_00]: We collect red cells, platelets, plasma, could be done in plasma centers while they collect plasma for variety of products and it could be used to collect themselves for transplantation usually
10:16.360 --> 10:29.153
[SPEAKER_00]: in oncology and hematologic diseases and more recently something that's very popular now and I think will become even more popular is called CART therapy.
10:29.994 --> 10:36.200
[SPEAKER_00]: These are specialized procedures to treat really bad cancers.
10:37.549 --> 10:43.812
[SPEAKER_00]: And it also will become more and more popular, I believe, in genetic engineering.
10:44.152 --> 10:58.258
[SPEAKER_00]: So in order to perform genetic engineering, you need cells and these cells circulate in the blood and we collect these cells and give them to labs where they are genetically manipulated and then brought back to the patient.
10:58.418 --> 10:59.279
[SPEAKER_02]: that's so interesting.
10:59.339 --> 11:04.382
[SPEAKER_02]: Thank you for making that clear because I've been not not sure in my head or how to connect the dots.
11:05.702 --> 11:13.547
[SPEAKER_02]: So as far as the plasma, you know, plasma for uses, that's the decepiration of different components.
11:14.228 --> 11:19.070
[SPEAKER_02]: And I think it implies plasma exchange as well, right?
11:19.271 --> 11:19.531
[SPEAKER_02]: Right.
11:19.571 --> 11:20.691
[SPEAKER_02]: That as a procedure.
11:20.711 --> 11:21.212
[SPEAKER_03]: Yeah.
11:21.392 --> 11:24.574
[SPEAKER_02]: And what has, has it been recommended for?
11:24.694 --> 11:25.774
[SPEAKER_02]: What type of conditions?
11:26.935 --> 11:28.236
[SPEAKER_02]: has been helpful for.
11:29.096 --> 11:33.998
[SPEAKER_00]: Plasma exchange has been used in probably over 80 different diseases.
11:34.618 --> 11:40.420
[SPEAKER_00]: The majority of these diseases are all immune diseases, how we call them, all immune diseases.
11:40.540 --> 11:48.363
[SPEAKER_00]: So basically it is something that your own immune system attacks itself and other organs.
11:49.323 --> 11:55.492
[SPEAKER_00]: So the immune system is the protective army of the body.
11:56.052 --> 12:04.624
[SPEAKER_00]: So it protects us from infections, it protects us from cancer, and other outside invaders, if you will.
12:05.465 --> 12:25.156
[SPEAKER_00]: So, in the autoimmune conditions, the immune system fails to recognize and differentiate itself from now self and it starts attacking self and it may attack the kidneys, it may attack the brain, it may attack the heart and other tissues.
12:26.417 --> 12:35.743
[SPEAKER_00]: And it does that by creating auto antibodies, which are proteins that attack self-tissue, that's why they're auto antibodies.
12:36.584 --> 12:46.290
[SPEAKER_00]: So these autoimmune diseases, there's a bunch of them in neurology, in the phrology, in variety of different specialties.
12:47.851 --> 12:56.659
[SPEAKER_00]: And by removing these auto antibodies from the blood, we help treat these diseases, usually in combination with other medications.
12:58.000 --> 13:00.703
[SPEAKER_01]: And how well does it work in your practice?
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[SPEAKER_00]: It depends.
13:02.507 --> 13:04.628
[SPEAKER_00]: It depends on many, on many things.
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[SPEAKER_00]: It depends on the disease.
13:06.949 --> 13:13.971
[SPEAKER_00]: It depends on how advanced the disease is, how much damage has already been created in different organs.
13:14.791 --> 13:18.412
[SPEAKER_00]: So the earlier you start in any treatment, until any disease is the better.
13:19.172 --> 13:27.179
[SPEAKER_00]: What happens with plasmic change, unfortunately, is that people don't know much about it, it's an obscure take.
13:27.960 --> 13:36.747
[SPEAKER_00]: Although it's approved and it's being available, it's a procedure that even well-educated physicians don't understand.
13:37.668 --> 13:44.211
[SPEAKER_00]: So, they ask for plasma for easy-sim-difficult cases, usually they're all last resort.
13:44.791 --> 13:49.213
[SPEAKER_00]: And by that time, it is difficult to achieve great results.
13:50.054 --> 13:56.977
[SPEAKER_00]: Nonetheless, we see some dramatic improvement in very difficult conditions where everything else is failed.
13:57.717 --> 14:11.853
[SPEAKER_00]: So it's very rewarding, and that's why I'm here practicing this for four years, is because we have success, not in every single case, but in many cases, and many times this success is very dramatic.
14:12.454 --> 14:17.900
[SPEAKER_00]: As I said, people have tried everything on earth, they didn't work, and they
14:18.400 --> 14:27.765
[SPEAKER_00]: finally come to us and all of a sudden they opened their eyes, they start talking again, they start moving, it's very rewarding.
14:28.505 --> 14:35.789
[SPEAKER_02]: And you were just showing me just a few things in your office, a related to patients you've treated, one of them was an athlete, right?
14:35.829 --> 14:42.833
[SPEAKER_02]: He yes, he was an eye condition that he couldn't see and he was a dark player, right?
14:42.873 --> 14:44.193
[SPEAKER_02]: And then with how many
14:47.770 --> 14:52.574
[SPEAKER_00]: Well, he had a condition called Myestina Grabis and I've been treating him for years.
14:55.576 --> 15:04.803
[SPEAKER_00]: But lately, as the pictures that you showed, he's been coming periodically to get three cleanses doing well.
15:05.763 --> 15:14.270
[SPEAKER_02]: Yeah, another picture you showed me was lots of kids that were born because you helped a mother to improve their condition.
15:19.383 --> 15:32.226
[SPEAKER_00]: It's a difficult question and I'm not sure I know the answer, but we have seen quite a few number of women who experience forced trimester miscarriages.
15:33.625 --> 15:44.636
[SPEAKER_00]: So, first-stream master miscarriages, he's characterized by somebody who has more than three or more miscarriages in the first-stream master.
15:45.617 --> 15:54.186
[SPEAKER_00]: And the women that we see have three or more, some have five, six, 11 miscarriages.
15:55.644 --> 16:02.247
[SPEAKER_00]: So the majority of these ladies, we have identified auto antibories.
16:02.287 --> 16:12.671
[SPEAKER_00]: So they have an all-emion condition, which is poorly defined, but they have a variety of antibories circulating in their blood.
16:13.632 --> 16:20.635
[SPEAKER_00]: And we believe that these antibories contribute to the miscarriages.
16:21.655 --> 16:32.285
[SPEAKER_00]: By removing them, either by plasma-freezes, or by attacking them with medications, such as intravenous immunoglobulin, we can solve the problem.
16:33.186 --> 16:36.869
[SPEAKER_00]: Unfortunately for all these women and to us,
16:37.770 --> 16:45.873
[SPEAKER_00]: We have this successful in the majority of these cases to to scale this women and have children.
16:46.153 --> 16:50.655
[SPEAKER_00]: And what is on the picture are the kids.
16:51.135 --> 16:52.676
[SPEAKER_00]: I call them my kids.
16:52.716 --> 16:56.357
[SPEAKER_00]: They're not, but I feel proud that I contributed.
16:56.617 --> 17:15.947
[SPEAKER_02]: Yeah, that's amazing, so autoimmune condition is really the mainstay of what Plasma Exchange is kind of indicated for right correct any inflammation and and just general inflammation right okay so how do you decide that how who comes to you for inflammation like it
17:17.164 --> 17:24.187
[SPEAKER_00]: Well, there are many tests today that indicate systemic inflammation.
17:24.247 --> 17:30.229
[SPEAKER_00]: I'm not talking about inflammation where you cut yourself and you have swelling of the fingers and all that.
17:30.689 --> 17:40.713
[SPEAKER_00]: But systemic inflammation leads to a variety of diseases from type to diabetes, to stroke, to cardiovascular disease, cancer and so forth.
17:41.553 --> 17:52.166
[SPEAKER_00]: So systemic inflammation can be measured with the variety of laboratory tests, blood tests, usually, biopsies, if needed, and all that.
17:52.206 --> 17:59.535
[SPEAKER_00]: So we do know that systemic inflammation plays a major role in ageing.
17:59.973 --> 18:03.214
[SPEAKER_00]: Yeah, that's the word inflamaging, inflamaging.
18:03.234 --> 18:04.414
[SPEAKER_00]: They're hand in hand.
18:04.454 --> 18:06.214
[SPEAKER_00]: Exactly, inflammation and aging.
18:06.994 --> 18:13.996
[SPEAKER_00]: And I think that this is the so-called longevity medicine attacks that inflamaging.
18:14.156 --> 18:15.996
[SPEAKER_00]: So how do we attack inflamaging?
18:16.536 --> 18:23.938
[SPEAKER_00]: Usually a single drug doesn't do the job because it's a very complex physiologic process or pathophysiologic process.
18:24.859 --> 18:35.497
[SPEAKER_00]: And we know that therapeutic plasma exchange can remove this inflammatory factors very effectively and attack inflammation on many different levels.
18:36.004 --> 18:36.304
[SPEAKER_02]: Yeah.
18:37.125 --> 18:37.365
[SPEAKER_02]: Right.
18:37.445 --> 18:43.071
[SPEAKER_02]: So inflammation is accumulating as we age whether or not the person has any disease.
18:43.451 --> 18:48.436
[SPEAKER_02]: So inflammation markers would keep a rising even if person looks perfectly healthy.
18:48.456 --> 18:48.977
[SPEAKER_02]: Sure.
18:49.077 --> 18:51.299
[SPEAKER_02]: But still, they are in a state of decline.
18:51.759 --> 18:54.041
[SPEAKER_02]: And that's one thing I think that's exciting
19:00.108 --> 19:06.369
[SPEAKER_02]: reverse that aging process and actually revert the the body into a younger state, right?
19:07.523 --> 19:15.485
[SPEAKER_00]: Correct, that's the goal, and by doing so, we expand the health span of people.
19:15.945 --> 19:23.807
[SPEAKER_00]: People in general are healthy over many years, until certain age comes, and then they start developing diseases.
19:24.327 --> 19:32.509
[SPEAKER_00]: In the United States, this border of health and disease is around 65, 70 years old.
19:33.149 --> 19:34.169
[SPEAKER_00]: Maybe a little earlier.
19:37.550 --> 19:53.767
[SPEAKER_00]: the health span is interrupted that people start getting diseases and fortunately or unfortunately we keep them alive because medicine has made tremendous progress over the last 50, 70 years.
19:54.387 --> 19:56.369
[SPEAKER_00]: So we know how to treat these diseases.
19:56.590 --> 19:59.112
[SPEAKER_00]: We don't know how to cure them, but we know how to treat them.
20:00.013 --> 20:06.536
[SPEAKER_00]: Unfortunately, we prolong the life of people with these diseases, but they're not healthy.
20:07.717 --> 20:10.038
[SPEAKER_00]: They're non-productive, they're not very happy.
20:10.892 --> 20:15.695
[SPEAKER_00]: They are suffering, and it takes an enormous amount of money to keep them alive.
20:16.896 --> 20:18.437
[SPEAKER_00]: So it is a problem.
20:18.497 --> 20:29.105
[SPEAKER_00]: So the goal of the so-called longevity medicine, it's a word that I don't like at all, but the goal here is to extend the health span.
20:29.665 --> 20:35.189
[SPEAKER_00]: To have people develop this disease is if at all, or longer health span.
20:37.370 --> 20:58.265
[SPEAKER_00]: If we can prolong the shell span of people with 2, 3 or 5 years, it will add tremendously to their productivity and life happiness and living a good life because people with injuries and diseases that they don't live a good life.
20:58.765 --> 21:04.649
[SPEAKER_00]: It's suffering with 72 pills every morning, so that's the goal.
21:04.929 --> 21:06.530
[SPEAKER_02]: Yeah, yeah, fantastic.
21:06.730 --> 21:13.213
[SPEAKER_02]: And that's, you know, most people I talk to, they say, I don't care how long I live, I just want to be healthy.
21:13.293 --> 21:14.994
[SPEAKER_02]: So that's really the goal.
21:15.034 --> 21:16.474
[SPEAKER_02]: That's what I'm trying to achieve.
21:16.514 --> 21:16.714
[SPEAKER_02]: Yeah.
21:16.995 --> 21:20.396
[SPEAKER_02]: So I'm curious, you're a Harvard trained immunologist, right?
21:20.716 --> 21:22.697
[SPEAKER_02]: And you are treating people with all kinds of
21:26.899 --> 21:34.222
[SPEAKER_02]: got into the longevity space, the word you'd like, but the promoting health rather than curing diseases.
21:34.582 --> 21:41.325
[SPEAKER_02]: So what promoted that shift in and as I mentioned, I don't like this word.
21:41.665 --> 21:53.549
[SPEAKER_00]: The longevity word is, I know it's getting now popularity and I'm beneficiary of the popularity, but the truth is that it is healthspot.
21:53.769 --> 21:55.230
[SPEAKER_00]: I have been a proponent of
21:56.090 --> 22:04.074
[SPEAKER_00]: healthy living, and there are the four plasma ferries that were two scientifically proven approaches to healthy living.
22:04.574 --> 22:08.396
[SPEAKER_00]: One is the Mediterranean diet and the other one is exercise.
22:08.917 --> 22:13.079
[SPEAKER_00]: These are all scientifically proven with clinical control clinical trials.
22:13.859 --> 22:21.881
[SPEAKER_00]: Now, we can add plasma ferrisis to that because we just finished a controlled placebo-controlled clinical trial in plasma ferrisis.
22:21.921 --> 22:27.022
[SPEAKER_00]: So we know that these contributes to extending life's path.
22:27.142 --> 22:28.202
[SPEAKER_00]: What did you get to show?
22:28.763 --> 22:30.623
[SPEAKER_00]: Study showed variety of different things.
22:30.683 --> 22:33.324
[SPEAKER_02]: Is it an animal study or human study, okay?
22:34.864 --> 22:37.605
[SPEAKER_00]: It's the only human study in Poulonjavit.
22:38.105 --> 22:41.166
[SPEAKER_00]: I see that it's clinically controlled, okay?
22:41.426 --> 22:55.290
[SPEAKER_00]: So I think that the most significant finding was that the biologic age of the patients who were treated as opposed to the non-treated one, the placebo control, their biologic age,
22:56.672 --> 23:14.484
[SPEAKER_00]: was much younger did that than their chronologic age and actually we have the ability to identify the biological age of different organs, not only the total body, but the different organs, you know, brain ages differently than the kidneys.
23:15.405 --> 23:36.385
[SPEAKER_00]: in the heart and so forth, so we can clarify every organ by a logic age, and we show that the immune system rejuvenates rejuvenates 7 to 9 years better than the non-treated group, you know, the placebo group, which did not get the treatment.
23:37.091 --> 23:39.233
[SPEAKER_00]: So the results are very encouraging.
23:39.293 --> 23:43.617
[SPEAKER_00]: We'll continue to do more research, but this so far the results are encouraging.
23:44.218 --> 23:56.510
[SPEAKER_00]: And overall, now we have the Mediterranean diet, exercise and plasma ferries that can really extend your lifespan, not necessarily, but you certainly, your health span.
23:56.750 --> 24:06.418
[SPEAKER_02]: Yeah, I was actually so I guess the nurse who was conducting the therapy for me, she actually went through to study herself.
24:06.699 --> 24:08.340
[SPEAKER_00]: She's the best nurse in the world.
24:09.401 --> 24:10.101
[SPEAKER_02]: She's amazing.
24:10.442 --> 24:13.284
[SPEAKER_02]: Yeah, but she was telling me, she had the frozen shoulder.
24:13.304 --> 24:13.805
[SPEAKER_00]: Right.
24:14.225 --> 24:21.151
[SPEAKER_02]: And that one away and she had thinning hair and she was really worried about that and that started to get better and better.
24:21.351 --> 24:21.571
[SPEAKER_00]: Right.
24:21.651 --> 24:37.700
[SPEAKER_00]: There are a variety of symptoms that come with aging, not necessarily a determined disease that are influenced, due to inflammation for sure, and they respond right away to the plasma exchange.
24:38.701 --> 24:44.004
[SPEAKER_00]: Usually, either arthritis that you had, other people have that, we had,
24:44.804 --> 24:51.210
[SPEAKER_00]: patients with all the immunolopeia, which is out to the immune conditions that leads to loss of hair.
24:51.890 --> 24:53.231
[SPEAKER_00]: The effect is dramatic.
24:53.732 --> 24:58.536
[SPEAKER_00]: They lose pieces of hair and all of a sudden it grows back.
24:58.556 --> 24:59.517
[SPEAKER_00]: It's amazing.
24:59.557 --> 25:00.638
[SPEAKER_00]: That's beautiful.
25:00.898 --> 25:03.020
[SPEAKER_02]: And how many sessions would that usually take?
25:04.213 --> 25:05.514
[SPEAKER_00]: We're still working on that.
25:05.574 --> 25:12.776
[SPEAKER_00]: I think that different diseases, different people require different number of sessions, usually between three and six.
25:13.237 --> 25:13.657
[SPEAKER_02]: I see.
25:14.337 --> 25:16.978
[SPEAKER_02]: What if someone just comes to you for a rejuvenation?
25:17.058 --> 25:20.880
[SPEAKER_02]: Just want to stay ahead of the game, maybe get a little younger.
25:20.900 --> 25:24.461
[SPEAKER_02]: So how many sessions would you recommend?
25:25.300 --> 25:29.383
[SPEAKER_00]: In the clinical study that are just described, we use six sessions.
25:30.483 --> 25:41.310
[SPEAKER_00]: This was based on preliminary studies that we did with the University of California in Berkeley, that indicated that there is a cumulative effect of hospital diseases.
25:41.831 --> 25:43.131
[SPEAKER_00]: The more treatments we did,
25:44.432 --> 25:50.037
[SPEAKER_00]: The more changes we saw in the different parameters that we measured.
25:50.898 --> 25:55.482
[SPEAKER_00]: So, six treatments is what is generally recommended.
25:55.682 --> 26:03.348
[SPEAKER_00]: I think that what we found in the current study is that the first two or three treatments are the most effective.
26:03.869 --> 26:06.431
[SPEAKER_02]: Okay, and these treatments are usually a matter of part.
26:07.673 --> 26:16.188
[SPEAKER_00]: Yes, we had three different treatment groups, one was a month apart, the other groups were two treatments per month for three months.
26:17.153 --> 26:22.655
[SPEAKER_01]: Okay, okay, so which one did better, the one that's farther apart or closer together?
26:22.775 --> 26:35.579
[SPEAKER_00]: Well, interestingly enough, it was not, they all improved, they all improved, but the group that received in addition to the Blazberg's change, intravenous immunoglobulin, which is part of the normal plasma.
26:36.259 --> 26:40.321
[SPEAKER_00]: So we added the small amount of heart-to-school IVIG
26:44.588 --> 26:48.230
[SPEAKER_00]: after each procedure had this made a big difference.
26:48.591 --> 26:53.333
[SPEAKER_02]: Okay, can you explain the IVIG people talk about that a lot these days?
26:53.794 --> 27:02.419
[SPEAKER_02]: What do you think made it so popular and can you tell us a little bit about that and the difference between that and the plasma produces or are they often given together?
27:03.148 --> 27:07.533
[SPEAKER_00]: So intravenous immunoglobulin is made from plasma.
27:08.654 --> 27:20.567
[SPEAKER_00]: Immunoglobulins are major component of human plasma and they are very important for the immune system, that's why they're called immunoglobulings.
27:21.388 --> 27:40.682
[SPEAKER_00]: There are four different kinds and the one called IGG is the most prominent one and I don't know if it's the most important but certainly a lot of the all-remune conditions are associated with all the antibodies of IGG class.
27:41.062 --> 27:46.006
[SPEAKER_00]: If we want to get deeper into this, this IGG one, this IGG two, this IGG three.
27:47.407 --> 27:51.772
[SPEAKER_00]: So people tell I VIG therapy which one are they using?
27:51.792 --> 27:58.959
[SPEAKER_00]: So the intravenous immunoglobulin is a preparation pharmaceutical preparation from Plasma.
27:59.620 --> 28:06.067
[SPEAKER_00]: It predominantly has IGG in it, but it has small amounts of IGA and IGM, right?
28:06.648 --> 28:08.229
[SPEAKER_00]: The other, the other immunoglobulin.
28:09.234 --> 28:16.767
[SPEAKER_00]: So initially I started using small amounts of IVRG as a replacement.
28:17.128 --> 28:18.450
[SPEAKER_00]: So we remove plasma.
28:20.166 --> 28:21.767
[SPEAKER_00]: And we remove everything that's in it.
28:22.827 --> 28:25.608
[SPEAKER_00]: We use the replacement fluid 5% out of it.
28:25.648 --> 28:28.790
[SPEAKER_00]: That's 65%, so we accomplished that.
28:29.510 --> 28:35.933
[SPEAKER_00]: But the immunoglobin is very, very important for your protection from infections and so forth.
28:36.753 --> 28:38.094
[SPEAKER_00]: We are not replacing those.
28:38.174 --> 28:46.158
[SPEAKER_00]: So I said, well, if we infuse a little bit of IVAG, this gets closer to normal plus.
28:47.458 --> 28:49.860
[SPEAKER_00]: So that was the initial idea.
28:50.041 --> 28:58.348
[SPEAKER_00]: I didn't know that it will have such a profound effect on DNA methylation.
28:58.368 --> 29:01.411
[SPEAKER_00]: That's how this biological cage clocks work.
29:02.172 --> 29:02.672
[SPEAKER_00]: But it did.
29:03.353 --> 29:08.457
[SPEAKER_00]: And I don't have the exact explanation of how this works.
29:09.658 --> 29:25.505
[SPEAKER_00]: But there is something, and we could get a little off-label here, but there is a study that was published from Johns Hopkins, Dr. Bob Montgomery, or famous nephrologist and the renal transplants, physicians.
29:26.165 --> 29:29.067
[SPEAKER_00]: He used plasma for disease.
29:30.367 --> 29:39.631
[SPEAKER_00]: followed by relatively small dose of IVIG to treat vinyl kidney rejection, very successful.
29:40.492 --> 29:44.914
[SPEAKER_00]: So, again, I don't think we know exactly the mechanism.
29:46.014 --> 29:50.676
[SPEAKER_00]: The idea is to suppress the immune system.
29:51.677 --> 29:54.798
[SPEAKER_00]: That's why people use a very high dose of IVIG.
29:55.218 --> 30:10.414
[SPEAKER_00]: So that's another different mechanism and it's very complicated and I'm not going to go into it, but there are different ways to use IVIG1 is to use very high doses to attack or immunity.
30:10.875 --> 30:12.537
[SPEAKER_00]: So it causes immunosuppression.
30:13.338 --> 30:18.402
[SPEAKER_00]: I believe it's more immunomodulation rather than a suppression, but these are semantics.
30:19.503 --> 30:31.334
[SPEAKER_00]: And the way we use it in combination with Plasma Exchange, with much smaller doses, which is obviously much less expensive, works really very well, both for renal transplantation.
30:32.094 --> 30:34.497
[SPEAKER_00]: rejection as well as in longevity.
30:35.158 --> 30:37.640
[SPEAKER_00]: I wish I knew the exact mechanism of action.
30:38.301 --> 30:47.931
[SPEAKER_00]: There is definitely influence on the different immunocompetence cells, they are cells in the body, in the blood.
30:48.672 --> 30:51.276
[SPEAKER_00]: that you have a lot to do with the immune system.
30:51.917 --> 31:02.251
[SPEAKER_00]: So we know that we influence those in a positive way and there is the replacement of antibodies, but that's as much as I know in the moment.
31:02.511 --> 31:05.035
[SPEAKER_02]: Does it help with fighting acute infections?
31:05.848 --> 31:07.709
[SPEAKER_00]: Well, it theoretically does.
31:08.130 --> 31:12.013
[SPEAKER_00]: I don't think it's being used universally to do that.
31:12.133 --> 31:18.638
[SPEAKER_00]: It's being used in patients who are born, immunodeficient, who are born with very low or absent high CG.
31:19.058 --> 31:19.418
[SPEAKER_02]: Okay.
31:19.959 --> 31:27.144
[SPEAKER_02]: And you've also used a plasma exchange to help people that's recovering from long haul colded, right?
31:27.545 --> 31:31.828
[SPEAKER_02]: So is that something you want to talk about?
31:32.348 --> 31:45.413
[SPEAKER_00]: I'm blamed for being the first to use plasma ferries for a long COVID and publish it with published that and we did extensive studies of why plasma ferries is helps in this condition.
31:46.874 --> 31:57.078
[SPEAKER_00]: Having said that, a long COVID is a very complicated disease and I don't think we know much about it.
31:57.859 --> 32:00.940
[SPEAKER_00]: And the reason for that is that long COVID is
32:02.775 --> 32:15.481
[SPEAKER_00]: political disease to a certain extent, and there isn't much much information about it because it's not being studied because there is no financial support for the studies that are necessary.
32:16.181 --> 32:20.543
[SPEAKER_00]: There are people who believe that long COVID is not a single disease, but...
32:22.695 --> 32:26.258
[SPEAKER_00]: It's a very complex matter.
32:27.098 --> 32:33.223
[SPEAKER_00]: Unfortunately, there are around 30 million people that suffer from this disease around the world.
32:34.084 --> 32:35.405
[SPEAKER_00]: There is no treatment for it.
32:35.445 --> 32:38.147
[SPEAKER_00]: The therapeutic plasma exchange helps some of them.
32:38.208 --> 32:40.469
[SPEAKER_00]: We have published our results.
32:41.350 --> 32:48.961
[SPEAKER_00]: in small group of patients about 65% success rate, which is better than nothing, but still it's an issue.
32:49.582 --> 32:56.653
[SPEAKER_00]: One of the problems that we see, especially today, as opposed to three years ago, is that people got infected.
32:58.142 --> 33:04.988
[SPEAKER_00]: three years ago and had symptoms and calm and show up three years after the disease started.
33:05.608 --> 33:13.375
[SPEAKER_00]: So there is already so much damage that the disease has caused that is difficult to predict where they are going to respond at all.
33:14.636 --> 33:21.001
[SPEAKER_00]: One thing we know is that it's certainly there is an autoimmunity in Lankovic.
33:21.802 --> 33:25.446
[SPEAKER_00]: kind of one common symptom is affecting peripheral nerves.
33:26.507 --> 33:35.676
[SPEAKER_00]: It affects the brain as well, but peripheral nerves is common and we are fairly successful in treating that part of the problem.
33:36.322 --> 33:45.807
[SPEAKER_02]: Okay, yeah, so I remember you said you had significant success for people who come to you for these long COVID symptoms.
33:46.347 --> 33:48.568
[SPEAKER_00]: They are dearly dearly the better.
33:48.588 --> 33:57.753
[SPEAKER_00]: They come up to years after they started, her chances, their chances are markedly diminished.
33:58.213 --> 34:03.796
[SPEAKER_02]: I see, and usually how many sessions does usually take for people to start noticing a difference?
34:04.636 --> 34:05.136
[SPEAKER_00]: It varies.
34:05.617 --> 34:06.037
[SPEAKER_00]: It varies.
34:06.077 --> 34:13.401
[SPEAKER_00]: Some people will respond right away with maybe 2-3 treatments, others will take 6 treatments.
34:15.162 --> 34:20.245
[SPEAKER_00]: Some will respond and they will come back because the disease exacerbates again.
34:20.826 --> 34:28.570
[SPEAKER_00]: It's definitely not a cure, it's a treatment and until we know more about the disease,
34:33.714 --> 34:39.518
[SPEAKER_02]: And I want to come back to the subject of longevity, the happy subject, keeping people healthy.
34:39.878 --> 34:52.687
[SPEAKER_02]: So I know you worked with very well-known researcher, Dr. Irina Combois, who was the one that was first designed the famous experiment of sewing two mice together, the young and old.
34:53.187 --> 35:00.392
[SPEAKER_02]: The younger mice started to manifest, of been symptoms of being a, old, and the older mice start to seem younger.
35:03.194 --> 35:20.688
[SPEAKER_02]: And so you also, you know, a lot of people thought that it was because the younger mice has something in the blood that's magical, that's helping the older mice, but we're just discussing that that's not the new perspective on the phenomenon.
35:20.748 --> 35:26.192
[SPEAKER_02]: So can you talk a little bit about what you think happened when these two mice are sewn together?
35:27.459 --> 35:39.549
[SPEAKER_02]: Well, there are a lot of things that happen when Yes, I don't really like, you know, yeah, I love animals and, you know, mice, you know, still, but anyhow, so the experiment happened.
35:40.269 --> 35:41.951
[SPEAKER_02]: The two animals that had direct.
35:42.411 --> 35:47.555
[SPEAKER_00]: The first thing when I discussed this, the first thing that I mentioned when I discussed this is
35:50.018 --> 35:51.699
[SPEAKER_00]: Remind people, you're not a mouse.
35:52.319 --> 36:04.603
[SPEAKER_00]: So everything that happens in experimental animals may teach us a lot of different basic science things, but they're not immediately applicable to humans.
36:05.123 --> 36:10.305
[SPEAKER_00]: The human body is unmasked, it's complexity.
36:10.765 --> 36:15.847
[SPEAKER_00]: There's no mouse that can come close to what the human body is in the complexity.
36:15.887 --> 36:16.667
[SPEAKER_00]: So a lot of things,
36:17.327 --> 36:26.874
[SPEAKER_00]: that happen in mice can lead us to certain conclusions and to try to mimic that in humans but it's not going to be the same.
36:27.454 --> 36:32.197
[SPEAKER_00]: And the same with the experiment you're referring to is called parabiasics.
36:32.858 --> 36:36.140
[SPEAKER_00]: And parabiasics is obviously impossible in humans.
36:37.221 --> 36:38.061
[SPEAKER_00]: You can do that.
36:46.367 --> 36:50.895
[SPEAKER_00]: On the subject, I publish a hypothesis that plasma exchange.
36:52.558 --> 36:56.740
[SPEAKER_00]: can be as close as we can get to a part of the Aussies he was.
36:58.140 --> 37:05.303
[SPEAKER_00]: Again, I had to get back to your question of finding the silver bullet in your blood.
37:06.163 --> 37:10.865
[SPEAKER_00]: I think I mentioned that the earlier there were millions of dollars spent.
37:12.165 --> 37:21.149
[SPEAKER_00]: And a lot of very capable and brilliant scientists have been looking to find this silver bullet.
37:22.009 --> 37:28.396
[SPEAKER_00]: And now it's 20 years later, and there is zero evidence that this exists.
37:28.736 --> 37:34.942
[SPEAKER_00]: I'm not saying it doesn't exist, but I'm saying that so far nobody has been able to identify them.
37:35.903 --> 37:42.810
[SPEAKER_00]: What we have been able to identify are substances that contribute to aging and inflammation.
37:44.712 --> 37:49.357
[SPEAKER_00]: in other people and in our experiments with humans and a certain age.
37:50.078 --> 38:06.434
[SPEAKER_00]: So we know now that if you compare the plasma components in people at age 20, 30, 40, 15, 60, there is a difference and by age 40, 45, the plasma components keep changing.
38:07.075 --> 38:19.545
[SPEAKER_00]: There is more accumulation of certain factors than we can identify plenty of them that contribute to a variety of diseases primarily by inflammation.
38:20.286 --> 38:27.472
[SPEAKER_00]: And other accumulation of other factors that contribute most prominently to Alzheimer's disease.
38:27.973 --> 38:33.797
[SPEAKER_00]: If you look at the plasma of patients with Alzheimer's disease, you will find all kinds of bad stuff.
38:34.698 --> 38:40.781
[SPEAKER_00]: So removing this best stuff with a ferries, which the word means to take away, is helpful.
38:41.481 --> 38:42.601
[SPEAKER_00]: Is that the whole answer?
38:42.681 --> 38:43.362
[SPEAKER_00]: No, it's not.
38:44.062 --> 38:48.584
[SPEAKER_00]: But as an arena, a label this process is dilution.
38:49.604 --> 38:55.667
[SPEAKER_00]: So when you connect to mice, their blood is diluted.
38:57.079 --> 38:59.141
[SPEAKER_00]: either way, both for both mice.
38:59.602 --> 39:02.505
[SPEAKER_00]: So these dilution diminishes the bad factors.
39:03.726 --> 39:08.611
[SPEAKER_02]: And some people also... And in the older mice, it carries the bad fact.
39:08.631 --> 39:14.757
[SPEAKER_00]: Yes, well, with the idea, is we had something to that process to rejuvenate.
39:15.118 --> 39:17.060
[SPEAKER_00]: We haven't been able to identify that.
39:17.720 --> 39:19.122
[SPEAKER_00]: At this point, it's mythology.
39:19.622 --> 39:28.789
[SPEAKER_00]: And what we do know, and people ignore the fact that the Yann Mouse became older.
39:30.350 --> 39:33.952
[SPEAKER_00]: Nobody talks about this, because it's not a pleasant subject.
39:34.373 --> 39:35.333
[SPEAKER_00]: Everybody goes out there.
39:35.774 --> 39:37.295
[SPEAKER_00]: The old mouse became younger.
39:37.895 --> 39:39.056
[SPEAKER_00]: Well, how about the other way?
39:39.316 --> 39:39.496
[SPEAKER_02]: Yeah.
39:40.580 --> 39:41.301
[SPEAKER_02]: Yeah, right.
39:41.821 --> 39:47.825
[SPEAKER_02]: So what is in the older mouse blood that's making life so much more unpleasant.
39:47.865 --> 39:57.892
[SPEAKER_00]: Well, and we do know we have been able to identify over the last 20 years a bunch of molecules that cause aging and cause inflammation.
39:58.993 --> 40:04.295
[SPEAKER_02]: So, can you give an idea of approaching how many molecules that are pro-aging and are dead?
40:04.475 --> 40:06.396
[SPEAKER_00]: Well, probably more than we know.
40:06.476 --> 40:11.938
[SPEAKER_00]: I mean, we, we, we discover all kinds of molecules that cause aging all the time.
40:12.558 --> 40:14.679
[SPEAKER_00]: The most recent one is I'll leave 11.
40:15.439 --> 40:23.062
[SPEAKER_00]: I'm not going to get into this, but now it's a conversational subject.
40:24.002 --> 40:27.363
[SPEAKER_00]: people want to make a more colonial antibody to kill hell.
40:27.563 --> 40:29.543
[SPEAKER_00]: I only learned how about the rest of them.
40:29.803 --> 40:30.023
[SPEAKER_02]: Right.
40:30.243 --> 40:32.104
[SPEAKER_00]: So it's complicated.
40:32.224 --> 40:32.524
[SPEAKER_02]: Right.
40:32.684 --> 40:34.104
[SPEAKER_02]: It's like a whack-a-mo most.
40:34.224 --> 40:34.544
[SPEAKER_02]: Yeah.
40:35.365 --> 40:39.446
[SPEAKER_02]: So Alina from Generation Lab actually gave a really nice analogy.
40:39.506 --> 40:43.046
[SPEAKER_02]: She was like, she said, well, think about a truckload of tomatoes.
40:43.907 --> 40:45.647
[SPEAKER_02]: And some are rotten and bad.
40:46.207 --> 40:51.748
[SPEAKER_02]: So do you want to make the whole truckload better by throwing more fresh tomatoes in there?
40:54.149 --> 40:56.951
[SPEAKER_02]: So the so the truck will can be better, right?
40:57.051 --> 40:59.092
[SPEAKER_02]: So that was a great analogy.
40:59.152 --> 41:00.032
[SPEAKER_00]: It was an analogy, yes.
41:00.252 --> 41:01.093
[SPEAKER_02]: Yeah, yeah.
41:01.153 --> 41:17.201
[SPEAKER_02]: So with the plasma ferrisis process that, you know, what I saw was that my blood was going through the machine and the plasma was separate out and was taken away and then you were giving me fresh albumin and then that got, you know,
41:21.083 --> 41:23.365
[SPEAKER_02]: blood cells and they get them back to me.
41:24.026 --> 41:28.170
[SPEAKER_02]: So I got this whole bag of just my own plasma.
41:28.790 --> 41:33.955
[SPEAKER_02]: So just that simple act of self has profound rejuvenation effects.
41:34.816 --> 41:44.564
[SPEAKER_02]: And the research, when it comes longevity, what parameters did it show as far as people improving and benefiting?
41:45.305 --> 41:52.993
[SPEAKER_00]: So, we mentioned the biological cage, so this was the main parameter that we found in Provee.
41:53.073 --> 42:01.221
[SPEAKER_00]: In addition to that we had clinical parameters that we followed, and the one was strength can strengthen.
42:01.841 --> 42:10.667
[SPEAKER_00]: The other one was Peter walking, and there are, you know, approved methodologies to do these things.
42:11.547 --> 42:17.751
[SPEAKER_00]: Balance, we measure balance, balance is extremely important for all the age.
42:17.771 --> 42:23.595
[SPEAKER_00]: There's a lot of debts and problems come from falls, injuries and so forth.
42:24.555 --> 42:27.277
[SPEAKER_00]: And we used a variety of...
42:29.265 --> 42:33.907
[SPEAKER_00]: question years that are given to AI to examine.
42:33.927 --> 42:44.451
[SPEAKER_00]: So we did a variety of clinical parameters, and we showed statistically significant difference in the treated versus the placebo patients.
42:46.592 --> 42:50.314
[SPEAKER_02]: Wow, this is such an incredible discussion, so have to learn from you.
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[SPEAKER_02]: You're such a pioneer and have trained a lot of providers and then a lot of lectures internationally.
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[SPEAKER_02]: So it's amazing to be sitting next to you and learn from you.
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[SPEAKER_02]: Any parting words of wisdom that you can share with the people who have followed the conversation this far.
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[SPEAKER_00]: stick to the Mediterranean diet and exercise every day.
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[SPEAKER_00]: Doesn't matter what exercise, not at all, whatever you like.
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[SPEAKER_00]: Like tennis, pickleball, we had a Chinese lady last week, and she's been coming here.
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[SPEAKER_00]: And after each treatment, she asked me, can I go and play pickleball now?
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[SPEAKER_00]: And she's 83 as all the looks, you know, little fragile in the middle.
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[SPEAKER_00]: And she goes and plays every day.
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[SPEAKER_00]: So if you like that, do it.
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[SPEAKER_00]: If not, just walk.
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[SPEAKER_02]: Uh-huh.
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[SPEAKER_02]: Wonderful.
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[SPEAKER_02]: Thank you, Dr. Kiprov.
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[SPEAKER_00]: You're very welcome.
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[SPEAKER_02]: Oh, so how do people find you?
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[SPEAKER_02]: Because you're in the Bay Area, right?
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[SPEAKER_02]: I guess, is this in San Francisco?
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[SPEAKER_02]: Are we in San Francisco?
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[SPEAKER_00]: No, we are in Milwaukee.
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[SPEAKER_00]: Oh, yes, sorry.
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[SPEAKER_02]: A gorgeous place.
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[SPEAKER_02]: Yeah, incredible view from your office.
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[SPEAKER_02]: So, and what's the best place where people can find you?
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[SPEAKER_00]: global afrizes.com.
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[SPEAKER_02]: Yes, waterfall, thank you so much.
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[SPEAKER_00]: You're very well, pleasure.
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[SPEAKER_03]: Thank you for listening to this episode, hope you enjoy the content, and if so, please rate and follow this podcast.
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[SPEAKER_03]: To reach me, you can contact uplift longevity center, and that is uplift with a why.
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[SPEAKER_03]: You can also subscribe to my YouTube channel,
