Dave Asprey┃From Survival to Human Upgrade: How Personalized Biohacking Can Transform Energy and Longevity

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You don't need to spend $ 2. 5 million over 20 years
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like I did. And you definitely don't need to spend
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$ 2 million a year obsessively tracking everything. It doesn't do
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much because what works for you is not what works
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for the person next to you. It is so highly personalized.
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And having done a lot of clients through Unlimited Life,
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every recommendation is different and it has to be personalized
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or it doesn't work. We're all unique.
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What if aging, energy, focus, and even the way you
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experience your own mind are far more changeable than you've
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been led to believe. Today, I sit down with pioneering entrepreneur,
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four-time New York Times bestselling author, and the father of biohacking,
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Dave Asprey, to explore how our ability to influence human
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biology may actually go. Dave shares how his own health crisis,
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reaching nearly 300 pounds, struggling with arthritis and chronic fatigue,
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and buying disability insurance at just 26, set him on
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a decades-long path of experimentation that helped launch the biohacking movement.
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We get into why he now sees biohacking as less
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about controlling the body and more about learning to intentionally
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change your state. How the mitochondria may be one of
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the keys to energy and longevity, why the future of
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health has to become deeply personalized, and how emerging technologies
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could radically shape the way we think about aging, performance,
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and human potential.
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I'm really excited to be here today with none other
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than the father of biohacking himself, Dave Asprey.
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Welcome, Dave. I'm really happy to be here.
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I'm going to share your bio and then we'll jump
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right in. Sound good?
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Sounds like a plan.
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Okay. Dave Asprey is a pioneering entrepreneur, four-time New York
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Times bestselling author, biohacker, founder of Bulletproof, founder and CEO
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of Upgrade Labs, founder of 40 Years of Zen and
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host of the Human Upgrade podcast. Widely recognized as the
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father of biohacking, he has spent more than two decades
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researching human performance, neuroscience, nutrition, and longevity. After overcoming obesity, prediabetes,
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and chronic health challenges through extensive self-experimentation, Dave coined the
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term biohacking, now recognized by Merriam-Webster. He founded Bulletproof and
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helped popularize functional coffee, MCT oil, and collagen protein, while
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also creating Upgrade Labs, the world's first human upgrade center,
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and 40 Years of Zen, an advanced neuroscience program focused
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on peak cognitive performance and personal transformation. Dave's work has
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been featured on CNN, Good Morning America, The New York Times, Wired,
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and other major media outlets. He's the author of best-selling books,
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including The Bulletproof Diet, Headstrong, Superhuman, Fast This Way, and
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and smarter, not harder. And I really want to mention,
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I think what I think is a fabulous book, heavily meditated.
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So we'd like to start off on a little bit
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of a personal note, and you are widely recognized as
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a person who introduced the term biohacking to the world.
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So looking back, What convinced you, I'm familiar with your background,
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many people probably are, of what you suffered as a
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child growing up in a home with a lot of
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mold and all that resulted from that. But what convinced
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you that aging, energy, and performance were much more programmable
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than most people believed? And then also, how has your
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definition of what biohacking is evolved since that point?
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I was starting to get a little desperate in my mid-20s.
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I'd hit as much as 300 pounds. I had arthritis
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since I was 14. And I didn't know what to do.
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I felt like I was in a car and I'm
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pressing the accelerator. It's all the way to the floor.
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And the car is slowing down. And I can press harder,
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but there's no more room for it to move. And
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I bought disability insurance when I was 26 years old.
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You don't do that. Because the doctor said, there's nothing
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wrong with you. But I don't have any gas left
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in the tank. So I started kind of out of desperation,
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hanging out with a group of people in their seventies,
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eighties and nineties in Palo Alto, California. And they were
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running the first longevity nonprofit group in the Bay area.
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And it was actually started by one of the guys
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who invented ethernet, the networking standard that we all use today,
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even now during this interview. And so this was an
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early tech guy saying, maybe we can live a lot longer.
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He started it in 1993. And if you look at
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what happened in the early aughts, that's when all the
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multi-billionaires started investing in longevity and the fruits are just
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happening now. So just very, very early days. Think homebrew
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computer club, but for longevity. When I met people in
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their 70s and 80s who had more energy than I did, well,
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they've reversed their age. They can do it, why can't I?
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And I started attending all the meetings and I learned
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from my elders, And then eventually they asked me to
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run the organization. So I ran the first longevity nonprofit
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in the Bay area for more than five years. And
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every month I interviewed the top experts in the field
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before most people thought it was really even a field.
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And people say, Dave, how do you know all this stuff?
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How can you do this? How can you have, you know, these,
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these clients spending, you know, hundreds of thousands of dollars
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a year with the VIP longevity practice on limited life.
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I'm like, well, It's not just me. We have full
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doctors and all that, but it's because I have been
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immersed in longevity for 25 years because I needed it
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from my own biology. And I just, my brain wasn't working.
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My body wasn't working. My gut wasn't working. Like nothing
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was working right. So I had to rebuild it. So
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call it enlightened self-interest. But the gift of that is
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that when my friend Mike, who was 88, would call
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me at 1130 at night and say, I have this
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great new idea. How's he calling me at 11.30 at night?
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Because I'm tired and he's not. I want that. And
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I got that and so much more just by the
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practice of biohacking. And what's changed over the years, there's
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been one change in the definition of biohacking since I
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started it. The original idea for biohacking came to me
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on the side of Mount Kailash, the holiest mountain in
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the world in a remote part of Western Tibet. I
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was learning meditation from the masters and doing some exploration.
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And I thought, why will no one under age even
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50 come to this longevity nonprofit group? And I realized
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it's because, well, if you're worried about longevity and you're
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20 years old, you're doing it wrong. You should be
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worried about finding a mate and making your mark in
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the world. So I just pondered and I recharacterized this idea.
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So we have a branding problem for longevity or anti-aging.
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The reality is the things that make old people young
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make young people powerful. So maybe I could talk to
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everyone about control over your biology. And so the definition
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when I launched this was the art and science of
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changing the environment around you and inside of you so
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you have control of your biology. About controlling your meat body.
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I started out with that because I think that's where
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the consciousness of the world was. And it was most
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accessible to people. And over the years, I've changed it
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to the art and science of changing the environment around
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you and inside of you so you have control over
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your state. And your state encompasses your body and your
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mind and your spirit. And people don't know this, but
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your biology is the antenna for your spirit anyway. So
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broken biology means it's harder to, harder but not impossible,
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to do some of the more exalted spiritual things. It's
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hard to be peaceful when your cells are falling apart.
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And I actually know that because I have a great
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genetic mutation in something called CCL2. When I get gut
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bacterial toxins or mold toxins or a lot of other things,
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I have about 10 times more tissue destruction as an
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immune response. So I feel the things that are affecting
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your biology that you may not feel, but they're making
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you old or giving you cancer. They punch me in
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the brain and the gut at the same time. So
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how do I know these things work or don't work?
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Because I can sense it. And then I can do
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the science and I can look at it. And this gift,
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even though it kind of sucks, has been something that's
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let me, in multiple books, write about things that weren't
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proven yet to the standards of big pharma. Not that
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their standards are actually that useful for proving things. But
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one of the examples, years ago I said there's a
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specific kind of MCT oil called C8 MCT that you
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can put in coffee. At the time, I used to
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call it Bulletproof Coffee. I have nothing to do with
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that company. My new coffee company, by the way, I'm
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drinking it right now, is called Danger Coffee. Danger because
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who knows what you might do. But I said put
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a specific kind of this coconut extract in because it
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works better. And here's the mechanistic science about why I
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think it works better. I cannot prove to you that
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it works better. And five years after the book comes out,
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university of California, San Diego says, Oh, that kind that
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Dave talked about. Yeah, it works better than everything else.
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How do you know it? Because you can feel it.
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So one of the most important things in the history of,
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of biohacking for thousands of years, we didn't call it that,
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but it's the same thing was observation. So we used
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to do as we take all of our weird people
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like me, Oh, by the way, I was on the
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autism spectrum. Now I'm just adjacent to it. And, uh, Yes,
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you can actually change where you are on the spectrum,
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but they would take our weird people and they'd put
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them in monasteries or caves or teepees. on the edge
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of town. And they'd say, study this, pay attention to
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paying attention and write down what you see and read
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all the scrolls from the last guys.
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Right.
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And then write everything down and hand it off to
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the next guy. Pretty soon we're going to learn something
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about the world, but we might all be dead by then.
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And that's okay. So, the original biohackers, they were shamans.
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They were meditators. They were keeping the keys of how
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do you run these dumb meat bodies? And all of
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them end up at the same thing that the world
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that we see in our normal state is not a very,
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it's a useful representation of the world, but it's not
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a very accurate one. So change your state, become more
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aware of the world and more aware of yourself. And
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maybe you'll be a better person.
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So your kind of biological hypersensitivity is both a blessing
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and a curse, but made you in many ways the
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ideal guinea pig for this kind of self-experimentation that helped
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you develop this movement and provide the leadership you provided.
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So if you look at our current society, even here
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in the U.S. or in the Western or in the
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modern world, it's pretty much the global world these days,
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but So you have people that are, you know, really
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not focused on health or concerned about health much at all.
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They're just a lack of education or interest. And then
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you have people that are aware of their health and
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probably would like to be healthier, live longer, but are
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probably not tuned into the biohacking movement or things like that.
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And then you have people that are involved in biohacking, supplementation,
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you know, more conscious around health or have more information.
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So maybe the middle one, people with a more conventional perspective,
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but also even in the world of biohacking, to what
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degree are we still misunderstanding what aging is all about? And, uh,
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and misunderstanding, uh, what, what really can contribute to long,
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both longevity and health span. And I mean, I still
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think there's this, a really strong cultural force that sees
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longevity as just this inevitable aging decline process, a process
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of entropy. So, um, so where are we with that?
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And what do you see that were the key things
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that were getting wrong? The key things in terms of
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our mind shift, but understanding the need to under the shift.
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There's a, Like a mechanistic biological answer and there's a
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metaphysical answer. Which one do you want?
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Probably both. Let's start with the physical one.
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Well, we know there's about 12 hallmarks of aging. And
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I wrote about these in Superhuman, which is my New
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York Times longevity book that's kind of set the template
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for a lot of the books that have come out afterwards.
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And so what can we do for each of those
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12 things? in order to reduce the effect of it
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so that the net result is longer life. Well, it
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turns out there's a lot. And it's been seven, eight
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years or something since I wrote that book. And we've
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got about 100 clients in unlimited.life. These are people, wealthy people,
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some billionaires pulling out the stops. And we do $ 50, 000
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or thereabouts of lab work on them to start them
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in the program. So we know everything. And then we
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do everything. And they're willing to do everything, including stem
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cell reprogramming and And gene therapy, things that I've done.
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And what we're finding is using validated statistical tables from
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our lead physician who has been an actuarial working with
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heads of state as well as on their longevity, as
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well as with insurance companies on predicting lifespan. We are
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making the predicted lifespan go up for these people. They're
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actually showing in their data that they're going to live
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longer within one year of starting. So the return on
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investment for that, they spend a year with some energy
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and some time and some money, and they're getting a
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year or more back. That's kind of interesting. So this
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works mechanistically. Now, our current best for humans is 122
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years old. At least that's in recent time. If you
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look at anything in India, there's lots of people 185
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years old that are written about. Some even in relatively
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recent times. And if you look in China, they talk
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about it. And even the Bible, Methuselah, 969 years old. Noah,
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400 years old. So, our current best, who the heck knows? So,
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I'll just say that it is possible to, at a minimum,
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be super healthy and to hit the longest possible lifespan
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for humans, which is 122.
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Right?
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We already know that. It's been done.
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Okay? Yeah.
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But the average lifespan in the US, 79.5. 80 years old.
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That's a big 40 years. That's a big gap. So
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that's a lot of room for expansion. And I want
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to go up to 180. I want 50% better than
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our current best. It doesn't seem that hard to do.
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So staying in the mechanistic model, how much of that
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is genetics and how much of it is what we
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can impact through biohacking on various forms?
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There are about 100 genes that.
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Super centenarians have that are different. And my friend James
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Clements flew around the world, gathered the genes from these
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people who are healthy over 100, and then gave them
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all to George Church, who did the research on this.
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So there's a genetic component, but it's not the only
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one by far. And there's some other interesting things. People
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who live over 100 have higher cholesterol, not lower cholesterol,
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because cholesterol is actually protective for a lot of toxins
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and things like that. A lot of these people smoked
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and drank, which are usually not a good thing, although
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I think there is actually, for cognitive function, there's a
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case for low-dose tobacco, well, ideally low-dose nicotine. But what's
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happening there is.
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Some people are doing it. Sometimes it's luck. Sometimes it's genetic.
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And sometimes it's the fact that a truck didn't hit
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you at some point in your life. And also infectious
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disease is a really big contributor that's underrepresented. We're finding
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more and more COVID or Epstein-Barr or in my case,
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the toxic mold stuff and Lyme disease co-infections. These have
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long lasting effects. In fact, if I looked at what
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are the things that make me less likely to hit
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my goal, It's a childhood full of illnesses and terrible genetics.
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But in the world of biohacking, we get to do
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gene therapy. So I've done two injections and we offer
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these to clients at Unlimited Life where a protein called
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Clotho that improves cognitive function and longevity, I've injected some
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signals for my cells to cause them to make more
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Clotho for the next year or two. So I've bumped
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my levels up and I've done the same thing with Volastatin,
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which helps you have muscles and lower fat even if
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you don't change your exercise or diet. These are things
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that young people have that old people lose. So we
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can now instruct your cells to make more of the
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young people juice. And those are types of gene therapy
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that are not inherited. If I was to have more children,
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which I'm not going to do, I wouldn't want to
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be in a position to hand those down. So I'm
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only changing my cells temporarily and not permanently. But would
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I go in and will I be able to in
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the next 10 years with or without any government's permission?
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To be able to go in and turn off the
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crappy genes that have caused so much of this suffering,
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you bet your ass I'm going to do that. I
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will edit my own genome.
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Before moving on to really talking about some of the
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key levers, and, of course, that's pretty high-tech stuff and
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probably available to some kind of elite-level biohacking.
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That's only today, Fleet Hall. We've got to pause for
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a second there. Yes, this is what the crazy billionaires do.
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But someone has to do it first. The first mobile
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phone in L.A. was like $ 40, 000, and now they're a
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dollar a month in Africa. If no one does this,
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it will never be available for them.
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Oh, I hear you, and I'm not in any way–
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being pejorative about it. I think it's fantastic that people
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are doing it. So I want to talk about that
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and some of the other levers that are available to
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more people. But before that, you mentioned a metaphysical response.
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So what would be your metaphysical response to the question?
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Well, it's very clear when you look at the math
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and the philosophy that our bodies are trying to translate
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the lowest level reality, which is a quantum reality, for
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us to be able to operate in it. And in
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a quantum space, Well, time is completely made up, and
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so is space. They're not real. They're just useful. I mean,
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I can feel the matter of my body. I can
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tap on this, and we know what time we're meeting
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for this, even though I might have been a minute late, right?
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But provably, those don't exist. And if they don't, the
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future and the past become highly malleable. So instead of saying, well,
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I'm going to live this amount of time, is that
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time even real? And what about history? It turns out
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there's a bunch of possible futures for us. Well, there's
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also a bunch of possible pasts. And you can prove
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this six ways from Sunday if you have a PhD
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in quantum physics. And the book that convinced me of
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this is the only thing that explains all of the shamanic,
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all of the Buddhist, and all of the Western approaches
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at the same time is this knowledge set. It's called biocentrism.
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And What that implies is that when you do the
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math around the quantum physics and you look at it
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from a philosophical perspective and you want to be able
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to explain all the observed phenomena, both the spiritual. life-death,
348
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all that kind of stuff, and the other physical things
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that we're aware of, this is the only solution I've
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been able to find. Beyond Biocentrism by Robert Lanzo is
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a good place to get started. But what that does,
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it provides an actual explanation for things like magic. things
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like altered states phenomena, things like these intense feelings of
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presence that you might sense at the top of a
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mountain or in a beautiful brook. You can't throw away
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the observed reality. And when you look at the history
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of science, the history of science was studying consciousness. And
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where I've ended up is that consciousness makes the universe
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and So the universe sits inside consciousness. Consciousness does not
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reside inside the universe. So we just have it backwards.
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And when you arrange things in that order, all of
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the weird stuff that is provable, like mind reading, or
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reading something blindfolded at the Beyond Conference, I had kids
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who could read with blindfolds on, provably in front of
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an audience, who learned intuition. If intuition exists, and we
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talk about it for two hours, you and I both,
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about how it exists, There has to be a mechanism.
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There has to be a reality in which that's real.
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And the idea is that our consciousness makes everything around
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us is the only thing that explains all of the things.
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And that means, fortunately, I can probably edit my own
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genes with my mind. Give me time.
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What if transformation isn't just about thinking differently, but feeling differently?
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Science shows us that true change happens when we align
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not just our minds, but also the neural networks in
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our hearts and guts. This heart-mind connection is the key
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00:21:35.039 --> 00:21:38.940
to deeper healing, resilience, and expanded awareness. That's why I
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00:21:39.019 --> 00:21:42.880
created the HeartMind All Access Membership and Community, a space
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00:21:42.940 --> 00:21:46.980
designed to help you rewire your nervous system, cultivate heart intelligence,
380
00:21:47.349 --> 00:21:51.210
and live with greater clarity and purpose. With over 1,000
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00:21:51.210 --> 00:21:55.990
hours of transformational teachings specifically curated to meet your needs,
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00:21:56.470 --> 00:22:02.589
you'll learn, from world-renowned meditation teachers, neuroscientists, and experts in neuroplasticity,
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00:22:03.009 --> 00:22:06.490
all sharing powerful tools to help you shift your mindset
384
00:22:06.930 --> 00:22:11.250
and heart set, regulate your emotions, and unlock your full potential.
385
00:22:12.069 --> 00:22:15.390
You'll also gain unlimited access to every summit and course
386
00:22:15.430 --> 00:22:20.710
we've ever produced, a treasure trove of wisdom worth over $ 10, 000
387
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and growing, plus live gatherings and an inspiring global community
388
00:22:23.690 --> 00:22:26.559
to support your journey. If you're ready to step into
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00:22:26.599 --> 00:22:29.720
a more heart centered, connected and conscious life, I invite
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00:22:29.759 --> 00:22:32.140
you to join us. Click the link to learn more
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00:22:32.420 --> 00:22:33.759
and start your journey today.
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Exactly.
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So before we return to the more mechanistic realm. You know,
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this could explain it, speculative, obviously. But, you know, you
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mentioned in some other societies, historically, people perhaps lived much longer,
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even than 122 years. China would be one place. The
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great Taoist masters of antiquity might be one place where
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that happened. They clearly weren't doing gene therapy, but perhaps
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through their contemplative practices, they were accessing the quantum field
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in such a way that that was shifting what was
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possible for them.
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Yeah, the Taoists are particularly powerful, and that lineage is
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tied in with ancient shamanic practice, ancient Buddhist practice. It's old,
404
00:23:21.230 --> 00:23:25.230
and it's very, very rich. The old tantric stuff, which
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was ultimately about longevity. In fact, tantra was a longevity practice.
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Taoism is a longevity practice. Most of the ancient practices
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all had, we want to live longer, right? Or even
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better yet, live forever, at least forever, as long as
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we want. So... I think there there's great value in
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what you're saying there. And some of the things that
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are possible in those States, I have learned having grandparents
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who worked for a national laboratory in the U S
413
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hardcore scientists, that's not possible. Therefore it isn't. But the
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reality is it is possible. And I've witnessed things and
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I have done things that I was raised as a
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child to believe are impossible. So I don't know what
417
00:24:05.220 --> 00:24:07.400
it is, but I do think that way back in
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the day, um, there are some people with some rituals
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and some knowledge and just some unique abilities who did
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live way longer than we think. And that's why it's
421
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written about in thousands of ancient books. It's not like
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one science fiction book from a thousand years ago. There's
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a lot of people who live longer than a hundred years.
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The only biohacking explanation for why we may have a
425
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lower lifespan is that it looks like every hundred or
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so years, our lifespan is dropping by a certain percentage
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as a species. And the explanation for that would be 11,000
428
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years ago when a comet hit the North Pole, as
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Graham Hancock talks about, it probably contained a lot of
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heavy isotopes like deuterium. And deuterium is a heavy hydrogen
431
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that causes excess oxidation and mitochondrial dysfunction. And some the
432
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crazy fringes of biohacking will say, oh, this changes everything,
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but it's in everything. So you can't really get away
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from it. We also have radioactive potassium that's in all
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the potassium we eat. So it could be that there's
436
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radiation on the planet, the potassium and the deuterium, and
437
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that those are causing errors in genetics. I'm not worried
438
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about those. Unless you're a billionaire with cancer, you can't
439
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afford to lower deuterium in your body. It's almost impossible.
440
00:25:36.069 --> 00:25:42.170
But what we're learning right now. The tech is coming
441
00:25:42.210 --> 00:25:44.490
online to just go in and repair your genes. Okay,
442
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so you have some gene drift over time. Who cares?
443
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Go in and fix them. We just did the first
444
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mitochondrial transplant. Literally, we're taking mitochondria from young people, putting
445
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them in an old person to heal a disease. The
446
00:25:55.329 --> 00:25:58.130
guy's 90 who just received them. And the company is
447
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raising more funding. And I'm working on putting together a
448
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potential venture fund in order to invest it more in
449
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these technologies that are going to change the world. Right.
450
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And do I want a mitochondrial transplant? Yeah, absolutely. Right.
451
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Younger mitochondria. We all want younger, like you want to
452
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take the battery out of your phone and get one
453
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that keeps the charge in it. So it'll stay charged longer.
454
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Of course you do. Let's do that for your brain.
455
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It's like, just the, we're living in science fiction right now.
456
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It's the coolest thing ever.
457
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Let's talk about that level of mitochondrial function in ourselves
458
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for a moment. So, um, You know, we have a
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medical system that's been more about sick care than health
460
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care and been focused on symptomology and so forth. We're
461
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all very familiar with that paradigm. And you've talked about.
462
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not just treating disease or not just preventing disease, but
463
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really upgrading the human condition, upgrading our biology, is what
464
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you've kind of been referencing now. And so the basic
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regenerative capacity within our biology goes down to the level
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of mitochondria, where our sort of life force energy is
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regenerated and created. So what are some of the basic
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things that any of us can be doing to.
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Repair, you know, because a lot of aging, I assume
470
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from what I've learned has to do with mitochondria becoming
471
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less robust. And so what can we do to begin
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to reverse that? And short of mitochondrial transplants when they
473
00:27:31.079 --> 00:27:33.400
come online, great, but short of that, what can we
474
00:27:33.440 --> 00:27:35.730
do to have healthier mitochondria?
475
00:27:37.109 --> 00:27:40.730
There's tons and tons of things you can do here.
476
00:27:41.369 --> 00:27:44.269
And for people really interested, Headstrong is my book that
477
00:27:44.309 --> 00:27:48.329
goes deepest in mitochondrial biology. It ended up sandwiched on
478
00:27:48.349 --> 00:27:51.150
the New York Times Science Monthly List, which is amazing
479
00:27:51.650 --> 00:27:52.809
to be able to do as an author. But it
480
00:27:52.849 --> 00:27:54.809
was between Homo Deus and Sapiens. I was like, I'm
481
00:27:54.829 --> 00:27:57.130
the meat in the sandwich between some very well-known books.
482
00:27:58.130 --> 00:28:05.259
And mitochondria, first thing is understand their nature. Mitochondria are
483
00:28:05.279 --> 00:28:08.579
a separate organism from what you think of as you.
484
00:28:09.140 --> 00:28:12.059
They're ancient bacteria that There's more of them than there
485
00:28:12.079 --> 00:28:14.380
are cells in your body because some cells in your body,
486
00:28:14.680 --> 00:28:17.869
there's tens of thousands of mitochondria embedded in the cell.
487
00:28:18.490 --> 00:28:21.970
And in seventh grade biology, you learn, oh, mitochondria, they're
488
00:28:21.990 --> 00:28:25.930
the power plants of the cell, which is actually sort
489
00:28:25.970 --> 00:28:30.079
of kind of true. You could also, though, say mitochondria
490
00:28:30.119 --> 00:28:32.180
are the puppet master of the cell and they control
491
00:28:32.259 --> 00:28:35.839
everything you do and they have their own consciousness. That
492
00:28:35.900 --> 00:28:39.640
is not your consciousness, right? Mitochondria are very fast. They
493
00:28:39.680 --> 00:28:42.900
sense reality long before you do. They vote with each other.
494
00:28:43.319 --> 00:28:45.910
They have a robust and active community where they talk
495
00:28:45.930 --> 00:28:48.869
to each other via different mechanisms. They share energy. They
496
00:28:48.930 --> 00:28:51.410
move parts of themselves around. And they do all this
497
00:28:51.609 --> 00:28:54.809
kind of like the repair crew of your body that's
498
00:28:54.849 --> 00:28:56.930
making sure your body is alive even if you're not
499
00:28:56.950 --> 00:29:03.009
paying attention. So ultimately, it's mitochondrial networks that are collaborating
500
00:29:03.069 --> 00:29:05.720
to figure out the local processes What's going on here?
501
00:29:05.799 --> 00:29:07.880
And then they're sharing that information up that eventually makes
502
00:29:07.900 --> 00:29:09.740
it to your nervous system and into your brain. Your
503
00:29:09.759 --> 00:29:12.420
brain has some control over big systems, but the mitochondria
504
00:29:12.519 --> 00:29:15.160
always sense everything first and decide what they're going to
505
00:29:15.200 --> 00:29:17.549
pass on to the nervous system and the brain. They're
506
00:29:17.589 --> 00:29:21.650
not you. And they do make power. They make heat.
507
00:29:22.490 --> 00:29:28.569
They make electricity. They make some, a few proteins and
508
00:29:29.089 --> 00:29:33.549
chemicals and things like that. But What's interesting is they
509
00:29:33.609 --> 00:29:37.650
also have a stress response because they're bacteria. Bacteria understand
510
00:29:37.670 --> 00:29:40.160
if they're in a stressful or safe environment. so they're
511
00:29:40.180 --> 00:29:43.839
tied to immune function inflammation aging and if your body
512
00:29:44.339 --> 00:29:47.220
because of the mitochondria believes that it's in a safe
513
00:29:47.259 --> 00:29:51.660
place and the nutrient sensing in the mitochondria go oh
514
00:29:51.700 --> 00:29:54.420
we have all the building blocks including selenium and zinc
515
00:29:54.480 --> 00:29:58.930
and all the things and we have enough energy to
516
00:29:59.480 --> 00:30:01.319
then we are going to do a good job of
517
00:30:01.380 --> 00:30:03.859
maintaining the system. But if they're rushed, they're in a
518
00:30:03.859 --> 00:30:06.000
hurry and they're missing things, they're going to be like
519
00:30:06.019 --> 00:30:09.160
you when you go to the gas station. You know,
520
00:30:09.200 --> 00:30:11.009
one of my tires is a little bit low, but
521
00:30:11.069 --> 00:30:13.710
not that low. Like I'll fill it up later. And
522
00:30:13.750 --> 00:30:17.430
my windshield washer fluid, it's empty, but I don't have
523
00:30:17.470 --> 00:30:18.970
time to go in and buy the thing because I'm
524
00:30:19.009 --> 00:30:21.250
in a rush. So I'll get to it later. And
525
00:30:21.289 --> 00:30:24.829
so your body will elegantly stop doing all of the
526
00:30:24.869 --> 00:30:28.500
things that it doesn't need to do if it doesn't
527
00:30:28.519 --> 00:30:30.240
have enough energy. But if you have enough energy and
528
00:30:30.279 --> 00:30:33.799
enough peace, your body will regenerate in a beautiful way.
529
00:30:33.839 --> 00:30:35.819
It's just most of us have broken that cycle. So
530
00:30:36.200 --> 00:30:39.420
how do you fix it without doing mitochondrial transplants or
531
00:30:39.440 --> 00:30:44.900
gene therapy? Well, the first thing is stop eating things
532
00:30:45.009 --> 00:30:50.289
and breathing things that directly poison your mitochondria. Now, this
533
00:30:50.309 --> 00:30:54.789
is going to make some people mad. In the human
534
00:30:54.829 --> 00:30:58.470
food system for thousands of years, we have this thing
535
00:30:58.529 --> 00:31:02.369
we do to remove toxins from our food. It's called
536
00:31:02.440 --> 00:31:05.130
processing our food. Now, ultra-processed food is really bad for you,
537
00:31:05.589 --> 00:31:09.609
but whole wheat, the outer part of the grain is
538
00:31:09.650 --> 00:31:12.509
toxic to mitochondria, even though it has some calories you
539
00:31:12.529 --> 00:31:16.140
can use. Long-term, it's bad. But white flour, which isn't
540
00:31:16.180 --> 00:31:18.920
particularly good for you either, it's just calories, it has very,
541
00:31:19.180 --> 00:31:23.700
very low toxin loads compared to whole wheat. So, we
542
00:31:23.720 --> 00:31:26.450
can survive on all kinds of plants, that are not
543
00:31:26.490 --> 00:31:28.809
very good for us, but they're better than starving to death.
544
00:31:29.250 --> 00:31:33.500
So we've made this kind of vegan death cult around
545
00:31:34.019 --> 00:31:36.680
eating foods that have almost no energy and have a
546
00:31:36.700 --> 00:31:40.180
very high toxin load that directly poison mitochondria. Examples of
547
00:31:40.220 --> 00:31:45.960
these would be oxalates and things like black beans or
548
00:31:46.019 --> 00:31:48.650
even sweet potatoes, which I used to recommend more. Almonds
549
00:31:48.710 --> 00:31:53.099
are very high. Raspberries. very high in oxalates that cause
550
00:31:53.099 --> 00:31:56.460
70% of kidney stones and in multiple studies directly poison
551
00:31:56.480 --> 00:32:01.500
your mitochondria. So eat less toxic plants and eat high
552
00:32:01.539 --> 00:32:04.859
quality animal foods that aren't poisoned with glyphosate, which is
553
00:32:05.400 --> 00:32:08.559
toxic for mitochondria as well. So eat the right plants,
554
00:32:09.240 --> 00:32:11.519
eat a low inflammation diet. This is going to help
555
00:32:11.539 --> 00:32:15.180
your mitochondria a lot. Things like coenzyme Q10. And then
556
00:32:15.670 --> 00:32:21.279
there's this weird trick. When I was on the side
557
00:32:21.299 --> 00:32:25.359
of Mount Kailash, returning earlier to the story in our interview,
558
00:32:25.380 --> 00:32:30.609
it's about 18,000 feet elevation. Very miserable. At that elevation,
559
00:32:30.660 --> 00:32:32.430
you should feel like you're dying because you kind of are.
560
00:32:32.769 --> 00:32:34.990
There is no air to breathe. You kind of have
561
00:32:35.029 --> 00:32:37.009
a headache. You sort of feel stunned all the time.
562
00:32:37.609 --> 00:32:40.890
Weird swelling. Sometimes you take a drug called Diamox so
563
00:32:40.910 --> 00:32:44.349
you don't get fluid in the lungs. This is not
564
00:32:44.650 --> 00:32:48.769
highly human compatible. And I've trained in high altitude mountaineering.
565
00:32:49.589 --> 00:32:54.049
So I'm walking around and a little Tibetan woman, half
566
00:32:54.170 --> 00:32:57.650
my height, brings me this little bowl of yak butter tea.
567
00:32:58.650 --> 00:33:00.859
And what I don't really normally tell in this story,
568
00:33:00.880 --> 00:33:05.099
it wasn't just yak butter tea. She woke up before us.
569
00:33:05.440 --> 00:33:07.920
There was maybe six or seven of us staying in
570
00:33:07.940 --> 00:33:10.619
a guest house. It was 10 degrees below zero and
571
00:33:10.640 --> 00:33:13.180
the wind is blowing at 30 miles an hour. And
572
00:33:14.640 --> 00:33:18.089
she wakes up early. She walks a quarter mile, breaks
573
00:33:18.130 --> 00:33:20.910
through the ice on the river, gets a kettle, fills
574
00:33:20.930 --> 00:33:24.250
it with water and walks back. Then she heats it
575
00:33:24.349 --> 00:33:28.380
up over burning yak dung because that's the only fuel available.
576
00:33:29.599 --> 00:33:32.619
Then she brews tea. Okay, great. Let's have some tea.
577
00:33:32.900 --> 00:33:33.339
No, no, no.
578
00:33:33.680 --> 00:33:35.460
Then she takes the tea and she pours it into
579
00:33:35.480 --> 00:33:39.180
a butter churn, adds some scoops of yak butter. And
580
00:33:39.200 --> 00:33:42.089
then this is what drove me crazy. For 10 minutes,
581
00:33:42.349 --> 00:33:45.900
she went cha-chunk, cha-chunk, cha-chunk in the butter churn. until
582
00:33:46.000 --> 00:33:47.859
it wasn't even that hot anymore. And it was all
583
00:33:47.900 --> 00:33:51.180
blended together. And then she served it to us and
584
00:33:51.200 --> 00:33:54.160
I drank it. And my brain turned on in a
585
00:33:54.180 --> 00:33:56.680
way that it hadn't turned on in two years before that,
586
00:33:56.700 --> 00:34:00.200
because of the mold toxins, is something magic happened. Like,
587
00:34:00.349 --> 00:34:03.109
what is this? And that was where the idea for
588
00:34:03.130 --> 00:34:08.030
Bulletproof Coffee came from. Like I noticed the shift and
589
00:34:08.050 --> 00:34:09.849
I came back to Silicon Valley and I started putting
590
00:34:10.309 --> 00:34:13.010
different kinds of butter in different kinds of tea and
591
00:34:13.050 --> 00:34:17.440
eventually realized mold-free coffee was really important because coffee would
592
00:34:17.480 --> 00:34:19.699
knock me out or not knock me out. And different
593
00:34:19.739 --> 00:34:22.550
cups did different things. And different butters did different things.
594
00:34:23.690 --> 00:34:27.750
So today, if you get Danger Coffee, which is my
595
00:34:27.789 --> 00:34:29.889
new coffee brand, you put in a little bit of
596
00:34:29.909 --> 00:34:32.190
grass-fed butter. It has to be grass-fed or it doesn't work.
597
00:34:32.789 --> 00:34:37.269
Danger Coffee contains trace minerals, high amounts of trace minerals
598
00:34:37.289 --> 00:34:40.889
that your mitochondria directly need. And the butter, when you
599
00:34:40.909 --> 00:34:43.230
put it in the coffee and maybe some MCT oil,
600
00:34:43.289 --> 00:34:46.179
you blend it up. It has to be blended. What
601
00:34:46.219 --> 00:34:50.119
happens is kind of magic because we didn't know this
602
00:34:50.179 --> 00:34:53.590
at the time when I started doing it. There's research
603
00:34:53.670 --> 00:34:57.309
from the University of Washington, Dr. Gerald Pollack, who has
604
00:34:57.369 --> 00:34:59.849
spoken at the Beyond Conference. He's in his 80s now.
605
00:35:00.329 --> 00:35:03.929
He's a water biologist. And he figured out that butter
606
00:35:04.110 --> 00:35:09.320
oil or MCT oil changes the structure of water when
607
00:35:09.360 --> 00:35:11.960
it touches the water so that there's a thin band
608
00:35:11.980 --> 00:35:16.210
of water that has a different viscosity, different thickness. And
609
00:35:16.269 --> 00:35:18.469
that is the type of water that is present inside
610
00:35:18.489 --> 00:35:23.340
your cells to make energy, to fold proteins, to make ATP.
611
00:35:24.219 --> 00:35:27.519
So when that little Tibetan woman was using her butter
612
00:35:27.539 --> 00:35:30.940
churn for 10 minutes in warm tea with yak butter,
613
00:35:31.400 --> 00:35:33.929
she was charging the water so it's the kind of
614
00:35:33.989 --> 00:35:36.849
water that your body uses to make energy. But if
615
00:35:36.889 --> 00:35:38.369
you and I were to drink a glass of water
616
00:35:38.409 --> 00:35:40.610
out of that same river without doing what she did,
617
00:35:41.070 --> 00:35:43.090
we would have had to use our precious body heat,
618
00:35:44.309 --> 00:35:47.530
to transform the water by holding it up against our
619
00:35:47.550 --> 00:35:50.219
cell membranes. So you want your mitochondria to work, put
620
00:35:50.260 --> 00:35:52.539
a little bit of butter in your Danger Coffee. Put
621
00:35:52.559 --> 00:35:53.960
a little bit of MCT in there and blend the
622
00:35:54.019 --> 00:35:56.980
crap out of it. And take some MCT oil, take
623
00:35:57.000 --> 00:36:03.800
some PQQ, take some spermidine, take some Timeline. There's a
624
00:36:03.820 --> 00:36:06.769
whole bunch of things, but minerals come first and vitamin
625
00:36:06.789 --> 00:36:11.670
DAKE comes first. So DangerCoffee.com, VitaminDAKE.com would be places to start. D-A-K-E.
626
00:36:12.849 --> 00:36:15.110
So I have a quick question about coffee. You're well
627
00:36:15.170 --> 00:36:17.980
known for creating the bulletproof coffee and now you have
628
00:36:18.000 --> 00:36:19.900
your brand Danger Coffee and I had my cup of
629
00:36:19.940 --> 00:36:24.440
Danger Coffee this morning. Something just came across the 1440
630
00:36:24.440 --> 00:36:29.239
News service today and it was about research around coffee
631
00:36:29.260 --> 00:36:31.300
and it was pointing out some Swedish studies and others
632
00:36:32.079 --> 00:36:34.949
pointing to all the health benefits of coffee. But it
633
00:36:34.989 --> 00:36:38.949
did point out that the brewing method makes a difference
634
00:36:39.409 --> 00:36:43.539
and they pointed to some risk in unfiltered coffee of
635
00:36:44.179 --> 00:36:47.380
there being too much. Maybe this is old research, but
636
00:36:48.219 --> 00:36:54.070
they were suggesting use filters as opposed to espresso or
637
00:36:54.159 --> 00:36:56.929
French press, or at least limit yourself to one cup
638
00:36:56.969 --> 00:36:58.829
of espresso or French press a day and filter the
639
00:36:58.889 --> 00:37:01.769
rest because otherwise you're going to have too much. I
640
00:37:01.789 --> 00:37:03.929
got it written down here. You probably know the answer
641
00:37:03.949 --> 00:37:04.369
to this.
642
00:37:04.409 --> 00:37:05.619
That's it.
643
00:37:05.769 --> 00:37:06.250
Exactly.
644
00:37:06.269 --> 00:37:07.110
Okay.
645
00:37:07.590 --> 00:37:09.130
So I have a directness on this.
646
00:37:09.920 --> 00:37:13.420
I've addressed this probably a hundred times since I started
647
00:37:13.480 --> 00:37:16.820
writing about longevity and coffee and biohacking and all that.
648
00:37:17.500 --> 00:37:20.139
So if you believe, if you're a member of the
649
00:37:20.179 --> 00:37:24.329
cholesterol cult, you believe that this life-giving compound causes heart disease,
650
00:37:24.349 --> 00:37:28.360
by the way, it does not. And I mean, I, God,
651
00:37:28.380 --> 00:37:30.340
we have so much evidence for that now. But if
652
00:37:30.380 --> 00:37:35.590
you believe that, then drinking unfiltered coffee, oh no, it
653
00:37:35.650 --> 00:37:39.309
might raise your cholesterol. Of course, it doesn't raise oxidized cholesterol.
654
00:37:39.409 --> 00:37:45.039
It actually raises beneficial cholesterol. And those two compounds, cafestrol
655
00:37:45.320 --> 00:37:49.820
and cowahol, are coffee oils, like coffee essential oils. And
656
00:37:49.940 --> 00:37:53.760
when you have espresso or French press coffee, they help
657
00:37:54.139 --> 00:37:57.190
the liver. They don't harm the liver, but it depends
658
00:37:57.230 --> 00:37:59.760
on what the definition of helping is. If you think
659
00:37:59.780 --> 00:38:03.099
cholesterol is bad, you're trying to suppress the way the
660
00:38:03.139 --> 00:38:07.059
body is shuttling energy and nutrients around, as well as
661
00:38:07.099 --> 00:38:11.019
making hormones, and 25% of your brain is cholesterol. It's
662
00:38:11.039 --> 00:38:14.260
kind of important. But the reason that I recommend coffee
663
00:38:14.360 --> 00:38:16.949
made with a metal filter, either French press or for me,
664
00:38:16.969 --> 00:38:21.550
I do two espressos every day as Americanos, and I
665
00:38:21.610 --> 00:38:24.150
have for more than 20 years. I always use a
666
00:38:24.190 --> 00:38:27.769
metal filter. because those coffee oils in studies cross the
667
00:38:27.809 --> 00:38:30.409
blood brain barrier and turn off inflammation in the brain.
668
00:38:30.909 --> 00:38:33.670
So the only way you can say that this metal
669
00:38:33.849 --> 00:38:36.360
filtered coffee is bad for you is if you also
670
00:38:36.409 --> 00:38:39.699
believe that cholesterol is bad for you. And the evidence
671
00:38:39.739 --> 00:38:42.079
is that inflammation is bad for you, but coffee oils
672
00:38:42.119 --> 00:38:45.639
are anti-inflammation. So I'd rather have high cholesterol and low
673
00:38:45.679 --> 00:38:49.190
inflammation than low cholesterol and high inflammation. And if we
674
00:38:49.210 --> 00:38:52.090
could just get that into Western medicine, a lot of
675
00:38:52.110 --> 00:38:54.099
the problems we have with heart disease are It's because
676
00:38:54.119 --> 00:38:57.159
we keep going after the wrong targets. And even LP
677
00:38:57.199 --> 00:38:59.219
little a is more important than cholesterol. So we just,
678
00:38:59.920 --> 00:39:03.340
we've been making some fundamental errors based on assumptions about
679
00:39:03.380 --> 00:39:04.619
reality that aren't true.
680
00:39:05.539 --> 00:39:08.579
So when you get lab work done and your cholesterol
681
00:39:08.840 --> 00:39:11.980
panel of the various types of cholesterol, and you know,
682
00:39:12.039 --> 00:39:15.949
they have the, that range within what's considered acceptable. So
683
00:39:16.030 --> 00:39:18.409
in the biohacking world, do you have a different range?
684
00:39:18.429 --> 00:39:21.090
Has that been defined or what you think is an
685
00:39:21.150 --> 00:39:22.829
acceptable range for cholesterol levels?
686
00:39:23.610 --> 00:39:27.239
You know, ideal range. It's just not that relevant.
687
00:39:29.150 --> 00:39:31.530
Right. So you don't, you don't think there are upper
688
00:39:31.590 --> 00:39:34.800
limits we should be concerned about, especially if we're drinking
689
00:39:35.440 --> 00:39:38.840
fresh coffee and buttered coffee and et cetera, et cetera.
690
00:39:39.340 --> 00:39:43.280
If you have APOE4, which is a gene that makes
691
00:39:43.340 --> 00:39:47.659
you have much higher risk of cardiovascular disease and dementia
692
00:39:47.679 --> 00:39:51.150
and Alzheimer's, The traditional advice has been, oh, eat less
693
00:39:51.409 --> 00:39:55.210
saturated fat and more monounsaturated fat because you're in a
694
00:39:55.230 --> 00:40:01.369
certain risk area. There's also familial hypercholesterolemia, which is when
695
00:40:01.409 --> 00:40:05.730
people have genetically very, very high cholesterol. Problem is the
696
00:40:05.750 --> 00:40:09.590
people who live longer have more cholesterol too. So what
697
00:40:09.730 --> 00:40:13.409
I recommend we do is we look at the factors
698
00:40:13.449 --> 00:40:16.880
that are more closely correlated with heart attacks and we
699
00:40:16.940 --> 00:40:22.179
track soft plaque. So in my case, for almost 20
700
00:40:22.179 --> 00:40:25.869
years now, I've had zero seed oils intentionally. I only
701
00:40:25.949 --> 00:40:29.590
eat tallow and butter and coconut oil and olive oil
702
00:40:30.869 --> 00:40:34.750
and steak, you know, animal fat and some avocados and
703
00:40:34.949 --> 00:40:37.380
occasional walnuts and stuff like that. But I do that
704
00:40:37.659 --> 00:40:40.780
and my olive oil limit to two ounces a day. So.
705
00:40:42.599 --> 00:40:44.519
What would happen if you did that and you're at
706
00:40:44.539 --> 00:40:47.059
high risk like I am? Well, what would happen is
707
00:40:47.099 --> 00:40:50.639
you'd have zero diffuse soft plaque anywhere in your body,
708
00:40:50.760 --> 00:40:52.500
which is what I have, even though I have high
709
00:40:52.559 --> 00:40:55.559
risk for that. I have two spots of soft plaque
710
00:40:55.599 --> 00:40:59.719
that are small in my heart. And those are as
711
00:40:59.760 --> 00:41:03.019
a result of spike protein injury from getting COVID that
712
00:41:03.059 --> 00:41:06.179
are healing and actually reducing based on my practice. I
713
00:41:06.219 --> 00:41:08.539
have the lowest level of fat in my muscles they've
714
00:41:08.599 --> 00:41:11.599
ever seen, according to a recent episode on my show.
715
00:41:12.150 --> 00:41:15.789
very little fat anywhere around my organs. Like I'm an
716
00:41:15.789 --> 00:41:19.070
18 year old, super healthy person from that perspective. And
717
00:41:19.110 --> 00:41:22.730
I follow this advice. So what I do look at
718
00:41:22.949 --> 00:41:26.800
in clients when I'm working with our medical team, and again,
719
00:41:26.860 --> 00:41:28.800
I'm not a doctor. I just get to help the
720
00:41:28.820 --> 00:41:33.019
doctors with how do we think systems biology and help
721
00:41:33.059 --> 00:41:37.760
our clients. And what you'll find is that looking at
722
00:41:37.800 --> 00:41:43.320
things like triglycerides, which is important. The ratio of triglycerides
723
00:41:43.530 --> 00:41:48.340
to total cholesterol is really important. It's always about metabolic function.
724
00:41:48.760 --> 00:41:51.019
If they have insulin resistance, they're going to be in trouble.
725
00:41:51.039 --> 00:41:54.280
If they don't have insulin resistance, it's amazing. They don't
726
00:41:54.320 --> 00:41:57.400
seem to have cardiovascular disease. And we also look at
727
00:41:57.579 --> 00:41:59.980
LP little a, which is something that new drugs are
728
00:42:00.019 --> 00:42:02.300
coming out that may be helpful. But the most important
729
00:42:02.320 --> 00:42:04.949
thing is something called homocysteine. You have a problem processing
730
00:42:04.969 --> 00:42:07.030
B vitamins. Let's give you the right ones for your genetics.
731
00:42:07.030 --> 00:42:10.130
80% of our clients are are taking the wrong B vitamins.
732
00:42:10.210 --> 00:42:12.619
And you can see it because homocysteine raises your heart
733
00:42:12.659 --> 00:42:16.019
attack risk more than cholesterol. And you can treat that
734
00:42:16.039 --> 00:42:17.780
with a supplement, which is why a big pharma doesn't
735
00:42:17.800 --> 00:42:20.159
like to talk about it because they can't patent the supplement.
736
00:42:21.619 --> 00:42:24.949
And then we look at something called C-reactive protein or
737
00:42:25.170 --> 00:42:29.110
HSCRP on your labs. That's also an independent risk factor.
738
00:42:29.670 --> 00:42:33.250
So homocysteine means genetic problem B vitamins. C-reactive protein means
739
00:42:33.369 --> 00:42:37.539
you have a bacterial infection or some other physical stressor
740
00:42:37.599 --> 00:42:40.090
somewhere in the body. And when you track those two
741
00:42:40.130 --> 00:42:42.710
things in something called HOMA, which is a history of
742
00:42:43.289 --> 00:42:47.889
their blood sugar levels, HbA1c, you get a good picture
743
00:42:47.909 --> 00:42:50.960
of your cardiovascular risk way better than this dumb cholesterol stuff.
744
00:42:51.039 --> 00:42:53.739
Problem is, statins are a multi-billion dollar market. They're not
745
00:42:53.760 --> 00:42:55.980
going to tell you the truth. They just aren't. Statins
746
00:42:56.019 --> 00:42:58.719
are generally bad for most people, but about 10% of
747
00:42:58.739 --> 00:43:02.559
the time, with certain genetics, certain circumstances, they're life-saving. And
748
00:43:02.719 --> 00:43:04.760
I just have to say this final thing about that fleet,
749
00:43:04.900 --> 00:43:06.360
because I know I'm on a bit of a rant here.
750
00:43:06.380 --> 00:43:12.460
In When we're examining medicines to see if they're worth taking,
751
00:43:12.920 --> 00:43:18.300
you look at the benefit versus risk ratio. And for statins,
752
00:43:18.619 --> 00:43:23.199
for every 100 people that take statins, one person gets
753
00:43:23.619 --> 00:43:27.420
a risk reduction. Everyone else gets side effects, which can
754
00:43:27.440 --> 00:43:30.320
be 30% to 50% of people. We know that they're
755
00:43:30.340 --> 00:43:35.019
harmful to mitochondria. They're a terrible solution for prevention, and
756
00:43:35.460 --> 00:43:40.190
they work post-heart attack in certain circumstances. But It's the
757
00:43:40.409 --> 00:43:43.710
most egregious case of marketing malfeasance I've seen in a
758
00:43:43.730 --> 00:43:47.230
long time. So not a fan, put it that way.
759
00:43:47.510 --> 00:43:49.710
But what do you do for all these things for
760
00:43:49.730 --> 00:43:52.170
your mitochondria? Well, you should probably put some butter in
761
00:43:52.190 --> 00:43:54.429
your coffee. At least that's what my evidence says.
762
00:43:55.880 --> 00:43:57.960
Is there a place, and this is kind of a
763
00:43:58.000 --> 00:44:01.690
personal interest of mine. My C-reactive protein is very low,
764
00:44:02.590 --> 00:44:05.239
but I do the LP small a, which is genetic.
765
00:44:06.320 --> 00:44:08.900
I have that, and you can do about that. I
766
00:44:08.940 --> 00:44:12.420
have a lot of, I think if I'm correct, a
767
00:44:12.760 --> 00:44:17.300
fair amount of free floating lipids in my blood. So
768
00:44:17.380 --> 00:44:21.099
I'm getting an arterial scan in the next few weeks
769
00:44:21.159 --> 00:44:24.780
just to check whether there's plaque there or not. But,
770
00:44:24.820 --> 00:44:27.780
you know, I finally got to a cardiologist and that's
771
00:44:27.800 --> 00:44:31.179
how I was able to get the scan done. And
772
00:44:31.420 --> 00:44:34.139
they were bringing up, well, you could go on statins.
773
00:44:34.199 --> 00:44:36.619
I said, no, no, no, no, I'm not going. Some
774
00:44:36.659 --> 00:44:38.590
of you have to really convince me that statins will
775
00:44:38.610 --> 00:44:40.809
be helpful maybe before I'd ever go anywhere near statins.
776
00:44:40.849 --> 00:44:43.010
But is there a place where one can kind of
777
00:44:43.050 --> 00:44:46.869
get the body of knowledge you just discussed to really
778
00:44:46.989 --> 00:44:48.869
look into that? Or do you have to really kind
779
00:44:48.889 --> 00:44:50.929
of look everywhere and be into the research and the
780
00:44:50.969 --> 00:44:54.309
studies yourself? Or has someone kind of put that together?
781
00:44:55.559 --> 00:44:59.139
If you read Superhuman, my longevity book, I go into
782
00:44:59.179 --> 00:45:03.880
a lot of detail about this stuff. And I do
783
00:45:03.900 --> 00:45:09.239
want to say, we think that lowering LP little a
784
00:45:09.719 --> 00:45:13.590
is probably going to be good for you. But we
785
00:45:13.630 --> 00:45:16.670
don't know if you have something that's on fire. I
786
00:45:16.750 --> 00:45:18.949
lowered the smoke. It doesn't mean the fire went out.
787
00:45:19.030 --> 00:45:21.010
It just means you have less smoke. And we're not
788
00:45:21.150 --> 00:45:24.150
sure about that with LP little a, but we think
789
00:45:24.230 --> 00:45:28.610
it's very likely. And there's actually a new drug that
790
00:45:28.639 --> 00:45:31.699
just got approved in the last couple of days that
791
00:45:32.039 --> 00:45:35.079
should lower LP little a, but it also lowers cholesterol
792
00:45:35.139 --> 00:45:40.179
in a crazy level. So there are ways, something called
793
00:45:40.199 --> 00:45:46.769
PCSK9 drugs that lower this. And there's even supplements like
794
00:45:46.869 --> 00:45:51.010
something called L-carnitine, which is common for mitochondrial function and
795
00:45:51.130 --> 00:45:59.139
for mitochondrial ability to eat fatty acids. You can probably
796
00:45:59.179 --> 00:46:02.949
get about 10% of reduction in Lp little a just
797
00:46:02.989 --> 00:46:06.769
from that. But there's big, big drugs on the market
798
00:46:06.849 --> 00:46:09.829
or about to come that lower it. Something called Bempadoic acid.
799
00:46:10.500 --> 00:46:12.239
But I went on bifidoic acid to see if I
800
00:46:12.280 --> 00:46:15.719
could lower my LP little a, which is mostly genetic.
801
00:46:16.019 --> 00:46:18.599
And it did drop dramatically. So did my ability to
802
00:46:18.659 --> 00:46:22.199
remember things because my cholesterol dropped. Cholesterol is necessary for
803
00:46:22.219 --> 00:46:25.440
your brain. It's like, it's the funniest thing. So I'm like,
804
00:46:25.500 --> 00:46:27.550
I think I'll quit taking that. Like, I don't care.
805
00:46:27.570 --> 00:46:30.699
I am healthy. Track your risk. Get a clearly scan
806
00:46:30.719 --> 00:46:32.650
of your arteries. If you don't have a problem, you
807
00:46:32.670 --> 00:46:37.250
don't have a problem. And if someone says, oh no, scary. Like,
808
00:46:37.269 --> 00:46:38.929
I don't know how much money they make when you're afraid.
809
00:46:38.949 --> 00:46:43.909
Mm-hmm. So we're getting towards the end of our time
810
00:46:43.949 --> 00:46:47.730
together today. And I'd like to ask you about kind
811
00:46:47.750 --> 00:46:51.570
of the future of biohacking, maybe in this context. So,
812
00:46:52.750 --> 00:46:56.039
you know, we're hearing more and more about personalized approaches
813
00:46:56.079 --> 00:46:59.820
to medicine. Part of that is the kind of concierge
814
00:46:59.860 --> 00:47:02.920
level of medicine, which is quite expensive and available to
815
00:47:02.960 --> 00:47:05.960
those with resources. And there's the higher end of a
816
00:47:06.019 --> 00:47:11.840
program like your program that you're doing, for people with
817
00:47:11.860 --> 00:47:14.360
a lot of resources, but it's great that somebody's doing
818
00:47:14.380 --> 00:47:17.820
that so we can learn. And then there's the idea
819
00:47:17.840 --> 00:47:21.199
of regenerative medicine. There's all these ideas about shifting our
820
00:47:21.239 --> 00:47:24.199
medical landscape and our whole mindset around that. And then
821
00:47:24.260 --> 00:47:27.550
biohacking within that. So where do you see the future
822
00:47:27.570 --> 00:47:28.530
of all this moving?
823
00:47:30.289 --> 00:47:35.130
You know, biohacking is about changing your state. So some
824
00:47:35.150 --> 00:47:37.809
people want To be a balloon animal, like you want
825
00:47:37.929 --> 00:47:41.829
big muscles and like, okay, that's your thing. That probably
826
00:47:41.889 --> 00:47:45.849
isn't as correlated with longevity as people think. Because strength
827
00:47:45.909 --> 00:47:48.449
and neuromuscular coupling, it seems to be more important than
828
00:47:48.489 --> 00:47:51.550
muscle mass, but you should have some of both. There's
829
00:47:52.030 --> 00:47:53.489
people who say, I want to be peaceful. Like, I
830
00:47:53.510 --> 00:47:55.170
just don't want to feel stress all the time. I
831
00:47:55.190 --> 00:47:57.550
don't want to feel fear all the time. And people say,
832
00:47:57.570 --> 00:47:59.320
I want to be young. Like, I would like to
833
00:47:59.380 --> 00:48:01.039
not age. And I've spent two and a half million
834
00:48:01.059 --> 00:48:04.099
dollars reversing my age and fixing all the weird genetics
835
00:48:04.139 --> 00:48:06.420
and stuff that I have. So I'm one of those two.
836
00:48:07.760 --> 00:48:10.590
And some people say, I just want an amazing relationship.
837
00:48:10.860 --> 00:48:13.590
I want to feel intimacy that I haven't had before.
838
00:48:13.630 --> 00:48:16.730
Or I just want to sleep really well. So the
839
00:48:16.769 --> 00:48:20.610
state you choose is the state you choose. And ultimately,
840
00:48:21.289 --> 00:48:23.369
what you'll find is you want to develop the ability
841
00:48:23.409 --> 00:48:27.170
to switch between states effortlessly so that you can be
842
00:48:27.610 --> 00:48:31.059
in a connected state. to the universe state of divine
843
00:48:31.199 --> 00:48:34.500
union with your partner or with the tree in front
844
00:48:34.519 --> 00:48:38.019
of you, whatever your thing is. And then you can immediately,
845
00:48:38.159 --> 00:48:41.920
without fear or stress, switch into focus mode and go
846
00:48:41.940 --> 00:48:44.579
mode and turn your brain on and be completely dialed
847
00:48:44.639 --> 00:48:47.070
in and focused and get all this stuff done. And
848
00:48:47.110 --> 00:48:48.969
then to be able to say, you know what? I'm
849
00:48:48.989 --> 00:48:51.329
going to just pause for a second. I'm going to
850
00:48:51.349 --> 00:48:53.610
come up with the perfect idea that no one's ever
851
00:48:53.690 --> 00:48:56.710
thought of before. And you're pulling your energy from somewhere else.
852
00:48:57.389 --> 00:49:00.170
it's that ability to switch. And maybe you want a
853
00:49:00.190 --> 00:49:03.599
brain that doesn't fade. And Fleet, something I haven't shared
854
00:49:03.639 --> 00:49:07.760
with you, even though we're friends, because it just came out,
855
00:49:08.559 --> 00:49:11.340
I just added some more technology to 40 Years of Zen,
856
00:49:11.360 --> 00:49:15.489
my neuroscience company, and we can measure cognitive fatigue. And I've,
857
00:49:17.030 --> 00:49:19.929
it's an annoying test. For 14 minutes, you stare at
858
00:49:20.000 --> 00:49:22.139
a screen and every one second a word comes up.
859
00:49:22.199 --> 00:49:25.559
It's no or go. And if it's go, you press
860
00:49:25.699 --> 00:49:28.199
the mouse button as fast as you can. So you
861
00:49:28.219 --> 00:49:31.389
got to stay focused for 14 minutes every second on
862
00:49:31.409 --> 00:49:34.489
a boring task. I used to have ADHD.
863
00:49:36.090 --> 00:49:36.210
Well.
864
00:49:37.449 --> 00:49:39.949
It turns out my response time was in the 80th
865
00:49:39.989 --> 00:49:42.469
percentile for my age, so my brain is very fast.
866
00:49:42.909 --> 00:49:47.789
But what was unprecedented is I'm in the 0.001% of
867
00:49:47.869 --> 00:49:50.809
people who had no variance in my response time at all,
868
00:49:50.829 --> 00:49:54.449
had no fatigue at all over the 14 minutes, where
869
00:49:54.489 --> 00:49:56.840
my final answer was just as fast and just as
870
00:49:56.929 --> 00:50:01.250
accurate as the first answer, and I missed two answers. Many, many,
871
00:50:01.309 --> 00:50:06.150
many standard deviations, less cognitive fatigue. From a guy who
872
00:50:06.210 --> 00:50:09.659
had chronic fatigue syndrome and fibromyalgia and crippling brain fog.
873
00:50:10.679 --> 00:50:13.280
From a guy whose psychiatrist looked at a brain scan
874
00:50:13.320 --> 00:50:16.340
when I was 30 and said, inside your brain is
875
00:50:16.380 --> 00:50:19.119
total chaos. I don't know how you're standing here in
876
00:50:19.139 --> 00:50:21.269
front of me. You have the best camouflage I've ever seen.
877
00:50:22.210 --> 00:50:24.710
So I'm from totally broken to the best in the
878
00:50:24.769 --> 00:50:28.630
world at having cognitive resilience. And if I can do
879
00:50:28.690 --> 00:50:32.309
this as a former 300-pound fat computer hacker who's been
880
00:50:32.369 --> 00:50:35.239
on book covers with my shirt off, I have the
881
00:50:35.380 --> 00:50:38.480
worst genes. I have the worst background. And I did this.
882
00:50:39.179 --> 00:50:41.579
So you can do this. Anyone listening to this, it
883
00:50:41.599 --> 00:50:44.110
will be much less work and much less money for you.
884
00:50:44.429 --> 00:50:45.670
You don't need to spend $ 2. 5 million over 20 years
885
00:50:45.690 --> 00:50:48.739
like I did. And you definitely don't need to spend
886
00:50:48.739 --> 00:50:53.440
$ 2 million a year obsessively tracking everything. It doesn't, it
887
00:50:53.460 --> 00:50:55.909
doesn't do much because what works for you is not
888
00:50:55.949 --> 00:50:57.929
what works for the person next to you. It is
889
00:50:58.269 --> 00:51:01.250
so highly personalized and having done a lot of clients
890
00:51:01.289 --> 00:51:05.030
through unlimited life, every recommendation is different and it has
891
00:51:05.050 --> 00:51:07.030
to be personalized or it doesn't work. We're all unique.
892
00:51:08.650 --> 00:51:12.090
So how does maybe the final question? So, you know,
893
00:51:12.719 --> 00:51:16.199
even just all the information you've covered, and we could
894
00:51:16.219 --> 00:51:19.079
have gone so much more deeply into so many different areas,
895
00:51:20.239 --> 00:51:26.530
is probably fairly daunting to the average person. And then
896
00:51:26.590 --> 00:51:29.150
we need to, not only there's all this information out there,
897
00:51:29.190 --> 00:51:31.090
now I need to actually learn enough to have my
898
00:51:31.250 --> 00:51:36.389
personalized pathway in this. How do I handle the... The
899
00:51:36.449 --> 00:51:38.469
daunting nature of that. So you can get started and
900
00:51:38.510 --> 00:51:40.489
have a pathway. You can feel, okay, I'm doing enough
901
00:51:40.530 --> 00:51:42.449
of the right things. I'm going to keep learning. I'm
902
00:51:42.510 --> 00:51:44.650
on a good path here. Instead of just going, oh
903
00:51:44.670 --> 00:51:46.030
my God, this is too complicated.
904
00:51:46.090 --> 00:51:51.030
It's too much. Sure. You can go to axo.health, A-X-O
905
00:51:51.050 --> 00:51:53.449
dot health. And we've got a platform where you can
906
00:51:53.719 --> 00:51:55.519
order lab tests. And I'm not trying to say, you
907
00:51:55.539 --> 00:51:58.619
can get lab tests all over the internet now. We've
908
00:51:58.639 --> 00:52:00.780
put together the panel of things that are most important
909
00:52:00.800 --> 00:52:03.500
according to my 20 plus years in the field and
910
00:52:03.539 --> 00:52:05.909
made it as affordable as possible. But once you get
911
00:52:05.929 --> 00:52:08.590
the results, it runs through an algorithm that's trained on
912
00:52:08.650 --> 00:52:12.230
everything I've ever said. And it makes recommendations, not medical recommendations,
913
00:52:12.349 --> 00:52:15.980
lifestyle recommendations to support whatever your goal is. Because it
914
00:52:16.019 --> 00:52:19.980
turns out, Fleet, making recommendations for someone without knowing what
915
00:52:20.000 --> 00:52:23.500
they want is a problem. So if you want longevity,
916
00:52:23.639 --> 00:52:26.539
but we make recommendation goals for physical performance, you'd be
917
00:52:26.579 --> 00:52:30.019
pissed off and vice versa. So we actually have a
918
00:52:30.239 --> 00:52:32.780
part of the system that talks to you. What do
919
00:52:32.800 --> 00:52:35.619
you really want? And the reality is we want performance
920
00:52:35.699 --> 00:52:38.619
and longevity, but unconsciously you want one more than the other.
921
00:52:38.739 --> 00:52:41.000
And we'll tease that out of you in a way
922
00:52:41.019 --> 00:52:43.079
that doesn't take very long so that that way we
923
00:52:43.099 --> 00:52:45.199
can tailor the goals so that based on this lab
924
00:52:45.219 --> 00:52:47.739
work and this lifestyle stuff, this is what to do
925
00:52:47.800 --> 00:52:50.269
to move the needle fastest. And then the other thing
926
00:52:50.309 --> 00:52:54.449
is don't worry about perfectionism, right? It just has to work.
927
00:52:54.820 --> 00:52:57.260
If you get 80% of it, you're going to completely
928
00:52:57.300 --> 00:53:00.059
shift your life. And I've seen people in six months,
929
00:53:00.480 --> 00:53:04.380
they lose 40 pounds, their brain turns on, they become
930
00:53:04.420 --> 00:53:08.780
more loving, they become more focused, they relax, like life
931
00:53:08.840 --> 00:53:11.760
just becomes better. So it doesn't take as long as
932
00:53:11.780 --> 00:53:12.090
you think.
933
00:53:13.869 --> 00:53:15.869
Well, I want to express just a lot of gratitude
934
00:53:15.929 --> 00:53:18.829
for your leadership in this movement, Dave, and your support
935
00:53:18.889 --> 00:53:23.639
for our future biohacking. And And really, personally, I've read
936
00:53:23.679 --> 00:53:27.619
most of your books. I'm a customer on Axel Health,
937
00:53:27.699 --> 00:53:30.690
and I found all of the resources you've been providing.
938
00:53:31.630 --> 00:53:33.849
I'm not quite ready to get to unlimited life yet.
939
00:53:33.909 --> 00:53:36.929
Maybe if HeartMind does better in the next few years,
940
00:53:37.010 --> 00:53:40.230
I can do that. But yeah, you've been an extraordinary
941
00:53:40.250 --> 00:53:43.699
help to me. personally, in terms of having more confidence
942
00:53:43.719 --> 00:53:45.539
that I'm doing enough of the right things about my
943
00:53:45.579 --> 00:53:49.489
health and my enlightened self-interest in terms of what my
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lifestyle goals are. So thank you very much for that.
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You're welcome. And you're looking well, my friend.
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Feel good. Feel good. So Dave Asprey, father of the
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biohacking movement. Thank you very much. Thank you for joining
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me on the Radical Responsibility Podcast. Remember, real change happens
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when we commit to our growth, face our challenges with compassion,
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and stay open to transformation. If you found this episode helpful,
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I encourage you to subscribe and help us spread the
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00:54:19.670 --> 00:54:23.570
message of healing and personal empowerment. Until next time, stay grounded,
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stay present, and stay true to yourself. Take care.