#156 - Biohacker Must-Do’s for Maximum Health Optimization and Longevity w/ Siim Land

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[SPEAKER_00]: I'm a big fan of just a regular, comprehensive blood panel, most of people I'm interacting with, you could call them like hobbies, longevity enthusiasts, or people who are preventive that you're trying to take care of the health and are curious about it.
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[SPEAKER_00]: So for most of these individuals, it just comes down to just optimization and trying to optimize all of their health and try to get as healthy as possible.
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[SPEAKER_01]: Welcome to the Dr. Joy Kong podcast.
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[SPEAKER_01]: This is where I have a chance to share with you some of the latest developments in the space of holistic health, longevity, and wellness.
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[SPEAKER_01]: I've always honored intellectual curiosity and scientific rigor, combined with real world practicality.
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[SPEAKER_01]: My goal is that what you learn here will help you live longer and live better.
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[SPEAKER_01]: Hope you enjoy the journey with me.
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[SPEAKER_01]: Hello, welcome back to the Dr. Joy Calm podcast.
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[SPEAKER_01]: I'm here to enhance your health to live your best and longest life possible.
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[SPEAKER_01]: So I've invited a wonderful expert and friend, Sim Land, welcome Sim.
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[SPEAKER_01]: Thank you for being here.
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[SPEAKER_02]: Yes.
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[SPEAKER_01]: Yes, so Sim is a super expert in longevity, despite his young age, but he has been very helpful in educating the public and providing.
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[SPEAKER_01]: some incredible content on YouTube and that's how I found Sim in the first place and he also has written books which is remarkable very very highly prolific so very admirable and Sim I'm so glad to have you back to share your expertise.
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[SPEAKER_00]: Yeah I'm a
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[SPEAKER_01]: Yeah, so, you know, having been in the longevity space for quite a while and having visited different clinics, you know, throughout different countries in the world, probably it's a little overwhelming.
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[SPEAKER_01]: I think for people who are in the biohacking space.
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[SPEAKER_01]: who want to optimize their health are so much going on.
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[SPEAKER_01]: Of course, in each biohacking conference, there's more and more technology.
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[SPEAKER_01]: So what do people do?
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[SPEAKER_01]: And how do they actually work on themselves?
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[SPEAKER_01]: Because the whole point is that this is individualized, right?
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[SPEAKER_01]: It's not a one-size-fits-all.
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[SPEAKER_01]: And everybody is, you know, you know, you know, you know, you know,
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[SPEAKER_01]: do the same thing because we need to see where each person is at.
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[SPEAKER_01]: So what are your thoughts on all these some different longevity clinics and what everyone is doing?
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[SPEAKER_01]: Do you feel that they're all doing amazing things?
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[SPEAKER_01]: Do you feel that some people are on the right track?
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[SPEAKER_01]: Some organizations do an incredible amount of tests and some are a little bit more tailored and limited and how much they test.
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[SPEAKER_01]: What are your thoughts?
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[SPEAKER_01]: Should people just go for the whole range of tests which can be pretty overwhelming?
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[SPEAKER_00]: Well, I guess the problem with what I like the framing is that we do want to be aware of as many biomarkers as reasonably possible about our health and the more you know,
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[SPEAKER_00]: the more insightful you can the more insightful it is and the more educated guess you can your decisions or you can make about your health.
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[SPEAKER_00]: So in one sense it's obviously very positive to test a lot of things and measure hundreds of biomarkers, etc., the same as supplements like yes, you could take hundreds of supplements out there, is it always necessary?
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[SPEAKER_00]: In most cases not, in most cases you get the majority of benefits from just the handful of supplements and you can eliminate a lot of supplements.
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[SPEAKER_00]: If you have an unlimited budget, obviously, then it doesn't really matter.
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[SPEAKER_00]: That's much, much, much money you spend on testing or supplements, etc.
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[SPEAKER_00]: So it depends a lot on the particular person's budget, then what their priorities are.
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[SPEAKER_00]: biggest problem is that if people test but they don't do anything about improving those results.
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[SPEAKER_00]: So if you don't really change anything and try to make the any marker better after testing it, then you just wasted your money or you don't really, you could even skip to testing all together.
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[SPEAKER_00]: So I think the most important thing about any testing is that, okay, if you're going to test whatever that is, blood work,
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[SPEAKER_00]: You know, MRI, CD scan, Dixis scan, VR2max, whatever the test you're taking, that you have to be willing to also improve on that marker, whatever the result is.
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[SPEAKER_00]: So let's say you get a VR2max score that is very low.
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[SPEAKER_00]: Yes, you know, that can be insightful that even if you don't improve it, you know that you're in a slightly lower VR2max and that puts you at a higher risk of mortality compared to people with a higher VR2max, for your age group, for example,
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[SPEAKER_00]: but it's still more important to actually try to improve the marker because even if you didn't test it, you just focused on improving the marker by doing cardiovascular exercise and following otherwise healthy diet and keeping a normal body weight, etc.
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[SPEAKER_00]: Then you would have a new and better off than by testing it than not doing anything to improve it.
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[SPEAKER_00]: So the foundation should be
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[SPEAKER_00]: just trying to live as healthy of a lifestyle as possible and trying to take care of everybody and follow our regular exercise routine, a regular healthy diet and maintaining normal body weight.
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[SPEAKER_00]: There's a baseline and if you follow all these fundamentals, then you can avoid a lot of unnecessary testing.
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[SPEAKER_00]: and you can also be sure that most of these biomarkers can be in a more normal or optimal spot to be in with.
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[SPEAKER_00]: But if you do test something then be willing to also adjust your lifestyle, adjust your diet, adjust your sleep routine, whatever it is based on the results that you're getting.
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[SPEAKER_00]: Because humans are kind of stubborn, you know, we are creatures of habit,
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[SPEAKER_00]: And if we do it for a very long time, we're unwilling to change them, or we're like, less eager to change, it's going to be very hard for a smoker to give up smoking even if they get diagnosed with a very serious disease, or alcohol, or whatever vices people might have that harm their health, if they've been doing them for decades, then it's very hard for them to quit and change it.
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[SPEAKER_00]: But even like small things, let's say someone likes their ice cream or, you know, let's say they stay up late to too much.
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[SPEAKER_00]: whatever the small thing may be, you know, even these small changes can be very difficult to change.
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[SPEAKER_00]: But if you do tests and there is, let's say, okay, you need to change this to improve this marker, then I would highly encourage people to do those changes, because then otherwise the testing was a waste of money, that makes sense.
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[SPEAKER_01]: Right, right.
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[SPEAKER_00]: Yeah, so, you know, let's say I'll start with pretty much like a minimal budget and even tests people can measure for free without paying anything.
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[SPEAKER_00]: So, ways of conference is one of the, I guess, more general biomarkers that can be very extremely insightful to your general health and body composition.
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[SPEAKER_00]: So we know Obesity is that for your health.
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[SPEAKER_00]: and ways of conference can be a very good estimate of your level of adiposity, especially the amount of visceral fat around your organs.
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[SPEAKER_00]: So the visceral fat gets stored in between muscles and around the organs and tends to more accumulate around the belly.
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[SPEAKER_00]: So if you have a very big, this kind of a beer belly or pot belly, then that tends to be a sign of more visceral fat.
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[SPEAKER_00]: that isn't inherently as bad as storing the weight around the building and just measuring your waste of confidence, you can get a reasonably good estimate of your especially visceral fat mass around the organs because yeah if it's kind of a
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[SPEAKER_00]: if they're with the waste of conferences bigger than your hips or conferences then that's like this imbalance between excessive visor of that and you know you might have still subcutaneous fetus wool under the skin that gets stored more on the hips in excess amounts but the ratio is what matters more so the waste of hip ratio.
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[SPEAKER_00]: So the waste should always be narrower than the hips, for both men and women.
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[SPEAKER_00]: So you measure the waste circumference around the belly button and the hips around the hips.
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[SPEAKER_00]: So that's, you know, free everyone can measure that and generally lower waste circumference is a better.
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[SPEAKER_00]: Another free, you know, test people can do
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[SPEAKER_00]: even something like push-ups or pull-ups, some sort of a body weight strength test.
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[SPEAKER_00]: How many push-ups can you do, how many pull-ups can you do, how many squats can you do, etc.
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[SPEAKER_00]: So muscle strength, the muscle mass are also associated with longevity and people with
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[SPEAKER_00]: higher muscle mass and higher muscle strength tend to be healthy as well because in order to achieve a higher muscle mass muscle strength you need to be doing some form of physical activity and you know the always you put into doing the physical activity make you healthier.
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[SPEAKER_00]: So to say that if you have a higher amount of pushups that you can do, that means you are putting in the work at other times.
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[SPEAKER_00]: Maybe not necessarily a gym, but maybe you have some sort of a physically active job, or maybe you grew up in a farm, or you have like a history of doing a lot of physical activity.
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[SPEAKER_00]: Those things still carry through for many years in the future.
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[SPEAKER_00]: But generally, yeah, just having a higher muscle strength that,
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[SPEAKER_00]: that measures grip correctly and it works the same way that a higher grip strength is associated with higher total muscle strength across entire body and it means that you've put in the work of increasing your muscle strength but you know it doesn't need to be a grip strength machine and it can be push ups or pull ups that I pull ups because in order to do a lot of pull ups you also need to be slightly lower body weight.
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[SPEAKER_00]: So that's kind of a good test because it includes body fat percentage, muscle mass, and muscle strength.
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[SPEAKER_00]: So if you were to be very strong, but you're not able to do any pull-ups, then it's kind of an imbalance between the strength and the body fat percentage because you probably have too much body fat.
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[SPEAKER_00]: Yes, you don't need to do like 20 or 30 pull-ups to be considered healthy,
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[SPEAKER_00]: a fit and healthy man should be able to do at least, you know, at least five at minimum, but you know, ideally over ten pull ups and women, you know, that least, you know, women do significant at the less pull ups and men, but, you know, at least one or two for a woman is still reasonably strong as a bit baseline strength for muscle, as a business that test
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[SPEAKER_00]: Well, for my 31st birthday last month, I did 33 pull-ups, so I'm trying to small challenge that every year for the birthday I'll try to kind of one off the pull-ups next year.
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[SPEAKER_00]: I'll try to do 32 again.
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[SPEAKER_00]: at least.
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[SPEAKER_00]: Yeah.
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[SPEAKER_01]: Wonderful.
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[SPEAKER_01]: That's a great goal.
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[SPEAKER_01]: Yeah.
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[SPEAKER_00]: Yeah.
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[SPEAKER_00]: And the last test that would say, you know, so let's say how do you measure your via 2x, which is another important biomarker of overall cardiovascular function and the higher via 2x eases associated also with the lower mortality risk and lower heart disease risk, et cetera.
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[SPEAKER_00]: So it's again, if you have a high via 2x,
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[SPEAKER_00]: with some physical activity.
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[SPEAKER_00]: Maybe you don't necessarily do like cardio work.
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[SPEAKER_00]: Let's go to exercise, but you're doing some for my physical activity that increases your video to max.
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[SPEAKER_00]: And the Cooper test is a free way to estimate your rear-to-max.
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[SPEAKER_00]: So you can find one-line calculators.
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[SPEAKER_00]: So how far can you run in 12 minutes?
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[SPEAKER_00]: The distance in kilometers or miles, and you can estimate your rear-to-max based on that.
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[SPEAKER_00]: So it's like a scientifically validated way to measure the rear-to-max without actually doing the rear-to-max test.
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[SPEAKER_01]: Now the rear-to-max test is a bit more accurate.
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[SPEAKER_00]: No, how far can you run in 12 minutes?
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[SPEAKER_00]: In 12 minutes?
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[SPEAKER_01]: So, you measure that in meters?
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[SPEAKER_00]: It can be miles as well, no matter.
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[SPEAKER_00]: Yes, just run as far as possible for 12 minutes.
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[SPEAKER_00]: The Cooper test we did in high school.
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[SPEAKER_00]: And the how far you run is the score.
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[SPEAKER_00]: And then there's like online calculators.
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[SPEAKER_00]: You can calculate your via to max from.
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[SPEAKER_00]: So then you get the view to max number.
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[SPEAKER_00]: The higher the view to max, then the feature you are.
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[SPEAKER_00]: So athletes have a view to max of 70s.
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[SPEAKER_00]: If sedentary people might have it in the 20s, depending on their age.
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[SPEAKER_00]: So it declines with age.
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[SPEAKER_00]: The older you are, the lower it can be.
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[SPEAKER_00]: And the unhealthier and the less fit you are, the lower the view to max is.
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[SPEAKER_00]: So you want to keep your view to max.
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[SPEAKER_00]: You know, above 20 for as long as possible, but the challenge is that if you have a view to max of 20, you know, 30 is already then, you know, it's going to drop to into the teens by the age of 50.
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[SPEAKER_00]: So once it's below 17, view a view to max, then that's considered like a frailty threshold that you're not able to be physically independent with your everyday activities.
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[SPEAKER_00]: You're not able to get off the toilet.
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[SPEAKER_00]: You're not going to be able to carry your
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[SPEAKER_00]: for just the quality of life-perspective you want to keep every atomax relatively high.
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[SPEAKER_01]: Um, with the best way to improve the O2 Max.
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[SPEAKER_00]: any form of her cardio will increase it.
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[SPEAKER_00]: So if you don't know where to start, just starting to do some form of cardio whether that be even just going for a jog, longer runs, whatever it is, any form of cardio will, especially in the beginning, will increase a view to max.
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[SPEAKER_00]: Going into more specifics, there are certain interval workouts as well that will increase.
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[SPEAKER_00]: So interval training is more effective for the extra max than low intensity steady state cardio.
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[SPEAKER_00]: But ideally, I want to do both, because there's pros and cons to both forms of exercise for low intensity cardio, the pro is that you can do it for a long time and very frequently without breaking your nervous system and you can recover from it very fast, especially if you do like this low intensity zone to cardio.
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[SPEAKER_00]: If you're doing slightly more in faster intensity,
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[SPEAKER_00]: then that can be more taxing because you're not in this zone two state which is characterized by low lactate and higher fat oxidation so the zone two you could do you know hours and hours without really burning out but doing a lot of zone three four can eventually tax your nervous system in the same way there's own five
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[SPEAKER_00]: You're not able to do interval training every day for 5 hours as straight, whereas realistically or theoretically you could do that with zone 2.
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[SPEAKER_00]: Like you could do 5 hours of zone 2 every day, it's just you don't have the time probably.
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[SPEAKER_00]: So that's why interval training can be a good way to get more benefits over yet to max in a shorter amount of time.
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[SPEAKER_00]: And yeah, from the studies, you want to get your view to Max, at least about 50 meters per kilogram limit.
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[SPEAKER_00]: So we don't have much data about, you know, is 60 better, maybe, you know, for some things, it might be better for cardiovascular disease mortality, it might be better, but we don't know yet.
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[SPEAKER_00]: We don't have that much data about people with a VRT max of 60 and above, but at least about 50, that's like a good goal.
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[SPEAKER_00]: So my goal with Langevite is to keep my VRT max of about 50 for at least until I'm 80 years old.
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[SPEAKER_00]: So there is actually one study of a 80 year old Norwegian man who had a VRT max of 50, which is pretty insane for our 80 year old, because VRT max of 50 is what a normal 35 year old person would have.
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[SPEAKER_00]: who doesn't, who isn't like an athlete.
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[SPEAKER_01]: So this is a person that's exercising consistently and especially cardio.
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[SPEAKER_00]: Yeah, he had a very consistent exercise routine.
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[SPEAKER_00]: He, yeah, several workouts per week.
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[SPEAKER_01]: Right.
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[SPEAKER_01]: But get out there and move and get your heart pumping.
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[SPEAKER_00]: Yeah, and obviously I also think the blood tests are very insightful.
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[SPEAKER_00]: I'm a big fan of blood tests.
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[SPEAKER_00]: So everyone has different opinions about health like what is healthy.
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[SPEAKER_00]: Some people will say, OK, I feel good.
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[SPEAKER_00]: I'm not obese.
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[SPEAKER_00]: I don't have diabetes or something that I'm healthy.
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[SPEAKER_00]: Yes, that is categorically true.
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[SPEAKER_00]: Health is the absence of disease.
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[SPEAKER_00]: Health is also many other things, right?
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[SPEAKER_00]: Health is a state of...
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[SPEAKER_00]: physical and mental well-being, it includes the absence of disease, but it also is something you can quantify.
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[SPEAKER_00]: How do you know you don't have a disease?
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[SPEAKER_00]: You need to measure it in some ways.
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[SPEAKER_00]: If you have high blood pressure, then you have hypertension, right?
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[SPEAKER_00]: We have certain diagnostic criteria that diagnose you with a particular chronic disease if you meet those criteria.
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[SPEAKER_00]: three or more of the following hydrolycerides, high waste of conference, high blood sugar, high blood pressure, and low HDL.
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[SPEAKER_00]: So if you have three or more of the following then your diagnosed as with metabolic syndrome, which eases associated with increased risk of diabetes, heart disease, and other chronic diseases.
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[SPEAKER_00]: So that's what you don't want.
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[SPEAKER_00]: So, blood markers are just a way to see what goes on inside you.
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[SPEAKER_00]: So, yes, you can feel good, but a lot of things you can't feel.
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[SPEAKER_00]: You can't feel really if you have high blood sugar.
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[SPEAKER_00]: You know, eventually if you have like very serious diabetes, you might feel it with neuropathy and, uh, ready, neuropathy and those kind of things that it actually starts to physically affect you.
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[SPEAKER_00]: But my old elevation in blood sugar, you know, let's say you're not in, you wouldn't feel pre diabetes, right?
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[SPEAKER_00]: You wouldn't feel any difference with pre diabetes.
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[SPEAKER_00]: Yes, you might have a little bit of extra weight, you might have a high waist circumference, so those are signs that you potentially could have pre diabetes even without testing your blood.
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[SPEAKER_00]: but you wouldn't otherwise feel pre-diabetes.
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[SPEAKER_00]: And even like regular diabetes probably wouldn't necessarily feel.
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[SPEAKER_00]: So testing those markers actually would show what it is inside, what it goes on inside you.
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[SPEAKER_00]: And you wouldn't definitely feel other markers.
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[SPEAKER_00]: You wouldn't feel homocysteine, which is a risk factor for heart disease.
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[SPEAKER_00]: You wouldn't feel different lipids, you wouldn't even feel the blood pressure.
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[SPEAKER_00]: So there's a lot of things that you intuitively, you could feel normal, but you don't necessarily actually know if there is something wrong because you don't feel most of these biomarkers.
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[SPEAKER_01]: And, and of course, cancer markers, how extensive should people be checking as far as screening for cancer?
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[SPEAKER_00]: Yeah, so I would much rather not try to find something that isn't there or you know not not trying to find something that is wrong and you know that is a risk of testing that you start testing things trying to find something you know that's something might be wrong so I much rather would take a more conservative approach to testing in general.
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[SPEAKER_00]: with blood tests, a lot of blood tests and markers, they can fluctuate, you can get some false positive tests with other more, let's say, advanced testing, like emirriors and stuff.
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[SPEAKER_00]: So you could go down a rabbit hole and do unnecessary, the extensive testing or spend unnecessary amounts of money.
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[SPEAKER_00]: But for cancer, I would just much rather focus on the health of fundamentals and even regular blood work,
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[SPEAKER_00]: can, you know, certain blood markers do correlate with increased risk of cancer as well.
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[SPEAKER_00]: So I would just read this.
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[SPEAKER_00]: If there's nothing wrong with those just your lifestyle and you're not smoking, you don't have a genetic history of cancer and your blood work is also normal.
21:00.074 --> 21:01.115
[SPEAKER_00]: You have low inflammation.
21:01.175 --> 21:04.719
[SPEAKER_00]: You have low blood sugar, low homocysteine.
21:04.779 --> 21:12.949
[SPEAKER_00]: And you know, just you otherwise have a healthy lifestyle then I wouldn't start to really chase, chase something
21:13.216 --> 21:25.008
[SPEAKER_01]: I've seen that in my patients who get not only start to chase and track all the time, but also the psychological burden of thinking something's really wrong with them.
21:25.888 --> 21:28.431
[SPEAKER_01]: I don't think that's actually that helpful.
21:29.812 --> 21:32.235
[SPEAKER_01]: Put them in a whole different mental space.
21:33.336 --> 21:40.843
[SPEAKER_00]: Yes, I've had a few markers that were abnormally high in one test, but if I tested them,
21:41.212 --> 21:58.876
[SPEAKER_00]: a few weeks later, there were normal, so there's some markers that just fluctuate, you know, heavy metals, confluxuate, certain inflammatory markers fluctuate, it's always, you know, if someone does a blood test or whatever test, then, you know, I think, you know, any good doctor would probably just retest first before doing anything else.
22:00.479 --> 22:00.619
[SPEAKER_01]: Mm-hmm.
22:00.639 --> 22:04.384
[SPEAKER_01]: It will hormone test be the fundamentals that you will suggest.
22:04.600 --> 22:07.884
[SPEAKER_00]: Yeah, I mean hormones are incredibly vital.
22:08.645 --> 22:14.813
[SPEAKER_00]: And I think hormones play a more important role in your well-being and quality of life.
22:16.015 --> 22:22.022
[SPEAKER_00]: So how you feel and what you're moods and just, yeah, how you feel in day-to-day.
22:22.723 --> 22:27.049
[SPEAKER_00]: But hormones also fluctuate, and hormones need to be taken in a context.
22:28.250 --> 22:28.971
[SPEAKER_00]: So,
22:30.402 --> 22:33.308
[SPEAKER_00]: because they can be very sensitive to various activities.
22:33.328 --> 22:36.334
[SPEAKER_00]: It is like sleep, your calorie intake.
22:36.354 --> 22:45.812
[SPEAKER_00]: You know, let's say testosterone, the testosterone is incredibly volatile to your, you know, just overall calorie intake and your body percentage.
22:45.995 --> 23:06.184
[SPEAKER_00]: if someone is, you know, let's say a platform and if they are 12% or 13% benefit, which is, you know, lean, but it's not very like shredded or very low benefit, then, you know, they're testosterone at 13% benefit would probably higher than if they were to be at 8% benefit.
23:06.785 --> 23:12.373
[SPEAKER_00]: Now, we set is the person with
23:12.455 --> 23:34.581
[SPEAKER_00]: slightly higher testosterone, maybe like 15, 20% higher testosterone than the 8% but if a person, we don't necessarily know because, you know, if you look at animal data, then then calorie restriction is the most potent way to extend lifespan non-genetic way to extend lifespan and calorie restriction would require you to be leaner, you know.
23:35.303 --> 23:56.839
[SPEAKER_00]: We don't have human data, obviously, about what would happen for humans if they do long-term color restriction for many decades, will they live longer if they are, you know, always single-lidged body fat percentage, we don't know, but it would be hard to say which one is healthier, because the third person who has, you know, 13% body fat,
23:57.089 --> 23:59.793
[SPEAKER_00]: Yeah, they're not obese, but they have slightly more body fat.
23:59.813 --> 24:08.324
[SPEAKER_00]: They have slightly higher testosterone, but they also would probably have slightly higher blood sugar and slightly higher lipids, slightly higher waste of confidence because of the increased body fat.
24:09.085 --> 24:10.067
[SPEAKER_00]: It's a matter of context.
24:10.287 --> 24:20.721
[SPEAKER_00]: So yes, the 8% person male for them, yeah, they're testosterone might be slightly lower, but their other biomarkers might be better, if that makes sense.
24:21.963 --> 24:25.948
[SPEAKER_00]: And likewise, they might regain some of the weight.
24:26.890 --> 24:37.069
[SPEAKER_00]: It's very common for at least the bodybuilders and fitness competitors to see a massive drop in their testosterone during their competitive season, and it's natural bodybuilders.
24:37.130 --> 24:47.329
[SPEAKER_00]: The pro bodybuilders, the opposite inject and take exogenous testosterone, but natural bodybuilders is very common for their testosterone to tank quite low.
24:47.309 --> 24:53.863
[SPEAKER_00]: into like the 200's, 300's will be pretty common for a stage lean fitness competitor to experience.
24:54.344 --> 24:59.053
[SPEAKER_00]: And yes, they feel awful during that time because they're very lean and low energy intake and low testosterone.
24:59.594 --> 25:03.984
[SPEAKER_00]: But usually what happens is after the competition, they just regain some healthy weight.
25:04.525 --> 25:07.090
[SPEAKER_00]: They go towards more 10% but if at,
25:07.070 --> 25:10.674
[SPEAKER_00]: you know so it's a short term adaptation short term phenomenon.
25:11.034 --> 25:18.442
[SPEAKER_01]: This is a little bit the reason behind low body fat relating correlating with the low testosterone.
25:18.843 --> 25:23.448
[SPEAKER_00]: But it's mostly just the restriction on energy, so you're just eating those calories.
25:24.509 --> 25:29.434
[SPEAKER_00]: And that results in less hormone production and lower thyroid levels.
25:30.435 --> 25:35.541
[SPEAKER_00]: Now there are ways to maintain slight higher testosterone levels even on a lower body
25:37.158 --> 25:44.603
[SPEAKER_00]: In my opinion, higher carb intake, and there are studies as well showing that higher carb intake.
25:45.562 --> 25:55.300
[SPEAKER_00]: helps with maintaining higher testosterone at a lower body for percentage because the higher carb intake maintains a better thyroid functioning as well at lower calorie intakes.
25:56.081 --> 26:00.970
[SPEAKER_00]: So, for thyroid and your hormones, the carbohydrates are incredibly valuable.
26:01.390 --> 26:08.363
[SPEAKER_00]: So, low carb, high protein diets consistently lower testosterone in men and
26:08.343 --> 26:18.557
[SPEAKER_00]: You know, yeah, it doesn't have to be low fat diet, but a slightly higher carb, maybe moderate fat diet tends to result in the best at testosterone, at least in males.
26:19.238 --> 26:23.564
[SPEAKER_00]: And the same for females, you know, carbohydrates tend to support female hormones as well.
26:24.225 --> 26:30.614
[SPEAKER_00]: So very restrictive diets usually lower, female hormones as well.
26:30.674 --> 26:36.342
[SPEAKER_00]: And you can result in some disruption in their menstrual cycle.
26:36.322 --> 26:43.150
[SPEAKER_00]: But yeah, for let's say longevity, then both six Romans are quite important for females.
26:44.791 --> 26:48.836
[SPEAKER_00]: There's like a different type of decline.
26:48.856 --> 26:54.462
[SPEAKER_00]: They have relatively normal hormones until menopause and after menopause, they drop close to zero.
26:54.682 --> 26:58.526
[SPEAKER_00]: Whereas for men, it's a kind of slow decline over the course of decades.
26:58.546 --> 27:03.612
[SPEAKER_00]: But it's not linear that it's for declines in the same speed for everyone.
27:03.997 --> 27:30.713
[SPEAKER_00]: There's going to be some 80-year-olds who have very high testosterone as well and some younger individuals who have lower testosterone, so it's genetic environmental and lifestyle related how I stay sleep, how much food are they eating, what other type of things they're doing, alcohol,
27:31.705 --> 27:37.986
[SPEAKER_00]: A single test, I guess, is not a very accurate picture for a foretest officer on a beast.
27:38.388 --> 27:51.287
[SPEAKER_01]: Yeah, and what about some people go for very extensive microbiome tests or toxic exposures, including heavy metal or other infectious agents?
27:51.928 --> 27:53.250
[SPEAKER_01]: So how important do you think is?
27:53.330 --> 28:06.049
[SPEAKER_01]: I mean, we know we live in a toxic world and also with a lot of underlying infections, pretty prevalent among the population.
28:06.468 --> 28:10.378
[SPEAKER_01]: How important it is, is it for us to be diving into that?
28:10.999 --> 28:18.278
[SPEAKER_00]: Well, for God's test, I think it's only worthwhile if you have some actual symptoms.
28:19.621 --> 28:20.443
[SPEAKER_00]: Some...
28:21.655 --> 28:34.890
[SPEAKER_00]: got related symptoms, some got related disorders, so it would be useful to just help the diagnosis, what is the particular issue and what things you could do to improve your symptoms.
28:35.651 --> 28:50.008
[SPEAKER_00]: For an otherwise healthy person who doesn't have any got related symptoms or got issues, I don't see a lot of value in testing your microbiome if you don't have any
28:50.478 --> 29:11.322
[SPEAKER_00]: think we actually understand the gut microbiome that will yet it's a very complex ecosystem and it's not that okay you just have this bacteria and this diversity and that means that you have perfect gut microbiome or something like that it's a very complex and context dependent as well so for some people
29:11.302 --> 29:22.702
[SPEAKER_00]: a specific composition in the microbiome might be beneficial, and for others they get more symptoms, etc.
29:22.782 --> 29:33.782
[SPEAKER_00]: So I would rather only test the microbiome if you actually are trying to improve something related to your gut health or food intolerance or something else like that.
29:34.117 --> 29:44.717
[SPEAKER_00]: And if you just follow a very diverse diet and you don't have symptoms, then chances are you're in a very good spot with your microbiome test as well.
29:44.737 --> 29:47.843
[SPEAKER_00]: So you wouldn't necessarily need to test it.
29:47.903 --> 29:51.350
[SPEAKER_00]: And the problem is also that there's a lot of commercial tests.
29:52.372 --> 29:55.197
[SPEAKER_00]: And most of these commercial tests,
29:55.598 --> 29:58.161
[SPEAKER_00]: aren't clinically validated.
29:59.162 --> 30:12.738
[SPEAKER_00]: So in the same with a lot of this epigenetic tests, they each company does his own thing in terms of what do they measure and how do they report it, et cetera.
30:13.599 --> 30:19.125
[SPEAKER_01]: So in the case of aging and current biological age, that's what you're referring to, right?
30:19.375 --> 30:21.097
[SPEAKER_00]: Yeah, so this epigenetic age tests.
30:21.238 --> 30:22.379
[SPEAKER_00]: They all measure different things.
30:22.740 --> 30:26.225
[SPEAKER_00]: They all say it's your biological age result, but they all give different results.
30:27.026 --> 30:28.929
[SPEAKER_00]: And the same with the problem, we've got micro-bound tests.
30:29.129 --> 30:33.556
[SPEAKER_00]: If you were to do the topmost popular, got micro-bound tests out there, they would all give different results.
30:34.958 --> 30:37.842
[SPEAKER_00]: In terms of your micro-bound.
30:37.862 --> 30:39.264
[SPEAKER_00]: So which one is the most accurate?
30:39.484 --> 30:45.653
[SPEAKER_00]: It's hard to tell because they're each of them, or all of them haven't been claimingly validated.
30:45.818 --> 30:46.779
[SPEAKER_01]: mm-hmm.
30:47.721 --> 30:52.227
[SPEAKER_00]: Yeah, the other question you had was toxicity.
30:52.768 --> 30:58.396
[SPEAKER_00]: So yeah, I mean, you can measure heavy metals in the blood.
30:58.837 --> 31:04.505
[SPEAKER_00]: The issue with that is also the short-term exposures can give you some different results.
31:05.125 --> 31:08.350
[SPEAKER_00]: So for example, I measured heavy metals in
31:09.511 --> 31:26.845
[SPEAKER_00]: January, this year, my lead was pretty high, like, so I take the same test I've taken the same test for several years and the same company and it's always been normal, but this year was something like 10 times higher.
31:26.993 --> 31:27.715
[SPEAKER_00]: reference range.
31:28.297 --> 31:35.017
[SPEAKER_00]: So okay, you know, but then I measured it again in a few weeks, maybe one month, and it was normal again.
31:35.057 --> 31:40.232
[SPEAKER_00]: So, you know, that's just an example that I was maybe exposed to some heavy metals.
31:40.634 --> 31:41.155
[SPEAKER_00]: Like,
31:41.978 --> 32:01.597
[SPEAKER_00]: in hailed some fumes or something like whatever it is like we do live in a world where there is more heavy metals in the environment and around us so you know I could have eaten something I could have breathed in something drank some water or something like that and it just could have registered as a high-laden number in that test.
32:01.957 --> 32:08.323
[SPEAKER_00]: So yeah and the same you know these would be probably worthwhile to measure these things
32:09.670 --> 32:22.735
[SPEAKER_00]: as well quite regularly at least heavy metals, but be aware that they do fluctuate as well and not necessarily if you have some of these heavy metals like aluminum or mercury, something like this, hi, that it.
32:24.048 --> 32:27.215
[SPEAKER_00]: doesn't necessarily mean that you have toxicity.
32:27.615 --> 32:30.401
[SPEAKER_00]: Me personally, you know, I didn't do anything.
32:30.421 --> 32:40.943
[SPEAKER_00]: I didn't start, you know, some people might go down around that they start some, you know, some detox protocol or some Galatian therapy if they see a high heavy metal result on their test.
32:41.935 --> 33:03.842
[SPEAKER_00]: You know, I'll be again like first retest and then consider possible options, you know, you know, I do a lot of Sonas, I think that is a very useful tool in this world where we are exposed more various heavy metals and you know, microplastics even and air pollution, et cetera.
33:04.733 --> 33:22.074
[SPEAKER_00]: So, I do it for other reasons, I do it for the cardiovascular benefits and just deals good but an additional bonus and additional motivation is that it does help to excrete heavy metals and possibly microplastics as well.
33:22.294 --> 33:26.860
[SPEAKER_00]: There are studies for heavy metals that you do sweat out heavy metals.
33:28.882 --> 33:35.452
[SPEAKER_00]: There's no direct evidence for micropossics yet, but I do think that it is possible.
33:36.233 --> 33:39.518
[SPEAKER_01]: Yeah, how significant is the problem of micropossics?
33:39.538 --> 33:50.835
[SPEAKER_01]: Because now there are people who are changing the clothes they're wearing, being concerned about, I guess, absorbing micropossics directly through the skin.
33:51.536 --> 33:54.180
[SPEAKER_01]: How much evidence is there that this is happening?
33:54.278 --> 34:04.591
[SPEAKER_00]: Well, I think, I guess there's no quantified ranking of what is the most effective way for your body to absorb them.
34:05.132 --> 34:12.401
[SPEAKER_00]: You're probably just eating microplastics is probably consuming them through your mouth, or drinking water that has microplastics.
34:12.421 --> 34:15.786
[SPEAKER_00]: That's probably the most direct way your body absorbs them.
34:16.126 --> 34:20.792
[SPEAKER_00]: They go through your gut, then absorbs through the bloodstream and spreads throughout the body.
34:20.772 --> 34:22.275
[SPEAKER_00]: you know, inhaling as well.
34:22.295 --> 34:23.577
[SPEAKER_00]: I mean, the microbasics are everywhere.
34:23.597 --> 34:36.102
[SPEAKER_00]: I actually was in a conference in Tokyo and someone had me at some sort of, uh, not a camera, everybody was like a, uh, like a lens and they showed, so it supposedly would show microplastics.
34:36.483 --> 34:40.350
[SPEAKER_00]: And yeah, it was like this blue lens and, uh, you know, cover everyone's,
34:40.904 --> 34:45.872
[SPEAKER_00]: went through everyone's clothes and you saw this small white kind of dots and those other stuff like micro plastics.
34:46.753 --> 34:51.501
[SPEAKER_00]: So as you show, yeah, like on your shoes, on your on your on your beard, on your hair.
34:52.262 --> 35:06.945
[SPEAKER_00]: So they everywhere, you know, they just exhaust few not from exhaust
35:06.925 --> 35:26.824
[SPEAKER_00]: different personal care products so they're everywhere you know and I think recently I even saw some headline that microplastics have seeped so deep into the earth that they're like at the level something like you know you know thousands of years ago was this kind of earth crusts
35:26.804 --> 35:31.075
[SPEAKER_00]: So the seeds so deep into the earth that they've kind of, you know, traveled back in time.
35:31.416 --> 35:39.577
[SPEAKER_00]: Obviously, you know, okay, no, there were no microplastics in the dinosaur times, but they've seeded so low that in the earth crossed their found that there.
35:39.978 --> 35:41.522
[SPEAKER_00]: So yeah, they're just everywhere.
35:42.869 --> 35:57.928
[SPEAKER_00]: Yeah, I don't see a way where we will be able to avoid them, you know, society would probably collapse if we stopped using plastics all together because they're so useful and they're just everywhere by now in industrial and just manufacturing purposes.
35:59.130 --> 36:04.877
[SPEAKER_00]: So yeah, we just have to find ways to deal with it and minimize our unnecessary exposure so you know, don't
36:06.157 --> 36:14.471
[SPEAKER_00]: don't microwave plastic top aware and eat from it, don't drink from a plastic bottle that is been sitting out in the sun.
36:15.693 --> 36:22.404
[SPEAKER_00]: Don't, yeah, just expose yourself to a lot of these unnecessary sources.
36:23.406 --> 36:24.648
[SPEAKER_00]: How much is from my clothes?
36:24.928 --> 36:25.870
[SPEAKER_00]: I do think that
36:27.031 --> 36:34.241
[SPEAKER_00]: Clothes can be quite a significant route of exposure because you're wearing a clothes all day.
36:35.764 --> 36:38.387
[SPEAKER_00]: So your skin is rubbing against that.
36:38.508 --> 36:47.140
[SPEAKER_00]: And from there, you break off this, not all plastics even, and very extremely small things are you inhale them from there and through the skin.
36:47.901 --> 36:55.452
[SPEAKER_00]: So yeah, I do think that it would be wise to try to, let's say, wear more natural fabrics and materials,
36:55.432 --> 37:15.330
[SPEAKER_00]: use a stainless steel cooking where wooden speciala and other plastic speciala glass food containers you try to use glass bottles when possible you know okay if you're an airport they don't have glass bottles maybe you have your own water container but you know
37:15.850 --> 37:26.167
[SPEAKER_00]: buying or plastic bottle, drinking it is not going to kill you, but unnecessary things you can try to remove.
37:26.407 --> 37:29.512
[SPEAKER_00]: Because unfortunately, I do think there are ways to excrete them.
37:29.612 --> 37:33.779
[SPEAKER_00]: So, you know, last two years ago or something, it was said that you just can't excrete them at all.
37:33.799 --> 37:35.121
[SPEAKER_00]: You just keep accumulating them.
37:35.442 --> 37:36.063
[SPEAKER_00]: Well, that's not true.
37:36.123 --> 37:40.710
[SPEAKER_00]: There's plenty of evidence to suggest that there are many ways to remove
37:41.382 --> 37:44.271
[SPEAKER_00]: at least from the blood, these microplastics.
37:45.274 --> 37:45.856
[SPEAKER_00]: So yeah.
37:46.518 --> 37:50.008
[SPEAKER_01]: And what will be the best way to remove them from the blood?
37:50.393 --> 37:52.676
[SPEAKER_00]: Well, the best way is probably blood donation.
37:52.996 --> 37:57.583
[SPEAKER_00]: So you just take out your blood and blood donation, you're giving it to someone else.
37:57.663 --> 38:02.569
[SPEAKER_00]: But obviously, that's life, life-threatening situation.
38:02.870 --> 38:06.494
[SPEAKER_00]: And it's better to save a life than to not give them the blood.
38:07.115 --> 38:18.190
[SPEAKER_00]: But there's also this therapeutic plasma exchange, which takes out the blood,
38:19.621 --> 38:41.460
[SPEAKER_00]: I mean, there are certain of these machines that also filter the blood and Ibo is a exacorporeal blood, ozoneation and oxygenation, so they also should ozone through the blood, which has antiviral effects mostly, and they should like blue light through the blood as well.
38:42.368 --> 38:48.399
[SPEAKER_00]: And that could also eliminate some extra microplastics from the blood.
38:48.700 --> 38:51.966
[SPEAKER_00]: So, yeah, just kind of filtering the blood and then directing it back into your body.
38:52.006 --> 38:57.396
[SPEAKER_00]: And that's probably the most effective way aside from blood donation where you're just taking out the blood.
38:58.017 --> 38:58.298
[SPEAKER_01]: Right.
38:58.398 --> 39:05.271
[SPEAKER_01]: So, perhaps there have been evidence that either Ibu or plasma freezes can actually remove microplastics.
39:05.588 --> 39:05.928
[SPEAKER_00]: Yeah.
39:06.429 --> 39:06.629
[SPEAKER_00]: Yeah.
39:06.729 --> 39:18.559
[SPEAKER_00]: So there's studies on firefighters, where these, I mean, it just makes sense from physics perspective that you just take out the blood that with a microprocessor inside.
39:18.599 --> 39:21.601
[SPEAKER_00]: So you would just remove them by virtue of that.
39:21.722 --> 39:26.606
[SPEAKER_00]: But yeah, and that applies to any other of these forever chemicals and heavy metals as well.
39:27.887 --> 39:35.393
[SPEAKER_00]: Obviously, you, you know, with a filtration,
39:36.841 --> 39:38.204
[SPEAKER_00]: the reason some evidence for that.
39:38.746 --> 39:39.006
[SPEAKER_01]: Yeah.
39:39.347 --> 39:43.537
[SPEAKER_01]: Well, let's talk about food sensitivity.
39:43.958 --> 39:45.963
[SPEAKER_01]: Should everyone test for food sensitivity?
39:46.043 --> 39:53.922
[SPEAKER_01]: Because I've heard of people who were having some health issues and then they check food sensitivity and realize, oh my goodness.
39:53.902 --> 40:02.914
[SPEAKER_01]: So, my body doesn't do well with this particular item, it has high sensitivity, when they remove it, a lot of the problems go away.
40:03.294 --> 40:12.206
[SPEAKER_01]: But we also know there's a lot of false positives and a lot of the red herring and the test can eliminate a lot of very healthy food.
40:12.647 --> 40:14.008
[SPEAKER_01]: So, what's your take on that?
40:14.549 --> 40:22.980
[SPEAKER_00]: Yeah, so the IGGE test that's supposed to measure as your allergies to different foods,
40:23.483 --> 40:25.766
[SPEAKER_00]: So that, you know, is very dependent on what you're eating.
40:26.568 --> 40:30.794
[SPEAKER_00]: So if you eat a lot of eggs, you're gonna get red flag on the eggs.
40:31.075 --> 40:33.038
[SPEAKER_00]: If you eat a lot of dairy, you'll get a red flag on the dairy.
40:33.378 --> 40:40.189
[SPEAKER_00]: Or at least, every, this IG test I've seen, everyone gets red on like eggs and dairy and grains or something like that.
40:40.209 --> 40:43.434
[SPEAKER_00]: So not everyone is allergic to eggs, good grains and dairy.
40:43.914 --> 40:49.002
[SPEAKER_00]: So it's just that your body produces, you know, this antibody is when you're eating them.
40:49.842 --> 41:01.084
[SPEAKER_00]: And if you eat a lot of certain foods like a lot of nuts or a lot of I don't know spinach or something, then you will, you might get this, you know, red or orange like on that.
41:02.246 --> 41:05.252
[SPEAKER_00]: So it doesn't necessarily mean that you are actually allergic to it.
41:06.447 --> 41:14.221
[SPEAKER_00]: And you might not even get symptoms, so I would only remove certain foods if you actually get some symptoms from them.
41:14.241 --> 41:21.775
[SPEAKER_00]: I don't see a reason if someone isn't allergic to gluten, why they would need to necessarily remove gluten.
41:22.336 --> 41:26.143
[SPEAKER_00]: I mean, it doesn't have any significant nutritional value, but
41:26.123 --> 41:34.058
[SPEAKER_00]: I guess you don't have to be necessarily worried about it if you don't have an actual gluten allergy And you don't get any symptoms.
41:34.078 --> 41:42.394
[SPEAKER_00]: Another place to like eggs and dairy as well You know eggs are very nutritious if you don't have an egg allergy you define you don't get any symptoms then
41:42.374 --> 41:43.878
[SPEAKER_00]: So why would you really remove it?
41:44.881 --> 41:58.358
[SPEAKER_00]: Maybe if you see some of your blood markers getting worse from eating eggs, then maybe it makes sense to reduce them or remove them, but there's generally eggs aren't going to move a needle on a lot of...
41:58.338 --> 42:00.101
[SPEAKER_00]: Buy markers in a negative way.
42:00.863 --> 42:06.913
[SPEAKER_00]: So the dietary cholesterol is not really going to raise a lot Of course cholesterol for most people.
42:06.933 --> 42:10.981
[SPEAKER_00]: There are some people for who it does, but for most people It's not going to do it.
42:11.602 --> 42:19.536
[SPEAKER_00]: So, you know, unless something like that then I don't see it like a reason To really remove eggs from that from that perspective
42:20.123 --> 42:22.025
[SPEAKER_01]: Well, what about an AD testing?
42:22.165 --> 42:24.128
[SPEAKER_01]: So now, I mean, it's a newer test.
42:24.148 --> 42:26.130
[SPEAKER_01]: And some people are getting into it.
42:26.511 --> 42:30.796
[SPEAKER_01]: Everyone is talking in the biohacking world, talking about an AD levels.
42:32.558 --> 42:40.387
[SPEAKER_01]: But I've also heard that when a person is older or even sicker, they have a higher level of an AD.
42:40.487 --> 42:43.431
[SPEAKER_01]: So what's your take on whether or not this is worth testing?
42:44.474 --> 42:58.804
[SPEAKER_00]: Yeah, well, with NAD, one of the latest, I guess, input of her from some experts is that for these tests, you know, they measure blood, NAD, but they don't measure
42:59.965 --> 43:03.332
[SPEAKER_00]: like intracellular or like tissue, specific NAD.
43:04.334 --> 43:08.302
[SPEAKER_00]: So it's not going to be that useful as a biomarker.
43:08.322 --> 43:17.141
[SPEAKER_00]: So it doesn't really tell you what your actual NAD status is because the intracellular NAD is what actually matters.
43:18.384 --> 43:19.105
[SPEAKER_00]: So
43:20.317 --> 43:23.763
[SPEAKER_00]: Personally, I wouldn't, you know, do an N80 test.
43:25.326 --> 43:30.034
[SPEAKER_00]: So the commercial and it tests, they're all a bit based on blood, like a blood spot.
43:30.936 --> 43:36.125
[SPEAKER_00]: So, you know, personally, I'm not gonna do an N80 test for that reason at the moment.
43:37.167 --> 43:37.768
[SPEAKER_01]: I see.
43:38.052 --> 43:51.588
[SPEAKER_00]: And I mean, yeah, it's one of those things that you might feel, so if you feel very tires, then that can be a sign of a lower NAD.
43:52.529 --> 43:55.593
[SPEAKER_00]: And vice versa, if you feel just in a great, you feel very energized.
43:56.374 --> 43:57.936
[SPEAKER_00]: Then you probably don't have NAD problems.
43:58.457 --> 44:03.823
[SPEAKER_00]: Because NAD's the most co-enzyme for energy metabolism,
44:03.803 --> 44:10.593
[SPEAKER_00]: So it's really directly to ATP production and ATP is the current energy currency of cells.
44:11.434 --> 44:23.753
[SPEAKER_00]: So if you control for your sleep, quality and duration, and then you can identify that, yes, I'm feeling tired.
44:24.020 --> 44:35.812
[SPEAKER_00]: irrespective of my sleep and irrespective of my diet and sunlight and those things then that might be a sign that you have low-rankity but I wouldn't yet test like blood blood-based, any detests at the moment.
44:36.373 --> 44:36.713
[SPEAKER_01]: I see.
44:37.434 --> 44:49.707
[SPEAKER_01]: Are there any other tests, blood urine, what are hair, any tests that you think are really important that you you often suggest to people?
44:49.957 --> 44:54.786
[SPEAKER_00]: Yeah, so I am a big fan of just the regular Comprehensive Blot Panel, you know, you're
44:56.453 --> 45:10.707
[SPEAKER_00]: Because most of people are, I guess, interacting with are, you could call them like hobbies, longevity enthusiasts, or people who are preventive that you're just trying to take care of the health and are curious about it.
45:11.888 --> 45:23.659
[SPEAKER_00]: So for most of these individuals, it just comes down to just optimization and they're trying to optimize all of their health and try to get as healthy as possible.
45:23.639 --> 45:41.779
[SPEAKER_00]: So I'm not really dealing with the sick population that much for this individual's specific imaging and advanced tests is more common for a general health optimization person than for them.
45:42.399 --> 45:50.288
[SPEAKER_00]: They don't necessarily need to go into very advanced testing because the basic tests already
45:50.268 --> 46:02.944
[SPEAKER_00]: can be very insightful and, you know, you're already following also the healthy lifestyle and the following fundamentals, then there's a very low likelihood that you need to do advanced imaging.
46:03.262 --> 46:03.622
[SPEAKER_01]: Yeah.
46:04.183 --> 46:08.406
[SPEAKER_01]: So for me, one of the most crucial ones is the glucose parameters.
46:09.027 --> 46:21.138
[SPEAKER_01]: So the glucose, the Himaloo and A1C and insulin level, those will give me a really great indicator of their blood sugar metabolism that's metabolic health.
46:21.858 --> 46:26.142
[SPEAKER_01]: So, and of course thyroid is really important and in hormones.
46:26.522 --> 46:32.087
[SPEAKER_01]: To me, these are kind of the bread and butter, right, for a general test.
46:33.097 --> 46:38.949
[SPEAKER_00]: Yeah, I'm you know, I definitely agree with the metabolic health and blood sugar.
46:40.312 --> 46:53.721
[SPEAKER_00]: So a lot of people, you know, struggle with that and it's one of those things that it's better to be optimized rather than normal with, so you know, let's take, let's take
46:53.819 --> 47:08.115
[SPEAKER_00]: like blood sugar isn't like a best marker, but a triglycerides are a good example of that, the triglyceride reference range is 150 milligrams per deciditer, anything below that is normal, but anything above 100,
47:08.348 --> 47:11.291
[SPEAKER_00]: He's associated with higher mortality and higher cardiovascular disease risks.
47:11.311 --> 47:15.035
[SPEAKER_00]: So a normal triglyceride level is actually already putting you into like increased risk.
47:15.816 --> 47:27.289
[SPEAKER_00]: So with triglycerides, which is a form of lipids, but it's the most best reflection of your metabolic health and insulin sensitivity.
47:27.329 --> 47:35.858
[SPEAKER_00]: So a lower triglyceride below the reference range is much better than a normal result.
47:36.158 --> 47:52.513
[SPEAKER_00]: same with like information, CRP levels, normal CRP in like let's say 1.5 milligrams per eacher that is already also in a higher risk category than something like 0.1 so close to 0.
47:52.915 --> 48:02.770
[SPEAKER_01]: And I want to ask you about imaging, because I know these longevity programs, they take people around and do a bunch of imaging, what do you think is the biggest bang for your buck?
48:02.790 --> 48:06.917
[SPEAKER_01]: What do you think is important or what tests are you excited about?
48:07.478 --> 48:13.607
[SPEAKER_00]: Yeah, so for scans, dexaskan, I think is the...
48:14.954 --> 48:23.424
[SPEAKER_00]: something that most people would benefit from as an information source, so you can, you know, measure your bone density with the blood test.
48:25.387 --> 48:36.540
[SPEAKER_00]: You can measure your bone density with any like fitness tests specifically, but yeah, the Texas can is very useful for measuring what your bone density.
48:37.145 --> 48:52.772
[SPEAKER_00]: And bonus is very outdated, I think, because people with high bone density, they're less likely to die from fractures and falls, if they do fall, and that is one of the leading causes of accidental deaths among the elderly people.
48:53.894 --> 49:01.347
[SPEAKER_00]: So having high bone density is very important, as you get older, for women, especially, I think
49:02.035 --> 49:19.082
[SPEAKER_00]: I deal, they perform in a pause, but if they haven't done that, then just after them in a pause as well, to see our day with very low bone entity or do they have high bone entity, that can be insightful to what they need to do, do they need to start really taking their
49:20.260 --> 49:24.484
[SPEAKER_00]: Resinance training more seriously or do they need some hormonal therapy to support that.
49:24.804 --> 49:29.649
[SPEAKER_00]: So there's a lot of valuable information you can get from a dexus scan for bone density.
49:29.689 --> 49:35.215
[SPEAKER_00]: Now the dexus can also measure things like visceral fat, your body fat, muscle mass, etc.
49:35.315 --> 49:47.787
[SPEAKER_00]: But for at least the visceral fat is a bit less accurate than a full body MRI for visceral fat, but it's still better than guessing what would your visceral fat be.
49:48.273 --> 49:48.834
[SPEAKER_01]: I see.
49:49.154 --> 49:49.535
[SPEAKER_01]: Okay.
49:50.116 --> 49:50.636
[SPEAKER_01]: That's great.
49:51.017 --> 49:54.221
[SPEAKER_01]: I bet you most people have not had a dexter scan.
49:54.241 --> 49:54.382
[SPEAKER_01]: Okay.
49:54.722 --> 49:57.646
[SPEAKER_01]: It would be a really, really helpful information.
49:58.027 --> 49:59.469
[SPEAKER_01]: Any other scans?
50:00.570 --> 50:00.831
[SPEAKER_00]: Yeah.
50:00.911 --> 50:16.693
[SPEAKER_00]: So there is, you know, more specific medical scans that are popular in
50:16.927 --> 50:29.637
[SPEAKER_00]: now although like a full body MRIs safe in the procedural sense like there's no radiation there's no harm maybe some people might get claustrophobic or something like that but you know there's no
50:29.887 --> 50:32.071
[SPEAKER_00]: you don't get radiation like you do from a CT scan.
50:33.212 --> 50:46.394
[SPEAKER_00]: But I guess, yeah, with an MRI, there is also the risk of positive, or getting some result that isn't an actual cancer, or something like that, that there's nothing wrong with you, actually, but there's always the risk for that.
50:46.474 --> 50:49.819
[SPEAKER_00]: But, you know, generally there's no direct harm.
50:49.799 --> 51:01.615
[SPEAKER_00]: from my MRI and I've gotten two in my life, two full body MRIs and yeah, it's just kind of
51:02.692 --> 51:19.710
[SPEAKER_00]: interesting, at least for me, like the longitudinal data that I would collect from that would be quite valuable if I'm going to do like, you know, maybe not every year, but every five years or something, if I do one, then I'll have a pretty good database to look at once I get older.
51:20.490 --> 51:31.602
[SPEAKER_00]: A CT scan is usually recommended for people over their 50s to see what's their coronary
51:31.582 --> 51:38.951
[SPEAKER_00]: And you know, that is a very valuable test because you'll see if you do have actually calcium in the arteries or not.
51:39.671 --> 51:54.829
[SPEAKER_00]: And for heart disease that is the kind of, you know, maybe not the ultimate biomarker, but it's a sign of already existing heart disease and a classification, which is a significant, you know, concern.
51:55.610 --> 51:59.715
[SPEAKER_00]: But the problem with the CT scan is that you know, you can do it
51:59.695 --> 52:14.175
[SPEAKER_00]: So if you do it in your 50s, you don't know when did that calcium come and what could have possibly caused it because you've never, for most people it's going to be their first CD scan.
52:14.556 --> 52:15.377
[SPEAKER_00]: So when did it happen?
52:15.477 --> 52:18.922
[SPEAKER_00]: Did it happen there are 20s, 30s or is it only like a recent phenomenon?
52:19.402 --> 52:22.767
[SPEAKER_00]: So it's hard to see or hard to interpret what would
52:23.962 --> 52:29.750
[SPEAKER_00]: you know, what would the the history of that specific score be?
52:30.872 --> 52:40.025
[SPEAKER_00]: Because it's a lot of, it's not like very dangerous amount of radiation, but it's, you know, I think it's like a few X-rays in one test.
52:40.666 --> 52:42.589
[SPEAKER_00]: So you wouldn't want to do it like every year.
52:42.749 --> 52:53.445
[SPEAKER_00]: You would want to probably do it if your doctor recommends you or tells you to do it, then the usually
52:54.927 --> 52:56.730
[SPEAKER_00]: a non-zero score.
52:57.791 --> 53:17.759
[SPEAKER_00]: If it's zero, then they generally don't recommend it that often, but if it's very high, let's say 500 or 1000, which is extremely high, or significantly high, then just monitor the progression, they would probably recommend you do it in a few years as well.
53:18.841 --> 53:24.208
[SPEAKER_00]: But I think
53:24.188 --> 53:31.101
[SPEAKER_00]: other tests or scans that have either less radiation or almost no radiation at all.
53:31.802 --> 53:43.884
[SPEAKER_00]: So I think in a few decades probably we will have much better technology that we're able to identify the council in the arteries with little to no radiation.
53:44.645 --> 53:46.669
[SPEAKER_00]: There is one form of
53:48.067 --> 54:03.966
[SPEAKER_00]: I guess calcium testing, without radiation it's the corner into my media thickness, so it's an ultrasound of the corroded arteries in the neck and with ultrasound you can see like narrowing of the arteries.
54:03.946 --> 54:08.672
[SPEAKER_00]: It has zero radiation, and it has pretty good value.
54:08.733 --> 54:19.267
[SPEAKER_00]: You can see if the arteries, the coronary doctors are narrowing or if they're extremely narrowed, and you can do it very frequently.
54:19.307 --> 54:23.052
[SPEAKER_00]: You can do it several times a year with no radiation.
54:23.588 --> 54:33.623
[SPEAKER_01]: So I know you have organized retreat and I'm very excited about your next retreat which would be in India.
54:34.083 --> 54:38.650
[SPEAKER_01]: Can you tell us a little bit about what's offered in this retreat in January?
54:38.690 --> 54:51.148
[SPEAKER_00]: Yes, I'm partnered with this clinic in India called Iwo and they have a seven-day program
54:51.955 --> 55:04.051
[SPEAKER_00]: people come to this five-star hotel in Chennai and they'll follow through different types of tests and scans over the course of the 70s.
55:04.932 --> 55:15.887
[SPEAKER_00]: So things like a blood-comprehensive blood panel that has 180 blood markers, Texas scan, yoga to max test, and there's full body MRI,
55:15.867 --> 55:24.117
[SPEAKER_00]: The character between intermediate thickness, the CD scan is also an option there, where it's a part of the program.
55:24.157 --> 55:38.213
[SPEAKER_00]: There's a lot of other tests like echocardiogram, liver scan, like a fiber scan, looks at the stiffening of the liver,
55:38.193 --> 56:01.855
[SPEAKER_00]: also things like physical training, physiotherapy, dental screening, I exam, skin nonetheless is a very comprehensive package coverage or yeah via to my
56:01.835 --> 56:23.708
[SPEAKER_00]: all of them kind of essential biomarkers and health markers plus a bit more advanced ones and they also are supported with these let's say physical basic physical functions so like you have a pt who helps with your form you have a physiotherapist etc
56:24.245 --> 56:35.635
[SPEAKER_00]: And yeah, all of it at this five-star hotel with the group that are eye-bring and other individuals who are also my join.
56:36.996 --> 56:39.579
[SPEAKER_00]: So yeah, I've been doing that for a few years now.
56:39.679 --> 56:43.022
[SPEAKER_00]: I think this January is going to be my sixth time.
56:43.062 --> 56:52.210
[SPEAKER_00]: So yeah, I like it a lot myself.
56:52.190 --> 56:56.396
[SPEAKER_00]: the staff is very meticulous and professional.
56:56.857 --> 56:58.259
[SPEAKER_00]: They're extremely helpful.
56:58.299 --> 57:01.804
[SPEAKER_00]: It's a very high quality clinic.
57:01.844 --> 57:04.288
[SPEAKER_00]: The owner is also very interested in longevity.
57:04.308 --> 57:17.607
[SPEAKER_00]: He's consulted with a lot of top doctors in the states and elsewhere, and they've created
57:18.852 --> 57:20.334
[SPEAKER_00]: relatively cheap cost.
57:20.554 --> 57:34.274
[SPEAKER_00]: So in United States, having this kind of a program would be, you know, 20,000, 25,000 with their accommodation, but in our retreat in January, it's going to be one fourth of that.
57:34.975 --> 57:38.380
[SPEAKER_01]: So yeah, the price is remarkable.
57:38.400 --> 57:40.584
[SPEAKER_01]: I mean, considering what you're getting.
57:41.064 --> 57:43.468
[SPEAKER_01]: So you said, is it a six day retreat?
57:44.069 --> 57:46.412
[SPEAKER_00]: It's as seven days and six nights.
57:46.662 --> 57:47.663
[SPEAKER_01]: seven day six nights.
57:48.204 --> 58:08.113
[SPEAKER_01]: Yeah, and in a luxury resort and and getting this full array of tests, it's pretty remarkable because I've seen prices around the world and so what you're offering is really it's so affordable and really exciting opportunity for people, I think.
58:08.093 --> 58:15.867
[SPEAKER_01]: And I definitely want to be there, so, and after the test, what else is offered in the program?
58:16.388 --> 58:20.736
[SPEAKER_01]: Are there basically protocols put together for people?
58:21.197 --> 58:22.539
[SPEAKER_01]: Are there therapies provided?
58:22.579 --> 58:24.162
[SPEAKER_01]: What else is available?
58:24.732 --> 58:31.361
[SPEAKER_00]: Yeah, they do have consultations with also specialized doctors to Chennai's called like the medical capital of India.
58:32.182 --> 58:35.806
[SPEAKER_00]: So they've got pretty much every medical expert you can think of.
58:36.748 --> 58:54.030
[SPEAKER_00]: And based on the results of your tests, you can consult with the cardiologist, nutritionist, physical therapist, eye doctor, neurologist, psychologists.
58:54.010 --> 59:01.219
[SPEAKER_00]: Every editor that you can think of available, therefore, consultation from a therapy site.
59:01.807 --> 59:08.138
[SPEAKER_00]: So it's not that much about treating diseases, they're not obviously going to help.
59:08.719 --> 59:17.034
[SPEAKER_00]: So whatever test results you get, they're not gonna be providing professional medical services or like medical treatments.
59:19.359 --> 59:25.309
[SPEAKER_00]: Certainly, yeah, treatments, they do provide all, you know, physiotherapy treatments and they have IVs.
59:25.710 --> 59:26.211
[SPEAKER_00]: So,
59:27.355 --> 59:43.845
[SPEAKER_00]: Vitamin IV is a good fine IVs, and, et cetera, they have some skin treatments, so hydrophasial and some other like CO2 laser and various skin treatments, dental treatments, so, you know, less medical treatments.
59:44.446 --> 59:48.233
[SPEAKER_00]: So I guess the value is that you go there, you spend that week,
59:48.213 --> 01:00:06.964
[SPEAKER_00]: And you're getting pretty much, you know, first of all, I think 99% of people haven't done that comprehensive testing, so they'll get pretty much, you know, they're not to mention not the only the MRI, which, you know, scans your entire body, but also your heart test, you'll be at max test, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of this, you know, you're getting a lot of
01:00:07.484 --> 01:00:11.168
[SPEAKER_00]: valuable information about your body that you haven't probably got in anywhere else.
01:00:11.788 --> 01:00:17.954
[SPEAKER_00]: So that's just establishes a very helpful and solid baseline of what your current health status right now.
01:00:18.735 --> 01:00:32.749
[SPEAKER_00]: And with that information, you know, if there are some things that need to be improved or something that is, let's say requires additional care, then with that, at least you have the information that
01:00:32.729 --> 01:00:40.444
[SPEAKER_00]: You can use back in your home country with your GP or one of the case maybe.
01:00:41.032 --> 01:00:41.593
[SPEAKER_01]: Hmm.
01:00:42.473 --> 01:00:42.794
[SPEAKER_01]: Yeah.
01:00:43.534 --> 01:00:44.015
[SPEAKER_01]: Amazing.
01:00:44.215 --> 01:00:50.501
[SPEAKER_01]: And you were so kind to offer my listeners a discount.
01:00:50.541 --> 01:00:51.922
[SPEAKER_01]: They put in Dr. Joy.
01:00:51.982 --> 01:00:56.707
[SPEAKER_01]: They can get a discount off their attendance, their program.
01:00:56.747 --> 01:00:58.148
[SPEAKER_01]: So very cool.
01:00:58.468 --> 01:00:59.109
[SPEAKER_01]: Very excited.
01:00:59.309 --> 01:01:01.131
[SPEAKER_01]: I really look forward to being there.
01:01:02.152 --> 01:01:09.739
[SPEAKER_01]: I love India and look forward to going back and visiting.
01:01:10.141 --> 01:01:12.546
[SPEAKER_01]: It's a close to the water.
01:01:12.586 --> 01:01:14.329
[SPEAKER_00]: Yeah, you can see the ocean.
01:01:14.430 --> 01:01:18.017
[SPEAKER_00]: The hotel is like next to beach.
01:01:18.137 --> 01:01:20.221
[SPEAKER_00]: You can see the beach and the ocean from there.
01:01:21.103 --> 01:01:29.500
[SPEAKER_00]: And yeah, you pick you up from the airport with a car, like the hotel, Shafir, pick you up.
01:01:29.986 --> 01:01:41.325
[SPEAKER_00]: take you to the hotel, you go through the treatments, you'll always have staff member from the Iowa Clinic helping you and taking you to the different tests and doctors.
01:01:42.547 --> 01:01:45.632
[SPEAKER_00]: During the day, you know, between lunchtime, we'll
01:01:46.237 --> 01:02:07.318
[SPEAKER_00]: have everyone in the program, so the guests from different parts of the world, we've had from Argentina, South Africa, Australia, Vietnam, Sweden, Finland, UK, Canada, U.S., so yeah, every time there's just people from different parts of the world, and yeah, we have a few seminars as well.
01:02:08.179 --> 01:02:15.687
[SPEAKER_00]: We are, me, some staff, some like a medical doctor or someone else is giving
01:02:15.667 --> 01:02:26.462
[SPEAKER_00]: So yeah, it's educational, it's very insightful, in terms of biomarkers and it's also a lot of fun because you'll meet a lot of different people from different parts of the world.
01:02:28.084 --> 01:02:35.194
[SPEAKER_01]: And well, the food, the very specially designed for biohacking purposes.
01:02:35.528 --> 01:02:43.326
[SPEAKER_00]: Yes, so there's a three restaurants in the hotel, there's a Chinese restaurant, an Indian restaurant, and I guess like Morris standard buffet.
01:02:43.947 --> 01:02:46.152
[SPEAKER_00]: Yeah, you can, the food is very high quality.
01:02:46.192 --> 01:02:50.101
[SPEAKER_00]: And you can ask for pretty much anything and they'll make it.
01:02:51.003 --> 01:02:52.727
[SPEAKER_00]: So there, if you want, okay.
01:02:52.707 --> 01:02:58.513
[SPEAKER_00]: I want sugar-free chocolate cake, so they'll go under that actually to make it for you.
01:02:58.553 --> 01:03:00.095
[SPEAKER_00]: That sounds amazing.
01:03:01.376 --> 01:03:01.537
[SPEAKER_01]: Wow.
01:03:02.177 --> 01:03:02.638
[SPEAKER_01]: Okay.
01:03:02.918 --> 01:03:04.200
[SPEAKER_01]: That's wonderful.
01:03:04.280 --> 01:03:10.867
[SPEAKER_01]: So the dates will be a January 5th to 11th, correct?
01:03:11.508 --> 01:03:11.988
[SPEAKER_00]: Yeah.
01:03:12.549 --> 01:03:14.571
[SPEAKER_00]: The first week of January.
01:03:15.612 --> 01:03:15.752
[SPEAKER_00]: Mm-hmm.
01:03:15.772 --> 01:03:22.039
[SPEAKER_01]: The first week, the first Monday of January.
01:03:22.323 --> 01:03:30.163
[SPEAKER_00]: Yeah, it's a seamland.co-retreat, so my website, that's where you'll find it.
01:03:30.764 --> 01:03:35.216
[SPEAKER_00]: So your website is www.seemland.co.
01:03:35.857 --> 01:03:39.707
[SPEAKER_01]: That's as I am L-A-N-D. Yeah.
01:03:40.362 --> 01:03:43.766
[SPEAKER_01]: dot CEO Yeah.
01:03:44.407 --> 01:03:45.749
[SPEAKER_01]: OK. OK.
01:03:46.190 --> 01:03:46.650
[SPEAKER_01]: Wonderful.
01:03:47.111 --> 01:03:47.431
[SPEAKER_01]: Yeah.
01:03:47.531 --> 01:03:49.414
[SPEAKER_01]: Thank you so much for sharing this.
01:03:49.434 --> 01:03:53.099
[SPEAKER_01]: And it's wonderful that you put these retreats together.
01:03:53.179 --> 01:03:56.563
[SPEAKER_01]: I think that's definitely what some people are looking for.
01:03:57.144 --> 01:04:01.049
[SPEAKER_01]: And for one, I was looking for something that's comprehensive.
01:04:01.229 --> 01:04:03.332
[SPEAKER_01]: That's accessible.
01:04:03.312 --> 01:04:14.424
[SPEAKER_01]: And it's amazing that it's not going to cause a normal and like it's going to be able to do that and to be able to experience a beautiful country So yeah, thank you so much for putting that together.
01:04:14.444 --> 01:04:15.725
[SPEAKER_00]: Yeah, my pleasure.
01:04:16.406 --> 01:04:16.766
[SPEAKER_01]: Okay.
01:04:17.247 --> 01:04:28.459
[SPEAKER_01]: All right, um, sim again appreciate your expertise and your pioneering spirit in this phase So I look forward to chatting with you again sometime
01:04:28.709 --> 01:04:31.956
[SPEAKER_01]: Thank you for listening to this episode.
01:04:32.276 --> 01:04:36.986
[SPEAKER_01]: Hope you enjoy the content and if so, please rate and follow this podcast.
01:04:37.006 --> 01:04:42.858
[SPEAKER_01]: To reach me, you can contact uplift longevity center and that is uplift with a Y.
01:04:43.119 --> 01:04:46.866
[SPEAKER_01]: You can also subscribe to my YouTube channel Joy Kong MD.
01:04:47.287 --> 01:04:48.169
[SPEAKER_01]: See you next time.