00:00.031 --> 00:06.219
[SPEAKER_01]: I think of this peptide BPC157, like one thing that unlocks many many functions.
00:06.259 --> 00:19.635
[SPEAKER_01]: So if you think of most peptides as a single key to unlock a particular function, BPC157 is like a key chain with a bunch of keys unlocking of wide variety of biological functions.
00:19.936 --> 00:27.625
[SPEAKER_01]: And that's why it can be so helpful for your musculoskeletal repair, for gut healing, for brain repair, for immune function.
00:27.605 --> 00:30.409
[SPEAKER_00]: Welcome to the Dr. Duay Kong podcast.
00:30.429 --> 00:37.418
[SPEAKER_00]: This is where I have a chance to share with you some of the latest developments in the space of holistic health, longevity and wellness.
00:37.859 --> 00:44.668
[SPEAKER_00]: I've always honored intellectual curiosity and scientific rigor, combined with real world practicality.
00:45.009 --> 00:49.414
[SPEAKER_00]: My goal is that what you learn here will help you live longer and live better.
00:49.715 --> 00:51.317
[SPEAKER_00]: Hope you enjoy the journey with me.
00:51.297 --> 00:56.124
[SPEAKER_01]: Welcome back to the Dr. Joy Kong podcast and today we're going to talk all about peptides.
00:56.525 --> 00:57.346
[SPEAKER_01]: So wipe peptides.
00:57.587 --> 00:59.550
[SPEAKER_01]: It seems to be all the rage right now.
01:00.231 --> 01:06.240
[SPEAKER_01]: It's because it actually works for a lot of people for a lot of problems and is fairly accessible.
01:06.501 --> 01:07.783
[SPEAKER_01]: It's not that expensive.
01:08.383 --> 01:10.707
[SPEAKER_01]: So what are peptides?
01:10.687 --> 01:13.771
[SPEAKER_01]: Peptides are these short chains of amino acids.
01:13.871 --> 01:17.495
[SPEAKER_01]: So we all know proteins are built of long chains of amino acids.
01:17.515 --> 01:18.777
[SPEAKER_01]: So these are really short.
01:19.477 --> 01:22.681
[SPEAKER_01]: And they perform huge variety of functions in the body.
01:23.102 --> 01:31.031
[SPEAKER_01]: So you may not know that there are over 300,000 peptides all swimming around in this body of ours.
01:31.832 --> 01:36.778
[SPEAKER_01]: And there are all coexisting, but each with their own mission.
01:36.758 --> 01:49.840
[SPEAKER_01]: So far, we've only identified about 7,000 of them, and routinely used probably just a few dozens, and there are about a hundred that been proved by the FDA for a particular medical condition.
01:50.361 --> 01:54.568
[SPEAKER_01]: So you will see mostly holistic practitioners that will be using this.
01:54.629 --> 01:58.395
[SPEAKER_01]: Of course, your primary card doctor probably will give you GLP ones to help you.
01:58.375 --> 02:06.665
[SPEAKER_01]: managed diabetes and lose weight, but the vast majority of peptides are really given out by holistic practitioners like me.
02:07.366 --> 02:13.213
[SPEAKER_01]: Just to illustrate why is so exciting for me and my practice.
02:13.593 --> 02:26.188
[SPEAKER_01]: Of course, I focus a lot on stem cell therapy because I consider that the big gun of transformation, because all of a sudden you're tapping into the intelligence that make us, which are
02:26.168 --> 02:29.031
[SPEAKER_01]: encoded in the DNA that are in these stem cells.
02:29.292 --> 02:35.359
[SPEAKER_01]: So when I give people stem cells, it gives them a huge blast of signals for regeneration.
02:35.679 --> 02:49.476
[SPEAKER_01]: But someone may have a particular problem, specific issues like the brain problem or some kind of autoimmune issue, or they may want to repair their tendons, then I can use peptides to
02:49.456 --> 02:51.921
[SPEAKER_01]: really target that particular organ.
02:52.001 --> 02:56.290
[SPEAKER_01]: So that gives me much more power as a healer, right?
02:56.310 --> 03:00.659
[SPEAKER_01]: I can actually tailor exactly what the problem is.
03:01.020 --> 03:06.672
[SPEAKER_01]: So a blast of signals through the stem cells, but more targeted signal to further.
03:06.652 --> 03:10.079
[SPEAKER_01]: trigger the body to go into a particular direction of repair.
03:10.620 --> 03:21.724
[SPEAKER_01]: So what's nice is that peptides now can address musculoskeletal problems, brain issues, mood, sleep, energy, autoimmune problems,
03:21.704 --> 03:24.147
[SPEAKER_01]: and or skin and hair, right?
03:25.108 --> 03:28.593
[SPEAKER_01]: Or if somebody wants to lose weight or they want to build muscles.
03:28.953 --> 03:31.577
[SPEAKER_01]: So now we have peptide or even sexual function.
03:31.877 --> 03:34.160
[SPEAKER_01]: Now we have peptides for all these things.
03:34.300 --> 03:36.143
[SPEAKER_01]: So that makes it very exciting.
03:36.343 --> 03:41.710
[SPEAKER_01]: So it's exciting to practice as a doctor these days, because we have all these tools.
03:41.870 --> 03:46.176
[SPEAKER_01]: And what's cool is that these are nature-based molecules.
03:46.156 --> 03:51.605
[SPEAKER_01]: So a lot of these are synthesized in the lab, but that's based on the sequence from nature, right?
03:51.625 --> 03:54.951
[SPEAKER_01]: So it's identical to what's occurring in your body.
03:55.632 --> 03:57.796
[SPEAKER_01]: So they're very, very little side effects.
03:57.816 --> 04:02.384
[SPEAKER_01]: So it's extraordinarily safe because they're already in your body.
04:02.845 --> 04:05.329
[SPEAKER_01]: And people always ask me, oh, can I...
04:05.309 --> 04:09.113
[SPEAKER_01]: take all these peptides, all at once, while they're eating your body all at once.
04:09.454 --> 04:15.841
[SPEAKER_01]: So there's 300,000 different kinds of peptides that are already flowing through your body.
04:16.462 --> 04:18.985
[SPEAKER_01]: And we've only identified about 7,000 of them.
04:19.325 --> 04:22.248
[SPEAKER_01]: So we are literally a walking universe of peptides.
04:22.829 --> 04:30.658
[SPEAKER_01]: Each with this mission to go into a particular organ to target particular receptors, to unlock a biological function.
04:30.638 --> 04:47.365
[SPEAKER_01]: And there are about a hundred that are FDA approved for particular medical conditions and routinely used by holistic practitioners like me about maybe 20 to 50 somewhere there is core group of peptides, most commonly 20 to 30 of them.
04:47.345 --> 04:49.588
[SPEAKER_01]: So what can they do, right?
04:49.648 --> 04:56.576
[SPEAKER_01]: So these peptides can help with hormone production, modulate immune function, help you with your sleep cycle.
04:57.477 --> 05:11.074
[SPEAKER_01]: They can reduce inflammation, they can help you with DNA functions, cell division, they can cause destruction of cancer cells, and they can help with sexual arousal, weight loss, et cetera.
05:11.054 --> 05:20.569
[SPEAKER_01]: So they have been attested for their safety and often at a hundred to a thousand votes of what we typically use.
05:21.190 --> 05:23.474
[SPEAKER_01]: And that's still extraordinarily safe.
05:23.875 --> 05:28.422
[SPEAKER_01]: So that's a beauty of modeling your therapy based on nature.
05:28.402 --> 05:36.831
[SPEAKER_01]: So, I like to talk about some peptides now, starting with the most famous peptide BPC-157.
05:36.871 --> 05:46.641
[SPEAKER_01]: So, I kind of lump the BPC-157 and TB-500 into the musculoskeletal repair, even though there are way beyond musculoskeletal repair.
05:47.122 --> 05:49.144
[SPEAKER_01]: So, let's talk about BPC-157.
05:49.184 --> 05:57.733
[SPEAKER_01]: So, it's the most widely used
05:57.713 --> 06:03.361
[SPEAKER_01]: And it does help with muscle, tendon, and bone repair.
06:03.821 --> 06:06.184
[SPEAKER_01]: And it's great also for gut healing.
06:06.565 --> 06:11.832
[SPEAKER_01]: So gut, mucoso, repair, prevents gastric ulcers.
06:12.453 --> 06:14.976
[SPEAKER_01]: It helps your bowel to heal.
06:15.477 --> 06:25.190
[SPEAKER_01]: And it promotes cellulose repair, and also protects your liver from toxic insults, like alcohol and antibiotics, et cetera.
06:25.350 --> 06:27.012
[SPEAKER_01]: And you can repair your teeth.
06:26.992 --> 06:28.354
[SPEAKER_01]: cornea and brain.
06:28.855 --> 06:37.327
[SPEAKER_01]: So I think of this peptide BPC 157, like a one thing that unlocks many, many functions.
06:37.347 --> 06:52.189
[SPEAKER_01]: So if you think of most peptides as a single key to unlock a particular function, these BPC 157 is like a key chain with a bunch of keys unlocking of wide variety of biological functions.
06:52.169 --> 07:02.620
[SPEAKER_01]: And that's why it can be so helpful for your musculoskeletal repair, for gut healing, for brain repair, for immune function is like you can't go wrong.
07:03.582 --> 07:07.466
[SPEAKER_01]: So we actually routinely add it to our stem cell therapy.
07:07.486 --> 07:11.550
[SPEAKER_01]: So we always add BPC-157 and TB-500.
07:11.731 --> 07:14.494
[SPEAKER_01]: With both of them are similar that they target so many organs.
07:14.574 --> 07:17.637
[SPEAKER_01]: They're both key chains of peptides.
07:17.617 --> 07:19.099
[SPEAKER_01]: So what else can it do?
07:19.119 --> 07:20.682
[SPEAKER_01]: It can also help with your mood.
07:21.042 --> 07:25.950
[SPEAKER_01]: So it can actually induce serotonin release in the brain and has anti-depressant effect.
07:26.811 --> 07:33.741
[SPEAKER_01]: It can modulate the serotonin and dopamine systems relieving behavioral disturbances.
07:34.322 --> 07:36.305
[SPEAKER_01]: So they are very neuroprotective.
07:36.365 --> 07:46.240
[SPEAKER_01]: So the EPC-1507 can protect neurons, promote nerve regeneration after transsections, or after spinal cord injury.
07:46.220 --> 07:56.877
[SPEAKER_01]: or traumatic brain injury, or nerve-pending nerve deaths, or demilation, it can also induce nitric oxide release.
07:57.418 --> 08:09.797
[SPEAKER_01]: It has a strong endogenic properties, so it helps to form new blood vessels, and it also protects the blood vessel walls and counteracts high blood pressure.
08:09.777 --> 08:15.418
[SPEAKER_01]: It can also help with thrombosis, or reducing the chance of forming clots.
08:16.101 --> 08:21.340
[SPEAKER_01]: It can upregulate the growth hormone receptor expression.
08:21.893 --> 08:28.339
[SPEAKER_01]: some of you probably have used things that promote growth hormone production like a poor moral in C.J.C.
08:28.359 --> 08:31.803
[SPEAKER_01]: 1295 and a test moral in et cetera.
08:32.243 --> 08:33.765
[SPEAKER_01]: But the B.P.C.
08:33.825 --> 08:38.990
[SPEAKER_01]: 157 can actually increase the number of the receptors, growth hormone receptors.
08:39.410 --> 08:44.195
[SPEAKER_01]: So that will further help the repair of throughout your body.
08:44.255 --> 08:46.117
[SPEAKER_01]: Right growth hormone helps with everything.
08:46.177 --> 08:47.498
[SPEAKER_01]: It's considered a youth hormone.
08:47.858 --> 08:50.601
[SPEAKER_01]: So it can help with
08:50.581 --> 08:53.227
[SPEAKER_01]: promote healing all throughout your body.
08:53.949 --> 09:07.560
[SPEAKER_01]: It also supports muscle building in response to resistance training and it reduces excessive pain perception and it all performs a sac acycle of ear for her peace infection.
09:07.540 --> 09:11.868
[SPEAKER_01]: at 1,000 the dose of acyclovia.
09:11.968 --> 09:17.018
[SPEAKER_01]: So it's very potent when it comes to an anti-viral properties.
09:17.519 --> 09:20.925
[SPEAKER_01]: It can also help with stress, urinary incontinence.
09:21.126 --> 09:26.055
[SPEAKER_01]: So when women get older, they when they cough and laugh and they leak urine, this can also be helpful.
09:26.035 --> 09:29.022
[SPEAKER_01]: So, what were some of the target conditions that's been studied?
09:29.583 --> 09:44.196
[SPEAKER_01]: So, Lyme disease HIV, chronic viral or intracellular infections, inflammatory conditions with elevation of CRP, the inflammation marker, and the C4A, and the ESR.
09:44.176 --> 10:12.748
[SPEAKER_01]: It also helps with corner artery disorder, diabetes, GI ulcers, and irritable bowel syndrome, or inflammatory bowel diseases, like prones and ulcerative colitis, helps with leaky gut with h-pallory infection, gird, so the gastric reflex, and tendon ligaments repair
10:12.728 --> 10:34.753
[SPEAKER_01]: acute pancreatitis, liver lesions, chemical sensitivity, allergies, surgical healing, traumatic brain injury, mold and toxin exposures, neurodegenerative diseases, depression, anxiety, urinary incontinence,
10:34.902 --> 10:46.739
[SPEAKER_01]: or hypotension, hypothyroidism, or thyroid resistance, it can boost mitochondria function, relieving pain symptoms, and can help with eye inflammation and dry eyes.
10:46.780 --> 10:49.183
[SPEAKER_01]: So as you can see, that's a long list.
10:49.784 --> 10:52.388
[SPEAKER_01]: And I wanna move on to the next group.
10:52.628 --> 10:53.890
[SPEAKER_01]: We have FIMAS.
10:53.870 --> 10:56.595
[SPEAKER_01]: which is a powerful immune organ and the pineal gland.
10:56.955 --> 11:00.301
[SPEAKER_01]: So both are crucial in the process of our aging.
11:00.742 --> 11:04.168
[SPEAKER_01]: So I want to talk with you a little bit about the thymus gland.
11:04.689 --> 11:09.938
[SPEAKER_01]: So the thymus gland actually shrinks and degenerates when we age.
11:09.918 --> 11:27.301
[SPEAKER_01]: They also degrades with obesity, too much calorie intake, genetics, inflammation, stress, pregnancy, toxins, hypothyroidism, or low growth hormone levels, chronic infection, or zinc deficiency.
11:27.361 --> 11:35.031
[SPEAKER_01]: So protein-secretivide thymas reach peak at age 10, and from there on is all downhill.
11:35.011 --> 11:39.558
[SPEAKER_01]: and stays at the steady low level from our mid-30s.
11:40.881 --> 11:48.132
[SPEAKER_01]: And the progressive thymic dysfunction and senescence in our immune system occurs with aging.
11:48.673 --> 11:53.982
[SPEAKER_01]: And this can result in increased susceptibility to infection.
11:53.962 --> 12:04.537
[SPEAKER_01]: inadequate immune response to vaccines, increased tendency for autoimmune diseases, increased cancer risk, and increased cardiovascular disease.
12:05.078 --> 12:20.661
[SPEAKER_01]: So there's overwhelming majority of patients with autoimmune diseases that actually have abnormal,
12:20.641 --> 12:25.386
[SPEAKER_01]: So what can thymic peptides do?
12:26.127 --> 12:39.882
[SPEAKER_01]: So thymic peptides can actually improve tissue repair and healing, improve host defense when it comes to infections, and it can reverse immune suppression of an inchronic infections, such as lime.
12:40.743 --> 12:44.667
[SPEAKER_01]: And it can increase antioxidant and glutathione production.
12:45.028 --> 12:47.931
[SPEAKER_01]: It can boost natural killer cell production.
12:47.911 --> 13:01.541
[SPEAKER_01]: And it can help shift your immune system from TH2 to TH1 response, so that is basically shifting your system from a inflammatory to more anti-inflammatory orientation.
13:01.581 --> 13:07.675
[SPEAKER_01]: So that's important in infection, cancer, hurt timers, reactions, or autoimmune disorders.
13:07.655 --> 13:13.187
[SPEAKER_01]: and it also can help bind neural toxins and endotoxins.
13:13.829 --> 13:15.593
[SPEAKER_01]: Anotoxins are produced by bacteria.
13:16.074 --> 13:24.212
[SPEAKER_01]: It can help cardiac regeneration and its protective after heart attack and also in congestive heart failure.
13:24.192 --> 13:41.401
[SPEAKER_01]: The peptides also promote neurological regeneration and is protective after stroke, traumatic brain injury, in Lyme disease, Alzheimer's, in other neuropathys or Parkinson's, and it can stimulate stem cell activity and proliferation.
13:41.982 --> 13:43.905
[SPEAKER_01]: Increase longevity.
13:43.885 --> 13:51.516
[SPEAKER_01]: And it has almost nonexistent side effects, even at 100 times the excess of the dosage.
13:52.157 --> 14:02.172
[SPEAKER_01]: And so, excellent safety profile with huge therapeutic window, I mean, even at a thousand fold, it's been demonstrated that it's still quite safe.
14:02.673 --> 14:13.048
[SPEAKER_01]: So, there are two that are commonly used that I want to talk about.
14:13.028 --> 14:22.143
[SPEAKER_01]: So, this is a peptide, a thymus peptide, found in all tissues and cell types, and this found in blood and bodily fluids.
14:22.724 --> 14:33.281
[SPEAKER_01]: So, in tears, saliva, sterile spinal fluid, wound fluid, and both platelets and white blood cells release TB4 into wound fluid.
14:33.502 --> 14:34.283
[SPEAKER_01]: So, very interesting.
14:35.064 --> 14:38.530
[SPEAKER_01]: And this TB4, or TB500,
14:38.797 --> 14:50.052
[SPEAKER_01]: which has shown regenerative activity after traumatic brain injury and or spinal cord injury stroke, MS, ischemic limb disease or cardiac damage.
14:50.412 --> 14:56.961
[SPEAKER_01]: It can support immunity, improve t-cell function, or it's antimicrobial.
14:57.462 --> 15:05.192
[SPEAKER_01]: It promotes endogenesis, so that can accelerate wound healing and collagen deposition.
15:05.172 --> 15:13.305
[SPEAKER_01]: It can calm muscle spasms, improve muscle tone, and stretches the connective tissue and maintain flexibility.
15:14.147 --> 15:16.410
[SPEAKER_01]: It also reduces inflammation and joint tissues.
15:17.212 --> 15:28.530
[SPEAKER_01]: It can prevent formation of adhesions and fibrosis bands in muscles, so reduce the fibrosis in muscles, tendons and ligaments.
15:28.510 --> 15:38.382
[SPEAKER_01]: It can promote hair growth and may help dry eyes, corneal injuries, lung fibrosis, fatty liver disease, a hepatic fibrosis.
15:38.903 --> 15:48.715
[SPEAKER_01]: It's also cardiovascular, so help with conditions of ischemia, especially a lot of corneal artery diseases, right?
15:48.735 --> 15:58.146
[SPEAKER_01]: It reduces systemic inflammation due to infections or infection
15:58.126 --> 16:00.030
[SPEAKER_01]: So that can cause a lot of inflammation.
16:00.070 --> 16:01.854
[SPEAKER_01]: So TB500 can reduce that.
16:02.496 --> 16:16.287
[SPEAKER_01]: And some of the target conditions include Lyme disease, HIV, malaria, chronic fatigue, fibromyalgia, autoimmune diseases, infections, heart attack, multiple sclerosis,
16:16.267 --> 16:28.808
[SPEAKER_01]: Alzheimer's, peripheral neuropathy, and it's really powerful therapy for the flu, or codes, or Ebola, Zika viruses, along with TELFA1.
16:29.188 --> 16:33.415
[SPEAKER_01]: So now we come to TELFA1, also called Thymison Alpha1.
16:33.395 --> 16:42.228
[SPEAKER_01]: This peptide from the thymus gland improves tissue repair and healing and improves host defense against infections.
16:42.829 --> 16:46.374
[SPEAKER_01]: It inhibits viral replication or cancer growth.
16:46.854 --> 17:03.098
[SPEAKER_01]: It can improve microcirculation improving stress tolerance increases anti-oxidant and glutes the agulethyhung production and reverses immune suppression in chronic fatigue or fibromyalgia or Lyme disease.
17:03.803 --> 17:07.092
[SPEAKER_01]: It can also, it calms inflammation and it fights cancer.
17:07.132 --> 17:09.759
[SPEAKER_01]: It can prevent and treat autoimmunity.
17:09.799 --> 17:18.943
[SPEAKER_01]: His level is significantly lower when a patient has severe infection or cancer.
17:18.923 --> 17:29.479
[SPEAKER_01]: It has been found to effectively reduce the incidence of flu from 19% to 5.5% compared to placebo.
17:29.499 --> 17:35.428
[SPEAKER_01]: So really, I mean, it reduced the chance of catching flu to a third, right?
17:35.448 --> 17:37.491
[SPEAKER_01]: So it's hugely beneficial.
17:38.152 --> 17:47.125
[SPEAKER_01]: And when injected into mice, when the mice is 3.5 months old, it increases their lifespan by 28%.
17:47.105 --> 17:51.729
[SPEAKER_01]: and it decreased the rate of cancer by 2.8 folds.
17:52.670 --> 18:01.878
[SPEAKER_01]: It also increases the relapse free time for cancer, so allow you to live cancer free for longer if you did have cancer.
18:02.579 --> 18:17.112
[SPEAKER_01]: And it's approved in over 30 countries as a vaccine adjunct, so as something you add on to when you get vaccines.
18:17.092 --> 18:31.692
[SPEAKER_01]: So FDA approved it under the orphan drug program and some of the targeted conditions include Lyme disease, HIV, chronic, viral or intracellular infections, immune deficiency.
18:31.807 --> 18:50.001
[SPEAKER_01]: chronic fatigue syndrome, fibromyalgia, autoimmune diseases, diabetes, allergies, chemical sensitivity, cancer, aging, and the prevention in travel situations, you know, prevention of, you know, catching problematic bugs.
18:49.981 --> 19:04.063
[SPEAKER_01]: So now we come to pineal gland, which has not been talked a lot about, but for anybody who's interested in meditation, you probably have heard about the pineal gland being thought of as the seed of the soul.
19:04.604 --> 19:11.415
[SPEAKER_01]: So that's where a lot of the activities are generated when a person meditates.
19:11.395 --> 19:17.844
[SPEAKER_01]: So the pineal gland, it's hugely important in our connection, in the spiritual realm.
19:18.345 --> 19:29.981
[SPEAKER_01]: So it's a unique organ that, in the middle of your brain, it regulates circadian rhythm and the pituratory function.
19:30.041 --> 19:37.572
[SPEAKER_01]: It synthesizes melatonin, which is the signaling molecule for natural environmental changes.
19:37.906 --> 19:46.056
[SPEAKER_01]: And influences the pineal gland influences a secretion of neurotransmitters in door fins and hormones.
19:46.557 --> 19:58.932
[SPEAKER_01]: Of course, we know Malatonin is associated with a lot of important functions, including bone metabolism, weight loss, cardiovascular health, and ass as a profound, anti-oxidant.
19:59.452 --> 20:07.542
[SPEAKER_01]: And is a mu-modulating, is anti-cancer.
20:07.522 --> 20:09.905
[SPEAKER_01]: is really important for optimal health.
20:10.626 --> 20:16.813
[SPEAKER_01]: Unfortunately, pineal gland has the highest classification rate among all organs of the body.
20:18.115 --> 20:28.888
[SPEAKER_01]: And pineal classification jeopardizes melatonin synthesis and is associated with a variety of neuronal damages, so neuronal diseases.
20:29.273 --> 20:33.621
[SPEAKER_01]: The majority of people have pineal gland classification by age 30.
20:34.743 --> 20:38.110
[SPEAKER_01]: So what are the pineal peptides that we commonly use?
20:38.130 --> 20:41.235
[SPEAKER_01]: So at our clinic, there are two that we use commonly.
20:41.456 --> 20:43.299
[SPEAKER_01]: Both are really exciting.
20:43.760 --> 20:46.325
[SPEAKER_01]: So one I love is called epitile.
20:46.505 --> 20:51.214
[SPEAKER_01]: We do recommend this for everybody because how can you not?
20:51.194 --> 20:57.909
[SPEAKER_01]: So for first of all, it's a four-meter asset long, and it's considered a potent bio-regulator.
20:58.009 --> 21:08.652
[SPEAKER_01]: When we call something bio-regulator, that means this peptide actually goes into the cells and interact with the DNA and produce long-term changes in the cells.
21:09.234 --> 21:11.278
[SPEAKER_01]: So it can...
21:11.258 --> 21:12.740
[SPEAKER_01]: change your gene expression.
21:12.760 --> 21:15.244
[SPEAKER_01]: So that fundamentally changes how the cells work.
21:15.945 --> 21:25.139
[SPEAKER_01]: So it's synthesized by the pineal gland, of course, and it helps increase the secretion of serotonin and melatonin in the pineal gland.
21:25.620 --> 21:30.027
[SPEAKER_01]: But one exciting thing that I wanted to tell people is this um,
21:30.007 --> 21:38.993
[SPEAKER_01]: ability to rejuvenate your cardiovascular system, which, of course, controls the rest of our body as well.
21:39.073 --> 21:45.130
[SPEAKER_01]: The healthy, the cardiovascular system is not healthy, then your organs are really going to suffer.
21:45.110 --> 21:50.057
[SPEAKER_01]: all your organs, right, are not going to get adequate nutrition or removal of waste products.
21:50.758 --> 22:06.662
[SPEAKER_01]: So one study was really fun because they tested 79 patients from age of 60 to 69 and all these people have coronary artery disease and what they did was that they gave them a few rounds of this appetite on.
22:06.642 --> 22:09.166
[SPEAKER_01]: So, they were only giving them twice a year.
22:09.227 --> 22:10.990
[SPEAKER_01]: Remember, this is a bioregulator.
22:11.130 --> 22:15.538
[SPEAKER_01]: So, it goes to your cells, nucleus, and change your DNA expression.
22:15.578 --> 22:22.390
[SPEAKER_01]: So, you don't really need to take it as often, because it changes the cells on a fundamental level.
22:22.370 --> 22:24.992
[SPEAKER_01]: And so the results are long lasting.
22:25.053 --> 22:33.941
[SPEAKER_01]: So what they did was that they gave these 79 patients with coronary artery disease, six rounds of appetite long.
22:33.981 --> 22:35.262
[SPEAKER_01]: Each round is only 15 days.
22:35.743 --> 22:41.068
[SPEAKER_01]: So twice a year, which means for three years, they gave them six rounds of appetite long.
22:41.088 --> 22:44.291
[SPEAKER_01]: And the control group just took placebo.
22:44.311 --> 22:49.035
[SPEAKER_01]: So when they followed them for 10 years, at the end of the 10 years,
22:49.420 --> 22:59.235
[SPEAKER_01]: the people who got the appetite on versus the one that got the placebo, their cardiovascular system is nine years younger than the placebo group.
22:59.896 --> 23:05.805
[SPEAKER_01]: And also the death rate from cardiovascular incidents went from 83% to 46%.
23:07.688 --> 23:11.173
[SPEAKER_01]: And that, of course, it's monumental, right?
23:11.233 --> 23:18.364
[SPEAKER_01]: So we're able
23:18.344 --> 23:21.027
[SPEAKER_01]: mortality, almost half of what it was.
23:21.608 --> 23:24.432
[SPEAKER_01]: So what else does this appetite on do?
23:25.133 --> 23:28.437
[SPEAKER_01]: It actually induces telomerase activity.
23:28.617 --> 23:34.886
[SPEAKER_01]: So you probably, most of you know that we have telomeres at the ends of our chromosomes.
23:35.707 --> 23:40.092
[SPEAKER_01]: And as we replicate, every time we replicate the telomerase shrinks.
23:40.513 --> 23:43.677
[SPEAKER_01]: But telomerase is the
23:43.657 --> 23:56.075
[SPEAKER_01]: But still, the trend is the telomeres get shorter and shorter, which means the DNA replication will start to accumulate mistakes, and that will cause deterioration of our cells.
23:56.516 --> 24:03.386
[SPEAKER_01]: So telomerase will help lengthen the telomeres, and apatalon actually induces telomerase activity.
24:03.827 --> 24:06.451
[SPEAKER_01]: So that helps restore the telomere length.
24:06.851 --> 24:12.820
[SPEAKER_01]: So then our cells won't make as many mistakes, and so it won't degenerate as much, right?
24:12.800 --> 24:21.877
[SPEAKER_01]: and it can slow down the aging of the reproductive system and restore the fertility in old female rats.
24:22.859 --> 24:29.090
[SPEAKER_01]: It can also increase T4 to T3 conversion, T3's active form of thyroid hormone.
24:29.110 --> 24:35.061
[SPEAKER_01]: So you want more T3, so you actually are getting the benefits of the thyroid hormone.
24:35.041 --> 24:46.280
[SPEAKER_01]: and increases or improves glucose tolerance and decrease insulin and triglyceride levels, so it helps with your carbohydrate metabolism.
24:46.881 --> 24:50.687
[SPEAKER_01]: And it activates gene expression and protein synthesis
24:50.667 --> 24:52.492
[SPEAKER_01]: for specific target tissues.
24:53.093 --> 24:59.429
[SPEAKER_01]: It can increase lifespan of mice from 14% of the mice reaching two years of age to 56%.
24:59.509 --> 25:07.630
[SPEAKER_01]: So all of a sudden you have four times more of these mice reaching two years of age.
25:07.610 --> 25:20.804
[SPEAKER_01]: what I consider epitile on is almost like the best insurance you can get, because it redrubonates your cardiovascular system, and also protects you against all age-related diseases, including cancer.
25:20.884 --> 25:29.113
[SPEAKER_01]: So I can't think of money better spent on this peptide than anything else.
25:29.454 --> 25:36.081
[SPEAKER_01]: So, of course, there are a lot of things you can do to improve your health and protect you, but this is a powerful signal.
25:36.061 --> 25:42.409
[SPEAKER_01]: that changes how your cells respond and function at a very, very foundational level.
25:43.350 --> 25:47.715
[SPEAKER_01]: A second peptide from the pineal gland is called pinealon.
25:48.676 --> 25:56.045
[SPEAKER_01]: And this is a peptide that's only three amino acids long and also considered a bioregulator.
25:56.105 --> 26:03.874
[SPEAKER_01]: So studies from Russia have shown that pinealon can slow the rate of aging of the brain.
26:03.854 --> 26:09.462
[SPEAKER_01]: measured by biological age indicators, and it acts directly on pineal gland.
26:09.743 --> 26:13.348
[SPEAKER_01]: It can protect against effects of hypoxia, so low oxygen.
26:13.849 --> 26:17.575
[SPEAKER_01]: It can increase levels of another peptide called irisin.
26:18.156 --> 26:22.963
[SPEAKER_01]: An irisin is important in neuron proliferation and differentiation.
26:23.484 --> 26:32.477
[SPEAKER_01]: So higher level of irisin has been linked to improved memory and cognition, and it modulates the beneficial impact
26:32.693 --> 26:35.038
[SPEAKER_01]: of exercise on the central nervous system.
26:35.879 --> 26:44.457
[SPEAKER_01]: The pinealon helps protect muscle cells during exercise, it promotes fat burning and promotes telomural lengthening as well.
26:45.198 --> 26:49.707
[SPEAKER_01]: It helps fight off effects of aging and oxidative stress.
26:49.687 --> 26:54.955
[SPEAKER_01]: It can also boost production of serotonin and help fight depression.
26:56.157 --> 27:03.948
[SPEAKER_01]: It also can help reset pineal gland to circadian rhythm, improve sleep, mood and blood pressure.
27:04.970 --> 27:18.310
[SPEAKER_01]: And it helps with poor memory, attention, difficulties, brain injury, stroke, high stress,
27:18.492 --> 27:24.904
[SPEAKER_01]: Alzheimer's, Parkinson's, multiple segrosis, neuro-aging, so pain in the nerves.
27:25.766 --> 27:36.265
[SPEAKER_01]: Neuritis, inflammation of the nerves, instead of lapathy, and demilating diseases, and helps to maintain the function of the brain in elderly patients.
27:36.245 --> 27:38.410
[SPEAKER_01]: So that's pretty impressive.
27:38.891 --> 27:43.221
[SPEAKER_01]: So that's this one definitely has been a new addition in our clinic.
27:43.241 --> 27:45.125
[SPEAKER_01]: So it's excited about it.
27:45.206 --> 27:46.368
[SPEAKER_01]: Now we're talking about the brain.
27:46.448 --> 27:51.480
[SPEAKER_01]: So why don't we go on to brain peptides because there are quite a few of them and pretty exciting.
27:51.660 --> 27:53.224
[SPEAKER_01]: Really brain is a tough one.
27:53.204 --> 28:10.133
[SPEAKER_01]: I was trained as a psychiatrist so I've been vitally interested in the brain and there was a reason I did not become a neurologist, I definitely thought about becoming a neurologist because at one point I thought I wanted to be a neuroscientist instead of being a doctor, I thought I was going to be a professor.
28:10.113 --> 28:30.872
[SPEAKER_01]: and studying the brain, but what I found out during medical school is that in neurologists were very happy because they can be quite effective and been such amazing detectives identifying what part of the brain caused the problem is a disease, but then that was the end of the story.
28:30.852 --> 28:35.919
[SPEAKER_01]: they couldn't tell people how to recover, and there were just very, very few tools.
28:36.439 --> 28:39.243
[SPEAKER_01]: It's a depressing profession to be on your knowledge.
28:39.383 --> 28:49.596
[SPEAKER_01]: At this point, unless they start utilizing some of these cutting-edge modalities that we have been encountering with the new age of regenerative medicine.
28:49.977 --> 28:57.006
[SPEAKER_01]: But if they're just sticking with a big pharma tools that we've been taught, they're not very effective, unfortunately.
28:57.466 --> 28:59.509
[SPEAKER_01]: Yeah, so I saw that a lot.
28:59.489 --> 29:03.935
[SPEAKER_01]: But now we have some of these peptides that hopefully some of them can start using.
29:04.316 --> 29:05.257
[SPEAKER_01]: One is called dihexa.
29:05.478 --> 29:08.882
[SPEAKER_01]: Dihexa is a peptide that can improve cognitive function.
29:09.283 --> 29:14.570
[SPEAKER_01]: It can support recovery from brain trauma and it can boost synaptic formations.
29:14.610 --> 29:17.254
[SPEAKER_01]: So help more synopsis to form, right?
29:17.294 --> 29:20.699
[SPEAKER_01]: These little tentacles from the neurons to to communicate with each other.
29:21.220 --> 29:25.686
[SPEAKER_01]: It can make nerve signals stronger and strengthen neuronal structures.
29:26.207 --> 29:29.091
[SPEAKER_01]: It can improve brain blood flow.
29:29.071 --> 29:41.588
[SPEAKER_01]: And it's a very potent signaling molecule because it's 10 million times more potent than brain derived neurotopic factors.
29:41.608 --> 29:50.961
[SPEAKER_01]: So we'll heard about this particular growth factor, BDNF, but this is 10 million times more potent.
29:50.941 --> 30:10.492
[SPEAKER_01]: So it can help in the repair of the brain and nerves and it can increase mental stamina, promote creative thinking skills, enhance conversational skills, improve problem solving and helping managing depression and improve focus, learning and memory.
30:10.773 --> 30:13.337
[SPEAKER_01]: So at our clinic, we definitely use it quite a bit.
30:13.317 --> 30:26.030
[SPEAKER_01]: also very often in kids we treat kids who have autism or autism spectrum disorders, but for brain conditions, this is a powerful tool and they usually comes in the capsule.
30:26.731 --> 30:34.279
[SPEAKER_01]: So another one that I consider it the big gun of brain peptides is called cerebral lysine.
30:34.299 --> 30:37.262
[SPEAKER_01]: This is like the holy grail of brain peptides.
30:37.823 --> 30:40.185
[SPEAKER_01]: It's pretty interesting because it's approved
30:40.165 --> 30:46.377
[SPEAKER_01]: and used as a prescription medication in a lot of countries in Europe, Asia, and Latin America.
30:47.199 --> 30:49.383
[SPEAKER_01]: It's approved for various neurological conditions.
30:49.984 --> 30:57.820
[SPEAKER_01]: It's most commonly used in stroke recovery, traumatic brain injury, vascular dementia, Alzheimer's disease, etc.
30:58.361 --> 31:01.347
[SPEAKER_01]: You know, a lot of various cognitive disorders.
31:01.327 --> 31:08.142
[SPEAKER_01]: One of the challenges is the proper liquid form is very difficult to obtain.
31:08.202 --> 31:13.153
[SPEAKER_01]: The hydrolyzed powder is much easier, but they don't work as well.
31:13.514 --> 31:17.563
[SPEAKER_01]: So, but at our clinic, we do have the liquid form.
31:17.543 --> 31:21.190
[SPEAKER_01]: So surable lysine, it's not a single peptide.
31:21.210 --> 31:32.111
[SPEAKER_01]: This is a huge number of a combination of peptides obtained from the brain of pigs, actually, pig brain extract.
31:32.171 --> 31:34.776
[SPEAKER_01]: So it has a concoction.
31:34.756 --> 31:36.258
[SPEAKER_01]: of brain peptides.
31:36.779 --> 31:46.031
[SPEAKER_01]: The active fragments in cerebral lysine are of very low molecular weight and they can penetrate the blood-brain barrier and reach neurons directly.
31:46.532 --> 32:03.936
[SPEAKER_01]: And it's been proven to have these neuroprotective and neuronal regenerative properties which can help with both central
32:03.916 --> 32:16.269
[SPEAKER_01]: So, it has been shown to improve efficiency within the brain's aerobic processes, so metabolic aerobic processes, and improve intracellular peptide synthesis.
32:16.730 --> 32:21.455
[SPEAKER_01]: It helps to shield neurons from oxidative damages and lactic cathidosis.
32:21.755 --> 32:28.843
[SPEAKER_01]: And it has been studied in Parkinson's, Alzheimer's, MS, ALS, TBI, and stroke.
32:28.823 --> 32:37.211
[SPEAKER_01]: It promotes a growth of new brain cells, which helps improve brain cell communication, enhancing learning capacity.
32:37.792 --> 32:44.058
[SPEAKER_01]: So the, I guess, classical way of using this peptide is IV infusions.
32:44.358 --> 32:45.919
[SPEAKER_01]: But that's not the most convenient trait.
32:45.939 --> 32:53.146
[SPEAKER_01]: So we do that in the clinic, but you can also do intramuscular injections, or even subcutaneous injections.
32:53.166 --> 32:56.029
[SPEAKER_01]: So we have all those at our clinic.
32:56.009 --> 32:59.777
[SPEAKER_01]: And the next peptide is cost ceiling.
33:00.338 --> 33:04.165
[SPEAKER_01]: So this has been traditionally prescribed for anxiety and depression.
33:04.927 --> 33:17.292
[SPEAKER_01]: And has been shown to be effective in many other conditions related to immune modulation or for PTSD, ADHD, and metabolic syndromes.
33:17.272 --> 33:22.396
[SPEAKER_01]: It has the neurotopic actions similar to nerve growth factors.
33:22.797 --> 33:27.141
[SPEAKER_01]: It promotes central and peripheral nervous system stimulation and rejuvenation.
33:27.801 --> 33:32.205
[SPEAKER_01]: It has significant end-zeolithic activities, so busting anxiety.
33:32.565 --> 33:35.848
[SPEAKER_01]: And acts as a stable, neural, psychotropic.
33:36.489 --> 33:47.278
[SPEAKER_01]: So, like a stable, a psychiatric medication that sends anti-depressant, anti-stress.
33:47.258 --> 33:53.386
[SPEAKER_01]: And it can positively influence the formation of memory and learning processes.
33:53.766 --> 34:13.350
[SPEAKER_01]: The clinical studies I've shown that effective saline is similar to that of tranquilizers at low dosages, but it doesn't have the unwanted side effects of the tranquilizers such as benzodiazepine, doesn't have the potential for amnesia with straw symptoms or dependence.
34:13.330 --> 34:25.730
[SPEAKER_01]: And experiments have also demonstrated that ceilings have been effective in preventing the accumulation of body fat and as shields neurons from neural toxins, inflammation and injury.
34:26.451 --> 34:36.267
[SPEAKER_01]: And it helps with neurological regeneration like in TBI, dramatic brain injury, Alzheimer's Parkinson's stroke, and toxin induced brain damages.
34:36.247 --> 34:37.770
[SPEAKER_01]: or nerve damages.
34:38.671 --> 34:39.914
[SPEAKER_01]: So that's ceiling.
34:40.114 --> 34:47.567
[SPEAKER_01]: So we have that both in injectable form or as a nasal spray, which is very effective as well, and they're convenient.
34:48.268 --> 34:50.132
[SPEAKER_01]: And then next one is CMax.
34:50.813 --> 34:54.880
[SPEAKER_01]: So CMax is great for cognition and attention.
34:54.860 --> 35:03.616
[SPEAKER_01]: It's a peptide that's derived from a fragment of a hormone called ACTH.
35:03.636 --> 35:08.084
[SPEAKER_01]: It can affect learning processes and exploratory behavior.
35:08.124 --> 35:15.097
[SPEAKER_01]: And it helps with regeneration and development, helps with pain perception and inflammatory processes.
35:15.759 --> 35:18.724
[SPEAKER_01]: It's developed in Russia in the 1980s.
35:18.704 --> 35:26.317
[SPEAKER_01]: and primarily is recognized for as powerful cognitive enhancing and neuroprotective benefits.
35:26.858 --> 35:40.982
[SPEAKER_01]: So in Russia and Ukraine, CMax is approved for medical use, including conditions such as stroke, ischemic stroke, cognitive disorders, and optic nerve atrophy.
35:40.962 --> 35:50.172
[SPEAKER_01]: It can stimulate neurogenesis, so formation and more neurons can accelerate nerve regeneration and improve neuromuscular performance.
35:51.453 --> 36:04.708
[SPEAKER_01]: And it's currently used successfully in treating patients with pathologies related to brain circulation, such as the amnesia or other problems of the central nervous system.
36:05.128 --> 36:09.653
[SPEAKER_01]: It can be used as a preventative measure to protect against chronic disease.
36:09.633 --> 36:14.643
[SPEAKER_01]: And, acutely, it can help improve memory and learning processes.
36:15.384 --> 36:20.755
[SPEAKER_01]: It has protective ability against metal induced cell toxicity.
36:21.356 --> 36:26.306
[SPEAKER_01]: It can also improve selective attention and modulate brain development.
36:26.847 --> 36:32.097
[SPEAKER_01]: So, helpful for ADHD, so it has a great potential in that.
36:32.077 --> 36:41.345
[SPEAKER_01]: It has a lot of anti- thrombotic and fibrin-nolidic effect, so breaking up fibrins and breaking up clots.
36:42.046 --> 36:54.337
[SPEAKER_01]: And that may play a significant role under conditions of these skimic damages, so of course in somebody has a clot thrown into the brain or the heart blocking artery causing tissue death.
36:54.698 --> 37:00.683
[SPEAKER_01]: This can have the effect of busting up the clot, so it can be helpful therapeutically.
37:00.663 --> 37:04.150
[SPEAKER_01]: and is also gastric protective, so protects the gastric lining.
37:04.551 --> 37:16.275
[SPEAKER_01]: He can also increase physical performance and adaptation capabilities when a high intensity exercise is in place, so that can, you know, help you performance.
37:16.255 --> 37:26.352
[SPEAKER_01]: So what were some of the target conditions, anxiety, depression, memory, improvement, ischemic events, heart, brain.
37:26.833 --> 37:28.336
[SPEAKER_01]: So that means stroke, right?
37:28.456 --> 37:36.289
[SPEAKER_01]: A nervous generation, ADHD, opioid withdrawal, and chronic diseases like ALAs, Parkinson's, Alzheimer's,
37:36.269 --> 37:53.329
[SPEAKER_01]: other prescribed possibilities are for, as a thrombolitic, breaking up, clots, for gastric protection to help with physical exertion and improvement of pain and also in metal toxicity.
37:54.050 --> 37:55.972
[SPEAKER_01]: So that was CMAX.
37:56.192 --> 38:01.298
[SPEAKER_01]: Again, we have injectable as well as nasal spray forms in our clinic.
38:01.278 --> 38:10.335
[SPEAKER_01]: And the next one is called PE2228, and this one is really, really awesome because it is incredibly helpful in depression.
38:10.876 --> 38:20.535
[SPEAKER_01]: So as a reformed psychiatrist, prior psychiatrist, I've written a lot of anti-depressants and a lot of things to help with depression.
38:20.515 --> 38:47.451
[SPEAKER_01]: Sometimes a person just doesn't improve so that's why you know you keep going to psychiatrists You could do round one hopefully works about 30% of people it works for about 30% of them They come back and then we may have to have to switch to another medication and sometimes so doesn't work And we may have to switch again or maybe there's partial improvement then we add another medication and We just keep you know it's sometimes it takes
38:47.431 --> 38:55.524
[SPEAKER_01]: months and months of going back and forth, and for some people, even for over a year, they're not improving.
38:55.564 --> 38:56.065
[SPEAKER_01]: What do you do?
38:56.565 --> 39:13.472
[SPEAKER_01]: This P2228 is a fast acting peptide in relieving depression, so generally, only needs four days for his antidepressant effect to take place, so for the SSRIs that we use commonly, we always say about two weeks.
39:13.452 --> 39:18.238
[SPEAKER_01]: takes about two weeks lead time before you notice the difference two to three weeks.
39:18.678 --> 39:29.992
[SPEAKER_01]: So this one is four days and it can improve mood and motivation, improve brains stress resilience, and increase neurogenesis and your plasticity.
39:30.152 --> 39:37.080
[SPEAKER_01]: So more neurons can form, can repair, and more synapses can form so it can
39:37.060 --> 39:45.387
[SPEAKER_01]: gain new ways of learning, of behavior patterns, and it can protect neurons from excessive glutamate.
39:45.427 --> 39:47.469
[SPEAKER_01]: So glutamate can be cytletoxic.
39:47.489 --> 39:51.513
[SPEAKER_01]: A lot of things can cause excessive glutamate release, including stress.
39:51.853 --> 39:59.339
[SPEAKER_01]: So this can help protect neurons against glutamate, and it helps improve memory and learning and may be effective for stroke recovery.
40:00.320 --> 40:05.785
[SPEAKER_01]: So that's this P2228
40:05.765 --> 40:11.054
[SPEAKER_01]: And then we have one peptide that's really helpful because so many people have sleep issues.
40:11.595 --> 40:15.582
[SPEAKER_01]: They have trouble falling asleep, staying asleep, so this is called DSIP.
40:16.063 --> 40:19.429
[SPEAKER_01]: It's delta sleep inducing peptide.
40:19.569 --> 40:26.642
[SPEAKER_01]: You probably know that delta sleep is the deepest and most restorative type of sleep that you can get.
40:26.622 --> 40:37.372
[SPEAKER_01]: and this DSIP helped with this neuroendocrine regulation to help the body naturally secret hormones to promote delta sleep.
40:38.173 --> 40:40.435
[SPEAKER_01]: So it's also an antioxidant.
40:41.136 --> 40:53.187
[SPEAKER_01]: It may help support the central nervous system and endocrine system by reducing the level of the damaging free radicals.
40:53.167 --> 40:56.652
[SPEAKER_01]: disturbed sleep patterns and improved sleep quality.
40:57.594 --> 41:00.538
[SPEAKER_01]: It can improve LH and growth hormone release.
41:01.119 --> 41:04.985
[SPEAKER_01]: It reduces persistent and chronic pain.
41:05.746 --> 41:09.131
[SPEAKER_01]: It can modulate cortisol production and fight stress.
41:09.651 --> 41:13.437
[SPEAKER_01]: It also can improve mood and reduce depression.
41:13.417 --> 41:19.548
[SPEAKER_01]: and it can prove brain function and lower the risk of heart disease and lowers blood pressure.
41:19.568 --> 41:28.585
[SPEAKER_01]: It can prevent cancer and reduce the side effects of chemotherapy and it can provide support for alcohol and drug withdrawal.
41:28.825 --> 41:33.113
[SPEAKER_01]: So that's the DSIP, the one that promotes delta sleep.
41:33.093 --> 41:54.983
[SPEAKER_01]: them we are we just finished the brain peptides now we're coming to something again this is a few peptides that help with growth hormone release and growth hormone affects a lot of things but what do we use it for these growth hormone peptides what are people the most excited about so people are excited about weight loss
41:54.963 --> 42:01.509
[SPEAKER_01]: muscle gain, busting fat, so that's really what they became popular for, but they are good for other things too.
42:01.890 --> 42:02.731
[SPEAKER_01]: So let me go over them.
42:03.091 --> 42:04.012
[SPEAKER_01]: So hypermoraline.
42:04.412 --> 42:06.254
[SPEAKER_01]: So a lot of people ask me about cymoraline.
42:06.274 --> 42:14.662
[SPEAKER_01]: That's an older peptide and because now we have better ones, so more effective, less side effects, so then we use better ones.
42:15.003 --> 42:21.409
[SPEAKER_01]: So in our clinic, we use mainly three of these
42:21.389 --> 42:40.630
[SPEAKER_01]: Upper Moralin is a very popular growth hormone releasing peptides, so there are also costs to create a gauze, so it's because it stimulates your pituitary territory to see create growth hormones, so it's considered highly efficient this upper Moralin and also very, very safe.
42:41.350 --> 42:51.261
[SPEAKER_01]: It stimulates growth hormones without having effect on the blood levels of prolactin and cortisol, like some other of the growth hormone releasing peptides.
42:51.241 --> 42:56.708
[SPEAKER_01]: It can mimic growl and promotes production and release of growth hormone.
42:56.728 --> 43:00.993
[SPEAKER_01]: There's no desensitization issues and it can improve sleep.
43:01.694 --> 43:19.797
[SPEAKER_01]: It has anti-aging benefits such as reduction in body fat, improved muscle strength, mass, strengthened bones, repaired joints and ligaments, and also can improve skin quality in increasing energy and vitality.
43:19.777 --> 43:23.726
[SPEAKER_01]: So you can see there's a multitude of benefits.
43:24.368 --> 43:26.653
[SPEAKER_01]: And then the next one is CJC 1295.
43:26.673 --> 43:31.224
[SPEAKER_01]: And that's a, again, a growth hormone releasing hormone.
43:32.005 --> 43:37.498
[SPEAKER_01]: And it's much more powerful when you combine that with Ipermoralid.
43:37.478 --> 43:45.427
[SPEAKER_01]: So actually when you combine the two, the efficacy is five times as much as each one alone.
43:45.568 --> 43:48.451
[SPEAKER_01]: So that's why we never give any one of these by themselves.
43:48.932 --> 43:50.213
[SPEAKER_01]: It's always in combination.
43:50.654 --> 43:59.284
[SPEAKER_01]: So the CDC 1295 also increases growth hormone secretion and IGF1 levels without product and elevation.
43:59.264 --> 44:05.377
[SPEAKER_01]: It increases muscle growth and fat loss, decreases recovery time and improves cognition.
44:05.999 --> 44:14.978
[SPEAKER_01]: It can increase cellular repair and regeneration and promote slow waves deep sleep, which is responsible for the highest level of muscle growth.
44:14.958 --> 44:17.203
[SPEAKER_01]: memory retention and rejuvenation.
44:17.263 --> 44:22.975
[SPEAKER_01]: So I do like the April Moral and CJC for to help people with sleep as well.
44:23.476 --> 44:30.672
[SPEAKER_01]: So of course energy, repair of everything, your muscles and your skin.
44:30.652 --> 44:36.780
[SPEAKER_01]: And you're brain, so it's these are really great hormones, so I tend to take them.
44:36.800 --> 44:45.532
[SPEAKER_01]: I usually take them for a few months and then I may take a month off and then I continue, because as we age, unfortunately the levels do not know.
44:46.393 --> 44:50.719
[SPEAKER_01]: So why don't we just give a little bit more of we had when we were younger?
44:50.699 --> 45:02.659
[SPEAKER_01]: Again, the combination of apromoral and CTC is five times more potent than each one alone and it can improve sleep quality down day three or two four.
45:02.919 --> 45:14.378
[SPEAKER_01]: So pretty quickly improves sleep quality and it can improve body composition, protect your heart, your neurons, your immune system, help with your muscles, also your metabolism.
45:14.358 --> 45:19.167
[SPEAKER_01]: And then another growth hormone releasing peptide has become very popular.
45:19.187 --> 45:20.169
[SPEAKER_01]: It's called Tessa Morlin.
45:21.010 --> 45:31.470
[SPEAKER_01]: And it actually initially, it was investigated for treating HIV patients to reduce the HIV drug-induced central obesity.
45:31.570 --> 45:35.758
[SPEAKER_01]: So people who have gainless weight around their gut.
45:35.738 --> 45:48.337
[SPEAKER_01]: And when they use it for 26 weeks, every day, daily use for 26 weeks, that led to a significant decrease in the visceral fat, and then also improve their lipid status.
45:48.538 --> 45:49.559
[SPEAKER_01]: That's how they were discovered.
45:50.481 --> 45:58.573
[SPEAKER_01]: They, of course, also increase IDF1 without changing glucose parameters, and they can increase
45:58.553 --> 46:16.393
[SPEAKER_01]: Protein synthesis and muscle growth and increase a breakdown of fat is shown to reduce body fat by 7.4% and improves fasting is a level reduces your triglyceride, which is the type of lipid that we would generally don't want to have too much.
46:16.373 --> 46:19.939
[SPEAKER_01]: And it can reduce the carotid, atherosclerosis.
46:20.119 --> 46:27.871
[SPEAKER_01]: So the classification in your carotid artery, because of that, it reduces the risk of cardiovascular events and improves heart health.
46:28.612 --> 46:32.418
[SPEAKER_01]: It can also reduce inflammatory markers like CRP.
46:32.939 --> 46:42.313
[SPEAKER_01]: It reduces fatty liver disease and improves cognition and memory and improves exercise capacity and energy, improves bone density,
46:42.293 --> 46:43.674
[SPEAKER_01]: and a new function.
46:44.015 --> 46:46.757
[SPEAKER_01]: So, Tesla, Maryland, and another one of my favorites.
46:47.879 --> 46:52.884
[SPEAKER_01]: Next one, we're going to talk about two peptides that's related to mitochondria.
46:53.624 --> 46:58.729
[SPEAKER_01]: So, a lot of people are getting to know that mitochondria is the powerhouse of our cells.
46:59.170 --> 47:03.834
[SPEAKER_01]: These are early bacteria that happen to know how to utilize oxygen to provide energy.
47:04.235 --> 47:08.419
[SPEAKER_01]: So, our cells grab them and now we are working together.
47:08.399 --> 47:23.760
[SPEAKER_01]: Unfortunately, as we are exposed to environmental toxins or aging process and the different you just from been alive, the oxidated damages, it can cause harm to mitochondria and that's how our cells all become sluggish.
47:24.220 --> 47:29.487
[SPEAKER_01]: Our immune system is not as vibrant and then we have lower energy etc.
47:29.527 --> 47:32.531
[SPEAKER_01]: So, how can we enhance our mitochondria function?
47:32.912 --> 47:35.976
[SPEAKER_01]: So, the most famous one is called MOTC.
47:35.956 --> 47:40.501
[SPEAKER_01]: So it must see, is a mitochondria encoded peptide.
47:40.521 --> 47:47.188
[SPEAKER_01]: So mitochondria actually have DNA sequences to encode, you know, produces peptide.
47:47.689 --> 47:50.212
[SPEAKER_01]: And this regulates metabolic homeostasis.
47:50.532 --> 47:51.953
[SPEAKER_01]: So keep things steady.
47:51.973 --> 48:02.445
[SPEAKER_01]: This peptide get into the nucleus to regulate the adaptive gene expression in the cell, in response to stress, to cellar stress.
48:02.465 --> 48:05.288
[SPEAKER_01]: So that improves mitochondria health.
48:05.268 --> 48:11.298
[SPEAKER_01]: It improves muscle building, fat loss, and reverses the senescence of cells.
48:11.558 --> 48:19.832
[SPEAKER_01]: So, the more senescent cells are, the less functional, not only less functional, they can also secrete molecules and signals that cause damage.
48:19.872 --> 48:25.521
[SPEAKER_01]: So, they're no good, but massac can help reduce that kind of aging in the cells.
48:25.501 --> 48:32.253
[SPEAKER_01]: and it can activate ANPK pathway to improve energy production and insulin sensitivity.
48:32.554 --> 48:42.312
[SPEAKER_01]: They can regulate carbohydrate metabolism, improve physical performance, and there's a trend towards increased lifespan.
48:42.292 --> 48:52.755
[SPEAKER_01]: And they also act primarily on muscles versus my formate acting primarily on liver when it comes to improve glucose metabolism.
48:53.176 --> 48:59.389
[SPEAKER_01]: So they have different mechanisms of helping with glucose metabolism or how carbohydrates are processed.
48:59.369 --> 49:09.003
[SPEAKER_01]: And it prevents the obesity that's a result when somebody gets a hysterectomy when ovaries were taken out.
49:09.504 --> 49:14.250
[SPEAKER_01]: And when ovaries are taken out, you know, it can induce obesity and insulin resistance.
49:14.651 --> 49:20.179
[SPEAKER_01]: So this mossy can actually prevent it.
49:20.159 --> 49:41.037
[SPEAKER_01]: And it can also increase brown fat activations, so that will reduce fat accumulation and brown fat is the good kind of fat, and it can help also reduce inflammatory invasion in the white adipose tissue, so prevent the inflammation in our white fat.
49:41.017 --> 49:48.716
[SPEAKER_01]: And it also reduces vascular calcification by activating the MPK pathway, so that's good for our heart as well.
49:48.797 --> 49:58.080
[SPEAKER_01]: So that's MOTC, good for a couple of hyperhygometabolism, for our heart, and also for energy production and muscle growth.
49:58.060 --> 50:00.304
[SPEAKER_01]: So and fat loss.
50:00.324 --> 50:19.134
[SPEAKER_01]: So that's another one that's you can call it mitochondria peptide or you can call it weight loss peptide So we use them use this for both of the both purposes and another mitochondria peptide is called SS31 So this is actually an anti-oxidin peptide that improves mitochondria function.
50:19.635 --> 50:23.241
[SPEAKER_01]: It protects and restores mitochondria structure
50:23.221 --> 50:28.892
[SPEAKER_01]: mitochondrial utility and promotes ATP synthesis and reduce electron leakage.
50:29.553 --> 50:39.031
[SPEAKER_01]: It reduces inflammation by inhibiting the release of pro-inflammatory cytokines and dampening the activation of the inflammatory pathways within cells.
50:39.873 --> 50:42.698
[SPEAKER_01]: It can inhibit oxidative stress,
50:42.678 --> 50:44.742
[SPEAKER_01]: increase exercise tolerance.
50:45.503 --> 50:56.684
[SPEAKER_01]: It can restore skeletal muscle function and improve outcomes in cardiac neurological respiratory, retinol, kidney, and aging-related diseases.
50:56.724 --> 50:59.269
[SPEAKER_01]: It's also heart-protective.
50:59.790 --> 51:02.475
[SPEAKER_01]: It can improve cardiac function, reduce
51:02.455 --> 51:05.361
[SPEAKER_01]: the ischemia and re-perfusion injury.
51:05.421 --> 51:17.746
[SPEAKER_01]: That's when the arteries are blocked and when it's re-prefused when the blood flow is restored, that can cause damage because of the of physiological process.
51:17.806 --> 51:22.135
[SPEAKER_01]: So this can help reduce that and enhance recovery after heart attack.
51:22.115 --> 51:35.317
[SPEAKER_01]: It's neural protective, this SS31 shows promise in protecting neurons from oxidative damages and improve mitochondria function in neurodegenerative diseases like Alzheimer's and Parkinson's.
51:36.559 --> 51:40.225
[SPEAKER_01]: So that's SS31.
51:40.205 --> 51:47.638
[SPEAKER_01]: Now, we come to the type of usage of peptides that so many people are excited about, which is weight loss.
51:47.979 --> 51:52.927
[SPEAKER_01]: Definitely, I see an epidemic of the obesity.
51:53.849 --> 51:56.494
[SPEAKER_01]: I mean, yeah, you see that everywhere.
51:56.734 --> 52:01.723
[SPEAKER_01]: In the US and in Europe as well, and now, you know, a lot of other countries.
52:01.703 --> 52:06.615
[SPEAKER_01]: So, this has become very popular, started with Uzempik.
52:07.237 --> 52:09.342
[SPEAKER_01]: That was popularized by the Kardashians.
52:09.703 --> 52:17.502
[SPEAKER_01]: At one point, they were running out of supply of Uzempik, which is the generic name of Sama Glutide.
52:17.482 --> 52:19.804
[SPEAKER_01]: because it works really, really well.
52:20.104 --> 52:29.894
[SPEAKER_01]: It's probably this group of peptides called GLP1s are the most effective weight loss medication we've seen by far.
52:30.574 --> 52:32.316
[SPEAKER_01]: So what's some of Glutide?
52:33.137 --> 52:36.039
[SPEAKER_01]: It's a GLP1 receptor agnist.
52:36.240 --> 52:39.423
[SPEAKER_01]: So GLP1 stands for glucogone-like peptide.
52:40.444 --> 52:46.189
[SPEAKER_01]: And this peptide, some of Glutide has been approved by the FDA in 2014.
52:46.169 --> 53:10.135
[SPEAKER_01]: as a, as a, as a, as a, as a, as a, as a, as a, as a, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as an, as
53:10.115 --> 53:20.068
[SPEAKER_01]: a successfully regulates appetite by restoring the signaling system that tells the body, I'm full, I don't want to eat anymore.
53:20.629 --> 53:30.402
[SPEAKER_01]: And it can be used for the treatment of diabetes, obesity, non-alcoholic fatty liver disease, and neurodegenerative diseases like Parkinson's and Alzheimer's.
53:30.382 --> 53:38.650
[SPEAKER_01]: So, it does have some side effects, nausea, of course, loss of appetite, maybe in digestion.
53:39.190 --> 53:44.596
[SPEAKER_01]: So, some people don't like it, can tolerate it, they want some appetite.
53:45.116 --> 53:49.280
[SPEAKER_01]: So, if you don't know appetite, then you loss a huge part of the pleasure of life, right?
53:49.881 --> 53:53.584
[SPEAKER_01]: So, the number of these JLP ones can't be evolving.
53:54.005 --> 53:59.730
[SPEAKER_01]: So, the next one is called turse appetite, that's very popular.
53:59.710 --> 54:02.614
[SPEAKER_01]: got hormones, GLP1 and GIP.
54:02.974 --> 54:09.624
[SPEAKER_01]: So together, they regulate appetite, metabolism, and blusher or in a synergistic manner.
54:10.004 --> 54:12.928
[SPEAKER_01]: So that's a brand name, manjara.
54:14.290 --> 54:21.019
[SPEAKER_01]: So it enhances insulin secretion and lowers blusher levels and improves insulin sensitivity.
54:21.139 --> 54:24.103
[SPEAKER_01]: So your cells actually respond to insulin better.
54:24.243 --> 54:26.106
[SPEAKER_01]: So you don't keep secreting insulin.
54:26.086 --> 54:38.411
[SPEAKER_01]: And a suppresses appetite, slows down gastric emptying, prolongs the feeling of fullness, reduces overall food intake, and improves lipid profile, also reduces inflammation.
54:39.052 --> 54:46.727
[SPEAKER_01]: So they've been investigated for their role in the non-alcoholic fatty liver disease.
54:46.707 --> 54:49.312
[SPEAKER_01]: which has shown good potential.
54:49.793 --> 55:00.115
[SPEAKER_01]: And is approved for the treatment of moderate to severe obstructive sleep apnea in adults when their sleep apnea is primarily due to obesity.
55:00.616 --> 55:07.129
[SPEAKER_01]: So this, of course, aims at weight loss and potentially reducing inflammation.
55:07.109 --> 55:31.263
[SPEAKER_01]: So, the Toseptite can also offer benefits in managing diastolic heart failure, reduces deaths and preventing hospitalizations, and enhances energy expenditure, so help you to utilize your energy, and it is demonstrated to result in greater weight loss when compared to semi-glutite and less side effects.
55:31.523 --> 55:34.467
[SPEAKER_01]: So, that's why it's become more popular.
55:34.447 --> 55:43.887
[SPEAKER_01]: And a third one, also, is getting popular, it's caught right a true tide, so who knows, who got all these names.
55:44.388 --> 55:51.443
[SPEAKER_01]: It's nicknamed Triple G. So, this is where the misnomer, I think, Triple Agnes...
55:51.423 --> 55:54.846
[SPEAKER_01]: Well, it's triple, not GLP.
55:54.866 --> 55:56.388
[SPEAKER_01]: Some people think it's GLP3.
55:56.428 --> 55:58.330
[SPEAKER_01]: This is just, they have triple action.
55:58.710 --> 56:00.152
[SPEAKER_01]: So we're, we're the actions.
56:00.772 --> 56:03.255
[SPEAKER_01]: It acts on three key hormones.
56:03.275 --> 56:06.478
[SPEAKER_01]: So GLP1, GIP, and glucocone.
56:06.999 --> 56:13.005
[SPEAKER_01]: And that helps regulate appetite, improve metabolic function, and it has this fat burning.
56:13.685 --> 56:21.413
[SPEAKER_01]: And it spends study for weight loss and the management of metabolic conditions
56:21.393 --> 56:25.138
[SPEAKER_01]: It seems to be more effective for weight loss than terzepotide.
56:25.759 --> 56:44.987
[SPEAKER_01]: In some phase two trials, participants lost an average of up to 24% of their body weight over 48 weeks at the highest dose, and phase three data showed potential weight loss of nearly 29% over 68 weeks.
56:46.604 --> 56:51.349
[SPEAKER_01]: And it can also help regulate blood sugar and it's a level, of course, that's when they do.
56:51.509 --> 56:55.614
[SPEAKER_01]: It preserves lean muscle mass during weight loss.
56:55.654 --> 57:00.779
[SPEAKER_01]: Because that's one of the concerns people have is that you're losing not just your fat, but also your muscles.
57:01.240 --> 57:10.309
[SPEAKER_01]: But the reticutide actually helps you preserve your lean body mass, which is a major advantage over other weight loss methods.
57:10.890 --> 57:15.835
[SPEAKER_01]: It can also improve your lip profile, improve your blood pressure.
57:15.815 --> 57:19.241
[SPEAKER_01]: and partially reduced the risk of heart disease.
57:20.023 --> 57:29.980
[SPEAKER_01]: And more than 85% of participant pints with fatty liver disease saw liver fat levels return to normal in one study.
57:30.040 --> 57:32.625
[SPEAKER_01]: So that's phenomenal, right, 85%.
57:32.605 --> 57:35.910
[SPEAKER_01]: seeing the fat level going to normal.
57:36.211 --> 57:47.850
[SPEAKER_01]: And a phase three trial showed that participants with obesity and knee osteoarthritis experienced significant pain relief in addition to weight loss.
57:47.990 --> 57:52.217
[SPEAKER_01]: So they got benefits for their knee osteoarthritis as well.
57:52.197 --> 58:00.047
[SPEAKER_01]: Another two way loss peptides that are pretty interesting, one is called five amino, one MQ.
58:00.107 --> 58:03.472
[SPEAKER_01]: This one actually regulates your NAD pathway.
58:03.492 --> 58:12.183
[SPEAKER_01]: So, it will hurt a lot about NAD, how that helps with energy level of your cells and helps with longevity, addiction, etc.
58:12.644 --> 58:15.167
[SPEAKER_01]: So, this five amino, one MQ.
58:15.147 --> 58:33.747
[SPEAKER_01]: inhibits this substance called NNMT, which is upregulated, so it's increased in white adipose tissue as we age, and this particular NNMT level correlates with body fat, so with your waist circumference.
58:33.727 --> 58:40.796
[SPEAKER_01]: So this particular peptide, 5 amino 1MQ actually inhibits this particular molecule.
58:41.236 --> 58:47.384
[SPEAKER_01]: An animal study showed that there's significant decrease in adipose tissue and body weight in a short amount of time.
58:47.884 --> 58:52.690
[SPEAKER_01]: It also enhances mitochondria function and repairs mitochondria damage.
58:53.131 --> 59:03.463
[SPEAKER_01]: So I could love this, you know, with the the
59:03.443 --> 59:28.320
[SPEAKER_01]: So this five amino, what I'm Q, increases your basal metabolic rate, improves your metabolic rate and targets fat, especially abdominal fat and improves neuromuscular function and increase the ability for your muscle to contract through the same mechanism as inhibiting the NNMT.
59:28.300 --> 59:41.119
[SPEAKER_01]: And on top of delayed muscle soreness after intense high volume workout that the five amino one MQ can help, it can also help lower cellular senescence, so prevent the aging of your cells.
59:41.720 --> 59:52.215
[SPEAKER_01]: So it's also considered body recombosition peptide that helps with maximal fat loss and maximal muscle preservation.
59:52.195 --> 59:55.699
[SPEAKER_01]: similar to the growth hormone releasing peptides.
59:55.879 --> 59:58.302
[SPEAKER_01]: They are also body-recomposition peptides.
59:59.063 --> 01:00:03.929
[SPEAKER_01]: And the last one in the group of weight loss peptides is called melanotanone.
01:00:04.209 --> 01:00:08.053
[SPEAKER_01]: So this is a peptide that induces skin pigmentation.
01:00:08.213 --> 01:00:13.900
[SPEAKER_01]: So melanin, right, melanotan, it can enhance melanin production.
01:00:13.880 --> 01:00:22.109
[SPEAKER_01]: and melanin actually prevents cellular damage in skin by absorbing, reflecting, and refracting light.
01:00:24.151 --> 01:00:27.935
[SPEAKER_01]: When you use it in tanning, I can help enhance your tanning.
01:00:28.376 --> 01:00:39.448
[SPEAKER_01]: And then you can be used to profit-lactically treat certain skin disorders, and it also can help prevent skin cancer.
01:00:39.428 --> 01:00:57.859
[SPEAKER_01]: It reduces the sun damage to the skin that's exposed to UV light and transform the cells to produce dark protective melanin and it can be safely combined with UV be light or sunlight and appears to act synergistically in the tanning process.
01:00:57.839 --> 01:01:17.098
[SPEAKER_01]: It boost neurogenesis, so it's not just causing your skin to darken, but it can help your brain cells to repair and protect against cognitive declines in Alzheimer's disease in animal models and reduces neural inflammation and improves functional recovery after stroke.
01:01:17.739 --> 01:01:22.564
[SPEAKER_01]: It also improves heart recovery and survival after heart attack.
01:01:22.544 --> 01:01:25.750
[SPEAKER_01]: And, of course, assimilates fat burning.
01:01:26.110 --> 01:01:29.837
[SPEAKER_01]: So this is a very interesting peptide melanotan.
01:01:30.378 --> 01:01:35.747
[SPEAKER_01]: Thank you, darker, happy brain function better, and also make you skinnier.
01:01:36.809 --> 01:01:37.971
[SPEAKER_01]: The protection heart tube.
01:01:37.991 --> 01:01:42.659
[SPEAKER_01]: So the next one I want to talk about is a untie my microbial peptide.
01:01:42.739 --> 01:01:44.923
[SPEAKER_01]: It's called LL37.
01:01:44.903 --> 01:01:52.899
[SPEAKER_01]: So this particular peptide is known for his ability to protect you against microbes.
01:01:53.400 --> 01:02:05.764
[SPEAKER_01]: It's stored in neutrophil, granules as an inactive precursor and is released as mature peptides when the neutrophils get stimulated.
01:02:05.744 --> 01:02:25.153
[SPEAKER_01]: So, the LL-37 is expressed in various cells and tissues such as circulating neutrophils, so that's y-bless cells, and other bone marrow cells, epithelial cells, off the skin, in the GI track, as well as in your lungs.
01:02:25.133 --> 01:02:26.576
[SPEAKER_01]: The production of L.O.
01:02:26.596 --> 01:02:41.269
[SPEAKER_01]: 37 in macrophages is stimulated by vitamin D, which, of course, is released by sunlight to the skin, and has broad spectrum of antimicrobial activities.
01:02:41.249 --> 01:02:46.298
[SPEAKER_01]: But anyhow, so just one point about the Sunlight and Vitamin D and L-37, right?
01:02:46.318 --> 01:02:47.199
[SPEAKER_01]: This is all connected.
01:02:47.239 --> 01:02:48.381
[SPEAKER_01]: Sunlight is good for you.
01:02:48.421 --> 01:02:49.143
[SPEAKER_01]: Don't forget.
01:02:49.163 --> 01:02:56.355
[SPEAKER_01]: It helps you with Vitamin D and that can stimulate this peptide, L-37.
01:02:56.335 --> 01:03:09.579
[SPEAKER_01]: And this peptide has broad spectrum of activities against bacteria, viruses, fungi, and then can play an important role in regulating the balance of pro and anti-inflammatory molecules.
01:03:10.080 --> 01:03:18.816
[SPEAKER_01]: And it can promote wound healing, inhibit biofilm formations, so that's the layer of the secretions from bacteria.
01:03:18.796 --> 01:03:25.027
[SPEAKER_01]: And several studies showed that LL37 was effective in treating certain cancer types.
01:03:25.628 --> 01:03:29.474
[SPEAKER_01]: It can inhibit gastric cancer cell proliferation.
01:03:31.798 --> 01:03:40.593
[SPEAKER_01]: So, it's a very interesting molecule, you know, has its own place as commonly used, you know, people utilize it in Lyme disease, etc.
01:03:40.653 --> 01:03:43.538
[SPEAKER_01]: chronic, debilitating infections.
01:03:43.923 --> 01:03:52.576
[SPEAKER_01]: Okay, another two peptides that's related to sexual function or, you know, things related to the sexual hormones.
01:03:52.956 --> 01:04:02.450
[SPEAKER_01]: So one is PT1141, which I'm pretty sure has gotten famous because it induces rapid onsite onset of sexual arousal.
01:04:03.412 --> 01:04:05.355
[SPEAKER_01]: And it acts at the level of the brain.
01:04:05.795 --> 01:04:06.977
[SPEAKER_01]: So
01:04:06.957 --> 01:04:11.583
[SPEAKER_01]: centrally, it tells you to have a sexual response.
01:04:12.264 --> 01:04:18.772
[SPEAKER_01]: It increases libido, induces erection, in men, and also vaginal blood flow in women.
01:04:19.293 --> 01:04:28.324
[SPEAKER_01]: It increases erection in 80% of men who do not respond to medications like biagra or seales, seales.
01:04:28.304 --> 01:04:31.310
[SPEAKER_01]: and is a derivative of the melanotent two.
01:04:32.372 --> 01:04:39.806
[SPEAKER_01]: It can induce sexual arousal by binding to a melanocorten receptors in hypothalamus.
01:04:40.407 --> 01:04:43.053
[SPEAKER_01]: So it's because it's derived from this melanotent two.
01:04:43.574 --> 01:04:48.603
[SPEAKER_01]: There has been occasionally people reporting it promoting darkening of skin as well.
01:04:48.643 --> 01:04:49.485
[SPEAKER_01]: So that's something.
01:04:49.465 --> 01:05:03.200
[SPEAKER_01]: to remember, Melanetian II was originally tested as a senseless tanning agent, but also seemed to cause sexual arousal and spontaneous erection in nine out of ten original male volunteers.
01:05:03.481 --> 01:05:06.208
[SPEAKER_01]: So that's how they got the idea.
01:05:06.188 --> 01:05:07.830
[SPEAKER_01]: Right, the men tend to.
01:05:08.431 --> 01:05:15.281
[SPEAKER_01]: And then they were trying to find out how can we tweak the molecule so it doesn't cause Darkening of the skin.
01:05:15.681 --> 01:05:18.145
[SPEAKER_01]: So that's how PT1-41 came about.
01:05:18.205 --> 01:05:29.140
[SPEAKER_01]: So it's actually have to be approved for a women and it increases the chance of women having a sexually gratifying experience.
01:05:29.160 --> 01:05:32.365
[SPEAKER_01]: So it increases the chance by 50%.
01:05:32.345 --> 01:05:37.091
[SPEAKER_01]: So that you can also take as an injectable or a nasal spray.
01:05:37.332 --> 01:05:47.125
[SPEAKER_01]: Of course, some people find the nasal spray to be a little more spontaneous than pulling out your needle and and doing injection about half an hour before sexual activity.
01:05:47.686 --> 01:05:48.887
[SPEAKER_01]: So everyone differs.
01:05:49.168 --> 01:05:53.934
[SPEAKER_01]: Some people may respond within half an hour, some people two hours.
01:05:54.415 --> 01:05:59.061
[SPEAKER_01]: So, you know, experiment to see what and how it works for you.
01:05:59.041 --> 01:06:05.029
[SPEAKER_01]: And another peptide that's related to sex hormones is called kiss peptin.
01:06:05.430 --> 01:06:09.856
[SPEAKER_01]: So this is actually a neural peptide secreted by hypothalamus.
01:06:09.876 --> 01:06:20.290
[SPEAKER_01]: It stimulates the nanoshope and releasing hormone to increase LH and FSH, which then triggers the release of estrogen, progesterone, and testosterone.
01:06:20.270 --> 01:06:23.014
[SPEAKER_01]: so it helps stimulate sexual arousal.
01:06:23.595 --> 01:06:30.686
[SPEAKER_01]: It can boost fertility and also cycle sexual mental health issues related to conception.
01:06:31.207 --> 01:06:42.885
[SPEAKER_01]: And it's been researched as a potential alternative to HCG infertility treatment, so HCG has been used for a long time, but this has been considered as an alternative.
01:06:42.865 --> 01:06:58.282
[SPEAKER_01]: increases both basal and HCG-stimulated progesterone secretion in the uterus and increases liver-antioxidins, boost, insulin secretion, and temporarily increases oxytocin.
01:06:58.322 --> 01:07:05.770
[SPEAKER_01]: So make you feel good, give you more sex hormones and stimulates sexual arousal and can boost or fertility.
01:07:05.870 --> 01:07:06.831
[SPEAKER_01]: So that's kiss pattern.
01:07:06.811 --> 01:07:19.771
[SPEAKER_01]: And the very last one I'm going to talk about is a ascetic peptide, generally considered an ascetic peptide, but it has a lot of other incredible benefits, but this one is the famous GHK copper.
01:07:19.811 --> 01:07:24.739
[SPEAKER_01]: So GHK copper is a copper peptide, first identified in the human plasma.
01:07:25.981 --> 01:07:27.503
[SPEAKER_01]: It's level decreases with age.
01:07:27.483 --> 01:07:33.894
[SPEAKER_01]: like every other good thing in life and it results in increased inflammation except for wisdom.
01:07:35.016 --> 01:07:41.407
[SPEAKER_01]: Resulting increased inflammation, cancers, activities, and tissue destruction.
01:07:42.028 --> 01:07:49.761
[SPEAKER_01]: So the more damage inflammation you have, the less GHA copper you're going to have, and it's generated after tissue injury.
01:07:50.146 --> 01:08:00.637
[SPEAKER_01]: is a powerful protector against injury and inflammation and it reduces oxidative damages that can occur after an injury.
01:08:00.657 --> 01:08:08.186
[SPEAKER_01]: It promotes wound healing by removing damaged and scarred tissue and generate new healthy tissue.
01:08:08.846 --> 01:08:15.073
[SPEAKER_01]: Estimulate collagen synthesis in skin fibroblast
01:08:15.053 --> 01:08:23.565
[SPEAKER_01]: But when it's used as a topical, it can increase collagen production by 70% and decrease fine lines and wrinkles by 27%.
01:08:23.605 --> 01:08:35.341
[SPEAKER_01]: So it can tighten loose skin and reverse thinning of old skin aged skin and improve skin firmness, elasticity and clarity.
01:08:36.263 --> 01:08:43.052
[SPEAKER_01]: It helps repair protective skin barriers and reduces photodamage.
01:08:43.032 --> 01:08:46.095
[SPEAKER_01]: hyperpigmentation and skin spots and lesions.
01:08:46.696 --> 01:09:09.158
[SPEAKER_01]: It can also reduce hair loss, increase hair growth and thickness in large hair follicle size, and then in addition to these aesthetic benefits, it can also help with lung health, liver health, promote bone repair, it can fight different cancer
01:09:09.138 --> 01:09:14.647
[SPEAKER_01]: regeneration fights anxiety and combat cognitive dysfunction.
01:09:15.108 --> 01:09:17.211
[SPEAKER_01]: So this is an amazing peptide.
01:09:17.632 --> 01:09:21.959
[SPEAKER_01]: So we also have it in both injectable form or in a serum.
01:09:22.420 --> 01:09:24.343
[SPEAKER_01]: Sometimes we combine that with exosomes.
01:09:24.583 --> 01:09:27.568
[SPEAKER_01]: It's great for micro-needling, you know, that micro-needling.
01:09:27.548 --> 01:09:41.196
[SPEAKER_01]: it's going to trigger more repairative processes so when you cause a controlled micro injury and then you add that with signals, it can trigger the cells to repair more effectively.
01:09:42.398 --> 01:09:48.190
[SPEAKER_01]: In addition to triggering your body's own repair mechanism, then you're amplifying the benefits.
01:09:48.170 --> 01:09:51.518
[SPEAKER_01]: So that's the GHK copper.
01:09:51.798 --> 01:09:58.313
[SPEAKER_01]: And of course, I put this peptide into my skin cream that I formulated, Cachara, on me.
01:09:58.714 --> 01:10:05.470
[SPEAKER_01]: So the the cream not only has GHK copper has other peptides, not really good for skin regeneration.
01:10:05.450 --> 01:10:15.204
[SPEAKER_01]: and has all the beneficial elements from a local core drive stem cells and a bunch of herbal extracts and antioxidants and pre-bottics.
01:10:15.604 --> 01:10:18.589
[SPEAKER_01]: So that is a cream that's incredible for skin repair.
01:10:19.029 --> 01:10:33.870
[SPEAKER_01]: If anybody's really interested in a, from just really a potent, potent cream that's really, really clean because I do, I make sure that there's no synthetic ingredients in there,
01:10:33.850 --> 01:10:42.443
[SPEAKER_01]: So there's nothing synthetic, nothing that can potentially cause issues with your hormones and your own cellular health.
01:10:42.904 --> 01:10:47.971
[SPEAKER_01]: So a very, very clean, but very potent cream.
01:10:48.091 --> 01:10:50.475
[SPEAKER_01]: So a lot of people actually use this cream.
01:10:50.455 --> 01:11:03.474
[SPEAKER_01]: to do micro-needling so that then you're driving this nutrient and all the nutrients even deeper because of micro-needling you're slightly penetrating the skin barrier.
01:11:03.794 --> 01:11:10.183
[SPEAKER_01]: So that's GHK copper and how I've used it and very helpful peptide.
01:11:10.423 --> 01:11:17.914
[SPEAKER_01]: That's also good for hair growth so when I produced our hair formula definitely this copper peptide will be included as well.
01:11:17.894 --> 01:11:34.940
[SPEAKER_01]: So that's it for my session on the peptides that we utilize at our clinic and the most some of the most popular and commonly used peptides by holistic practitioners.
01:11:35.241 --> 01:11:37.945
[SPEAKER_01]: So people asked a lot,
01:11:39.123 --> 01:11:46.112
[SPEAKER_01]: It's not as easy, so there's a huge controversy about peptides and what's allowed, what's not allowed.
01:11:47.234 --> 01:11:52.681
[SPEAKER_01]: But the good thing is that a lot of them have been approved by the FDA.
01:11:53.602 --> 01:12:03.375
[SPEAKER_01]: And there's a lot of safety and efficacy studies behind these peptides, especially these
01:12:04.418 --> 01:12:06.362
[SPEAKER_01]: most insurance companies will not cover this.
01:12:07.425 --> 01:12:10.692
[SPEAKER_01]: So just like a lot of really wonderful therapies are not covered.
01:12:10.833 --> 01:12:12.216
[SPEAKER_01]: Your supplements are not covered.
01:12:12.877 --> 01:12:23.642
[SPEAKER_01]: And a lot of the really really wonderful therapies save and effective proven by research are not approved not covered.
01:12:23.622 --> 01:12:47.678
[SPEAKER_01]: So this same category, this is how changes are made, this is how we change medicine is by utilizing and paving away and showing the data and showing what has been happening using these modalities and whether, you know, new uses also discovered by experiments like this.
01:12:47.939 --> 01:12:50.102
[SPEAKER_01]: This is considered a type of experiment.
01:12:50.082 --> 01:12:55.554
[SPEAKER_01]: peptides, you're using this because it's not FDA-approved, then is considered an experiment.
01:12:55.915 --> 01:13:08.243
[SPEAKER_01]: So, I'm experimenting on myself every day and so are a lot of biohackers in a lot of people who are seeking relief of their symptoms.
01:13:08.223 --> 01:13:13.215
[SPEAKER_01]: So, I hope you found this helpful, and I hope you find it fascinating.
01:13:13.837 --> 01:13:24.763
[SPEAKER_01]: This peptide branch of medicine is really exciting because we can't really use a fine tuned
01:13:24.743 --> 01:13:32.053
[SPEAKER_01]: Later beam, in a sense, to target where what biological function we want to affect in the human body.
01:13:32.113 --> 01:13:34.997
[SPEAKER_01]: So that's it for today and thank you so much.
01:13:35.257 --> 01:13:40.023
[SPEAKER_01]: Feel free to contact our clinic if you're interested in Charles Health in Los Angeles.
01:13:40.484 --> 01:13:47.653
[SPEAKER_01]: We can do virtual consultations throughout the country, and we can individualize what you need.
01:13:47.854 --> 01:13:48.895
[SPEAKER_01]: Because
01:13:48.875 --> 01:13:54.843
[SPEAKER_01]: There's so much nuances to what a person may need depending on their own body.
01:13:55.263 --> 01:14:10.302
[SPEAKER_01]: So, we'll help you navigate and you can find us at charra-health.com and or the phone number is A18356-A232 and I hope you really enjoyed this and are inspired and you're going to get some help.
01:14:10.402 --> 01:14:18.072
[SPEAKER_01]: If you're dealing with any issues, get some help from these remarkable peptides and share it with your friends and family.
01:14:18.052 --> 01:14:19.354
[SPEAKER_01]: Okay, bye now.
01:14:19.654 --> 01:14:32.372
[SPEAKER_00]: Thank you for listening to this episode, hope you enjoy the content, and if so, please rate and follow this podcast to reach me, you can contact uplift longevity center, and that is uplift with a Y.
01:14:32.613 --> 01:14:36.378
[SPEAKER_00]: You can also subscribe to my YouTube channel, Joy Kong, MD.
01:14:36.799 --> 01:14:37.680
[SPEAKER_00]: See you next time!