# Gene Silencing
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gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene. gene silencing can occur during either transcription or translation and is often used in research. In particular, methods used to silence genes are being increasingly used to produce therapeutics to combat cancer and other diseases, such as infectious diseases and neurodegenerative disorders.
Gene Silencing Driving Drug Development for Rare Diseases with Dietrich Stephan NeuBase Therapeutics TRANSCRIPT
Dietrich Stephan PhD, CEO, NeuBase Therapeutics discusses the history of research into the genetic basis of all diseases, NeuBase's PATrOL™ platform allowing for intelligent design of drugs that engage with a malfunctioning gene, and the company's therapies in development for Huntington's disease a…
Interview with Cozzarelli Prize Winner John Rossi
"MicroRNA-directed transcriptional gene silencing in mammalian cells"
Effects of DNA Methylation on Chromatin Structure and Transcription (Dirk Schübeler)
In this episode of the Epigenetics Podcast, we caught up with Dr. Dirk Schübeler, Director of the Friedrich Miescher Institute (FMI) in Basel, Switzerland, to talk about his work on the effects of DNA methylation on chromatin structure and transcription.
Dirk Schübeler was born in Germany and s…
Alnylam, gene-silencing and biotech in 2020: the pharmaphorum podcast
Anlnylam’s Brendan Martin joined the pharmaphorum podcast for episode 23 to talk about his company’s work in gene-silencing and how it could offer a route to target the current coronavirus pandemic.
CpG Islands, DNA Methylation, and Disease (Adrian Bird)
In this episode of the Epigenetics Podcast, we caught up with Sir Adrian Bird, Buchanan Professor of Genetics at the University of Edinburgh to talk about his work on CpG islands, DNA methylation, and the role of DNA methylation in human diseases.
Adrian Bird has been a pioneer in studying the …
Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.07.20.211573v1?rss=1
Authors: Pacini, G., Dunkel, I., Mages, N., Mutzel, V., Timmermann, B., Marsico, A., Schulz, E. G.
Abstract:
To ensure dosage compensation between the sexes, one randomly chosen X chromosome is silenced in eac…
Mature MicroRNAs Trigger RNA Interference-Like Gene Silencing in Zebrafish, Chicken and Mice
Creative Biolabs files technical advances and professional academic reports on mRNA therapy and puts them in a podcast column.
Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab
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Webinar on the strategy and preliminary results for “AAV-mediated Gene Silencing for the Treatment of Alexander Disease” presented by Drs. Guangping Gao, Jun Xie, and Dominic Gessler from the University of Massachusetts Medical School. This version is audio only - the full video ve…
A Closer Look At Lecanemab Donanemab And Amyloid
In this podcast Dr Anna Volkmer, convenes a panel of world-renowned experts from University College London. They discuss the discovery of amyloid and its role in Alzheimer’s Disease and take an in-depth look into the latest developments surrounding Lecanemab and Donanemab, monoclonal antibodies (mA…
Essentials: Genes & the Inheritance of Memories Across Generations | Dr. Oded Rechavi
In this Huberman Lab Essentials episode, my guest is Dr. Oded Rechavi, a professor at Tel Aviv University who studies genetics, epigenetics and the inheritance of acquired traits. We discuss how DNA, RNA and epigenetic mechanisms determine what information can pass between generations, and why acqu…
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